HRP20230990T1 - Antigen specifična imunoterapija za fuzijske proteine covid-19 i postupci uporabe - Google Patents
Antigen specifična imunoterapija za fuzijske proteine covid-19 i postupci uporabe Download PDFInfo
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- HRP20230990T1 HRP20230990T1 HRP20230990TT HRP20230990T HRP20230990T1 HR P20230990 T1 HRP20230990 T1 HR P20230990T1 HR P20230990T T HRP20230990T T HR P20230990TT HR P20230990 T HRP20230990 T HR P20230990T HR P20230990 T1 HRP20230990 T1 HR P20230990T1
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- Prior art keywords
- fusion protein
- protein according
- immunogenic
- cho cell
- immunogenic composition
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- 102000037865 fusion proteins Human genes 0.000 title claims 24
- 108020001507 fusion proteins Proteins 0.000 title claims 24
- 238000000034 method Methods 0.000 title claims 3
- 208000025721 COVID-19 Diseases 0.000 title claims 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 230000002163 immunogen Effects 0.000 claims 10
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 3
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 2
- 108070000030 Viral receptors Proteins 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 241001678559 COVID-19 virus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229940021993 prophylactic vaccine Drugs 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000003146 transient transfection Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6056—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (15)
1. Fuzijski protein koji sadrži veznu domenu virusnog receptora i Fc fragment, pri čemu su vezna domena virusnog receptora i Fc fragment povezani peptidnim veznikom, i pri čemu fuzijski protein sadrži sljedeću sekvencu:
[image]
2. Fuzijski protein prema zahtjevu 1, naznačen time što je fuzijski protein homodimer.
3. Fuzijski protein prema bilo kojem od zahtjeva 1 ili 2, naznačen time što je Fc fragment glikoziliran.
4. Imunogeni pripravak koji sadrži fuzijski protein prema bilo kojem od zahtjeva 1-3 i farmaceutski prihvatljiv nosač.
5. Imunogeni pripravak prema zahtjevu 4, nadalje sadrži pomoćno sredstvo.
6. Postupak proizvodnje fuzijskog proteina prema bilo kojem od zahtjeva 1-3, navedeni postupak sadrži prolaznu transfekciju nukleinske kiseline koja kodira fuzijski protein prema bilo kojem od zahtjeva 1-3 u HEK293 ili CHO stanicu, pri čemu transfektirani HEK293 ili CHO stanica eksprimira fuzijski protein, ili stabilno transfektira nukleinsku kiselinu kodiranjem za fuzijski protein u CHO stanici, pri čemu rekombinantna CHO stanica eksprimira fuzijski protein, i pri čemu je prinos pročišćenog ili izoliranog fuzijskog proteina veći od 20 mg/L u transfektiranim stanicama.
7. Stanica transficirana nukleinskom kiselinom koja kodira fuzijski protein prema bilo kojem od zahtjeva 1-3 za ekspresiju navedenog fuzijskog proteina, poželjno pri čemu je stanica HEK293 stanica ili CHO stanica.
8. cDNA koja kodira fuzijski protein prema bilo kojem od zahtjeva 1-3.
9. Ekspresijski vektor koji sadrži cDNA prema zahtjevu 8.
10. Fuzijski protein prema bilo kojem od zahtjeva 1-3 ili imunogeni pripravak prema bilo kojem od zahtjeva 4 ili 5 za uporabu u terapiji i/ili kao lijek.
11. Fuzijski protein prema bilo kojem od zahtjeva 1-3 ili imunogeni pripravak prema bilo kojem od zahtjeva 4 ili 5 za uporabu u povećanju proizvodnje antitijela kod subjekta.
12. Fuzijski protein prema bilo kojem od zahtjeva 1-3 ili imunogeni pripravak prema bilo kojem od zahtjeva 4 ili 5 za uporabu u liječenju i/ili profilaksi virusne infekcije, poželjno virusa SARS-CoV-2, poželjnije COVID-19.
13. Fuzijski protein prema bilo kojem od zahtjeva 1-3 ili imunogeni pripravak prema bilo kojem od zahtjeva 4 ili 5 za uporabu kao profilaktičko, terapeutsko i/ili dopunsko cjepivo.
14. Fuzijski protein ili imunogeni pripravak za uporabu prema bilo kojem od zahtjeva 11, 12 ili 13 kada se koristi kao terapeutsko ili dopunsko cjepivo, pri čemu subjekt ima mjerljiv titar antitijela protiv navedene virusne infekcije prije davanja fuzijskog proteina ili imunogenog pripravka.
15. Fuzijski protein ili imunogeni pripravak za uporabu u skladu prema bilo kojem od zahtjeva 11, 12 ili 13 kada se koristi kao profilaktičko cjepivo, pri čemu subjekt nije imao antitijela prije primjene fuzijskog proteina ili imunogenog pripravka.
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063008497P | 2020-04-10 | 2020-04-10 | |
| US202063008515P | 2020-04-10 | 2020-04-10 | |
| US202063008509P | 2020-04-10 | 2020-04-10 | |
| US202063008503P | 2020-04-10 | 2020-04-10 | |
| US202063041582P | 2020-06-19 | 2020-06-19 | |
| US202063041574P | 2020-06-19 | 2020-06-19 | |
| US202063041579P | 2020-06-19 | 2020-06-19 | |
| US202063041584P | 2020-06-19 | 2020-06-19 | |
| US202063048939P | 2020-07-07 | 2020-07-07 | |
| US202063068911P | 2020-08-21 | 2020-08-21 | |
| US202063068843P | 2020-08-21 | 2020-08-21 | |
| US202063068775P | 2020-08-21 | 2020-08-21 | |
| US202063068805P | 2020-08-21 | 2020-08-21 | |
| US202063068894P | 2020-08-21 | 2020-08-21 | |
| EP21720949.3A EP3972987B1 (en) | 2020-04-10 | 2021-04-09 | Antigen specific immunotherapy for covid-19 fusion proteins and methods of use |
| PCT/US2021/026577 WO2021207599A1 (en) | 2020-04-10 | 2021-04-09 | Antigen specific immunotherapy for covid-19 fusion proteins and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230990T1 true HRP20230990T1 (hr) | 2023-12-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230990TT HRP20230990T1 (hr) | 2020-04-10 | 2021-04-09 | Antigen specifična imunoterapija za fuzijske proteine covid-19 i postupci uporabe |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11213581B2 (hr) |
| EP (2) | EP4248983A3 (hr) |
| JP (1) | JP2023522597A (hr) |
| KR (1) | KR20220167317A (hr) |
| CN (1) | CN116096733A (hr) |
| AU (2) | AU2021253926B2 (hr) |
| BR (1) | BR112022020486A2 (hr) |
| CA (1) | CA3146464C (hr) |
| DK (1) | DK3972987T3 (hr) |
| FI (1) | FI3972987T3 (hr) |
| HR (1) | HRP20230990T1 (hr) |
| HU (1) | HUE062716T2 (hr) |
| IL (1) | IL297064A (hr) |
| LT (1) | LT3972987T (hr) |
| SI (1) | SI3972987T1 (hr) |
| WO (1) | WO2021207599A1 (hr) |
| ZA (1) | ZA202210992B (hr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112500498B (zh) * | 2020-02-26 | 2022-09-06 | 四川大学 | 新型冠状病毒疫苗及其制备方法和应用 |
| KR20220167317A (ko) * | 2020-04-10 | 2022-12-20 | 악스톤 바이오사이언시스 코퍼레이션 | Covid-19 융합 단백질에 대한 항원 특이적 면역요법 및 사용 방법 |
| CN117440825A (zh) * | 2020-12-16 | 2024-01-23 | 芬雷疫苗学院 | 基于SARS-CoV-2病毒的受体结合结构域的疫苗组合物在保护性免疫的发展中的用途 |
| JP2024502783A (ja) * | 2020-12-23 | 2024-01-23 | ザ ユニバーシティー オブ メルボルン | コロナウイルスワクチン |
| KR20220109996A (ko) * | 2021-01-29 | 2022-08-05 | (주)셀트리온 | 사스-코로나바이러스-2 융합 단백질 및 이를 포함하는 면역원성 조성물 |
| CN114014940B (zh) * | 2021-11-25 | 2022-11-15 | 华兰基因工程有限公司 | 一种2019-nCoV表面蛋白受体结合区融合蛋白制备方法 |
| CN113980135B (zh) * | 2021-12-27 | 2022-04-19 | 三优生物医药(上海)有限公司 | 一种结合冠状病毒双特异性抗体的抗药抗体及其制备方法和应用 |
| WO2023154402A2 (en) * | 2022-02-09 | 2023-08-17 | University Of Maryland, College Park | Compositions and methods for fcrn-targeted intranasal coronavirus vaccination |
| WO2023212579A1 (en) * | 2022-04-25 | 2023-11-02 | Boost Biopharma, Inc. | Recombinant polypeptides containing at least one immunogenic fragment and uses thereof |
| KR20240009373A (ko) * | 2022-07-12 | 2024-01-22 | 에스케이바이오사이언스(주) | SARS-CoV-2 백신 부스터 조성물 |
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| CN116096733A (zh) | 2023-05-09 |
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| BR112022020486A2 (pt) | 2023-01-17 |
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