HRP20231507T1 - Emulzije za liječenje vaginalnih infekcija - Google Patents

Emulzije za liječenje vaginalnih infekcija Download PDF

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Publication number
HRP20231507T1
HRP20231507T1 HRP20231507TT HRP20231507T HRP20231507T1 HR P20231507 T1 HRP20231507 T1 HR P20231507T1 HR P20231507T T HRP20231507T T HR P20231507TT HR P20231507 T HRP20231507 T HR P20231507T HR P20231507 T1 HRP20231507 T1 HR P20231507T1
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Croatia
Prior art keywords
emulsion
weight
concentration
percent
emulsion according
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HRP20231507TT
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English (en)
Inventor
Marion Noe
Christian Noe
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Profem Gmbh
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Priority claimed from EP17201650.3A external-priority patent/EP3482743A1/de
Priority claimed from EP17201651.1A external-priority patent/EP3482744A1/de
Application filed by Profem Gmbh filed Critical Profem Gmbh
Publication of HRP20231507T1 publication Critical patent/HRP20231507T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (15)

1. Emulzija koja ima vodenu fazu i uljnu fazu koja sadrži antifungalno sredstvo i NSAIL, naznačena time što (a) je NSAIL diklofenak u koncentraciji od 0,1 do 0,5 težinskih postotaka, indometacin u koncentraciji od 0,1 do 0,4 težinskih postotaka, naproksen u koncentraciji od 1 do 5 težinskih postotaka, ibuprofen u koncentraciji od 0,5 do 2,5 težinskih postotaka, deksibuprofen u koncentraciji od 0,25 do 1,25 težinskih postotaka, ketoprofen u koncentraciji od 0,25 do 1,25 težinskih postotaka, mefenaminska kiselina u koncentraciji od 0,5 do 4 težinskih postotaka, ili lornoksikam u koncentraciji od 0,02 do 0,04 težinskih postotaka, gdje je NSAIL u obliku soli; time što (b) je težinski omjer vodene faze prema uljnoj fazi u navedenoj emulziji između vrijednosti 2,0 i 2,7, pri čemu se težinski omjer izračunava uključujući materijal otopljen u fazama, pri čemu emulgatori nisu uključeni ni u vodenu fazu ni u uljnu fazu, te time što (c) pH emulzije nije manji od vrijednosti 6,5 i nije veći od 8,5, po mogućnosti u području od 7,0 do 8,0.
2. Emulzija prema patentnom zahtjevu 1 , naznačena time što je u obliku masti ili kreme.
3. Emulzija prema patentnom zahtjevu 1 ili 2, naznačena time što je emulzija polukruta.
4. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 3, naznačena time što je antifungalno sredstvo nistatin, ciklopiroks ili ciklopiroksolamin, ili antifungalno sredstvo odabrano iz skupine azola, poželjno klotrimazol, flukonazol, mikonazol, itrakonazol, tiokonazol, vorikonazol, bifonazol, ekonazol, izokonazol, fentikonazol, sertakonazol, ketokonazol, posakonazol, kvilsekonazol, otesekonazol (VT-1161) ili ibrexafungerp (SCY-078), posebno klotrimazol.
5. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 4, naznačena time što je NSAIL diklofenak i on je sadržan u rasponu koncentracija od 0,2-0,4 težinskih postotaka emulzije.
6. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 5, pri čemu sadrži konzervans aktivan u pH području emulzije, pri čemu je konzervans poželjno fenoksietanol ili propilen glikol ili njihova kombinacija, ili dekvalinijev klorid.
7. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 6, naznačena time što dodatno sadrži antibiotik aktivan protiv bakterijskih klica, pri čemu je navedeni antibiotik poželjno fosfomicin, klindamicin, metronidazol, nitrofurantoin, nitrofurazon, nitrofurantoin, nifuratel, nifuroksacin, nitroksolin, trimetoprim, sulfadiazin ili kotrimoksazol.
8. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 7, naznačena time što je dodatno sadržan antiseptik, poželjno u količini dovoljnoj za akutnu antimikrobnu aktivnost, pri čemu je antiseptik poželjno kvaterna amonijeva sol, poželjno odabrana iz skupine koju čine: benzalkonijev klorid, poželjno u koncentraciji od najmanje 0,2 težinskih postotaka; dekvalinijev klorid, poželjno u koncentraciji od najmanje 0,2 težinskih postotaka; i fenoksietanola, poželjno u koncentraciji od najmanje 2 težinska postotka.
9. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 8 za uporabu u liječenju vaginalnih gljivičnih infekcija, posebno kroničnih vaginalnih gljivičnih infekcija, pri čemu je liječenje po mogućnosti lokalno liječenje.
10. Emulzija za uporabu prema patentnom zahtjevu 9, naznačena time što je vaginalna gljivična infekcija mješovita vaginalna infekcija Candida albicans i bakterijama kao što su Enterobakter, E.coli, Klebsijela pneumonija, Gardnerela vaginalis, Prevotela spp.
11. Emulzija za uporabu prema patentnom zahtjevu 9 ili 10, naznačena time što je vaginalna gljivična infekcija kandidomikoza, posebno vulvovaginalna kandidijaza.
12. Postupak za proizvodnju emulzije prema bilo kojem od patentnih zahtjeva 1 do 8, naznačena time što se u proizvodnji emulzije NSAIL unosi preko vodene faze.
13. Postupak za proizvodnju emulzije prema bilo kojem od patentnih zahtjeva 1 do 8, naznačena time što je NSAIL inkorporiran kao fina kristalna ili mikronizirana sol u emulziju koja sadrži antifungalno sredstvo.
14. Postupak za proizvodnju emulzije prema bilo kojem od patentnih zahtjeva 1 do 8, naznačena time što se NSAIL uvodi u emulziju koja sadrži antifungalno sredstvo preko hidrogela.
15. Postupak za proizvodnju emulzije prema patentnom zahtjevu 7 ili 8, pri čemu je dodavanje materijala takvo da osigurava terapeutski učinkovit antibakterijski učinak.
HRP20231507TT 2017-11-14 2018-11-14 Emulzije za liječenje vaginalnih infekcija HRP20231507T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17201650.3A EP3482743A1 (de) 2017-11-14 2017-11-14 Emulsionen zur behandlung von scheideninfektionen
EP17201651.1A EP3482744A1 (de) 2017-11-14 2017-11-14 Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen
PCT/EP2018/081253 WO2019096857A1 (de) 2017-11-14 2018-11-14 Emulsionen zur behandlung von schleimhautinfektionen
EP18799563.4A EP3709968B1 (de) 2017-11-14 2018-11-14 Emulsionen zur behandlung von schleimhautinfektionen

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HRP20231507T1 true HRP20231507T1 (hr) 2024-03-01

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HRP20231508TT HRP20231508T1 (hr) 2017-11-14 2018-11-14 Emulzije za lokalno liječenje dermalnih infekcija i infekcija sluznice
HRP20231507TT HRP20231507T1 (hr) 2017-11-14 2018-11-14 Emulzije za liječenje vaginalnih infekcija

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US (3) US11266600B2 (hr)
EP (2) EP3709968B1 (hr)
JP (2) JP7419241B2 (hr)
KR (2) KR102657908B1 (hr)
CN (2) CN111601585B (hr)
AU (2) AU2018367122A1 (hr)
BR (2) BR112020009458A2 (hr)
CA (2) CA3082727A1 (hr)
CL (2) CL2020001273A1 (hr)
ES (2) ES2963980T3 (hr)
HR (2) HRP20231508T1 (hr)
HU (1) HUE064253T2 (hr)
IL (2) IL274630A (hr)
MX (2) MX2020005055A (hr)
PL (2) PL3709968T3 (hr)
RS (1) RS64869B1 (hr)
UA (2) UA126597C2 (hr)
WO (2) WO2019096857A1 (hr)

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AU2018367122A1 (en) * 2017-11-14 2020-06-04 Profem Gmbh Emulsions for the topical treatment of dermal infections and mucosal infections
CN112691075B (zh) * 2020-12-31 2023-06-20 海南海神同洲制药有限公司 一种硝酸舍他康唑乳膏及其制备方法
CN113520993B (zh) * 2021-07-30 2022-07-29 海南海神同洲制药有限公司 一种低粘度硝酸舍他康唑乳膏的制备方法及其制备的产品

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