HU192771B - Process for producing phospholipide- and sphingolipide-amides and pharmaceutical compositions containing them - Google Patents

Process for producing phospholipide- and sphingolipide-amides and pharmaceutical compositions containing them Download PDF

Info

Publication number
HU192771B
HU192771B HU822492A HU249282A HU192771B HU 192771 B HU192771 B HU 192771B HU 822492 A HU822492 A HU 822492A HU 249282 A HU249282 A HU 249282A HU 192771 B HU192771 B HU 192771B
Authority
HU
Hungary
Prior art keywords
acid
formula
amide
sphingosine
amine
Prior art date
Application number
HU822492A
Other languages
English (en)
Hungarian (hu)
Inventor
Valle Francesco Della
Aurelio Romeo
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of HU192771B publication Critical patent/HU192771B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HU822492A 1981-08-03 1982-08-03 Process for producing phospholipide- and sphingolipide-amides and pharmaceutical compositions containing them HU192771B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT49031/81A IT1171432B (it) 1981-08-03 1981-08-03 Amidi organiche derivate da lipidi azotati utilizzabili come farmaci

Publications (1)

Publication Number Publication Date
HU192771B true HU192771B (en) 1987-07-28

Family

ID=11269438

Family Applications (1)

Application Number Title Priority Date Filing Date
HU822492A HU192771B (en) 1981-08-03 1982-08-03 Process for producing phospholipide- and sphingolipide-amides and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (3) US4757053A (enExample)
EP (1) EP0072286B2 (enExample)
JP (2) JPS5843942A (enExample)
KR (1) KR880000042B1 (enExample)
AT (1) ATE23165T1 (enExample)
AU (1) AU561811B2 (enExample)
DE (1) DE3273983D1 (enExample)
DK (1) DK159204C (enExample)
ES (3) ES514683A0 (enExample)
FI (1) FI75829C (enExample)
GR (1) GR76234B (enExample)
HU (1) HU192771B (enExample)
IE (1) IE53644B1 (enExample)
IL (1) IL66454A0 (enExample)
IT (1) IT1171432B (enExample)
NO (1) NO161314C (enExample)
NZ (1) NZ201439A (enExample)
PL (1) PL141417B1 (enExample)
PT (1) PT75363B (enExample)
YU (3) YU43085B (enExample)
ZA (1) ZA825585B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1171432B (it) * 1981-08-03 1987-06-10 Fidia Farmaceutici Amidi organiche derivate da lipidi azotati utilizzabili come farmaci
US5189017A (en) * 1982-07-23 1993-02-23 Ciba-Geigy Corporation Use of sugar derivatives for the prophylaxis and treatment of virus infections
US5334583A (en) * 1982-07-23 1994-08-02 Ciba-Geigy Corp. Use of sugar derivatives for the prophylaxis and treatment of virus infections
ATE45744T1 (de) * 1984-07-25 1989-09-15 Ciba Geigy Ag Phosphatidylverbindungen, verfahren zu ihrer herstellung und ihre verwendung.
EP0174912A3 (de) * 1984-09-13 1986-06-04 Ciba-Geigy Ag Phosphorverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
LU85971A1 (fr) * 1985-06-25 1987-01-13 Oreal Nouveaux composes lipidiques amphiphiles, leur procede de preparation et leurs applications,notamnent en cosmetique et en dermopharmacie
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US5434190A (en) * 1986-08-08 1995-07-18 Colgate-Palmolive Co. N-aryl and N-cycloalkyl neoalkanamide insect repellents
DE3819870A1 (de) * 1987-06-12 1988-12-29 Hoerrmann Wilhelm Arzneimittel auf der basis von fett-amino-alkoholen
US5534553A (en) * 1987-06-12 1996-07-09 Hoerrmann; Wilhelm Drug containing fatty amino alcohols or derivatives thereof
EP0299201A3 (de) * 1987-06-12 1990-08-22 Wilhelm Dr. Hoerrmann Fett-Aminoalkohol enthaltendes Arzneimittel
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
US6362003B1 (en) 1992-02-24 2002-03-26 Coulter Corporation Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof
US6509192B1 (en) * 1992-02-24 2003-01-21 Coulter International Corp. Quality control method
DE4229877C2 (de) * 1992-09-04 1994-09-15 Max Delbrueck Centrum Phospho- bzw. Phosphono-(N-acyl)-serine und ihre Herstellung
US5346914A (en) * 1993-05-14 1994-09-13 Abbott Laboratories (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
US5635536A (en) * 1994-12-07 1997-06-03 Pharmacia & Upjohn Aktiebolag Emulsion suitable for administering a sphingolipid
JP3874215B2 (ja) * 1997-08-07 2007-01-31 Ｎｓｋワーナー株式会社 ワンウェイクラッチおよびワンウェイクラッチ用外輪・ 保持器組立体
US6092636A (en) * 1997-08-07 2000-07-25 Nsk-Warner K.K. Oneway clutch
AU2001252506A1 (en) * 2000-04-19 2001-10-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
US6756504B2 (en) 2000-04-19 2004-06-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
AU2003217791A1 (en) 2002-02-28 2003-09-16 A And D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
EP1499306A4 (en) 2002-04-12 2007-03-28 Merck & Co Inc BICYCLIC AMIDE
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
FR2839310A1 (fr) * 2002-05-03 2003-11-07 Pasteur Institut Nouveau procede de preparation d' alpha-glycosylceramides, nouveaux derives alpha-glycosylceramide et leurs applications
WO2003094842A2 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
KR100496566B1 (ko) * 2002-06-11 2005-06-23 주식회사 포스코 탈황능이 향상된 무연탄을 이용한 용선용 탈황제
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
CN107434814B (zh) * 2017-07-14 2019-05-03 中国科学院化学研究所 改性共轭聚合物及其制备方法和应用
JP2019161542A (ja) * 2018-03-15 2019-09-19 オンキヨー株式会社 振動板およびこれを用いたスピーカーユニット、ヘッドホン、並びにイヤホン、振動板の製造方法
KR102503769B1 (ko) * 2020-07-10 2023-02-27 솔루스바이오텍 주식회사 측쇄 지방산을 포함하는 신규한 스핑고지질과 그의 용도
CN115260091B (zh) * 2022-08-05 2025-06-06 深圳市迪克曼生物科技有限公司 含环状羧酸的神经酰胺类化合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH349592A (de) * 1956-06-06 1960-10-31 Ciba Geigy Verfahren zur Herstellung von ungesättigten, aliphatischen Aminodiolen
BE569345A (enExample) * 1957-07-12
GB1064293A (en) * 1963-07-15 1967-04-05 Bellon Labor Sa Roger Substituted 2-pyrrylketones
US3418325A (en) * 1965-12-23 1968-12-24 Bofors Ab Method of producing a product between meso-inositol and nicotinic acid
US3901893A (en) * 1970-05-18 1975-08-26 Richter Gedeon Vegyeszet New dihydro-lysergic acid derivative
HU169073B (enExample) * 1974-05-28 1976-09-28
US4064249A (en) * 1974-05-28 1977-12-20 Richter Gedeon Vegyeszeti Gyar Rt. Compounds with ergoline skeleton
DE2629135A1 (de) * 1976-06-29 1978-01-12 Nattermann A & Cie Neue phospholipid-derivate von prostaglandinen und verfahren zu ihrer herstellung
JPS565491A (en) * 1979-06-19 1981-01-20 Nattermann A & Cie Nnoleyl derivative of phosphatidylethanolamine* its manufacture and medicine containing same for lipemia and arteriosclerosis
IT1171432B (it) * 1981-08-03 1987-06-10 Fidia Farmaceutici Amidi organiche derivate da lipidi azotati utilizzabili come farmaci

