HUE034777T2 - Monoclonal Antibodies Against Klaudin-18 To Treat Cancer - Google Patents

Monoclonal Antibodies Against Klaudin-18 To Treat Cancer Download PDF

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Publication number
HUE034777T2
HUE034777T2 HUE10011776A HUE10011776A HUE034777T2 HU E034777 T2 HUE034777 T2 HU E034777T2 HU E10011776 A HUE10011776 A HU E10011776A HU E10011776 A HUE10011776 A HU E10011776A HU E034777 T2 HUE034777 T2 HU E034777T2
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HU
Hungary
Prior art keywords
seq
positions
cdr3
cdr2
cdr1
Prior art date
Application number
HUE10011776A
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English (en)
Hungarian (hu)
Inventor
Ugur Sahin
Oezlem Tuereci
Dirk Usener
Stefan Fritz
Christoph Uherek
Gunda Brandenburg
Harald Gerhard Geppert
Anja Kristina Schroeder
Philippe Thiel
Original Assignee
Ganymed Pharmaceuticals Gmbh
Johannes Gutenberg Univ Mainz Vertreten Durch Den Praesidenten
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Application filed by Ganymed Pharmaceuticals Gmbh, Johannes Gutenberg Univ Mainz Vertreten Durch Den Praesidenten filed Critical Ganymed Pharmaceuticals Gmbh
Publication of HUE034777T2 publication Critical patent/HUE034777T2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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