HRP20231508T1 - Emulzije za lokalno liječenje dermalnih infekcija i infekcija sluznice - Google Patents

Emulzije za lokalno liječenje dermalnih infekcija i infekcija sluznice Download PDF

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Publication number
HRP20231508T1
HRP20231508T1 HRP20231508TT HRP20231508T HRP20231508T1 HR P20231508 T1 HRP20231508 T1 HR P20231508T1 HR P20231508T T HRP20231508T T HR P20231508TT HR P20231508 T HRP20231508 T HR P20231508T HR P20231508 T1 HRP20231508 T1 HR P20231508T1
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Croatia
Prior art keywords
emulsion
weight
concentration
percent
infection
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HRP20231508TT
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English (en)
Inventor
Marion Noe
Christian Noe
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Profem Gmbh
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Priority claimed from EP17201650.3A external-priority patent/EP3482743A1/de
Priority claimed from EP17201651.1A external-priority patent/EP3482744A1/de
Application filed by Profem Gmbh filed Critical Profem Gmbh
Publication of HRP20231508T1 publication Critical patent/HRP20231508T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Oncology (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (15)

1. Emulzija za lokalno liječenje dermalnih infekcija i infekcija sluznice, posebno urogenitalnih zaraznih bolesti, naznačena time što se antimikrobno sredstvo odabrano između antibiotika i antiseptika i NSAIL koristi u kombinaciji, pri čemu (a) je NSAIL diklofenak u koncentraciji od 0,1 do 0,5 težinskih postotaka, indometacin u koncentraciji od 0,1 do 0,4 težinskih postotaka, naproksen u koncentraciji od 1 do 5 težinskih postotaka, ibuprofen u koncentraciji od 0,5 do 2,5 težinskih postotaka, deksibuprofen u koncentraciji od 0,25 do 1,25 težinskih postotaka, ketoprofen u koncentraciji od 0,25 do 1,25 težinskih postotaka, mefenaminska kiselina u koncentraciji od 0,5 do 4 težinska postotka, ili lorniksokam u koncentraciji od 0,02 do 0,04 težinskih postotaka, pri čemu je NSAIL u obliku soli; (b) težinski omjer vodene i uljane faze u navedenoj emulziji je između vrijednosti 2,0 i 2,7, pri čemu se težinski omjer izračunava uključujući građe otopljene u fazama, pri čemu emulgatori nisu uključeni ni u vodenu ni u uljanu fazu, i (c) pH emulzije nije manji od vrijednosti 6,5 i ne veći od 8,5, po mogućnosti u području 7,0 do 8.
2. Emulzija prema patentnom zahtjevu 1, koja dodatno sadrži antifungalno sredstvo.
3. Emulzija prema patentnom zahtjevu 1 ili 2, u obliku masti, kreme, šampona ili štapića, poželjno za lokalno liječenje dermalnih infekcija, poželjno dalje da sadrži miris, poželjno terpen, posebno farnezol.
4. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 3, naznačena time što je antimikrobno sredstvo antibiotik, poželjno fosfomicin, klindamicin, metronidazol, nitrofurantoin, nitrofurazon, nitrofurantoin, nifuratel, nifuroksacin, nitroksolin, trimetoprim, sulfadiazin ili kotrimoksazol; ili je antimikrobno sredstvo antiseptik, poželjno odabran iz skupine koju čine: benzalkonijev klorid, poželjno u koncentraciji od najmanje 0,2 težinskih postotaka; dekvalinijev klorid, poželjno u koncentraciji od najmanje 0,2 težinskih postotaka; i fenoksietanol, poželjno u koncentraciji od najmanje 2 težinskih postotaka.
5. Emulzija prema bilo kojem od patentnih zahtjeva 2 do 4, naznačena time što je antifungalno sredstvo nistatin, ciklopiroks ili ciklopiroksolamin, ili antifungalno sredstvo iz skupine azola, poželjno klotrimazol, flukonazol, mikonazol, itrakonazol, tiokonazol, vorikonazol, bifonazol. ekonazol, izokonazol, fentikonazol, sertakonazol, ketokonazol, posakonazol, kvilsekonazol, otesekonazol (VT-1161) ili ibrexafungerp (SCY-078).
6. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 5, za uporabu u lokalnom liječenju zaraznih bolesti, posebno za uporabu u lokalnom liječenju dermalnih i urogenitalnih zaraznih bolesti, poželjno, pri čemu je zarazna bolest kronična zarazna bolest.
7. Emulzija za uporabu prema patentnom zahtjevu 6, naznačena time što je zarazna bolest mukozna infekcija, posebno urogenitalna infekcija, poželjno mikrobna urogenitalna infekcija, posebno ženska mikrobna urogenitalna infekcija, poželjno pri čemu je mikrobna urogenitalna infekcija bakterijska urogenitalna infekcija.
8. Emulzija za uporabu prema patentnom zahtjevu 6 ili 7, naznačena time što je zarazna bolest mješovita vaginalna infekcija Candida albicans i bakterijama kao što su Enterobacter, E.coli, Klebsiella pneumoniae, Gardnerella vaginalis, Prevotella spp.
9. Emulzija za uporabu prema bilo kojem od patentnih zahtjeva 6 do 8, naznačena time što je zarazna bolest asimptomatska ili simptomatska bakterijska vaginoza ili asimptomatska ili simptomatska disbioza glavića penisa i/ili muške uretre.
10. Emulzija za uporabu prema patentnom zahtjevu 9, naznačena time što je infektivna bolest dermalna gljivična infekcija, poželjno odabrana između kandidamikoza i malasezijamikoza, ili akni, poželjno pri čemu se emulzija prerađuje u stik za akne.
11. Emulzija prema bilo kojem od patentnih zahtjeva 1 do 5, za uporabu u lokalnom liječenju ženskog cistitisa i za lokalno liječenje partnera (glavić penisa, početna trećina uretre).
12. Emulzija, poželjno šamponi prema bilo kojem od patentnih zahtjeva 1 do 5, za tretiranje gubitka kose.
13. Emulzija prema bilo kojem od patentnih zahtjeva 3 do 5, za uporabu u lokalnom liječenju atopijskog dermatitisa.
14. Postupak za proizvodnju emulzije prema bilo kojem od patentnih zahtjeva 1 do 5, naznačena time što se u proizvodnji emulzije NSAIL unosi preko vodene faze.
15. Postupak za proizvodnju emulzije prema bilo kojem od patentnih zahtjeva 2 do 5, naznačena time što je NSAIL ugrađen kao fina kristalna ili mikronizirana sol u emulziju koja sadrži antifungalno sredstvo.
HRP20231508TT 2017-11-14 2018-11-14 Emulzije za lokalno liječenje dermalnih infekcija i infekcija sluznice HRP20231508T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17201650.3A EP3482743A1 (de) 2017-11-14 2017-11-14 Emulsionen zur behandlung von scheideninfektionen
EP17201651.1A EP3482744A1 (de) 2017-11-14 2017-11-14 Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen
EP18799567.5A EP3709969B1 (de) 2017-11-14 2018-11-14 Emulsionen zur topischen behandlung von dermalen infektionen und schleimhautinfektionen
PCT/EP2018/081264 WO2019096863A1 (de) 2017-11-14 2018-11-14 Emulsionen zur topischen behandlung von dermalen infektionen und schleimhautinfektionen

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HRP20231508T1 true HRP20231508T1 (hr) 2024-03-01

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HRP20231508TT HRP20231508T1 (hr) 2017-11-14 2018-11-14 Emulzije za lokalno liječenje dermalnih infekcija i infekcija sluznice
HRP20231507TT HRP20231507T1 (hr) 2017-11-14 2018-11-14 Emulzije za liječenje vaginalnih infekcija

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US (3) US11266600B2 (hr)
EP (2) EP3709968B1 (hr)
JP (2) JP7378409B2 (hr)
KR (2) KR102658716B1 (hr)
CN (2) CN111601585B (hr)
AU (2) AU2018367116A1 (hr)
BR (2) BR112020009454A2 (hr)
CA (2) CA3082727A1 (hr)
CL (2) CL2020001273A1 (hr)
ES (2) ES2963977T3 (hr)
HR (2) HRP20231508T1 (hr)
HU (1) HUE064253T2 (hr)
IL (2) IL274631A (hr)
MX (2) MX2020005056A (hr)
PL (2) PL3709969T3 (hr)
RS (1) RS64869B1 (hr)
UA (2) UA126597C2 (hr)
WO (2) WO2019096857A1 (hr)

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UA126597C2 (uk) * 2017-11-14 2022-11-02 Профем Ґмбх Емульсії для місцевого лікування інфекцій шкіри і слизових оболонок
CN112691075B (zh) * 2020-12-31 2023-06-20 海南海神同洲制药有限公司 一种硝酸舍他康唑乳膏及其制备方法
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