TNSN94030A1 - Derives de la cephalosporine, compositions pharmaceutiques les contenant et procede de fabrication - Google Patents

Derives de la cephalosporine, compositions pharmaceutiques les contenant et procede de fabrication

Info

Publication number
TNSN94030A1
TNSN94030A1 TNTNSN94030A TNSN94030A TNSN94030A1 TN SN94030 A1 TNSN94030 A1 TN SN94030A1 TN TNSN94030 A TNTNSN94030 A TN TNSN94030A TN SN94030 A TNSN94030 A TN SN94030A TN SN94030 A1 TNSN94030 A1 TN SN94030A1
Authority
TN
Tunisia
Prior art keywords
hydrogen
nukethyl
arylyukyl
cephalosporin derivatives
aralkyl
Prior art date
Application number
TNTNSN94030A
Other languages
English (en)
Inventor
Angehrn Peter
Wei Chung-Chen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TNSN94030A1 publication Critical patent/TNSN94030A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LES DERIVES DE LA CEPHALOSPORINE DE LA FORMULE GENERALE (I) DANS LAQUELLE R1 EST UN GROUPE ACYLE DERIVE D'UN ACIDE CARBOXYLIQUE ; R2 EST DE L'HYDROGENE, UN RADICAL HYDROXY, ALKYLE INFERIEUR-Qm, CYCLOALKYLE, ALKOXY INFERIEUR, ALCENYLE INFERIEUR, CYCLOALCENYLE, ALCYNYLE INFERIEUR, ARALKYL-Qm, ARYL-Qm, ARYLOXY, ARALKOXY OU UN NOYAU HETEROCYCLIQUE, LES GROUPE ALKYLE INFERIEUR, CYCLOALKYLE, ALKOXY INFERIEUR, ALCENYLE INFERIEUR, CYCLOALCENYLE, ALCYNYLE INFERIEUR, ARALKYLE, ARYLE, ARYLOXY, ARALKOXY ET LE NOYAU HETEROCYCLIQUE ETANT NON SUBSTITUE OU SUBSTITUE PAR AU MOINS UN GROUPE CHOISI PARMI LES RADICAUX CARBOXY, AMINO, NITRO, CYANO, ALKYLE INFERIEUR, ALKOXY INFERIEUR, HYDROXY, HALOGNE, CONR4R5- N(R5)COOR9-, R50C0- OU R5COO- OU R4 EST DE L'HYDROGENE, UN ALKYLE INFERIEUR OU UN CYCLOALKYLE ; R5 EST DE L'HYDROGENE OU UN ALKYLE INFERIEUR ; R9 EST DE L'HYDROGENE, UN ALKYLE INFERIEUR, UN ALCENYLE INFERIEUR OU UN GROUPE PROTECTEUR D'ACIDE CARBOXYLIQUE ; Q EST -CO- OU - SO2- ; m EST 0 OU 1 ; n EST 0, 1 OU 2 ; AINSI QUE LEURS ESTERS FACILEMENT HYDROLYSABLES, LES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CES COMPOSES ET LES HYDRATES DES COMPOSES DE FORMULE I ET DE LEURS ESTERS AINSI QUE DE LEURS SELS. LES PRODUITS SONT ACTIFS DU POINT DE VUE BACTERICIDE
TNTNSN94030A 1993-04-16 1994-04-13 Derives de la cephalosporine, compositions pharmaceutiques les contenant et procede de fabrication TNSN94030A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4868893A 1993-04-16 1993-04-16
US08/213,562 US5523400A (en) 1993-04-16 1994-03-21 Cephalosporin antibiotics

Publications (1)

Publication Number Publication Date
TNSN94030A1 true TNSN94030A1 (fr) 1995-04-25

Family

ID=21955891

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN94030A TNSN94030A1 (fr) 1993-04-16 1994-04-13 Derives de la cephalosporine, compositions pharmaceutiques les contenant et procede de fabrication

Country Status (7)

Country Link
US (1) US5523400A (fr)
KR (1) KR100309516B1 (fr)
EC (1) ECSP941068A (fr)
RO (1) RO114965B1 (fr)
TN (1) TNSN94030A1 (fr)
UY (1) UY23757A1 (fr)
YU (1) YU19494A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812323A1 (fr) * 1995-02-27 1997-12-17 F. Hoffmann-La Roche Ag Derives de 3-pyrrolidylidene-2-one-cephalosporines
US5804577A (en) * 1995-09-12 1998-09-08 Hoffmann-La Roche Inc. Cephalosporin derivatives
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
TW446707B (en) * 1996-10-22 2001-07-21 Hoffmann La Roche Cephalosporin pyridinium derivatives
EP0841339B1 (fr) 1996-11-06 2007-02-21 Basilea Pharmaceutica AG Dérivés de vinylpyrrolidone-céphalosporine
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
US6114541A (en) * 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
ID28433A (id) * 1998-06-22 2001-05-24 Hoffmann La Roche Turunan propenil sefalosporin
US6384214B1 (en) 1999-07-05 2002-05-07 Basilea Pharmaceutica Ag Process for producing cephalosporin derivatives
US7662955B2 (en) * 2003-03-20 2010-02-16 Orchid Chemicals And Pharmaceuticals Ltd. Process for the preparation of cefoxitin
US7105659B2 (en) * 2003-06-02 2006-09-12 Aurobind - Pharma Ltd. Process for preparing cefdinir
US20090214600A1 (en) * 2008-02-25 2009-08-27 Debrouse Daniel R Methods and compositions for gastric resistant oral formulations for intestinal delivery
EP2862569A1 (fr) 2011-09-09 2015-04-22 Cubist Pharmaceuticals, Inc. Procédés pour traiter des infections intrapulmonaires
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
BR112015023523B8 (pt) 2013-03-15 2023-03-07 Merck Sharp & Dohme Composições farmacêuticas e recipiente de forma de dosagem única
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
AU2014233637A1 (en) 2013-09-09 2015-03-26 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN105418641B (zh) * 2015-12-30 2018-08-10 广东金城金素制药有限公司 一种原研制品质头孢曲松钠及其药物制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496562A (en) * 1977-03-14 1985-01-29 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-cephem-4-carboxylic acid esters
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
CA1213882A (fr) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporines
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
US5171854A (en) * 1987-05-26 1992-12-15 Bayer Aktiengesellschaft Substituted vinylcephalosporins
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
ES2185634T3 (es) * 1993-04-16 2003-05-01 Basilea Pharmaceutica Ag Derivados de cefalosporina.

Also Published As

Publication number Publication date
RO114965B1 (ro) 1999-09-30
YU19494A (sh) 1998-05-15
UY23757A1 (es) 1994-10-03
ECSP941068A (es) 1994-11-16
US5523400A (en) 1996-06-04
KR100309516B1 (ko) 2006-05-25

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