DK3387019T3 - Relaxin-immunoglobulinfusionsproteiner og anvendelsesfremgangsmåder - Google Patents
Relaxin-immunoglobulinfusionsproteiner og anvendelsesfremgangsmåder Download PDFInfo
- Publication number
- DK3387019T3 DK3387019T3 DK16873899.5T DK16873899T DK3387019T3 DK 3387019 T3 DK3387019 T3 DK 3387019T3 DK 16873899 T DK16873899 T DK 16873899T DK 3387019 T3 DK3387019 T3 DK 3387019T3
- Authority
- DK
- Denmark
- Prior art keywords
- relaxin
- methods
- proteins
- immunoglobulin infusion
- immunoglobulin
- Prior art date
Links
- 238000001802 infusion Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562265344P | 2015-12-09 | 2015-12-09 | |
PCT/US2016/065779 WO2017100540A2 (en) | 2015-12-09 | 2016-12-09 | Relaxin immunoglobulin fusion proteins and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3387019T3 true DK3387019T3 (da) | 2022-01-10 |
Family
ID=59013561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16873899.5T DK3387019T3 (da) | 2015-12-09 | 2016-12-09 | Relaxin-immunoglobulinfusionsproteiner og anvendelsesfremgangsmåder |
Country Status (6)
Country | Link |
---|---|
US (2) | US11161891B2 (da) |
EP (2) | EP4011919A3 (da) |
DK (1) | DK3387019T3 (da) |
ES (1) | ES2903257T3 (da) |
PT (1) | PT3387019T (da) |
WO (1) | WO2017100540A2 (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3522911B1 (en) | 2016-10-07 | 2021-12-08 | Beth Israel Deaconess Medical Center, Inc. | Compositions comprising relaxin and methods of use thereof |
KR20230146098A (ko) * | 2018-05-23 | 2023-10-18 | 화이자 인코포레이티드 | GUCY2c에 특이적인 항체 및 이의 용도 |
TW202120536A (zh) * | 2019-07-31 | 2021-06-01 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
KR20220141315A (ko) * | 2020-02-12 | 2022-10-19 | 더 스크립스 리서치 인스티튜트 | 지속성 gm-csf 및 사용 방법 |
Family Cites Families (44)
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
US5911997A (en) | 1995-06-07 | 1999-06-15 | Connetics Corporation | Relaxin-like factor and methods and uses thereof |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
AU6777196A (en) | 1995-08-15 | 1997-03-12 | Connective Therapeutics Inc. | Method of promoting angiogenesis |
US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
NZ517184A (en) | 1999-07-13 | 2004-02-27 | Bolder Biotechnology Inc | Immunoglobulin fusion proteins that are cytokines or growth factors joined to an Immunoglobulin domain |
ATE474854T1 (de) | 2000-01-27 | 2010-08-15 | Medimmune Llc | Rsv neutralisierende antikörper mit sehr hohen affinität |
US6723702B2 (en) | 2000-02-09 | 2004-04-20 | Ras Medical, Inc. | Use of relaxin treat diseases related to vasoconstriction |
AU2012211451A1 (en) | 2000-03-01 | 2012-08-30 | Applied Molecular Evolution, Inc. | High potency recombinant antibodies and method for producing them |
EP2341075A1 (en) * | 2000-03-01 | 2011-07-06 | MedImmune, LLC | Antibodies binding to the f protein of a respiratory syncytial virus (rsv) |
EP2412384A1 (en) | 2000-11-28 | 2012-02-01 | MedImmune, LLC | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
US6740747B2 (en) | 2001-04-20 | 2004-05-25 | Azad Kaushik | Bovine VDJ cassette, BF1H1, suitable for antigenization |
US20080260731A1 (en) | 2002-03-01 | 2008-10-23 | Bernett Matthew J | Optimized antibodies that target cd19 |
US20050186526A1 (en) | 2002-11-01 | 2005-08-25 | Bas Medical, Inc. | Methods and systems for enabling and stabilizing tooth movement |
US6984128B2 (en) | 2002-11-01 | 2006-01-10 | Bas Medical, Inc. | Methods for enabling and stabilizing tooth movement |
