GB2128984B
(en)
*
|
1982-05-12 |
1985-05-22 |
Hoffmann La Roche |
Diaza-bicyclic compounds
|
ZA833214B
(en)
*
|
1982-05-12 |
1983-12-28 |
Hoffmann La Roche |
Bicyclic compounds
|
DE3315464A1
(de)
*
|
1983-04-28 |
1984-10-31 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
|
US4801721A
(en)
*
|
1984-08-16 |
1989-01-31 |
Ryan James W |
Stereospecific synthesis of carboxyalkyl peptides
|
US4692438A
(en)
*
|
1984-08-24 |
1987-09-08 |
Hoffmann-La Roche Inc. |
Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
|
US4940718A
(en)
*
|
1985-04-30 |
1990-07-10 |
Eli Lilly And Company |
7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
|
US4826992A
(en)
*
|
1985-04-30 |
1989-05-02 |
Eli Lilly And Company |
2,3-(Dihydro) bicyclic pyrazolidinones
|
US4902707A
(en)
*
|
1985-04-30 |
1990-02-20 |
Eli Lilly And Company |
Bicyclic pyrazolidinones, compositions and use
|
DE3677253D1
(de)
*
|
1985-04-30 |
1991-03-07 |
Lilly Co Eli |
7-substituierte bicyclische pyrazolidinone.
|
ZW11586A1
(en)
*
|
1985-07-01 |
1987-12-30 |
Hoffmann La Roche |
Bicyclic compounds
|
US4832763A
(en)
*
|
1985-10-15 |
1989-05-23 |
Westinghouse Electric Corp. |
Method of stress-relief annealing a magnetic core containing amorphous material
|
DE3542794A1
(de)
*
|
1985-12-04 |
1987-06-11 |
Bayer Ag |
Antihypertensives kombinationspraeparat
|
EP0254032A3
(en)
*
|
1986-06-20 |
1990-09-05 |
Schering Corporation |
Neutral metalloendopeptidase inhibitors in the treatment of hypertension
|
EP0566157A1
(en)
|
1986-06-20 |
1993-10-20 |
Schering Corporation |
Neutral metalloendopeptidase inhibitors in the treatment of hypertension
|
GB8629875D0
(en)
*
|
1986-12-15 |
1987-01-28 |
Hoffmann La Roche |
Pyridazodiazepine derivatives
|
US5262436A
(en)
*
|
1987-03-27 |
1993-11-16 |
Schering Corporation |
Acylamino acid antihypertensives in the treatment of congestive heart failure
|
US4956490A
(en)
*
|
1989-03-09 |
1990-09-11 |
Merck & Co., Inc. |
Process for preparing benzylpyruvic acids and esters
|
ZA902661B
(en)
*
|
1989-04-10 |
1991-01-30 |
Schering Corp |
Mercapto-acyl amino acids
|
DE3917255A1
(de)
*
|
1989-05-26 |
1990-11-29 |
Schopf Masch |
Verfahren und vorrichtung zum aufnehmen eines flugzeugbugfahrwerks durch einen flugzeugschlepper
|
US5011938A
(en)
*
|
1989-10-02 |
1991-04-30 |
Eli Lilly And Company |
7-substituted bicyclic pyrazolidinones
|
EP0502075A1
(en)
*
|
1989-11-21 |
1992-09-09 |
Schering Corporation |
Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
|
WO1991009840A1
(en)
*
|
1989-12-22 |
1991-07-11 |
Schering Corporation |
Mercaptocycloacyl aminoacid endopeptidase inhibitors
|
US5075302A
(en)
*
|
1990-03-09 |
1991-12-24 |
Schering Corporation |
Mercaptoacyl aminolactam endopeptidase inhibitors
|
US5173506A
(en)
*
|
1990-08-16 |
1992-12-22 |
Schering Corporation |
N-(mercaptoalkyl)ureas and carbamates
|
DE59107840D1
(de)
*
|
1990-11-21 |
1996-06-27 |
Ciba Geigy Ag |
Silylierte Acylphosphinoxide
|
US5208230A
(en)
*
|
1990-12-21 |
1993-05-04 |
Merrell Dow Pharmaceuticals |
Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
|
JPH06506201A
(ja)
*
|
1991-03-19 |
1994-07-14 |
ノバルティス アクチエンゲゼルシャフト |
新規な除草性、殺ダニ性および殺虫性活性化合物
|
TW216770B
(el)
*
|
1991-07-23 |
1993-12-01 |
Hoffmann La Roche |
|
US5457196A
(en)
*
|
1991-09-27 |
1995-10-10 |
Merrell Dow Pharmaceuticals Inc. |
2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
|
CA2078759C
(en)
*
|
1991-09-27 |
2003-09-16 |
Alan M. Warshawsky |
Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
|
US5455242A
(en)
*
|
1991-09-27 |
1995-10-03 |
Merrell Dow Pharmaceuticals Inc. |
Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
|
US5442062A
(en)
*
|
1991-10-24 |
1995-08-15 |
The Upjohn Company |
Imidazole derivatives and pharmaceutical compositions containing the same
|
JPH06107661A
(ja)
*
|
1991-10-24 |
1994-04-19 |
Upjohn Co:The |
イミダゾール誘導体およびこれを有効成分とする医薬組成物
|
US5972990A
(en)
*
|
1992-04-10 |
1999-10-26 |
Brigham And Women's Hospital, Inc. |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
|
US5977160A
(en)
*
|
1992-04-10 |
1999-11-02 |
Brigham And Women's Hospital, Inc. |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
|
US5552397A
(en)
*
|
1992-05-18 |
1996-09-03 |
E. R. Squibb & Sons, Inc. |
Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
|
US5646276A
(en)
*
|
1992-05-13 |
1997-07-08 |
Bristol-Myers Squibb Co. |
Diazepine containing dual action inhibitors
|
DE69325904T2
(de)
*
|
1992-05-15 |
1999-12-09 |
Merrell Pharma Inc |
MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN
|
EP0570764B1
(de)
*
|
1992-05-18 |
2001-07-18 |
F.Hoffmann-La Roche & Co. Aktiengesellschaft |
Asymmetrische Hydrierung
|
US5238932A
(en)
*
|
1992-05-20 |
1993-08-24 |
Merrell Dow Pharmaceuticals Inc. |
Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
|
WO1994010193A1
(en)
*
|
1992-10-30 |
1994-05-11 |
Merrell Dow Pharmaceuticals Inc. |
Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
|
JPH072859A
(ja)
*
|
1993-01-28 |
1995-01-06 |
Upjohn Co:The |
ピラゾール誘導体およびこれを有効成分とする医薬組成物
|
US5476395A
(en)
*
|
1993-03-01 |
1995-12-19 |
Methode Electronics, Inc. |
Planar fuse panel
|
DK0634175T3
(da)
*
|
1993-07-15 |
2001-04-30 |
Hoffmann La Roche |
Farmaceutisk kombination, der indeholder en hæmmer af renin-angiotensin-systemet og en endothelin-antagonist
|
DK0750631T3
(da)
*
|
1994-02-14 |
2000-10-23 |
Merrell Pharma Inc |
Mercaptoacetylamido-1,3,4,5-tetrahydrobenzo[c]azepin-3-ondisulfidderivater som enkephalinase- og ACE-inhibitorer
|
CA2183320C
(en)
*
|
1994-02-14 |
1999-10-26 |
Gary A. Flynn |
Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
|
US5530013A
(en)
*
|
1994-02-14 |
1996-06-25 |
American Home Products Corporation |
Venlafaxine in the inducement of cognition enhancement
|
EP0746566A1
(en)
*
|
1994-02-14 |
1996-12-11 |
Merrell Pharmaceuticals Inc. |
Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
|
PT745081E
(pt)
*
|
1994-02-14 |
2002-04-29 |
Merrell Pharma Inc |
Derivados de dissulfureto de inda-2-mercaptoacetilamida uteis como inibidores da encefalinase
|
US5484783A
(en)
*
|
1994-03-24 |
1996-01-16 |
Merrell Dow Pharmaceuticals Inc. |
Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
|
JPH09510476A
(ja)
*
|
1994-03-24 |
1997-10-21 |
メリル・フアーマシユウテイカルズ・インコーポレイテツド |
低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のアミノアセチルメルカプト誘導体
|
ATE246927T1
(de)
*
|
1994-03-24 |
2003-08-15 |
Merrell Pharma Inc |
Cholesterin senkende mercaptoacetylamiddisulfidderivate
|
US5756466A
(en)
|
1994-06-17 |
1998-05-26 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
US5587375A
(en)
*
|
1995-02-17 |
1996-12-24 |
Bristol-Myers Squibb Company |
Azepinone compounds useful in the inhibition of ACE and NEP
|
US5877313A
(en)
*
|
1995-05-17 |
1999-03-02 |
Bristol-Myers Squibb |
Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
|
US5635504A
(en)
*
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Co. |
Diazepine containing dual action inhibitors
|
US5650408A
(en)
*
|
1995-06-07 |
1997-07-22 |
Karanewsky; Donald S. |
Thiazolo benzazepine containing dual action inhibitors
|
FR2777888B1
(fr)
*
|
1998-04-27 |
2004-07-16 |
Hoechst Marion Roussel Inc |
Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
|
FR2777889B1
(fr)
*
|
1998-04-27 |
2004-07-09 |
Hoechst Marion Roussel Inc |
Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
|
AU2003200034B2
(en)
*
|
1998-04-27 |
2006-07-20 |
Aventis Pharma S.A. |
New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
|
US6703500B2
(en)
|
1998-08-19 |
2004-03-09 |
Vertex Pharmaceuticals, Incorporated |
Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
|
US6177565B1
(en)
*
|
1998-08-19 |
2001-01-23 |
Vertex Pharmaceuticals Inc. |
Process for synthesizing piperazic acid
|
US6559304B1
(en)
|
1998-08-19 |
2003-05-06 |
Vertex Pharmaceuticals Incorporated |
Method for synthesizing caspase inhibitors
|
FR2788276B1
(fr)
*
|
1999-01-12 |
2001-02-16 |
Hoechst Marion Roussel Inc |
NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
|
WO2001021259A2
(en)
*
|
1999-09-21 |
2001-03-29 |
Emory University |
Use and compositions for treating platelet-related disorders using anagrelide
|
US20030113330A1
(en)
*
|
1999-11-08 |
2003-06-19 |
Uhal Bruce D. |
Methods for treating pulmonary fibrosis
|
US8101363B2
(en)
|
2000-12-14 |
2012-01-24 |
The Brigham And Women's Hospital, Inc. |
Inflammatory markers as tools in the detection and prevention of diabetes mellitus and as tools to aid in the selection of agents to be used for the prevention and treatment of diabetes
|
GB0119305D0
(en)
|
2001-04-12 |
2001-10-03 |
Aventis Pharma Gmbh |
Mercaptoacetylamide derivatives,a process for their preparation and their use
|
SI3072978T1
(sl)
|
2002-05-09 |
2018-11-30 |
The Brigham And Women's Hospital, Inc. |
1L1RL-1 kot marker za kardiovaskularne bolezni
|
US20040110241A1
(en)
*
|
2002-12-06 |
2004-06-10 |
Segal Mark S. |
Materials and methods for monitoring vascular endothelial function
|
JP2006521287A
(ja)
*
|
2002-12-20 |
2006-09-21 |
エスティ.ジェイムス アソシエイト エルエルシー/フェイバー リサーチ シリーズ |
医薬製剤用の高圧圧縮
|
WO2004078761A1
(en)
*
|
2003-03-06 |
2004-09-16 |
Ranbaxy Laboratories Limited |
Enantiomerically pure cilazapril,process for preparation
|
AU2003247159A1
(en)
*
|
2003-07-07 |
2005-01-21 |
Hetero Drugs Limited |
A novel process for the preparation of cilazapril
|
ES2567135T3
(es)
|
2003-08-29 |
2016-04-20 |
The Brigham And Women's Hospital, Inc. |
Derivados de hidantoína como inhibidores de necrosis celular
|
CA2549236C
(en)
|
2003-12-05 |
2017-06-13 |
The Cleveland Clinic Foundation |
Risk markers for cardiovascular disease
|
US7803838B2
(en)
*
|
2004-06-04 |
2010-09-28 |
Forest Laboratories Holdings Limited |
Compositions comprising nebivolol
|
WO2005122682A2
(en)
|
2004-06-18 |
2005-12-29 |
Ranbaxy Laboratories Limited |
Process for the preparation of esters of piperazic acid
|
JP5020086B2
(ja)
|
2004-10-06 |
2012-09-05 |
ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド |
治療後の全身炎症性マーカーの達成レベルの関連性
|
JP2008528507A
(ja)
*
|
2005-01-21 |
2008-07-31 |
ニトロメッド インコーポレーティッド |
複素環式の酸化窒素供与体基を含む心血管化合物、組成物および使用方法
|
EP1848424B1
(en)
*
|
2005-01-31 |
2017-04-05 |
Mylan Laboratories, Inc |
Pharmaceutical composition comprising hydroxylated nebivolol
|
KR101310037B1
(ko)
|
2005-05-31 |
2013-09-24 |
밀란 인크. |
네비볼롤을 함유하는 조성물
|
US8119358B2
(en)
|
2005-10-11 |
2012-02-21 |
Tethys Bioscience, Inc. |
Diabetes-related biomarkers and methods of use thereof
|
DE602006000402T8
(de)
|
2006-06-02 |
2009-04-09 |
Teva Pharmaceutical Industries Ltd. |
Stabile Zubereitung enthaltend eine feuchtigkeitsempfindliche aktive Substanz und Verfahren zur Herstellung der Zubereitung.
