AU2106000A - Method for producing robenidine or derivatives thereof - Google Patents
Method for producing robenidine or derivatives thereofInfo
- Publication number
- AU2106000A AU2106000A AU21060/00A AU2106000A AU2106000A AU 2106000 A AU2106000 A AU 2106000A AU 21060/00 A AU21060/00 A AU 21060/00A AU 2106000 A AU2106000 A AU 2106000A AU 2106000 A AU2106000 A AU 2106000A
- Authority
- AU
- Australia
- Prior art keywords
- alcohol
- general formula
- water mixture
- robenidine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a novel method for producing robenidine or derivatives thereof of general formula (I) wherein X means a halogen atom, using hydrazine hydrate and a cyanogen compound as the starting materials. The two educts are first converted into a diaminoguanidine of general formula (III) in a C1-4 alcohol or a C1-4 alcohol-water mixture as the solvent or in an aprotic polar organic solvent, Y being a halogen atom or tosyl. Said diaminoguanidine is then directly reacted with a p-halobenzaldehyde of general formula (IV) without isolation in a C1-4 alcohol, a C1-4 alcohol-water mixture or in an aprotic polar organic solvent-water mixture as the solvent to form the end product.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100097 | 1999-01-06 | ||
EP99100097 | 1999-01-06 | ||
US14610799P | 1999-07-29 | 1999-07-29 | |
US60146107 | 1999-07-29 | ||
PCT/EP2000/000050 WO2000040549A1 (en) | 1999-01-06 | 2000-01-05 | Method for producing robenidine or derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2106000A true AU2106000A (en) | 2000-07-24 |
Family
ID=56289987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU21060/00A Abandoned AU2106000A (en) | 1999-01-06 | 2000-01-05 | Method for producing robenidine or derivatives thereof |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1140806B1 (en) |
AT (1) | ATE241596T1 (en) |
AU (1) | AU2106000A (en) |
ES (1) | ES2199762T3 (en) |
WO (1) | WO2000040549A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105030744B (en) | 2015-07-09 | 2019-04-19 | 广州英赛特生物技术有限公司 | Application of the substituted benzene guanidine derivatives as polymyxins antibiotic synergist |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA927394A (en) * | 1968-07-01 | 1973-05-29 | American Cyanamid Company | Substituted guanidines, compositions and method of preparation |
US4575560A (en) * | 1985-02-25 | 1986-03-11 | American Cyanamid Company | Insecticidal diaminoguanidine hydrazone compounds |
-
2000
- 2000-01-05 AU AU21060/00A patent/AU2106000A/en not_active Abandoned
- 2000-01-05 ES ES00901065T patent/ES2199762T3/en not_active Expired - Lifetime
- 2000-01-05 AT AT00901065T patent/ATE241596T1/en not_active IP Right Cessation
- 2000-01-05 EP EP00901065A patent/EP1140806B1/en not_active Expired - Lifetime
- 2000-01-05 WO PCT/EP2000/000050 patent/WO2000040549A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1140806A1 (en) | 2001-10-10 |
EP1140806B1 (en) | 2003-05-28 |
ES2199762T3 (en) | 2004-03-01 |
WO2000040549A1 (en) | 2000-07-13 |
ATE241596T1 (en) | 2003-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL359183A1 (en) | Novel triazolo pyrimidine compounds | |
DE60300986D1 (en) | PROCESS FOR PREPARING A PHARMACEUTICALLY ACTIVE COMPOUND (GRANISETRON) | |
TW200619201A (en) | Process for the preparation of pyrazoles | |
UA85428C2 (en) | Process for the preparation of c-2, c-3 substituted n-alkylated indoles, intemdiates and process for the preparation thereof | |
PL356929A1 (en) | Process for the synthesis of a known tetrazol derivative | |
AU2106000A (en) | Method for producing robenidine or derivatives thereof | |
DE60112325D1 (en) | CYCLISATION PROCESS STEP IN THE PREPARATION OF CHINOLONES AND NAPHTHYRIDINES | |
TW200740763A (en) | A method for preparing 5-hydroxy-1-alkyl pyrazole derivatives | |
AP2001002194A0 (en) | Novel process for the preparation of pyrazolopyrimidinones. | |
KR20090094025A (en) | Process for the preparation of abacavir | |
IL145449A0 (en) | Processes for preparing pesticidal intermediates | |
AU2003242896A1 (en) | Solvent-free process for the preparation of diketopyrrolopyrrole derivatives | |
EP1092720A3 (en) | Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof | |
NZ513551A (en) | Novel process for preparing alendronic acid | |
Lyubov’N et al. | Hydroamination of 2-ethynyl-4, 5, 6, 7-tetrahydroindoles: Toward 2-substituted amino derivatives of indole | |
RS40804A (en) | Process for reacting alkaloids and use of the reaction products in the preparation of medicaments | |
GB0222426D0 (en) | Chemical process | |
CA2471666A1 (en) | An improved process for the preparation of oxcarbazepine and related intermediates | |
DK1250335T3 (en) | Process and intermediates for the preparation of imidazopyridines | |
Lee et al. | Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates | |
GB2425309A (en) | C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers | |
CA2005596A1 (en) | Preparation of 2-amino-4-fluoropyrimidine derivatives | |
DK1023272T3 (en) | Process for the preparation of alkoxytriazolinones | |
AU2004309056A1 (en) | Process for the preparation of triazolopyrimidines | |
Cui et al. | Visible-light promoted N-aminoalkylation of quinazolinones |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |