HU199842B - Process for producing pyridazodiazepines and pharmaceutical compositions comprising same - Google Patents

Process for producing pyridazodiazepines and pharmaceutical compositions comprising same Download PDF

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Publication number
HU199842B
HU199842B HU875409A HU540983A HU199842B HU 199842 B HU199842 B HU 199842B HU 875409 A HU875409 A HU 875409A HU 540983 A HU540983 A HU 540983A HU 199842 B HU199842 B HU 199842B
Authority
HU
Hungary
Prior art keywords
formula
compound
compounds
acid
phenyl
Prior art date
Application number
HU875409A
Other languages
English (en)
Hungarian (hu)
Inventor
Michael R Attwood
Geoffrey Lawton
Sally Redshaw
Cedric H Hassall
Robert W Lambert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HU199842B publication Critical patent/HU199842B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
HU875409A 1982-05-12 1983-05-09 Process for producing pyridazodiazepines and pharmaceutical compositions comprising same HU199842B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (1)

Publication Number Publication Date
HU199842B true HU199842B (en) 1990-03-28

Family

ID=26282820

Family Applications (3)

Application Number Title Priority Date Filing Date
HU875409A HU199842B (en) 1982-05-12 1983-05-09 Process for producing pyridazodiazepines and pharmaceutical compositions comprising same
HU831589A HU195965B (en) 1982-05-12 1983-05-09 Process for producing bicyclic diaza compounds and therapeutic preparations containing same
HU875410A HU198935B (en) 1982-05-12 1983-05-09 Process for producing bicyclic diaza compounds and pharmaceutical compositions comprising same

Family Applications After (2)

Application Number Title Priority Date Filing Date
HU831589A HU195965B (en) 1982-05-12 1983-05-09 Process for producing bicyclic diaza compounds and therapeutic preparations containing same
HU875410A HU198935B (en) 1982-05-12 1983-05-09 Process for producing bicyclic diaza compounds and pharmaceutical compositions comprising same

Country Status (32)

Country Link
US (3) US4512924A (en, 2012)
EP (1) EP0094095B1 (en, 2012)
KR (1) KR890002106B1 (en, 2012)
AR (1) AR240940A1 (en, 2012)
AU (1) AU567873B2 (en, 2012)
BG (1) BG61123B2 (en, 2012)
CA (1) CA1234568A (en, 2012)
CS (2) CS249128B2 (en, 2012)
CU (1) CU21532A3 (en, 2012)
DE (2) DE3381884D1 (en, 2012)
DK (1) DK160612C (en, 2012)
DO (1) DOP1983004163A (en, 2012)
DZ (1) DZ540A1 (en, 2012)
ES (6) ES8407049A1 (en, 2012)
FI (1) FI77244C (en, 2012)
FR (1) FR2531956B1 (en, 2012)
GB (1) GB2128984B (en, 2012)
GR (1) GR77462B (en, 2012)
HK (1) HK91692A (en, 2012)
HU (3) HU199842B (en, 2012)
IE (1) IE56480B1 (en, 2012)
IL (1) IL68620A (en, 2012)
IT (1) IT1212738B (en, 2012)
LU (2) LU84803A1 (en, 2012)
MC (1) MC1515A1 (en, 2012)
MY (1) MY102889A (en, 2012)
NL (2) NL8301640A (en, 2012)
NO (1) NO160368C (en, 2012)
PT (1) PT76681B (en, 2012)
SE (1) SE461792B (en, 2012)
SG (1) SG81192G (en, 2012)
ZW (1) ZW9883A1 (en, 2012)

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IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
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NL930055I1 (nl) 1993-09-01
IT8321000A0 (it) 1983-05-09
MY102889A (en) 1993-03-31
GB8305505D0 (en) 1983-03-30
EP0094095B1 (de) 1990-09-19
FR2531956B1 (fr) 1987-02-20
PT76681A (en) 1983-06-01
NL930055I2 (nl) 1993-10-01
NO160368B (no) 1989-01-02
ES522291A0 (es) 1984-08-16
AR240940A2 (es) 1991-03-27
IL68620A0 (en) 1983-09-30
FI77244C (fi) 1989-02-10
FI77244B (fi) 1988-10-31
DE3317290A1 (de) 1983-11-17
DZ540A1 (fr) 2004-09-13
US4772701A (en) 1988-09-20
CS249128B2 (en) 1987-03-12
KR840004754A (ko) 1984-10-24
SE461792B (sv) 1990-03-26
GB2128984A (en) 1984-05-10
FR2531956A1 (fr) 1984-02-24
ES8800170A1 (es) 1987-11-01
ES528630A0 (es) 1986-06-16
IL68620A (en) 1987-11-30
KR890002106B1 (ko) 1989-06-19
SE8302716L (sv) 1983-11-13
ES8407049A1 (es) 1984-08-16
CU21532A3 (en) 1987-06-09
GR77462B (en, 2012) 1984-09-24
BG61123B2 (bg) 1996-11-29
SG81192G (en) 1993-01-29
PT76681B (en) 1986-05-20
IE831084L (en) 1983-11-12
FI831661A0 (fi) 1983-05-12
DK160612B (da) 1991-04-02
HK91692A (en) 1992-11-27
ES8601994A1 (es) 1985-11-16
DK160612C (da) 1991-09-23
NO831675L (no) 1983-11-14
LU88299I2 (fr) 1994-09-09
US4658024A (en) 1987-04-14
NL8301640A (nl) 1983-12-01
AR240940A1 (es) 1991-03-27
IT1212738B (it) 1989-11-30
CS402191A3 (en) 1992-10-14
MC1515A1 (fr) 1984-02-10
FI831661L (fi) 1983-11-13
ZW9883A1 (en) 1984-11-21
LU84803A1 (fr) 1985-03-21
AU567873B2 (en) 1987-12-10
GB2128984B (en) 1985-05-22
DK194783A (da) 1983-11-13
ES528628A0 (es) 1987-07-16
AU1436483A (en) 1983-11-17
EP0094095A2 (de) 1983-11-16
IE56480B1 (en) 1991-08-14
ES8505173A1 (es) 1985-05-16
DE3381884D1 (de) 1990-10-25
NO160368C (no) 1989-04-12
DK194783D0 (da) 1983-05-02
ES554935A0 (es) 1987-11-01
ES8706672A1 (es) 1987-07-16
HU195965B (en) 1988-08-29
SE8302716D0 (sv) 1983-05-11
CA1234568A (en) 1988-03-29
ES528627A0 (es) 1985-11-16
ES528625A0 (es) 1985-05-16
ES8607970A1 (es) 1986-06-16
EP0094095A3 (en) 1984-11-21
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US4512924A (en) 1985-04-23
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