HUP0103778A2 - Eljárás 1,5-diaril-3-szubsztituált pirazolok előállítására - Google Patents

Eljárás 1,5-diaril-3-szubsztituált pirazolok előállítására

Info

Publication number
HUP0103778A2
HUP0103778A2 HU0103778A HUP0103778A HUP0103778A2 HU P0103778 A2 HUP0103778 A2 HU P0103778A2 HU 0103778 A HU0103778 A HU 0103778A HU P0103778 A HUP0103778 A HU P0103778A HU P0103778 A2 HUP0103778 A2 HU P0103778A2
Authority
HU
Hungary
Prior art keywords
group
general formula
formula
compound
way
Prior art date
Application number
HU0103778A
Other languages
English (en)
Inventor
Ahmed F. Abdel-Magid
Bruce D. Harris
Cynthia A. Maryanoff
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of HUP0103778A2 publication Critical patent/HUP0103778A2/hu
Publication of HUP0103778A3 publication Critical patent/HUP0103778A3/hu
Publication of HU228678B1 publication Critical patent/HU228678B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/083—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A találmány (I) általános képletű 1,5-diaril-3-szubsztituáltpirazolszármazékok előállítására vonatkozik. Az (I) általánosképletben R1, R2, R3 és R4 azonos vagy eltérő jelentésselhidrogénatomot, halogénatomot, alkilcsoportot, alkoxicsoportot,aminocsoportot, acetamidocsoportot, fenilcsoportot, hidroxilcsoportot,alkilszulfonilcsoportot, alkiltiocsoportot, nitrocsoportot,trifluormetilcsoportot vagy omega-trifluormetil-alkoxicsoportot jelentvagy R1 és R2 vagy R3 és R4 azzal a fenilcsoporttal, amelyhezkapcsolódnak, adott esetben szubsztituált naftilcsoportot alkotnak. Atalálmány értelmében úgy járnak el, hogy valamely (II) általánosképletű vegyületet - a képletben R3 és R4 jelentése a fenti -borostyánkő-savanhidriddel és egy alkoholát típusú bázissalreagáltatnak, majd egy így kapott (III) általános képletű vegyületet -a képletben R3 és R4 jelentése a fenti - valamely (IV) általánosképletű vegyülettel - a képletben R1 és R2 jelentése a fenti -reagáltatnak, ezután egy így kapott (V) általános képletű vegyületet -a képletben R1, R2, R3 és R4 jelentése a fenti - valamely ROHáltalános képletű alkohollal - a képletben R jelentése alkilcsoportvagy cikloalkilcsoport - reagáltatnak, és egy így kapott (VI)általános képletű észtert - a képletben R1, R2, R3, R4, és R jelentésea fenti - N<metilhidroxilamin-hidrokloriddal és egy bázissalreagáltatnak. Ó
HU0103778A 1999-08-03 2000-08-01 Process for preparing 1,5-diaryl-3-substituted pyrazoles HU228678B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14699799P 1999-08-03 1999-08-03
PCT/US2000/020917 WO2001009102A2 (en) 1999-08-03 2000-08-01 Process for preparing 1,5-diaryl-3-substituted pyrazoles

Publications (3)

Publication Number Publication Date
HUP0103778A2 true HUP0103778A2 (hu) 2002-05-29
HUP0103778A3 HUP0103778A3 (en) 2002-07-29
HU228678B1 HU228678B1 (en) 2013-05-28

Family

ID=22519936

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103778A HU228678B1 (en) 1999-08-03 2000-08-01 Process for preparing 1,5-diaryl-3-substituted pyrazoles

Country Status (26)

Country Link
US (4) US6384233B1 (hu)
EP (2) EP1144382B1 (hu)
JP (2) JP4886951B2 (hu)
KR (1) KR100646883B1 (hu)
CN (1) CN1219771C (hu)
AR (1) AR032589A1 (hu)
AT (2) ATE281437T1 (hu)
AU (2) AU779353B2 (hu)
BR (1) BR0006978B1 (hu)
CA (2) CA2636755C (hu)
CZ (2) CZ299710B6 (hu)
DE (2) DE60015496T2 (hu)
DK (1) DK1413575T3 (hu)
ES (2) ES2232482T3 (hu)
HK (1) HK1040081B (hu)
HU (1) HU228678B1 (hu)
IL (2) IL142341A0 (hu)
MY (1) MY122496A (hu)
NO (1) NO318467B1 (hu)
NZ (1) NZ510890A (hu)
PL (1) PL201799B1 (hu)
PT (2) PT1413575E (hu)
RU (1) RU2243967C2 (hu)
TW (1) TWI234562B (hu)
WO (1) WO2001009102A2 (hu)
ZA (1) ZA200103533B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1413575E (pt) * 1999-08-03 2006-12-29 Ortho Mcneil Pharm Inc Processo para a preparação derivados de ácido (1, 5-diaril) pirazol-3-il]propanóico
JP2006522164A (ja) * 2003-04-03 2006-09-28 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体−５のジアリール置換ピラゾール修飾因子
MXPA06003121A (es) * 2003-08-19 2006-06-27 Day Glo Color Corp Colorantes polimericos.
EP2805957A1 (de) 2013-05-23 2014-11-26 hameln rds gmbh Kristalline Formen von Trinatrium-Zink-Diethylen-triaminpentaessigsäure
CN111018785B (zh) * 2019-12-26 2022-02-11 武汉科技大学 一种1-（4-氯苯基）-3-吡唑醇的合成方法及应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164381A (en) 1986-05-29 1992-11-17 Ortho Pharmaceutical Corporation Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
US4826868A (en) * 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
US5078780A (en) 1986-10-22 1992-01-07 Ciba-Geigy Corporation 1,5-diphenylpyrazole-3-carboxylic acid derivatives for the protection of cultivated plants
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
US4898952A (en) * 1987-05-29 1990-02-06 Ortho Pharmaceutical Corporation Regioselective synthesis of a 1,5-disubstituted pyrazole
JPH0699382B2 (ja) * 1987-06-17 1994-12-07 富士写真フイルム株式会社 Ｎ−メチル−α−ジアルキルアミノアセトヒドロキサム酸誘導体
US5130421A (en) * 1988-03-24 1992-07-14 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US4896952A (en) * 1988-04-22 1990-01-30 International Business Machines Corporation Thin film beamsplitter optical element for use in an image-forming lens system
US5154381A (en) * 1988-12-02 1992-10-13 Malinao Michael M Microphone boom holder
US5032588A (en) * 1989-12-08 1991-07-16 Abbott Laboratories Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
US5117054A (en) * 1991-09-26 1992-05-26 Ortho Pharmaceutical Corporation N-hydroxy, N-methyl propanamides
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5387602A (en) 1993-08-30 1995-02-07 Ortho Pharmaceutical Corporation 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
US5412151A (en) * 1993-10-22 1995-05-02 Eastman Chemical Company Thermosetting coating compositions
JPH0944014A (ja) * 1995-08-03 1997-02-14 Canon Inc 加熱用フィルム、加熱加圧部材、加熱装置及び画像形成装置
US5843958A (en) * 1996-11-27 1998-12-01 Ortho Pharmaceutical Corporation Arylpyrazoles as leukotriene inhibitors
PT1413575E (pt) * 1999-08-03 2006-12-29 Ortho Mcneil Pharm Inc Processo para a preparação derivados de ácido (1, 5-diaril) pirazol-3-il]propanóico

Also Published As

Publication number Publication date
ATE342254T1 (de) 2006-11-15
EP1413575B1 (en) 2006-10-11
HK1040081B (zh) 2005-05-13
WO2001009102A3 (en) 2001-08-16
EP1413575A2 (en) 2004-04-28
NO20011652L (no) 2001-05-23
ZA200103533B (en) 2002-05-02
CA2636755A1 (en) 2001-02-08
CN1337951A (zh) 2002-02-27
JP4886951B2 (ja) 2012-02-29
US20040230060A1 (en) 2004-11-18
CZ299710B6 (cs) 2008-10-29
EP1144382A2 (en) 2001-10-17
ATE281437T1 (de) 2004-11-15
CZ20011202A3 (cs) 2001-09-12
US20060004208A1 (en) 2006-01-05
CA2346142C (en) 2008-10-14
DE60031315D1 (de) 2006-11-23
KR20010075571A (ko) 2001-08-09
NO318467B1 (no) 2005-03-21
US20020128487A1 (en) 2002-09-12
PT1413575E (pt) 2006-12-29
ES2274171T3 (es) 2007-05-16
EP1144382B1 (en) 2004-11-03
EP1144382A3 (en) 2002-09-11
BR0006978A (pt) 2001-06-19
JP2003506359A (ja) 2003-02-18
US6613914B2 (en) 2003-09-02
CZ299711B6 (cs) 2008-10-29
PL347025A1 (en) 2002-03-11
AU6752600A (en) 2001-02-19
PL201799B1 (pl) 2009-05-29
HU228678B1 (en) 2013-05-28
CN1219771C (zh) 2005-09-21
DK1413575T3 (da) 2006-12-27
US20020032336A1 (en) 2002-03-14
AU2005201660A1 (en) 2005-05-12
HUP0103778A3 (en) 2002-07-29
PT1144382E (pt) 2005-02-28
DE60031315T2 (de) 2007-04-26
TWI234562B (en) 2005-06-21
RU2243967C2 (ru) 2005-01-10
US7247745B2 (en) 2007-07-24
JP2012051929A (ja) 2012-03-15
DE60015496D1 (de) 2004-12-09
CA2636755C (en) 2010-10-19
US6953860B2 (en) 2005-10-11
IL171712A (en) 2010-04-29
IL142341A0 (en) 2002-03-10
CA2346142A1 (en) 2001-02-08
HK1040081A1 (en) 2002-05-24
AU779353B2 (en) 2005-01-20
ES2232482T3 (es) 2005-06-01
EP1413575A3 (en) 2004-10-06
MY122496A (en) 2006-04-29
US6384233B1 (en) 2002-05-07
NZ510890A (en) 2003-09-26
WO2001009102A2 (en) 2001-02-08
DE60015496T2 (de) 2005-10-27
NO20011652D0 (no) 2001-04-02
BR0006978B1 (pt) 2010-11-30
AR032589A1 (es) 2003-11-19
EP1413575A9 (en) 2005-06-29
KR100646883B1 (ko) 2006-11-17

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