US7189539B2 (en) | 2003-11-25 | 2007-03-13 | Bristol-Myers Squibb Company | Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1 |
US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
CA2563433C (en) | 2004-04-30 | 2010-07-13 | Bas Medical, Inc. | Methods and compositions for control of fetal growth via modulation of relaxin |
TW200636064A (en) * | 2004-10-28 | 2006-10-16 | Centocor Inc | Anti-respiratory syncytial virus antibodies, antigens and uses thereof |
US20070293485A1 (en) | 2006-06-03 | 2007-12-20 | John Lim | Drug administration methods |
RU2512933C2 (ru) | 2008-05-16 | 2014-04-10 | Кортера, Инк. | Способ лечения хронической сердечной недостаточности |
CN106177914A (zh) | 2008-05-16 | 2016-12-07 | 科尔泰拉公司 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
US20100041603A1 (en) | 2008-05-16 | 2010-02-18 | Corthera, Inc. | Method of Promoting Wound Healing |
BRPI0912653A2 (pt) | 2008-05-16 | 2019-09-24 | Corthera Inc | método de prevenção de parto prematuro |
EP2396036B1 (en) | 2009-02-13 | 2017-06-28 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
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RU2564900C2 (ru) | 2010-03-10 | 2015-10-10 | Дзе Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. | Модулирование аквапоринов релаксином |
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WO2012169822A2 (ko) | 2011-06-10 | 2012-12-13 | 강원대학교산학협력단 | 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물 |
WO2012170977A1 (en) | 2011-06-10 | 2012-12-13 | President And Fellows Of Harvard College | Modulation of pancreatic beta cell proliferation |
AR087020A1 (es) * | 2011-07-01 | 2014-02-05 | Bayer Ip Gmbh | Polipeptidos de fusion de relaxina y usos de los mismos |
WO2013007563A1 (en) | 2011-07-08 | 2013-01-17 | Bayer Intellectual Property Gmbh | Fusion proteins releasing relaxin and uses thereof |
JP2015509091A (ja) | 2012-01-09 | 2015-03-26 | ザ スクリプス リサーチ インスティテュート | ヒト化抗体 |
US10774132B2 (en) | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
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US10259863B2 (en) | 2013-01-11 | 2019-04-16 | The California Institute For Biomedical Research | Bovine fusion antibodies |
CN112225817A (zh) | 2013-07-11 | 2021-01-15 | 斯克利普斯研究所 | 卷曲螺旋免疫球蛋白融合蛋白及其组合物 |
WO2015188132A1 (en) | 2014-06-06 | 2015-12-10 | The California Institute For Biomedical Research | Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof |
WO2018013483A1 (en) | 2016-07-11 | 2018-01-18 | The California Institute For Biomedical Research | Kv1.3 channel blocking peptides and uses thereof |
-
2016
- 2016-12-09 EP EP21203381.5A patent/EP4011919A3/en not_active Withdrawn
- 2016-12-09 US US16/060,384 patent/US11161891B2/en active Active
- 2016-12-09 DK DK16873899.5T patent/DK3387019T3/da active
- 2016-12-09 WO PCT/US2016/065779 patent/WO2017100540A2/en active Application Filing
- 2016-12-09 ES ES16873899T patent/ES2903257T3/es active Active
- 2016-12-09 EP EP16873899.5A patent/EP3387019B1/en active Active
- 2016-12-09 PT PT168738995T patent/PT3387019T/pt unknown
-
2021
- 2021-08-26 US US17/458,136 patent/US20220048969A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4011919A3 (en) | 2022-10-12 |
PT3387019T (pt) | 2022-01-14 |
WO2017100540A3 (en) | 2017-07-20 |
EP4011919A2 (en) | 2022-06-15 |
ES2903257T3 (es) | 2022-03-31 |
US20190263882A1 (en) | 2019-08-29 |
EP3387019B1 (en) | 2021-10-20 |
WO2017100540A2 (en) | 2017-06-15 |
US20220048969A1 (en) | 2022-02-17 |
EP3387019A4 (en) | 2019-04-17 |
US11161891B2 (en) | 2021-11-02 |
EP3387019A2 (en) | 2018-10-17 |
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