DK4186920T3 - Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse - Google Patents

Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse Download PDF

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Publication number
DK4186920T3
DK4186920T3 DK22203969.5T DK22203969T DK4186920T3 DK 4186920 T3 DK4186920 T3 DK 4186920T3 DK 22203969 T DK22203969 T DK 22203969T DK 4186920 T3 DK4186920 T3 DK 4186920T3
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Denmark
Prior art keywords
ultra
methods
long
fusion proteins
acting insulin
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DK22203969.5T
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English (en)
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DK4186920T5 (da
Inventor
Thomas M Lancaster
Todd C Zion
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Akston Biosciences Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
DK22203969.5T 2018-06-29 2019-06-28 Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse DK4186920T5 (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201862692507P 2018-06-29 2018-06-29
US201862692498P 2018-06-29 2018-06-29
US201862693814P 2018-07-03 2018-07-03
US201862696645P 2018-07-11 2018-07-11
US201862698648P 2018-07-16 2018-07-16
US201862702167P 2018-07-23 2018-07-23
US201862719347P 2018-08-17 2018-08-17
US201862740735P 2018-10-03 2018-10-03
US201862743358P 2018-10-09 2018-10-09
US201862774682P 2018-12-03 2018-12-03
US201862781378P 2018-12-18 2018-12-18
US201862781368P 2018-12-18 2018-12-18
US201962824176P 2019-03-26 2019-03-26
US201962827809P 2019-04-01 2019-04-01
US201962837188P 2019-04-22 2019-04-22
EP21207279.7A EP4011908B1 (en) 2018-06-29 2019-06-28 Ultra-long acting insulin-fc fusion proteins and methods of use

Publications (2)

Publication Number Publication Date
DK4186920T3 true DK4186920T3 (da) 2024-03-25
DK4186920T5 DK4186920T5 (da) 2024-07-22

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Family Applications (4)

Application Number Title Priority Date Filing Date
DK19826154.7T DK3655006T3 (da) 2018-06-29 2019-06-28 Ultralangtidsvirkende insulin-Fc-fusionsproteiner og fremgangsmåder til anvendelse deraf
DK21207279.7T DK4011908T5 (da) 2018-06-29 2019-06-28 Ultralangtidsvirkende insulin-FC-fusionsproteiner og fremgangsmåder til anvendelse deraf
DK22203969.5T DK4186920T5 (da) 2018-06-29 2019-06-28 Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse
DK21164434.9T DK3892628T3 (da) 2018-06-29 2019-06-28 Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK19826154.7T DK3655006T3 (da) 2018-06-29 2019-06-28 Ultralangtidsvirkende insulin-Fc-fusionsproteiner og fremgangsmåder til anvendelse deraf
DK21207279.7T DK4011908T5 (da) 2018-06-29 2019-06-28 Ultralangtidsvirkende insulin-FC-fusionsproteiner og fremgangsmåder til anvendelse deraf

Family Applications After (1)

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DK21164434.9T DK3892628T3 (da) 2018-06-29 2019-06-28 Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse

Country Status (15)

Country Link
US (8) US10961294B2 (da)
EP (5) EP4011908B1 (da)
JP (2) JP7417277B2 (da)
KR (1) KR20210029210A (da)
CN (1) CN113038964A (da)
AU (1) AU2019291945A1 (da)
BR (1) BR112020026777A2 (da)
CA (1) CA3104144A1 (da)
DK (4) DK3655006T3 (da)
FI (2) FI4011908T3 (da)
HR (4) HRP20221418T1 (da)
HU (4) HUE062719T2 (da)
LT (4) LT4186920T (da)
SI (4) SI3892628T1 (da)
WO (1) WO2020006529A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018107117A1 (en) 2016-12-09 2018-06-14 Akston Biosciences Corporation Insulin-fc fusions and methods of use
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
FI4011908T3 (fi) 2018-06-29 2023-08-04 Akston Biosciences Corp Ultrapitkävaikutteiset insuliini-Fc-fuusioproteiinit ja niiden käyttömenetelmät
WO2021011827A1 (en) * 2019-07-16 2021-01-21 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
WO2021126584A1 (en) 2019-12-19 2021-06-24 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
LT3972987T (lt) 2020-04-10 2023-09-25 Akston Biosciences Corporation Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
JP7532638B2 (ja) * 2020-07-24 2024-08-13 チアンスー ジェンサイエンス インコーポレイテッド インスリン－Ｆｃ融合タンパク質及びその応用
JP2024502720A (ja) * 2020-12-14 2024-01-23 イーライ リリー アンド カンパニー 糖尿病を治療する方法
WO2023004406A2 (en) 2021-07-23 2023-01-26 Akston Biosciences Corporation Insulin-fc fusion proteins and methods of use to treat cancer
WO2023064711A2 (en) * 2021-10-14 2023-04-20 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
TW202339790A (zh) 2021-11-15 2023-10-16 美商美國禮來大藥廠 可保存之調配物
TW202342552A (zh) * 2022-03-16 2023-11-01 大陸商北京拓界生物醫藥科技有限公司 人胰島素類似物、其融合蛋白及醫藥用途
WO2023247640A1 (en) * 2022-06-23 2023-12-28 Sanofi Single chain insulins and fc conjugates thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040601A1 (en) 2001-06-08 2003-02-27 Ivan Diers Method for making insulin precursors and insulin analog precursors
US7169894B2 (en) * 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20100143479A1 (en) 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
EP2408470A4 (en) 2009-03-20 2012-08-29 Smartcells Inc SOLUBLE NONDEPOT INSULIN CONJUGATE AND ITS USE
CA2754408A1 (en) * 2009-03-30 2010-10-14 Boehringer Ingelheim International Gmbh Fusion proteins comprising canine fc portions
CN101891823B (zh) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 一种Exendin-4及其类似物融合蛋白
JP2013535467A (ja) * 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
WO2012015681A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
AR087433A1 (es) 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
WO2013074598A1 (en) * 2011-11-18 2013-05-23 Merck Sharp & Dohme Corp. Fc CONTAINING POLYPEPTIDES HAVING INCREASED ANTI-INFLAMMATORY PROPERTIES AND INCREASED FcRN BINDING
KR102041412B1 (ko) 2011-12-30 2019-11-11 한미사이언스 주식회사 면역글로불린 Ｆｃ 단편 유도체
CN103509118B (zh) * 2012-06-15 2016-03-23 郭怀祖 胰岛素-Fc融合蛋白
WO2014028711A1 (en) * 2012-08-17 2014-02-20 Dresser-Rand Company System and method for detecting stall or surge in radial compressors
WO2014093387A1 (en) * 2012-12-10 2014-06-19 Kindred Biosciences, Inc. Vegf receptor fusion proteins for veterinary use
UA119533C2 (uk) 2013-02-26 2019-07-10 Ханмі Фарм. Ко., Лтд. Аналог інсуліну та його застосування
US10287336B2 (en) * 2014-09-18 2019-05-14 AskGene Pharma, Inc. Feline erythropoietin receptor agonists
BR112017004544A2 (pt) * 2014-10-06 2018-01-23 Univ Case Western Reserve insulina de cadeia simples, composição farmacêutica e método para tratar diabetes mellitus
CA2964918A1 (en) * 2014-10-20 2016-04-28 Case Western Reserve University Halogenated insulin analogues of enhanced biological potency
WO2016105545A2 (en) 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
CN107428814A (zh) * 2015-01-20 2017-12-01 卡斯西部储备大学 具有选择性信号传导特性和降低的促有丝分裂性的胰岛素类似物
JP2018504911A (ja) * 2015-01-29 2018-02-22 ネックスヴェット オーストラリア プロプライエタリー リミテッド 治療及び診断剤
WO2016133372A2 (ko) 2015-02-17 2016-08-25 한미약품 주식회사 지속형 인슐린 또는 이의 아날로그 결합체
RU2745801C2 (ru) * 2015-05-04 2021-04-01 Аподжиникс Аг Одноцепочечные белки-агонисты рецептора cd40
AR105616A1 (es) * 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
JP6983075B2 (ja) 2015-06-02 2021-12-17 ノヴォ ノルディスク アー／エス 極性の組換え延長部を有するインスリン
CN114874312A (zh) 2015-11-16 2022-08-09 Ubi蛋白公司 用于延长蛋白质半衰期的方法
KR20240115933A (ko) * 2016-05-04 2024-07-26 암젠 인크 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인
EP3481413A4 (en) * 2016-07-08 2020-01-08 Askgene Pharma, Inc. FUSION PROTEIN WITH LEPTIN AND METHOD FOR THE PRODUCTION AND USE THEREOF
AU2017298565B2 (en) * 2016-07-22 2021-08-19 The Walter And Eliza Hall Institute Of Medical Research Insulin analogs
BR112019005637A2 (pt) 2016-09-23 2019-07-30 Hanmi Pharm Ind Co Ltd análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
EP3526246A1 (en) * 2016-10-17 2019-08-21 Vetoquinol SA Modified antibody constant region
WO2018107117A1 (en) 2016-12-09 2018-06-14 Akston Biosciences Corporation Insulin-fc fusions and methods of use
UY37629A (es) 2017-03-07 2018-10-31 Univ Case Western Reserve Análogos de insulina de cadena simple estabilizados por un cuarto puente disulfuro
US10572594B2 (en) 2017-08-01 2020-02-25 Intuit Inc. Extracting domain-specific actions and entities in natural language commands recognized based on edition and recognition scores
BR112020002871A2 (pt) 2017-08-15 2020-07-28 Kindred Biosciences, Inc. variantes fc de igg para uso veterinário
CN112423741A (zh) 2018-04-16 2021-02-26 犹他大学研究基金会 葡萄糖反应性胰岛素
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
FI4011908T3 (fi) 2018-06-29 2023-08-04 Akston Biosciences Corp Ultrapitkävaikutteiset insuliini-Fc-fuusioproteiinit ja niiden käyttömenetelmät
CN113286810A (zh) 2018-09-25 2021-08-20 Absci有限责任公司 蛋白质纯化方法
CN112789289A (zh) 2018-10-05 2021-05-11 诺和诺德股份有限公司 包含胰岛素肽和egf(a)肽的双功能化合物
EP3883957A4 (en) 2018-11-19 2022-08-17 Case Western Reserve University SINGLE-CHAIN INSULIN ANALOGUES WITH POLYALANIN C DOMAIN SUB-SEGMENTS
CA3139946A1 (en) 2019-05-17 2020-11-26 Case Western Reserve University Variant single-chain insulin analogues
WO2021011827A1 (en) 2019-07-16 2021-01-21 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
CA3144989A1 (en) 2019-07-31 2021-02-04 Eli Lilly And Company Insulin analogs and methods of using the same
WO2021126584A1 (en) 2019-12-19 2021-06-24 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use

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Publication number Publication date
KR20210029210A (ko) 2021-03-15
DK3655006T3 (da) 2022-02-21
JP2021530210A (ja) 2021-11-11
LT4011908T (lt) 2023-09-11
EP3655006B1 (en) 2021-11-17
JP7510728B2 (ja) 2024-07-04
LT3655006T (lt) 2022-03-10
HRP20220091T1 (hr) 2022-04-15
HRP20230991T1 (hr) 2023-12-08
HUE060471T2 (hu) 2023-03-28
US20200157171A1 (en) 2020-05-21
EP4344738A2 (en) 2024-04-03
LT3892628T (lt) 2022-12-12
HRP20240408T1 (hr) 2024-06-07
SI4186920T1 (sl) 2024-05-31
AU2019291945A1 (en) 2021-01-14
CN113038964A (zh) 2021-06-25
FI4186920T3 (fi) 2024-03-20
US20200157169A1 (en) 2020-05-21
CA3104144A1 (en) 2020-01-02
US10870686B2 (en) 2020-12-22
US20200157170A1 (en) 2020-05-21
US20220009990A1 (en) 2022-01-13
EP4344738A3 (en) 2024-05-22
FI4011908T3 (fi) 2023-08-04
EP4186920B1 (en) 2024-01-03
US11673934B2 (en) 2023-06-13
HUE062719T2 (hu) 2023-11-28
LT4186920T (lt) 2024-04-25
SI4011908T1 (sl) 2023-10-30
DK4011908T5 (da) 2024-08-12
HUE058005T2 (hu) 2022-06-28
EP4011908B1 (en) 2023-06-07
US10947292B2 (en) 2021-03-16
US20200407413A1 (en) 2020-12-31
HRP20221418T1 (hr) 2023-01-06
US20220017590A1 (en) 2022-01-20
US10851147B2 (en) 2020-12-01
HUE065725T2 (hu) 2024-06-28
US10961294B2 (en) 2021-03-30
SI3892628T1 (sl) 2023-01-31
EP4186920A1 (en) 2023-05-31
US20200231646A1 (en) 2020-07-23
DK3892628T3 (da) 2022-11-14
EP3655006A1 (en) 2020-05-27
JP7417277B2 (ja) 2024-01-18
BR112020026777A2 (pt) 2021-03-30
WO2020006529A1 (en) 2020-01-02
EP3892628B1 (en) 2022-09-07
DK4186920T5 (da) 2024-07-22
EP3655006A4 (en) 2021-01-13
EP3892628A1 (en) 2021-10-13
DK4011908T3 (da) 2023-08-07
EP4011908A1 (en) 2022-06-15
US11261229B2 (en) 2022-03-01
US20240101635A1 (en) 2024-03-28
SI3655006T1 (sl) 2022-04-29
JP2024045117A (ja) 2024-04-02
US11773151B2 (en) 2023-10-03

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