IT8321000A0 - Composti biciclici ad attivita'anti-ipertensiva - Google Patents

Composti biciclici ad attivita'anti-ipertensiva

Info

Publication number
IT8321000A0
IT8321000A0 IT8321000A IT2100083A IT8321000A0 IT 8321000 A0 IT8321000 A0 IT 8321000A0 IT 8321000 A IT8321000 A IT 8321000A IT 2100083 A IT2100083 A IT 2100083A IT 8321000 A0 IT8321000 A0 IT 8321000A0
Authority
IT
Italy
Prior art keywords
bicyclic compounds
hypertensive activity
hypertensive
activity
bicyclic
Prior art date
Application number
IT8321000A
Other languages
English (en)
Other versions
IT1212738B (it
Inventor
Michael Richard Attwood
Cedric Herbert Hassall
Robert Wilson Lambert
Geoffrey Lawton
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IT8321000A0 publication Critical patent/IT8321000A0/it
Application granted granted Critical
Publication of IT1212738B publication Critical patent/IT1212738B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
IT8321000A 1982-05-12 1983-05-09 Composti biciclici ad attivita'anti-ipertensiva IT1212738B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (2)

Publication Number Publication Date
IT8321000A0 true IT8321000A0 (it) 1983-05-09
IT1212738B IT1212738B (it) 1989-11-30

Family

ID=26282820

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8321000A IT1212738B (it) 1982-05-12 1983-05-09 Composti biciclici ad attivita'anti-ipertensiva

Country Status (32)

Country Link
US (3) US4512924A (it)
EP (1) EP0094095B1 (it)
KR (1) KR890002106B1 (it)
AR (1) AR240940A1 (it)
AU (1) AU567873B2 (it)
BG (1) BG61123B2 (it)
CA (1) CA1234568A (it)
CS (2) CS249128B2 (it)
CU (1) CU21532A3 (it)
DE (2) DE3317290A1 (it)
DK (1) DK160612C (it)
DO (1) DOP1983004163A (it)
DZ (1) DZ540A1 (it)
ES (6) ES522291A0 (it)
FI (1) FI77244C (it)
FR (1) FR2531956B1 (it)
GB (1) GB2128984B (it)
GR (1) GR77462B (it)
HK (1) HK91692A (it)
HU (3) HU198935B (it)
IE (1) IE56480B1 (it)
IL (1) IL68620A (it)
IT (1) IT1212738B (it)
LU (2) LU84803A1 (it)
MC (1) MC1515A1 (it)
MY (1) MY102889A (it)
NL (2) NL8301640A (it)
NO (1) NO160368C (it)
PT (1) PT76681B (it)
SE (1) SE461792B (it)
SG (1) SG81192G (it)
ZW (1) ZW9883A1 (it)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
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US20160024098A1 (en) 2013-03-15 2016-01-28 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
AU2014235854B2 (en) 2013-03-21 2019-04-11 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
JP2018531951A (ja) 2015-10-27 2018-11-01 ユープラシア ファーマシューティカルズ インク． 局所麻酔薬の徐放性製剤

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US4772701A (en) 1988-09-20
GR77462B (it) 1984-09-24
ES8505173A1 (es) 1985-05-16
CS249128B2 (en) 1987-03-12
HK91692A (en) 1992-11-27
FR2531956A1 (fr) 1984-02-24
SE461792B (sv) 1990-03-26
US4512924A (en) 1985-04-23
AR240940A2 (es) 1991-03-27
ES528630A0 (es) 1986-06-16
NO831675L (no) 1983-11-14
EP0094095A3 (en) 1984-11-21
CS402191A3 (en) 1992-10-14
DK194783D0 (da) 1983-05-02
GB8305505D0 (en) 1983-03-30
NO160368B (no) 1989-01-02
FI831661L (fi) 1983-11-13
CA1234568A (en) 1988-03-29
ES554935A0 (es) 1987-11-01
IE56480B1 (en) 1991-08-14
DOP1983004163A (es) 1988-09-20
DK160612B (da) 1991-04-02
NL930055I2 (nl) 1993-10-01
NO160368C (no) 1989-04-12
FI77244C (fi) 1989-02-10
HU195965B (en) 1988-08-29
ES8601994A1 (es) 1985-11-16
NL8301640A (nl) 1983-12-01
ES528627A0 (es) 1985-11-16
FI77244B (fi) 1988-10-31
MY102889A (en) 1993-03-31
GB2128984B (en) 1985-05-22
AU567873B2 (en) 1987-12-10
ES8607970A1 (es) 1986-06-16
US4658024A (en) 1987-04-14
DE3317290A1 (de) 1983-11-17
IE831084L (en) 1983-11-12
ES8800170A1 (es) 1987-11-01
LU88299I2 (fr) 1994-09-09
DZ540A1 (fr) 2004-09-13
PT76681A (en) 1983-06-01
HU199842B (en) 1990-03-28
DK160612C (da) 1991-09-23
PT76681B (en) 1986-05-20
EP0094095B1 (de) 1990-09-19
KR890002106B1 (ko) 1989-06-19
IL68620A (en) 1987-11-30
LU84803A1 (fr) 1985-03-21
SG81192G (en) 1993-01-29
ES528625A0 (es) 1985-05-16
DE3381884D1 (de) 1990-10-25
ES8407049A1 (es) 1984-08-16
IT1212738B (it) 1989-11-30
ES522291A0 (es) 1984-08-16
EP0094095A2 (de) 1983-11-16
ZW9883A1 (en) 1984-11-21
ES8706672A1 (es) 1987-07-16
ES528628A0 (es) 1987-07-16
MC1515A1 (fr) 1984-02-10
SE8302716L (sv) 1983-11-13
NL930055I1 (nl) 1993-09-01
DK194783A (da) 1983-11-13
SE8302716D0 (sv) 1983-05-11
AU1436483A (en) 1983-11-17
FI831661A0 (fi) 1983-05-12
HU198935B (en) 1989-12-28
FR2531956B1 (fr) 1987-02-20
CU21532A3 (en) 1987-06-09
GB2128984A (en) 1984-05-10
AR240940A1 (es) 1991-03-27
KR840004754A (ko) 1984-10-24
BG61123B2 (bg) 1996-11-29
IL68620A0 (en) 1983-09-30

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