HUE029670T2 - Preparations containing pneumococcal antigens - Google Patents
Preparations containing pneumococcal antigens Download PDFInfo
- Publication number
- HUE029670T2 HUE029670T2 HUE12197549A HUE12197549A HUE029670T2 HU E029670 T2 HUE029670 T2 HU E029670T2 HU E12197549 A HUE12197549 A HU E12197549A HU E12197549 A HUE12197549 A HU E12197549A HU E029670 T2 HUE029670 T2 HU E029670T2
- Authority
- HU
- Hungary
- Prior art keywords
- seq
- antigen
- amino acid
- acid sequence
- ahol ahol
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title claims 46
- 102000036639 antigens Human genes 0.000 title claims 46
- 108091007433 antigens Proteins 0.000 title claims 46
- 239000000203 mixture Substances 0.000 title claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 150000001412 amines Chemical class 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 241000283073 Equus caballus Species 0.000 claims 2
- 235000019788 craving Nutrition 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- CMFIWMWBTZQTQH-IDTAVKCVSA-N 9-[(2r,3r,4s,5s)-3,4-dihydroxy-5-(2-methylpropylsulfanylmethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CSCC(C)C)O[C@H]1N1C(NC=NC2=O)=C2N=C1 CMFIWMWBTZQTQH-IDTAVKCVSA-N 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 241001417527 Pempheridae Species 0.000 claims 1
- 206010040844 Skin exfoliation Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 230000003460 anti-nuclear Effects 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 230000035618 desquamation Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 208000001848 dysentery Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- IXSZQYVWNJNRAL-UHFFFAOYSA-N etoxazole Chemical compound CCOC1=CC(C(C)(C)C)=CC=C1C1N=C(C=2C(=CC=CC=2F)F)OC1 IXSZQYVWNJNRAL-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000012133 immunoprecipitate Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 150000004682 monohydrates Chemical class 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000013618 particulate matter Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000005070 sphincter Anatomy 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 230000002024 thermoprotective effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0714963.6A GB0714963D0 (en) | 2007-08-01 | 2007-08-01 | Compositions comprising antigens |
| US96686607P | 2007-08-29 | 2007-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE029670T2 true HUE029670T2 (en) | 2017-03-28 |
Family
ID=38529101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12197549A HUE029670T2 (en) | 2007-08-01 | 2008-08-01 | Preparations containing pneumococcal antigens |
Country Status (20)
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DK2283857T3 (da) | 2005-06-27 | 2019-10-28 | Glaxosmithkline Biologicals Sa | Vaccinesammensætning omfattende konjugerede native N. Meningitidis kapselpolysaccharider |
| US8241643B2 (en) | 2008-03-17 | 2012-08-14 | Intercell Ag | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
| ATE523204T1 (de) | 2009-02-16 | 2011-09-15 | Karlsruher Inst Technologie | Cd44v6-peptide als bakterielle infektionsinhibitoren |
| CA2764022A1 (en) * | 2009-06-01 | 2010-12-09 | Novartis Ag | Combinations of pneumococcal rrgb clades |
| AU2010273708B2 (en) | 2009-06-29 | 2015-10-01 | Children's Medical Center Corporation | Vaccines and compositions against Streptococcus pneumoniae |
| BR112012008338A2 (pt) * | 2009-09-10 | 2019-09-24 | Novartis Ag | combinação de vacinas contra doenças do trato respiratório. |
| US9649372B2 (en) | 2009-12-22 | 2017-05-16 | Sanofi Pasteur Limited | Immunogenic compositions and related methods |
| US20130039947A1 (en) | 2010-03-12 | 2013-02-14 | Children's Medical Center Corporation | Novel immunogens and methods for discovery and screening thereof |
| GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| US11291635B2 (en) | 2010-07-06 | 2022-04-05 | Glaxosmithkline Biological Sa | Virion-like delivery particles for self-replicating RNA molecules |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| CA2804396C (en) | 2010-07-06 | 2021-06-29 | Novartis Ag | Liposomes with lipids having an advantageous pka-value for rna delivery |
| HRP20160805T1 (hr) | 2010-07-06 | 2016-08-12 | Glaxosmithkline Biologicals Sa | Imuniziranje velikih sisavaca malim dozama rna |
| LT3243526T (lt) | 2010-07-06 | 2020-02-10 | Glaxosmithkline Biologicals S.A. | Rnr pristatymas, skirtas keleto imuninio atsako paleidimui |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| FI2608805T4 (fi) | 2010-08-23 | 2025-08-07 | Wyeth Llc | NEISSERIA MENINGITIDIS rLP2086 -ANTIGEENIEN STABIILEJA FORMULAATIOITA |
| US20130189351A1 (en) | 2010-08-31 | 2013-07-25 | Novartis Ag | Lipids suitable for liposomal delivery of protein coding rna |
| SI3981427T1 (sl) | 2010-08-31 | 2022-08-31 | Glaxosmithkline Biologicals S.A. | Pegilirani liposomi za dostavo imunogen-kodirajoče RNA |
