AU2106000A - Method for producing robenidine or derivatives thereof - Google Patents

Method for producing robenidine or derivatives thereof

Info

Publication number
AU2106000A
AU2106000A AU21060/00A AU2106000A AU2106000A AU 2106000 A AU2106000 A AU 2106000A AU 21060/00 A AU21060/00 A AU 21060/00A AU 2106000 A AU2106000 A AU 2106000A AU 2106000 A AU2106000 A AU 2106000A
Authority
AU
Australia
Prior art keywords
alcohol
general formula
water mixture
robenidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU21060/00A
Inventor
Paul Hanselmann
Stefan Hildebrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of AU2106000A publication Critical patent/AU2106000A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a novel method for producing robenidine or derivatives thereof of general formula (I) wherein X means a halogen atom, using hydrazine hydrate and a cyanogen compound as the starting materials. The two educts are first converted into a diaminoguanidine of general formula (III) in a C1-4 alcohol or a C1-4 alcohol-water mixture as the solvent or in an aprotic polar organic solvent, Y being a halogen atom or tosyl. Said diaminoguanidine is then directly reacted with a p-halobenzaldehyde of general formula (IV) without isolation in a C1-4 alcohol, a C1-4 alcohol-water mixture or in an aprotic polar organic solvent-water mixture as the solvent to form the end product.
AU21060/00A 1999-01-06 2000-01-05 Method for producing robenidine or derivatives thereof Abandoned AU2106000A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99100097 1999-01-06
EP99100097 1999-01-06
US14610799P 1999-07-29 1999-07-29
US60146107 1999-07-29
PCT/EP2000/000050 WO2000040549A1 (en) 1999-01-06 2000-01-05 Method for producing robenidine or derivatives thereof

Publications (1)

Publication Number Publication Date
AU2106000A true AU2106000A (en) 2000-07-24

Family

ID=56289987

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21060/00A Abandoned AU2106000A (en) 1999-01-06 2000-01-05 Method for producing robenidine or derivatives thereof

Country Status (5)

Country Link
EP (1) EP1140806B1 (en)
AT (1) ATE241596T1 (en)
AU (1) AU2106000A (en)
ES (1) ES2199762T3 (en)
WO (1) WO2000040549A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030744B (en) 2015-07-09 2019-04-19 广州英赛特生物技术有限公司 Application of the substituted benzene guanidine derivatives as polymyxins antibiotic synergist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA927394A (en) * 1968-07-01 1973-05-29 American Cyanamid Company Substituted guanidines, compositions and method of preparation
US4575560A (en) * 1985-02-25 1986-03-11 American Cyanamid Company Insecticidal diaminoguanidine hydrazone compounds

Also Published As

Publication number Publication date
ES2199762T3 (en) 2004-03-01
ATE241596T1 (en) 2003-06-15
EP1140806A1 (en) 2001-10-10
EP1140806B1 (en) 2003-05-28
WO2000040549A1 (en) 2000-07-13

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase