HUE027731T2 - Új európai PRRSV-törzs - Google Patents
Új európai PRRSV-törzs Download PDFInfo
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- HUE027731T2 HUE027731T2 HUE12704409A HUE12704409A HUE027731T2 HU E027731 T2 HUE027731 T2 HU E027731T2 HU E12704409 A HUE12704409 A HU E12704409A HU E12704409 A HUE12704409 A HU E12704409A HU E027731 T2 HUE027731 T2 HU E027731T2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10064—Methods of inactivation or attenuation by serial passage
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10071—Demonstrated in vivo effect
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Claims (12)
- m Z $73 Clj earéjmí PRRSV-törzs igénypontok ;î, Európai típusn sériés reprodrÉÂs és légzésiem szindróma vírus ψΜRSV), amely az Európai Sejitenyészet Gyűjteményben (ECACC) ECACG 11012501 nyilvántartási szánon letétbe helyezett törzs,
- 2, Európai fíptisu Sértés reprodtifíéiós és légzőszervi szindróma vims (PRRSV), amely az Európai Ssjttenyészet Gyűjtemény bee |B€ACC) EÇAÇÇ 11012502 számon tóétbe helyezett törzs, J, A 2. igénypont szerinti PRRSV, amely setttényészetben Só-szoros passzálással oly módon leit legyengítve, melynek eredményeként i módi®sított vírus sertésbe vagy egyéb, PRRSY-re fogékony emlősbe történd bejuttatást követően nem képes a PRRSV betegség klinikai tünetéit kiváltani, azonban képes olyan immunreakeiot indukálni, amely az emlőst im-Manlzl|a a PRRSV patogéa alakjaival szemben,
- 4, Eljárás a 2, igénypont szerinti élő,legyengíteti PRRSV előállítására, mely eljárás magában foglalja égy 1, igénypont szerinti, 'MÄ 104-en növesztett európai típusú PRRSV nem MA 104 emlős sejtekhez történő adaptálását, S; Vakcina sertések FERSY-fertőzéssei szembeni védettségének kialakítására, mely vak-eina 2, igénypont szerinti élő, legyengített PRRSY-t és győgyászatilag elfogadható hordozót tartalmaz,
- 6. Az 5, igénypont szerinti vakcina, amely tartalmaz mvabbá egy vagy több legpngííett vagy ínakílvált nem*FRRSV patogént vagy annak antigén hatási anyagát. f, A. Ói. igénypont szerinti vakcina, ahol a nem-PRRSV patogének a következők közül vannak kiválasztva: Pseudorabies vírus, sértési nil uenza vírus, sertés parvovirus, transzmisszibiiis gastroenteritis vims, Escherichia coli, Erysipelo rhusiopatbiae, Bordetella bronehiseptica, Salmonella oholeraesuiSi, Haemophilus pamsuis, Pastenmlla moltoeida, Streptococcus suis. Mycoplasma hyopneumomae és Aeimohaciiius pleuropneumoniae.5, Az 5, igénypont szerinti vakcina, amely tartalmaz még a következőkből álló csoportból kiválasztott egy vagy több további európai PRESV-torzset Is: Eelystad vírwtöfzs (Lelystad jugent (CDI-NL-2.9I), valamint m alábbi nyilvántartási számokon letétbe helyeseit egyéb törzsek: iCAÜC 04102703, ECACC 04102702, ECACC 04102704, CNCM Mo, I-Ü40, CNCM :1.1:387, CNCM 1-1388, ATCC VR 2332, VR 2385, VR 2386, YR 2429, VR 2474, és VR 2402; CNCM 1-1102:, CNCM: 1-114¾ CNCM 1-1387, CNCM 1-1388, vagy ECACC V9307Ö108; vagy egy egyesült államokbeli törzset, pl. észak-amerikai PRRS-virust pT7P129A; ATCC VR-2332, ATCC VR-2368; ATCC VR-2495; ATCC VR 2385, ATCC VR 2310* ATCC VR 2429, ATCC VR 2474, és ATCC VR 2402.
- 9. Az 5. igénypont szerinti vakcina, amely tartalmaz egy intradermális vagy mtramuszku-láris adagolásra alkalmas hordozót.
- 10. Az 5. igénypont szerinti vakcina, amely fagyasztva szárított.
- 11. Az 5. igénypont szerinti vakcina, amely legalább 10' vimsrészecskét íartaitnáz,
- 12. Eljárás PRRS leküzdésére alkalmas élő, legyengített vakcina előállításán, Mely éljá-fás magában foglalja egy 2. igénypont szerinti élő, legyengített PRRSV gyógyászaítlag elfogadható hordozóval történő összekeverésék 13. A 12, igénypont szerinti ei|árá% áhöl az élő, legyengített PRRS V tartalmaz egy vagy több további európai PRRSV-iörzsei is, amely (ek) a kővetkező nyilvántartási számokon letétbe helyezett PRRSV-törzsekből álló csoportból van(nák) kiválasztva: ECACC §4102703, ECACC 04102702, ECACC 04102704, CNCM 1-1140, CNCM 1-138? és CNCM 1-1388. 14. A 12. igénypont szerinti eljárás, áltól az élő, legyengíteti PRRSV tartalmaz továbbá egy adjuvánst,
- 15. Az 5-11. Igénypontok bármelyike szerinti vakcina sertés sertések mpoőukeiós és iégzőszervi szindrómája (PRRS) elleni immunizálására történő alkalmazásra.
- 16. Vakcina a 15. igénypont szerinti alkalmazásra, ahol az említeti sertés a vakeinálást követően nem mutat tüdőd változásokat.
- 17-PRRS-víms, amelynek nokleofidszökvenciája legalább 95 %-ban homológ az 1. vagy 10. azonosítószámú szekvenciaként (SEQ 1D NO:l vagy SEQ ID NO: 10) bemutatótt szekvenciával 18, A 17. igénypont szerinti PRRS-vírns, amely az 1. vagy 10. azónösioszamú szekvenciaként (SEQ ! D NO: 1 vagy SEQ ID NO: 10) bemutatóit brr.
- 19, Vakcina sertések PRRSVkfeziözésse! szembeni védettségének kialakítására, amely vakcina tartalmaz egy 17. vagy 18. igény pent szerinti PRRS-vírasi és egy gyögyaszaíilag él-fogadható hordozót, ahol az említett PRRS-vírus az 1. azonosítószámú szekvenciaként (SEQ 1D NO:l) bemutatott nukIeotidszekvenciával hír, vagy amely egy legyengíteti PRRS-vírus, amelynek nukleoíMs^^ 95 %-ban homológ az 1, azososífoszátnü szekven ciaként (SEQ 1D NO; 1) bemutatott nukleotklszckvenclával. 20, A 19. igénypont szertníí vakcina, amely taraimaz továbbá egy vagy több legyengíteti vagy inaktiváií nem~PERS V jsatogént vagy annak antigén hatású anyagát. 21, A 20. igénypont szerinti vakcina, ahol az említett nem-PRRSV patogenek a következők közöl vannak kiválasztva:: Pseudomhiea virus, sétdésinfluenza vírus, sertés parvovirus, fomszmksziMis gastroenteritis vírus, Eimtaádm coli, Erysípdo fousiopaibiae, Bordetella bronchi sepíiea, Salmonella choleraesuis, Haemophilus parasuís, Pasteurelia múltoddá. Streptococcus suis, Mycoplasma hyöpneumoniae és Actinobacíllus pleuropneumoniae.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201161444074P | 2011-02-17 | 2011-02-17 |
Publications (1)
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HUE027731T2 true HUE027731T2 (hu) | 2016-10-28 |
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HUE12704409A HUE027731T2 (hu) | 2011-02-17 | 2012-02-14 | Új európai PRRSV-törzs |
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US (4) | US8765142B2 (hu) |
EP (2) | EP2675475B1 (hu) |
JP (1) | JP5788027B2 (hu) |
KR (2) | KR102183276B1 (hu) |
CN (2) | CN103370078B (hu) |
AR (2) | AR085272A1 (hu) |
AU (2) | AU2012217169B2 (hu) |
BR (2) | BR112013021076B1 (hu) |
CA (1) | CA2826341C (hu) |
CL (1) | CL2013002379A1 (hu) |
CO (1) | CO6791570A2 (hu) |
CY (1) | CY1116835T1 (hu) |
DK (2) | DK2959916T3 (hu) |
EA (2) | EA038012B1 (hu) |
ES (2) | ES2550258T3 (hu) |
HR (1) | HRP20151031T1 (hu) |
HU (1) | HUE027731T2 (hu) |
ME (1) | ME02271B (hu) |
MX (2) | MX355058B (hu) |
MY (2) | MY161198A (hu) |
PH (1) | PH12017500962A1 (hu) |
PL (2) | PL2959916T3 (hu) |
PT (2) | PT2675475E (hu) |
RS (1) | RS54231B1 (hu) |
SG (1) | SG192820A1 (hu) |
SI (1) | SI2675475T1 (hu) |
SM (1) | SMT201500236B (hu) |
TW (2) | TWI665303B (hu) |
UA (2) | UA112768C2 (hu) |
WO (1) | WO2012110489A2 (hu) |
Families Citing this family (26)
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EA031432B1 (ru) | 2011-02-17 | 2019-01-31 | Бёрингер Ингельхайм Ветмедика Гмбх | Способ получения вируса репродуктивно-респираторного сидрома свиней prrs |
EA038012B1 (ru) | 2011-02-17 | 2021-06-23 | Бёрингер Ингельхайм Ветмедика Гмбх | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса |
US8906385B2 (en) | 2011-12-01 | 2014-12-09 | University Of Maryland, College Park | Interferon-inducing porcine reproductive and respiratory syndrome virus isolate |
JP6386999B2 (ja) | 2012-05-17 | 2018-09-05 | ゾエティス・エルエルシー | ブタ生殖および呼吸症候群(prrs)ウイルスに対する離乳前の効果的なワクチン接種 |
US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
US9457073B2 (en) * | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
US9149518B2 (en) | 2012-12-07 | 2015-10-06 | The Board Of Trustees Of The University Of Illinois | Porcine reproductive and respiratory syndrome virus compositions and uses thereof |
US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
EA039060B1 (ru) * | 2013-12-20 | 2021-11-29 | Бёрингер Ингельхайм Ветмедика Гмбх | Вариант вируса ppcc, способ его получения с помощью молекулы нуклеиновой кислоты, конструкции днк или клетки и его применение для лечения и профилактики ррсс |
US10280199B2 (en) | 2014-02-07 | 2019-05-07 | Phibro Animal Health Corporation | Coronavirus proteins and antigens |
AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
TWI670085B (zh) * | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
PT3212182T (pt) | 2014-10-27 | 2019-07-29 | Pharmacosmos Holding As | Tratamento ou prevenção da anemia em mamíferos não humanos em período de gestação e ninhada |
CN106924726B (zh) * | 2015-12-29 | 2021-02-09 | 普莱柯生物工程股份有限公司 | 一种用于预防猪繁殖与呼吸综合征的疫苗组合物及其制备方法和应用 |
EP3454893A4 (en) * | 2016-05-11 | 2020-01-01 | Phibro Animal Health Corporation | COMPOSITION WITH ANTIGENS AND A MUCUTINE ADJUVAN AND METHOD FOR USE |
US10279031B2 (en) | 2016-05-11 | 2019-05-07 | Phibro Animal Health Corporation | Composition comprising antigens and a mucosal adjuvant and a method for using |
PT3534939T (pt) | 2016-11-03 | 2023-04-20 | Boehringer Ingelheim Vetmedica Gmbh | Vacina contra parvovírus porcino e vírus da síndrome reprodutiva e respiratória porcina e métodos da sua produção |
CN110072547B (zh) * | 2016-12-14 | 2024-04-30 | 硕腾服务有限责任公司 | 断奶前对抗欧洲猪繁殖与呼吸综合征(prrs)病毒株的有效疫苗接种 |
US11013796B2 (en) | 2018-08-30 | 2021-05-25 | Iowa State University Research Foundation, Inc. | Porcine parainfluenza virus type 1 isolates and immunogenic compositions therefrom |
EP3953370A1 (en) | 2019-04-04 | 2022-02-16 | Boehringer Ingelheim Animal Health USA Inc. | Porcine circovirus type 3 (pcv3) vaccines, and production and uses thereof |
CN110735005B (zh) * | 2019-11-26 | 2023-01-10 | 广西大学 | Siv和prrsv多重rt-pcr快速检测试剂盒及引物 |
CN111676247A (zh) * | 2020-06-30 | 2020-09-18 | 扬州大学 | 一株猪繁殖与呼吸综合征病毒1型分离株感染性克隆构建、拯救与应用 |
EP4185321A2 (en) | 2020-07-24 | 2023-05-31 | Boehringer Ingelheim Animal Health USA Inc. | Combination porcine vaccine |
CN113862230B (zh) * | 2021-09-30 | 2023-08-08 | 中牧实业股份有限公司 | 一种猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用 |
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