DK3972987T3 - Antigenspecifik immunterapi til COVID-19-fusionsproteiner og fremgangsmåder til anvendelse deraf - Google Patents
Antigenspecifik immunterapi til COVID-19-fusionsproteiner og fremgangsmåder til anvendelse deraf Download PDFInfo
- Publication number
- DK3972987T3 DK3972987T3 DK21720949.3T DK21720949T DK3972987T3 DK 3972987 T3 DK3972987 T3 DK 3972987T3 DK 21720949 T DK21720949 T DK 21720949T DK 3972987 T3 DK3972987 T3 DK 3972987T3
- Authority
- DK
- Denmark
- Prior art keywords
- covid
- antigen
- methods
- fusion proteins
- specific immunotherapy
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6056—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063008503P | 2020-04-10 | 2020-04-10 | |
| US202063008509P | 2020-04-10 | 2020-04-10 | |
| US202063008497P | 2020-04-10 | 2020-04-10 | |
| US202063008515P | 2020-04-10 | 2020-04-10 | |
| US202063041579P | 2020-06-19 | 2020-06-19 | |
| US202063041582P | 2020-06-19 | 2020-06-19 | |
| US202063041584P | 2020-06-19 | 2020-06-19 | |
| US202063041574P | 2020-06-19 | 2020-06-19 | |
| US202063048939P | 2020-07-07 | 2020-07-07 | |
| US202063068911P | 2020-08-21 | 2020-08-21 | |
| US202063068805P | 2020-08-21 | 2020-08-21 | |
| US202063068843P | 2020-08-21 | 2020-08-21 | |
| US202063068775P | 2020-08-21 | 2020-08-21 | |
| US202063068894P | 2020-08-21 | 2020-08-21 | |
| PCT/US2021/026577 WO2021207599A1 (en) | 2020-04-10 | 2021-04-09 | Antigen specific immunotherapy for covid-19 fusion proteins and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3972987T3 true DK3972987T3 (da) | 2023-07-31 |
Family
ID=75640036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21720949.3T DK3972987T3 (da) | 2020-04-10 | 2021-04-09 | Antigenspecifik immunterapi til COVID-19-fusionsproteiner og fremgangsmåder til anvendelse deraf |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11213581B2 (da) |
| EP (2) | EP3972987B1 (da) |
| JP (1) | JP2023522597A (da) |
| KR (1) | KR20220167317A (da) |
| CN (1) | CN116096733A (da) |
| AU (2) | AU2021253926B2 (da) |
| BR (1) | BR112022020486A2 (da) |
| CA (1) | CA3146464C (da) |
| DK (1) | DK3972987T3 (da) |
| FI (1) | FI3972987T3 (da) |
| HR (1) | HRP20230990T1 (da) |
| HU (1) | HUE062716T2 (da) |
| IL (1) | IL297064A (da) |
| LT (1) | LT3972987T (da) |
| SI (1) | SI3972987T1 (da) |
| WO (1) | WO2021207599A1 (da) |
| ZA (1) | ZA202210992B (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112500498B (zh) * | 2020-02-26 | 2022-09-06 | 四川大学 | 新型冠状病毒疫苗及其制备方法和应用 |
| LT3972987T (lt) * | 2020-04-10 | 2023-09-25 | Akston Biosciences Corporation | Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai |
| WO2022127946A1 (es) * | 2020-12-16 | 2022-06-23 | Instituto Finlay De Vacunas | Uso de composiciones vacunales basadas en el dominio de unión al receptor del virus sars-cov-2 en el desarrollo de una inmunidad protectora |
| JP2024502783A (ja) * | 2020-12-23 | 2024-01-23 | ザ ユニバーシティー オブ メルボルン | コロナウイルスワクチン |
| KR20220109996A (ko) * | 2021-01-29 | 2022-08-05 | (주)셀트리온 | 사스-코로나바이러스-2 융합 단백질 및 이를 포함하는 면역원성 조성물 |
| CN114014940B (zh) * | 2021-11-25 | 2022-11-15 | 华兰基因工程有限公司 | 一种2019-nCoV表面蛋白受体结合区融合蛋白制备方法 |
