DK3431507T3 - Fusionsprotein omfattende nervevækstfaktor og fremstillingsfremgangsmåde og anvendelse deraf - Google Patents
Fusionsprotein omfattende nervevækstfaktor og fremstillingsfremgangsmåde og anvendelse deraf Download PDFInfo
- Publication number
- DK3431507T3 DK3431507T3 DK17765867.1T DK17765867T DK3431507T3 DK 3431507 T3 DK3431507 T3 DK 3431507T3 DK 17765867 T DK17765867 T DK 17765867T DK 3431507 T3 DK3431507 T3 DK 3431507T3
- Authority
- DK
- Denmark
- Prior art keywords
- manufacture
- fusion protein
- growth factor
- nerve growth
- comprehensive nerve
- Prior art date
Links
- 108010025020 Nerve Growth Factor Proteins 0.000 title 1
- 102000015336 Nerve Growth Factor Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229940053128 nerve growth factor Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610159303 | 2016-03-18 | ||
PCT/CN2017/077025 WO2017157325A1 (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子融合蛋白、制备方法及其用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3431507T3 true DK3431507T3 (da) | 2024-01-02 |
Family
ID=59850520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17765867.1T DK3431507T3 (da) | 2016-03-18 | 2017-03-17 | Fusionsprotein omfattende nervevækstfaktor og fremstillingsfremgangsmåde og anvendelse deraf |
Country Status (7)
Country | Link |
---|---|
US (4) | US11883464B2 (da) |
EP (3) | EP3431507B1 (da) |
CN (5) | CN114671940B (da) |
DK (1) | DK3431507T3 (da) |
ES (1) | ES2966133T3 (da) |
HU (1) | HUE064504T2 (da) |
WO (2) | WO2017157326A1 (da) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114671940B (zh) * | 2016-03-18 | 2023-09-26 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子突变体 |
CN113845583B (zh) * | 2020-06-28 | 2023-08-11 | 江苏中新医药有限公司 | 一种修饰的重组人神经生长因子及其制备方法 |
EP4247841A1 (en) * | 2020-11-19 | 2023-09-27 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Long-acting nerve growth factor polypeptides and uses thereof |
CN115894705A (zh) * | 2021-09-30 | 2023-04-04 | 三生国健药业(上海)股份有限公司 | 一种β-NGF融合蛋白、其制备方法及用途 |
CN116916946A (zh) * | 2021-11-19 | 2023-10-20 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子在制备用于治疗或改善生殖系统疾病的药物中的用途 |
EP4342485A1 (en) * | 2022-09-23 | 2024-03-27 | Dompe' Farmaceutici S.P.A. | Ngf for the treatment of spasticity |
CN115813951B (zh) * | 2022-11-10 | 2023-07-21 | 北京昱龙盛世生物科技有限公司 | 转基因干细胞及其用于治疗失眠症或睡眠障碍的用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5349055A (en) | 1992-03-06 | 1994-09-20 | Persson Hakan B | Nerve growth factor having altered receptor binding specificities |
US5728803A (en) | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
US7452863B1 (en) * | 1997-04-29 | 2008-11-18 | Genentech, Inc. | NGF variants |
EP1689865A2 (en) * | 2003-10-23 | 2006-08-16 | Monika Holmberg | A novel mutated nerve growth factor beta gene, proteins encoded thereby, and products and methods related thereto |
DE602005010047D1 (de) * | 2004-01-19 | 2008-11-13 | Nsgene As | Nervenwachstumsfaktor sezernierende menschliche therapeutische zellen |
CN100413535C (zh) * | 2004-05-21 | 2008-08-27 | 舒泰神(北京)药业有限公司 | 神经生长因子在制备有效减轻体重的药物中的应用 |
ITRM20060367A1 (it) * | 2006-07-13 | 2008-01-14 | Lay Line Genomics Spa | Muteine del hngf usi terapeutici e composizioni farmaceutiche |
