CN109153709A - 神经生长因子突变体 - Google Patents
神经生长因子突变体 Download PDFInfo
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- CN109153709A CN109153709A CN201780017019.9A CN201780017019A CN109153709A CN 109153709 A CN109153709 A CN 109153709A CN 201780017019 A CN201780017019 A CN 201780017019A CN 109153709 A CN109153709 A CN 109153709A
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- growth factor
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A—HUMAN NECESSITIES
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Abstract
神经生长因子突变体，为序列表SEQ ID No：3至SEQ ID No：21中任意一条所示的氨基酸序列。其优点在于：神经生长因子突变可以减轻疼痛副作用，属于生物制药领域。
Description
PCT国内申请，说明书已公开。
Claims (18)
- PCT国内申请，权利要求书已公开。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210214942.4A CN114671942A (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN202210214938.8A CN114671941B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN202210214934.XA CN114671940B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610159303 | 2016-03-18 | ||
| CN2016101593037 | 2016-03-18 | ||
| PCT/CN2017/077038 WO2017157326A1 (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210214934.XA Division CN114671940B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN202210214942.4A Division CN114671942A (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN202210214938.8A Division CN114671941B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109153709A true CN109153709A (zh) | 2019-01-04 |
| CN109153709B CN109153709B (zh) | 2022-05-27 |
Family
ID=59850520
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210214934.XA Active CN114671940B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN201780017019.9A Active CN109153709B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN202210214938.8A Active CN114671941B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN201780017018.4A Active CN109071678B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子融合蛋白、制备方法及其用途 |
| CN202210214942.4A Withdrawn CN114671942A (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210214934.XA Active CN114671940B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210214938.8A Active CN114671941B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
| CN201780017018.4A Active CN109071678B (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子融合蛋白、制备方法及其用途 |
| CN202210214942.4A Withdrawn CN114671942A (zh) | 2016-03-18 | 2017-03-17 | 神经生长因子突变体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US11883464B2 (zh) |
| EP (3) | EP3431507B1 (zh) |
| CN (5) | CN114671940B (zh) |
| DK (1) | DK3431507T3 (zh) |
| ES (1) | ES2966133T3 (zh) |
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| HUE064504T2 (hu) | 2016-03-18 | 2024-03-28 | Staidson Beijing Biopharmaceuticals Co Ltd | Idegi növekedési faktort tartalmazó fúziós fehérje, valamint elõállítási eljárása és alkalmazása |
| CN113845583B (zh) * | 2020-06-28 | 2023-08-11 | 江苏中新医药有限公司 | 一种修饰的重组人神经生长因子及其制备方法 |
| WO2022105847A1 (en) | 2020-11-19 | 2022-05-27 | Staidson (Beijing) Biopharmaceuticals Co. , Ltd. | Long-acting nerve growth factor polypeptides and uses thereof |
| CN115894705A (zh) * | 2021-09-30 | 2023-04-04 | 三生国健药业（上海）股份有限公司 | 一种β-NGF融合蛋白、其制备方法及用途 |
| WO2023088351A1 (zh) * | 2021-11-19 | 2023-05-25 | 舒泰神（北京）生物制药股份有限公司 | 神经生长因子在制备用于治疗或改善生殖系统疾病的药物中的用途 |
| EP4342485A1 (en) * | 2022-09-23 | 2024-03-27 | Dompe' Farmaceutici S.P.A. | Ngf for the treatment of spasticity |
| CN115813951B (zh) * | 2022-11-10 | 2023-07-21 | 北京昱龙盛世生物科技有限公司 | 转基因干细胞及其用于治疗失眠症或睡眠障碍的用途 |
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- 2017-03-17 WO PCT/CN2017/077038 patent/WO2017157326A1/zh active Application Filing
- 2017-03-17 CN CN202210214934.XA patent/CN114671940B/zh active Active
- 2017-03-17 US US16/085,984 patent/US11883464B2/en active Active
- 2017-03-17 CN CN201780017019.9A patent/CN109153709B/zh active Active
- 2017-03-17 CN CN202210214938.8A patent/CN114671941B/zh active Active
- 2017-03-17 US US16/085,977 patent/US11213568B2/en active Active
- 2017-03-17 EP EP17765867.1A patent/EP3431507B1/en active Active
- 2017-03-17 DK DK17765867.1T patent/DK3431507T3/da active
- 2017-03-17 CN CN201780017018.4A patent/CN109071678B/zh active Active
- 2017-03-17 WO PCT/CN2017/077025 patent/WO2017157325A1/zh active Application Filing
- 2017-03-17 EP EP23203486.8A patent/EP4292649A3/en active Pending
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| HUE064504T2 (hu) | 2024-03-28 |
| CN109071678A (zh) | 2018-12-21 |
| CN109153709B (zh) | 2022-05-27 |
| US20200331977A1 (en) | 2020-10-22 |
| US11883464B2 (en) | 2024-01-30 |
| ES2966133T3 (es) | 2024-04-18 |
| WO2017157325A1 (zh) | 2017-09-21 |
| CN114671940A (zh) | 2022-06-28 |
| DK3431507T3 (da) | 2024-01-02 |
| CN114671940B (zh) | 2023-09-26 |
| EP3431507B1 (en) | 2023-11-22 |
| EP4292649A3 (en) | 2024-02-21 |
| US20190105373A1 (en) | 2019-04-11 |
| US20220088136A1 (en) | 2022-03-24 |
| CN114671941A (zh) | 2022-06-28 |
| WO2017157326A1 (zh) | 2017-09-21 |
| EP3431507A4 (en) | 2019-08-14 |
| CN114671941B (zh) | 2023-09-26 |
| EP3431507A1 (en) | 2019-01-23 |
| EP4292649A2 (en) | 2023-12-20 |
| CN109071678B (zh) | 2022-05-20 |
| EP3431494B1 (en) | 2024-05-01 |
| US20230241169A1 (en) | 2023-08-03 |
| CN114671942A (zh) | 2022-06-28 |
| EP3431494A4 (en) | 2020-01-01 |
| US11213568B2 (en) | 2022-01-04 |
| EP3431494A1 (en) | 2019-01-23 |
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