| CA2809758C (en) | 2010-09-10 | 2021-07-13 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| CN103269713B (zh) | 2010-10-11 | 2016-01-20 | 诺华有限公司 | 抗原递送平台 |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| MY163871A (en) | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
| CN104623666A (zh) | 2011-04-29 | 2015-05-20 | 西莱克塔生物科技公司 | 用于诱导调节性b细胞的致耐受性合成纳米载体 |
| KR102084509B1 (ko) | 2011-05-11 | 2020-03-05 | 칠드런'즈 메디컬 센터 코포레이션 | 변형 비오틴-결합 단백질, 그 융합 단백질 및 응용 |
| EP3854413A1 (en) | 2011-07-06 | 2021-07-28 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| BR112014000236A2 (pt) | 2011-07-06 | 2017-02-14 | Novartis Ag | lipossomas com razão n:p útil para a liberação de moléculas de rna, composição e uso de ditos lipossomas |
| HUE041800T2 (hu) | 2011-08-31 | 2019-05-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNS bejuttatására |
| CN104114695B (zh) * | 2011-10-05 | 2018-04-17 | 洛克菲勒大学 | 二聚噬菌体溶素 |
| CA2854934A1 (en) * | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| US20150132339A1 (en) | 2012-03-07 | 2015-05-14 | Novartis Ag | Adjuvanted formulations of streptococcus pneumoniae antigens |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MX351993B (es) | 2012-03-09 | 2017-11-03 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| US9764027B2 (en) | 2012-09-18 | 2017-09-19 | Glaxosmithkline Biologicals Sa | Outer membrane vesicles |
| KR20140075196A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| WO2014124228A1 (en) * | 2013-02-07 | 2014-08-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
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| EP4387597A1 (en) | 2021-08-16 | 2024-06-26 | GlaxoSmithKline Biologicals SA | Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof |
| CA3231684A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
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-
2007
- 2007-08-01 GB GBGB0714963.6A patent/GB0714963D0/en not_active Ceased
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2008
- 2008-08-01 PT PT121975494T patent/PT2572726T/pt unknown
- 2008-08-01 CN CN201410192895.3A patent/CN104001165B/zh not_active Expired - Fee Related
- 2008-08-01 US US12/733,010 patent/US20110243976A1/en not_active Abandoned
- 2008-08-01 SI SI200831646A patent/SI2572726T1/sl unknown
- 2008-08-01 JP JP2010518777A patent/JP2010535025A/ja active Pending
- 2008-08-01 AU AU2008281438A patent/AU2008281438A1/en not_active Abandoned
- 2008-08-01 AP AP2010005173A patent/AP2010005173A0/en unknown
- 2008-08-01 PL PL12197549.4T patent/PL2572726T3/pl unknown
- 2008-08-01 CN CN200880108017A patent/CN101801409A/zh active Pending
- 2008-08-01 EA EA201070200A patent/EA018137B1/ru not_active IP Right Cessation
- 2008-08-01 EP EP08826694A patent/EP2197484A2/en not_active Withdrawn
- 2008-08-01 DK DK12197549.4T patent/DK2572726T3/en active
- 2008-08-01 ES ES12197549.4T patent/ES2580957T3/es active Active
- 2008-08-01 EP EP12197549.4A patent/EP2572726B1/en active Active
- 2008-08-01 HU HUE12197549A patent/HUE029670T2/en unknown
- 2008-08-01 BR BRPI0813892A patent/BRPI0813892A2/pt not_active IP Right Cessation
- 2008-08-01 CA CA2695169A patent/CA2695169A1/en not_active Abandoned
- 2008-08-01 WO PCT/IB2008/002866 patent/WO2009016515A2/en not_active Ceased
-
2010
- 2010-03-01 CO CO10023973A patent/CO6260103A2/es not_active Application Discontinuation
-
2013
- 2013-11-06 JP JP2013230378A patent/JP5838193B2/ja not_active Expired - Fee Related
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2014
- 2014-06-06 US US14/298,764 patent/US20140348868A1/en not_active Abandoned
-
2016
- 2016-06-16 HR HRP20160685TT patent/HRP20160685T1/hr unknown
- 2016-06-28 CY CY20161100580T patent/CY1117689T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009016515A3 (en) | 2009-08-13 |
| AP2010005173A0 (en) | 2010-02-28 |
| AU2008281438A1 (en) | 2009-02-05 |
| CN104001165B (zh) | 2018-08-14 |
| CA2695169A1 (en) | 2009-02-05 |
| EA018137B1 (ru) | 2013-05-30 |
| PL2572726T3 (pl) | 2016-12-30 |
| CO6260103A2 (es) | 2011-03-22 |
| EP2572726A1 (en) | 2013-03-27 |
| EP2572726B1 (en) | 2016-05-04 |
| DK2572726T3 (en) | 2016-07-04 |
| US20140348868A1 (en) | 2014-11-27 |
| PT2572726T (pt) | 2016-08-05 |
| SI2572726T1 (sl) | 2016-08-31 |
| WO2009016515A2 (en) | 2009-02-05 |
| GB0714963D0 (en) | 2007-09-12 |
| EP2197484A2 (en) | 2010-06-23 |
| BRPI0813892A2 (pt) | 2017-05-09 |
| CN101801409A (zh) | 2010-08-11 |
| US20110243976A1 (en) | 2011-10-06 |
| JP2014034578A (ja) | 2014-02-24 |
| JP5838193B2 (ja) | 2016-01-06 |
| CY1117689T1 (el) | 2017-05-17 |
| EA201070200A1 (ru) | 2010-08-30 |
| JP2010535025A (ja) | 2010-11-18 |
| ES2580957T3 (es) | 2016-08-30 |
| HRP20160685T1 (hr) | 2016-07-15 |
| CN104001165A (zh) | 2014-08-27 |
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