Also Published As

Publication number Publication date
NO161314C (no) 1989-08-02
IT1171432B (it) 1987-06-10
FI822672A0 (fi) 1982-07-30
US4757053A (en) 1988-07-12
ES8602616A1 (es) 1985-12-16
ES8608480A1 (es) 1986-07-16
IT8149031A0 (it) 1981-08-03
ES545241A0 (es) 1986-07-16
DE3273983D1 (en) 1986-12-04
PT75363A (en) 1982-09-01
NZ201439A (en) 1986-02-21
ES8501735A1 (es) 1984-12-16
IE53644B1 (en) 1989-01-04
DK346282A (da) 1983-02-04
YU42913B (en) 1988-12-31
JPS5843942A (ja) 1983-03-14
GR76234B (enExample) 1984-08-04
DK159204B (da) 1990-09-17
JPH0512329B2 (enExample) 1993-02-17
AU561811B2 (en) 1987-05-21
ATE23165T1 (de) 1986-11-15
PL237756A1 (en) 1985-05-07
YU73485A (en) 1986-02-28
PL141417B1 (en) 1987-07-31
YU43085B (en) 1989-02-28
NO161314B (no) 1989-04-24
EP0072286B2 (en) 1992-12-09
IT8149031A1 (it) 1983-02-03
IL66454A0 (en) 1982-12-31
KR880000042B1 (ko) 1988-02-20
DK159204C (da) 1991-03-11
FI75829C (fi) 1988-08-08
US4897381A (en) 1990-01-30
FI75829B (fi) 1988-04-29
YU73585A (en) 1986-02-28
AU8672682A (en) 1983-02-10
JPH0558976A (ja) 1993-03-09
YU42914B (en) 1988-12-31
FI822672L (fi) 1983-02-04
EP0072286A1 (en) 1983-02-16
YU168982A (en) 1986-02-28
PT75363B (en) 1984-12-10
US4897382A (en) 1990-01-30
ES514683A0 (es) 1984-12-16
ZA825585B (en) 1983-06-29
KR840001170A (ko) 1984-03-28
ES533004A0 (es) 1985-12-16
EP0072286B1 (en) 1986-10-29
IE821863L (en) 1983-02-03
NO822631L (no) 1983-02-04

Similar Documents

Publication Publication Date Title
EP0072286B2 (en) Organic amide compounds derived from nitrogenous lipids
US3868416A (en) Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives
US5216023A (en) Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament
SK64993A3 (en) Hydroxamic acid derivatives, method of their preparation and medicaments with their content
SK283201B6 (sk) Amidínové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukt
EP1009750B1 (fr) Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et leurs applications therapeutiques
FI71556C (fi) Foerfarande foer framstaellning av 5-(paradeuterofenyl)-5-fenylhydantoin, vilken aer ett laekemedel anvaendbart mot konvulsioner.
CA2004190A1 (en) New lysosphingolipid derivitives
FI98459C (fi) Menetelmä terapeuttisesti käyttökelpoisten 5-etano-2,3,4,5-1H-2-bentsatsepin-7-olikarbamaattijohdannaisten valmistamiseksi
EP0007441B1 (en) N - (n-acetyl-l-methionyl) - 3,4 -diethoxy-carbonyloxy-phenethylamine, process for preparing same and a pharmaceutical composition containing said compound.
EP0970042B1 (en) 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
EP0559625A2 (en) Esters of L-carnitine and acyl L-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same
EP0396080B1 (en) New serine derivatives, process for their preparation and their use in human therapy
TW202515554A (zh) Slc6a19功能之含雙環雜芳基之哌啶抑制劑
SK94793A3 (en) N-[[4,5-dihydroxy-and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo- -2-anthracene-yl] carbonyl] amino acids useful in the therapy of osteorticular affections
JP3125101B2 (ja) 光学異性ヒダントインの分割方法
JPH0455188B2 (enExample)
CA2329637A1 (fr) Derives d'(alpha-aminophosphino) peptides et compositions les contenant
EP0112606A1 (en) Threo-adrenalinecarboxylic acid, processes for the production thereof, and pharmaceutical compositions thereof
JPH10158267A (ja) 新規プリン誘導体およびこれを含む医薬組成物
Di Stefano et al. Synthesis and preliminary evaluation of L-dopa/benserazide conjugates as dual acting codrugs
FR3067711A1 (fr) Inhibiteurs de la catechol-o-methyl-transferase (comt)
TWI522358B (zh) 四氫咪唑并〔１，５－ａ〕吡衍生物的鹽，其製備方法及其在醫藥上的應用
FR2598422A1 (fr) Pseudo-peptide comportant au moins la sequence de l'acide g-glutamyl-aspartique ou l'un de ses derives, son utilisation dans la preparation d'une composition pharmaceutique et composition pharmaceutique en resultant
PL164981B1 (pl) Sposób wytwarzania nowych enancjomerów pochodnych 2-tetrahydrofuranu PL PL PL

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee