HU211860A9 - 3-amino-chromans and thiochromans derivatives - Google Patents

3-amino-chromans and thiochromans derivatives Download PDF

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Publication number
HU211860A9
HU211860A9 HU95P/P00717P HU9500717P HU211860A9 HU 211860 A9 HU211860 A9 HU 211860A9 HU 9500717 P HU9500717 P HU 9500717P HU 211860 A9 HU211860 A9 HU 211860A9
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HU
Hungary
Prior art keywords
formula
compound
alkyl
alkenyl
trifluoromethyl
Prior art date
Application number
HU95P/P00717P
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English (en)
Hungarian (hu)
Inventor
Rolf Noreen
Svante Bertil Ross
Seth Olov Thorberg
Lars-Gunnar Larsson
Lucy Anna Renyi
Daniel Dungan Sohn
Bjoern Eric Svensson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of HU211860A9 publication Critical patent/HU211860A9/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Threshing Machine Elements (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Liquid Crystal Substances (AREA)
  • Harvester Elements (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Medicinal Preparation (AREA)
HU95P/P00717P 1989-12-22 1995-06-30 3-amino-chromans and thiochromans derivatives HU211860A9 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives

Publications (1)

Publication Number Publication Date
HU211860A9 true HU211860A9 (en) 1995-12-28

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
HU95P/P00717P HU211860A9 (en) 1989-12-22 1995-06-30 3-amino-chromans and thiochromans derivatives

Country Status (42)

Country Link
EP (1) EP0460169B1 (enExample)
JP (1) JP2879972B2 (enExample)
KR (1) KR0178991B1 (enExample)
CN (1) CN1037438C (enExample)
AT (1) ATE138918T1 (enExample)
AU (1) AU641204B2 (enExample)
CA (1) CA2047237C (enExample)
CY (1) CY1991A (enExample)
CZ (1) CZ283630B6 (enExample)
DE (1) DE69027311T2 (enExample)
DK (1) DK0460169T3 (enExample)
DZ (1) DZ1469A1 (enExample)
EG (1) EG19749A (enExample)
ES (1) ES2087993T3 (enExample)
FI (1) FI102177B1 (enExample)
GR (1) GR3020497T3 (enExample)
HK (1) HK55897A (enExample)
HR (1) HRP920851B1 (enExample)
HU (1) HU211860A9 (enExample)
ID (1) ID945B (enExample)
IE (1) IE80753B1 (enExample)
IL (1) IL96712A (enExample)
IS (1) IS1665B (enExample)
LT (1) LT3967B (enExample)
LV (2) LV10449B (enExample)
MX (1) MX23889A (enExample)
NO (1) NO180336C (enExample)
NZ (1) NZ236407A (enExample)
PH (1) PH30797A (enExample)
PL (3) PL164608B1 (enExample)
PT (1) PT96304B (enExample)
RU (1) RU2092483C1 (enExample)
SA (1) SA90110186B1 (enExample)
SE (1) SE8904361D0 (enExample)
SG (1) SG48043A1 (enExample)
SI (1) SI9012429B (enExample)
SK (1) SK280261B6 (enExample)
TW (1) TW221056B (enExample)
UA (1) UA34416C2 (enExample)
WO (1) WO1991009853A1 (enExample)
YU (2) YU47936B (enExample)
ZA (1) ZA909708B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
CA2048846A1 (en) * 1990-08-15 1992-02-16 Craig Steven Hoechstetter Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and aminothiochromanes
IL100858A (en) * 1991-02-08 1996-03-31 Lilly Co Eli Ring-substituted 2-amino-1,2 3,4- tetrahydronaphthalenes and 3-aminochromanes pharmaceutical compositions containing them and methods for their preparation
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703377D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
BR0206512A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
CN1592745A (zh) 2001-01-16 2005-03-09 阿斯特拉曾尼卡有限公司 治疗用苯并－γ－吡喃酮化合物
MXPA03006261A (es) * 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos terapeuticos de cromano.
RU2193559C1 (ru) * 2001-05-16 2002-11-27 Пермская государственная фармацевтическая академия 2,4-ксилидид и м-фенетидид 2-ацетилиминокумарин-3-карбоновой кислоты, обладающие антикоагулянтной активностью
WO2003007956A1 (en) 2001-07-20 2003-01-30 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
US20080221193A1 (en) * 2006-12-22 2008-09-11 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
CN116655242A (zh) * 2023-05-10 2023-08-29 东北大学 一系列有机-无机杂化金属卤化物玻璃材料及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22522A (en) * 1985-09-03 1988-10-17 Ciba Geigy Ag 3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
IL96712A0 (en) 1991-09-16
PH30797A (en) 1997-10-17
PT96304A (pt) 1991-09-30
DK0460169T3 (da) 1996-09-23
KR920701193A (ko) 1992-08-11
EG19749A (en) 1996-01-31
SI9012429B (sl) 1998-10-31
PL164608B1 (pl) 1994-08-31
ATE138918T1 (de) 1996-06-15
PL293065A1 (en) 1992-08-10
IL96712A (en) 1995-08-31
PT96304B (pt) 1998-09-30
FI913943A0 (fi) 1991-08-21
CN1052669A (zh) 1991-07-03
LV11894A (lv) 1997-12-20
CA2047237C (en) 2003-02-11
CN1037438C (zh) 1998-02-18
UA34416C2 (uk) 2001-03-15
YU47936B (sh) 1996-05-20
CA2047237A1 (en) 1991-06-23
ZA909708B (en) 1991-08-28
GR3020497T3 (en) 1996-10-31
DE69027311T2 (de) 1996-10-24
CY1991A (en) 1997-09-05
DZ1469A1 (fr) 2004-09-13
YU72191A (sh) 1995-01-31
LV10449B (en) 1995-10-20
FI102177B (fi) 1998-10-30
NO913273L (no) 1991-10-08
DE69027311D1 (en) 1996-07-11
ES2087993T3 (es) 1996-08-01
NZ236407A (en) 1993-08-26
LTIP1730A (en) 1995-08-25
CZ283630B6 (cs) 1998-05-13
SE8904361D0 (sv) 1989-12-22
HRP920851B1 (en) 2000-02-29
IS1665B (is) 1997-07-04
NO180336C (no) 1997-04-02
JPH04503682A (ja) 1992-07-02
EP0460169B1 (en) 1996-06-05
HRP920851A2 (en) 1995-10-31
IS3662A7 (is) 1991-06-23
MX23889A (es) 1993-10-01
IE904535A1 (en) 1991-07-03
FI102177B1 (fi) 1998-10-30
HK55897A (en) 1997-05-09
PL164592B1 (pl) 1994-08-31
NO913273D0 (no) 1991-08-21
SA90110186B1 (ar) 2001-11-11
JP2879972B2 (ja) 1999-04-05
EP0460169A1 (en) 1991-12-11
CZ657890A3 (cs) 1998-02-18
AU6977091A (en) 1991-07-24
YU47923B (sh) 1996-05-20
IE80753B1 (en) 1999-01-13
LV10449A (lv) 1995-02-20
RU2092483C1 (ru) 1997-10-10
TW221056B (enExample) 1994-02-11
YU242990A (sh) 1993-10-20
LV11894B (en) 1998-05-20
SK657890A3 (en) 1999-10-08
SI9012429A (en) 1997-12-31
SG48043A1 (en) 1998-04-17
PL164609B1 (en) 1994-08-31
PL293066A1 (en) 1992-08-10
KR0178991B1 (ko) 1999-03-20
NO180336B (no) 1996-12-23
AU641204B2 (en) 1993-09-16
LT3967B (en) 1996-05-27
WO1991009853A1 (en) 1991-07-11
SK280261B6 (sk) 1999-10-08
ID945B (id) 1996-09-20

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