| CN113980135B (zh) * | 2021-12-27 | 2022-04-19 | 三优生物医药(上海)有限公司 | 一种结合冠状病毒双特异性抗体的抗药抗体及其制备方法和应用 |
| WO2023154402A2 (en) * | 2022-02-09 | 2023-08-17 | University Of Maryland, College Park | Compositions and methods for fcrn-targeted intranasal coronavirus vaccination |
| WO2023212579A1 (en) * | 2022-04-25 | 2023-11-02 | Boost Biopharma, Inc. | Recombinant polypeptides containing at least one immunogenic fragment and uses thereof |
| WO2024014943A1 (ko) * | 2022-07-12 | 2024-01-18 | 에스케이바이오사이언스 주식회사 | Sars-cov-2 백신 부스터 조성물 |
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| EP2413969A4 (en) | 2009-03-30 | 2012-09-05 | Boehringer Ingelheim Int | FUSION PROTEINS WITH DOG FC ELEMENTS |
| CN101891823B (zh) | 2010-06-11 | 2012-10-03 | 北京东方百泰生物科技有限公司 | 一种Exendin-4及其类似物融合蛋白 |
| WO2012015692A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| AU2011282977A1 (en) | 2010-07-28 | 2013-02-21 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| AR087433A1 (es) | 2011-08-08 | 2014-03-26 | Merck Sharp & Dohme | Analogos de insulina n-glicosilados |
| EP2780463A4 (en) | 2011-11-18 | 2015-07-01 | Merck Sharp & Dohme | FC-CONTAINING POLYPEPTIDES WITH INCREASED INFLAMMATORY FEATURES AND INCREASED FCRN BINDING |
| KR102041412B1 (ko) | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Ｆｃ 단편 유도체 |
| CN103509118B (zh) | 2012-06-15 | 2016-03-23 | 郭怀祖 | 胰岛素-Fc融合蛋白 |
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| WO2015080973A1 (en) | 2013-11-26 | 2015-06-04 | Baylor College Of Medicine | A novel sars immunogenic composition |
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| WO2016105545A2 (en) | 2014-12-24 | 2016-06-30 | Case Western Reserve University | Insulin analogues with enhanced stabilized and reduced mitogenicity |
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| CN107810202A (zh) | 2015-02-17 | 2018-03-16 | 韩美药品株式会社 | 长效胰岛素或胰岛素类似物复合物 |
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| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
| CN114835795A (zh) | 2015-11-16 | 2022-08-02 | Ubi蛋白公司 | 用于延长蛋白质半衰期的方法 |
| CN110267674A (zh) | 2016-07-08 | 2019-09-20 | 奥美药业有限公司 | 包含瘦素的融合蛋白及其生产和使用方法 |
| TWI774694B (zh) | 2016-09-23 | 2022-08-21 | 南韓商韓美藥品股份有限公司 | 具有降低對胰島素受體之親和力之胰島素類似物及其用途 |
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| WO2019035010A1 (en) | 2017-08-15 | 2019-02-21 | Kindred Biosciences, Inc. | IGG VARIANTS FOR VETERINARY USE |
| US20210214412A1 (en) | 2018-04-16 | 2021-07-15 | University Of Utah Research Foundation | Glucose-responsive insulin |
| US11696948B2 (en) * | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| EP4344738A3 (en) | 2018-06-29 | 2024-05-22 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| JP2022502039A (ja) | 2018-09-25 | 2022-01-11 | エイビーエスシーアイ・エルエルシー | タンパク質精製方法 |
| CN112789289A (zh) | 2018-10-05 | 2021-05-11 | 诺和诺德股份有限公司 | 包含胰岛素肽和egf(a)肽的双功能化合物 |
| EP3883957A4 (en) | 2018-11-19 | 2022-08-17 | Case Western Reserve University | SINGLE-CHAIN INSULIN ANALOGUES WITH POLYALANIN C DOMAIN SUB-SEGMENTS |
| EP3969467A4 (en) | 2019-05-17 | 2023-07-05 | Case Western Reserve University | VARIANT SINGLE STREAM INSULIN ANALOGS |