CN101260398B (zh) * | 2007-03-07 | 2013-06-05 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子基因定位改造动物及其制备方法和应用 |
KR20100111273A (ko) * | 2007-12-20 | 2010-10-14 | 사이토스 바이오테크놀로지 아게 | 신경성장인자 콘쥬게이트 및 그 용도 |
EP2512511B1 (en) | 2009-11-19 | 2015-01-07 | Merck Serono S.A. | Humanized antibodies against human il-22ra |
NZ611076A (en) * | 2010-12-01 | 2015-09-25 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
CN102898514B (zh) * | 2011-07-28 | 2015-04-29 | 中国人民解放军军事医学科学院生物工程研究所 | 重组人神经生长因子缺失突变体及其制备方法和用途 |
CN103159843B (zh) * | 2011-12-19 | 2014-11-05 | 中国科学院生物物理研究所 | 具有低免疫副作用的神经生长因子突变体的制备方法及其药物应用价值 |
CN103376248B (zh) | 2012-04-26 | 2016-06-01 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子活性定量测定方法 |
CN105273087A (zh) * | 2014-07-14 | 2016-01-27 | 复旦大学 | NGF-Fc融合蛋白及其制备方法 |
CN114671940B (zh) | 2016-03-18 | 2023-09-26 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子突变体 |
-
2017
- 2017-03-17 CN CN202210214934.XA patent/CN114671940B/zh active Active
- 2017-03-17 WO PCT/CN2017/077038 patent/WO2017157326A1/zh active Application Filing
- 2017-03-17 CN CN201780017018.4A patent/CN109071678B/zh active Active
- 2017-03-17 US US16/085,984 patent/US11883464B2/en active Active
- 2017-03-17 CN CN201780017019.9A patent/CN109153709B/zh active Active
- 2017-03-17 WO PCT/CN2017/077025 patent/WO2017157325A1/zh active Application Filing
- 2017-03-17 US US16/085,977 patent/US11213568B2/en active Active
- 2017-03-17 HU HUE17765867A patent/HUE064504T2/hu unknown
- 2017-03-17 EP EP17765867.1A patent/EP3431507B1/en active Active
- 2017-03-17 CN CN202210214942.4A patent/CN114671942A/zh not_active Withdrawn
- 2017-03-17 ES ES17765867T patent/ES2966133T3/es active Active
- 2017-03-17 CN CN202210214938.8A patent/CN114671941B/zh active Active
- 2017-03-17 EP EP17765868.9A patent/EP3431494B1/en active Active
- 2017-03-17 DK DK17765867.1T patent/DK3431507T3/da active
- 2017-03-17 EP EP23203486.8A patent/EP4292649A3/en active Pending
-
2021
- 2021-11-19 US US17/455,870 patent/US20220088136A1/en not_active Abandoned
-
2023
- 2023-02-07 US US18/165,801 patent/US20230241169A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2966133T3 (es) | 2024-04-18 |
US20230241169A1 (en) | 2023-08-03 |
US20220088136A1 (en) | 2022-03-24 |
CN114671940B (zh) | 2023-09-26 |
EP3431507B1 (en) | 2023-11-22 |
US20200331977A1 (en) | 2020-10-22 |
EP3431494B1 (en) | 2024-05-01 |
EP3431494A1 (en) | 2019-01-23 |
CN114671941A (zh) | 2022-06-28 |
WO2017157326A1 (zh) | 2017-09-21 |
EP3431507A1 (en) | 2019-01-23 |
CN109153709A (zh) | 2019-01-04 |
US20190105373A1 (en) | 2019-04-11 |
US20240131114A1 (en) | 2024-04-25 |
US11213568B2 (en) | 2022-01-04 |
CN109071678A (zh) | 2018-12-21 |
EP4292649A3 (en) | 2024-02-21 |
CN109153709B (zh) | 2022-05-27 |
WO2017157325A1 (zh) | 2017-09-21 |
US11883464B2 (en) | 2024-01-30 |
CN114671942A (zh) | 2022-06-28 |
EP3431494A4 (en) | 2020-01-01 |
HUE064504T2 (hu) | 2024-03-28 |
CN114671940A (zh) | 2022-06-28 |
CN109071678B (zh) | 2022-05-20 |
CN114671941B (zh) | 2023-09-26 |
EP3431507A4 (en) | 2019-08-14 |
EP4292649A2 (en) | 2023-12-20 |
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