HUP0101988A2 - Eljárás intravénás beadásra alkalmas immunglobulinok és más immunglobulin termékek előállítására - Google Patents

Eljárás intravénás beadásra alkalmas immunglobulinok és más immunglobulin termékek előállítására

Info

Publication number
HUP0101988A2
HUP0101988A2 HU0101988A HUP0101988A HUP0101988A2 HU P0101988 A2 HUP0101988 A2 HU P0101988A2 HU 0101988 A HU0101988 A HU 0101988A HU P0101988 A HUP0101988 A HU P0101988A HU P0101988 A2 HUP0101988 A2 HU P0101988A2
Authority
HU
Hungary
Prior art keywords
immunoglobulin
intravenous administration
product
purification
igg
Prior art date
Application number
HU0101988A
Other languages
English (en)
Inventor
Inga Laursen
Borge Teisner
Original Assignee
Statens Serum Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26150417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0101988(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Statens Serum Institut filed Critical Statens Serum Institut
Publication of HUP0101988A2 publication Critical patent/HUP0101988A2/hu
Publication of HUP0101988A3 publication Critical patent/HUP0101988A3/hu
Publication of HU228076B1 publication Critical patent/HU228076B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány immunglobulin G (IgG) nyers plazmafehérje-frakcióból valótisztítási eljárására vonatkozik. Az eljárás számos lépésből áll, és alépések közül az anion- és kationcserélő kromatográfiás tisztítástelőnyösen sorba kapcsolt oszlopokon végezik. A tisztítási eljárássorán előnyösen 5,0-6,0 pH-értékű és 5-25 mM molaritású acetátpufferthasználtak. A találmány oltalmi körébe tartozik a találmány szerintieljárással előállított immunglobulin termék is. A találmány olyanimmunglobulin termékre vonatkozik, melynek tisztasága 98%-nál nagyobb,az IgG monomer- és dimertartalma 98,5%-nál nagyobb, az IgA-tartalma 4mg IgA/1-nél kisebb és 0,5%-nál kisebb mennyiségben tartalmazpolimereket és aggregátumokat. Az említett termék stabilizálószerkéntnem tartalmaz detergenst, PEG-t vagy albumint. A termék stabil, vírus-biztos, folyékony és közvetlen intravénás beadásra alkalmas. Ó
HU0101988A 1998-06-09 1999-06-09 Process for producing immunoglobulins for intravenous administration and other immunoglobulin products HU228076B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98201909 1998-06-09
US10205598P 1998-09-28 1998-09-28
PCT/DK1999/000312 WO1999064462A1 (en) 1998-06-09 1999-06-09 Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Publications (3)

Publication Number Publication Date
HUP0101988A2 true HUP0101988A2 (hu) 2001-09-28
HUP0101988A3 HUP0101988A3 (en) 2004-10-28
HU228076B1 HU228076B1 (en) 2012-10-29

Family

ID=26150417

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101988A HU228076B1 (en) 1998-06-09 1999-06-09 Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Country Status (23)

Country Link
EP (4) EP1493751A1 (hu)
JP (1) JP5478519B2 (hu)
KR (1) KR100501263B1 (hu)
CN (1) CN1196714C (hu)
AT (1) ATE277950T1 (hu)
AU (1) AU753468B2 (hu)
BR (1) BR9911131A (hu)
CA (1) CA2330170C (hu)
CZ (1) CZ297199B6 (hu)
DE (1) DE69920693T2 (hu)
DK (1) DK1084147T3 (hu)
ES (1) ES2229784T3 (hu)
HK (2) HK1151044A1 (hu)
HU (1) HU228076B1 (hu)
ID (1) ID27417A (hu)
IL (1) IL140155A (hu)
NZ (1) NZ509135A (hu)
PL (1) PL196770B1 (hu)
PT (1) PT1084147E (hu)
RU (1) RU2197500C2 (hu)
SK (1) SK288128B6 (hu)
TR (1) TR200100303T2 (hu)
WO (1) WO1999064462A1 (hu)

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Also Published As

Publication number Publication date
DE69920693T2 (de) 2005-11-03
CN1311797A (zh) 2001-09-05
CA2330170C (en) 2010-11-02
EP1084147B1 (en) 2004-09-29
IL140155A0 (en) 2002-02-10
JP2011102314A (ja) 2011-05-26
CZ20004534A3 (en) 2001-06-13
TR200100303T2 (tr) 2001-06-21
CA2330170A1 (en) 1999-12-16
EP2272870A1 (en) 2011-01-12
PL344671A1 (en) 2001-11-19
ES2229784T3 (es) 2005-04-16
PT1084147E (pt) 2005-01-31
SK18662000A3 (sk) 2001-07-10
HUP0101988A3 (en) 2004-10-28
KR20010052733A (ko) 2001-06-25
SK288128B6 (sk) 2013-10-02
EP2270044B1 (en) 2014-11-05
DE69920693D1 (de) 2004-11-04
HK1151045A1 (en) 2012-01-20
KR100501263B1 (ko) 2005-07-18
IL140155A (en) 2005-12-18
DK1084147T3 (da) 2004-10-25
RU2197500C2 (ru) 2003-01-27
CZ297199B6 (cs) 2006-09-13
AU753468B2 (en) 2002-10-17
HU228076B1 (en) 2012-10-29
PL196770B1 (pl) 2008-01-31
EP1493751A1 (en) 2005-01-05
EP2272870B1 (en) 2013-05-08
ATE277950T1 (de) 2004-10-15
RU2001101454A (ru) 2003-01-20
JP5478519B2 (ja) 2014-04-23
HK1151044A1 (en) 2012-01-20
BR9911131A (pt) 2001-03-06
AU4257299A (en) 1999-12-30
EP1084147A1 (en) 2001-03-21
ID27417A (id) 2001-04-05
EP2270044A1 (en) 2011-01-05
CN1196714C (zh) 2005-04-13
NZ509135A (en) 2002-10-25
WO1999064462A1 (en) 1999-12-16

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