| WO2021011827A1 (en) | 2019-07-16 | 2021-01-21 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| CN114174348A (zh) | 2019-07-31 | 2022-03-11 | 伊莱利利公司 | 胰岛素类似物及其使用方法 |
| CN114846025A (zh) | 2019-12-19 | 2022-08-02 | 阿卡斯通生物科学公司 | 超长效胰岛素-Fc融合蛋白及其使用方法 |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| CN111333704B (zh) | 2020-02-24 | 2021-01-12 | 军事科学院军事医学研究院微生物流行病研究所 | 新型冠状病毒covid-19疫苗、制备方法及其应用 |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| LT3972987T (lt) * | 2020-04-10 | 2023-09-25 | Akston Biosciences Corporation | Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| CN111647077B (zh) * | 2020-06-02 | 2021-02-09 | 深圳市因诺赛生物科技有限公司 | 新型冠状病毒(sars-cov-2)刺突蛋白结合分子及其应用 |
| CN112480268B (zh) * | 2020-12-10 | 2021-08-03 | 北京康乐卫士生物技术股份有限公司 | 一种新型冠状病毒的重组亚单位疫苗及其应用 |
-
2021
- 2021-04-09 LT LTEPPCT/US2021/026577T patent/LT3972987T/lt unknown
- 2021-04-09 SI SI202130062T patent/SI3972987T1/sl unknown
- 2021-04-09 JP JP2022561619A patent/JP2023522597A/ja active Pending
- 2021-04-09 EP EP21720949.3A patent/EP3972987B1/en active Active
- 2021-04-09 IL IL297064A patent/IL297064A/en unknown
- 2021-04-09 US US17/226,690 patent/US11213581B2/en active Active
- 2021-04-09 DK DK21720949.3T patent/DK3972987T3/da active
- 2021-04-09 AU AU2021253926A patent/AU2021253926B2/en active Active
- 2021-04-09 HU HUE21720949A patent/HUE062716T2/hu unknown
- 2021-04-09 EP EP23176042.2A patent/EP4248983A3/en active Pending
- 2021-04-09 BR BR112022020486A patent/BR112022020486A2/pt unknown
- 2021-04-09 CN CN202180036445.3A patent/CN116096733A/zh active Pending
- 2021-04-09 CA CA3146464A patent/CA3146464C/en active Active
- 2021-04-09 KR KR1020227039307A patent/KR20220167317A/ko unknown
- 2021-04-09 FI FIEP21720949.3T patent/FI3972987T3/fi active
- 2021-04-09 WO PCT/US2021/026577 patent/WO2021207599A1/en unknown
- 2021-04-09 HR HRP20230990TT patent/HRP20230990T1/hr unknown
- 2021-12-07 US US17/544,293 patent/US11707517B2/en active Active
-
2022
- 2022-09-12 AU AU2022231665A patent/AU2022231665B2/en active Active
- 2022-10-06 ZA ZA2022/10992A patent/ZA202210992B/en unknown
-
2023
- 2023-07-20 US US18/355,601 patent/US20240016921A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI3972987T3 (fi) | 2023-07-25 |
| SI3972987T1 (sl) | 2023-10-30 |
| AU2022231665B2 (en) | 2024-02-22 |
| EP3972987A1 (en) | 2022-03-30 |
| US20240016921A1 (en) | 2024-01-18 |
| US11707517B2 (en) | 2023-07-25 |
| EP4248983A2 (en) | 2023-09-27 |
| CA3146464C (en) | 2024-03-12 |
| HUE062716T2 (hu) | 2023-11-28 |
| US20210346490A1 (en) | 2021-11-11 |
| HRP20230990T1 (hr) | 2023-12-08 |
| EP3972987B1 (en) | 2023-06-07 |
| US20220088182A1 (en) | 2022-03-24 |
| LT3972987T (lt) | 2023-09-25 |
| AU2021253926B2 (en) | 2022-07-21 |
| ZA202210992B (en) | 2023-08-30 |
| EP4248983A3 (en) | 2024-01-24 |
| US11213581B2 (en) | 2022-01-04 |
| JP2023522597A (ja) | 2023-05-31 |
| IL297064A (en) | 2022-12-01 |
| WO2021207599A1 (en) | 2021-10-14 |
| AU2021253926A1 (en) | 2022-02-24 |
| WO2021207599A9 (en) | 2022-01-06 |
| KR20220167317A (ko) | 2022-12-20 |
| BR112022020486A2 (pt) | 2023-01-17 |
| AU2022231665A1 (en) | 2022-10-06 |
| CA3146464A1 (en) | 2021-10-14 |
| CN116096733A (zh) | 2023-05-09 |
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