|
US20070281000A1
(en)
*
|
2006-06-02 |
2007-12-06 |
Michael Fox |
Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
|
CA2659082A1
(en)
|
2006-06-07 |
2007-12-21 |
Tethys Bioscience, Inc. |
Markers associated with arteriovascular events and methods of use thereof
|
US20080008751A1
(en)
*
|
2006-07-10 |
2008-01-10 |
Michael Fox |
Stable formulation comprising a combination of a moisture sensitive drug and a second drug and manufacturing procedure thereof
|
WO2008131224A2
(en)
|
2007-04-18 |
2008-10-30 |
Tethys Bioscience, Inc. |
Diabetes-related biomarkers and methods of use thereof
|
US7828840B2
(en)
*
|
2007-11-15 |
2010-11-09 |
Med Institute, Inc. |
Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
|
GB2460915B
(en)
|
2008-06-16 |
2011-05-25 |
Biovascular Inc |
Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
|
EP2221299A3
(en)
|
2009-02-11 |
2010-11-03 |
Dr. Reddy's Laboratories Ltd. |
Preparation of cilazapril intermediates
|
JP2013518618A
(ja)
|
2010-02-01 |
2013-05-23 |
ザ・ホスピタル・フォー・シック・チルドレン |
再狭窄を治療および予防するための遠隔虚血コンディショニング
|
KR20190000368A
(ko)
|
2010-03-31 |
2019-01-02 |
더 호스피탈 포 식 칠드런 |
심근 경색 후 결과를 개선시키기 위한 원격 허혈 처치의 사용
|
AU2011237461B2
(en)
|
2010-04-08 |
2015-11-26 |
The Hospital For Sick Children |
Use of remote ischemic conditioning for traumatic injury
|
WO2012049646A1
(en)
|
2010-10-12 |
2012-04-19 |
Ranbaxy Laboratories Limited |
Process for the preparation of an intermediate of cilazapril
|
EP2537534B1
(en)
|
2011-06-22 |
2014-12-17 |
Hexal AG |
Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.
|
BR112014001283A2
(pt)
|
2011-07-18 |
2017-02-21 |
Critical Care Diagnostics Inc |
métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício
|
RU2654484C1
(ru)
|
2012-05-11 |
2018-05-21 |
Ресет Терапьютикс, Инк. |
Карбазолсодержащие сульфонамиды в качестве модуляторов криптохрома
|
AU2013296803B2
(en)
|
2012-08-01 |
2018-03-08 |
Eric Ostertag |
Free flowing, frozen compositions comprising a therapeutic agent
|
JP2016514693A
(ja)
|
2013-03-15 |
2016-05-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ハイブリッド型ネクロトーシス阻害剤
|
RU2015144689A
(ru)
|
2013-03-21 |
2017-04-25 |
ЮПРАКСИЯ ФАРМАСЬЮТИКАЛЗ ЮЭсЭй ЭлЭлСи |
Композиция для инъекций с замедленным высвобождением и способ ее применения для лечения воспаления в суставах и связанной с такими воспалениями боли
|
TWI690521B
(zh)
|
2014-04-07 |
2020-04-11 |
美商同步製藥公司 |
作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
|
PT3206672T
(pt)
|
2015-10-27 |
2018-06-20 |
Eupraxia Pharmaceuticals Inc |
Formulações de libertação prolongada de anestésicos locais
|