HRP20230113T3 - Rna koji sadrži modificirane nukleozide i metode njegove upotrebe - Google Patents
Rna koji sadrži modificirane nukleozide i metode njegove upotrebeInfo
- Publication number
- HRP20230113T3 HRP20230113T3 HRP20230113TT HRP20230113T HRP20230113T3 HR P20230113 T3 HRP20230113 T3 HR P20230113T3 HR P20230113T T HRP20230113T T HR P20230113TT HR P20230113 T HRP20230113 T HR P20230113T HR P20230113 T3 HRP20230113 T3 HR P20230113T3
- Authority
- HR
- Croatia
- Prior art keywords
- oligoribonucleotide
- vitro synthesized
- mip
- ifn
- synthesized mrna
- Prior art date
Links
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Claims (3)
1. Upotreba Ψ ili m1Ψ (1-metilpseudouridina) u in vitro sintetiziranoj mRNA, oligoribonukleotidne ili poliribonukleotidne molekule za smanjenje imunogenosti spomenute in vitro sintetizirane mRNA, oligoribonukleotidne ili poliribonukleotidne molekule,
naznačena time da smanjenje u imunogenosti spomenute in vitro sintetizirane mRNA, oligoribonukleotidne ili poliribonukleotidne molekule sadrži Ψ ili se m1Ψ detektira barem sljedećom metodom, koja metoda se sastoji od koraka:
a) spajanja mišje ili ljudske dendritične stanice s in vitro sintetiziranom mRNA, oligoribonukleotidne ili poliribonukleotidne molekule koja sadrži Ψ ili m1Ψ i, zasebno, spajanja mišje ili ljudske dendritične stanice s in vitro sintetiziranom mRNA, oligoribonukleotidne li poliribonukleotidne molekule koja ne sadrži Ψ ili m1Ψ; i
b) mjerenja kvantitete IL-12, IFN-α, TNF-α, RANTES-a, MIP-1α, MIP-1β, IL-6, IFN-β ili IL-8 izlučenih u reakciji spajanja mišje ili ljudske dendritične stanice s in vitro sintetiziranom mRNA, oligoribonukleotidne ili poliribonukleotidne molekule koja sadrži T ili m1T, ili, zasebno mjerenja kvantitete IL-12, IFN-α, TNF-α, RANTES-a, MIP-1α, MIP-1β, IL-6, IFN-β ili IL-8 izlučenih u reakciji spajanja mišje ili ljudske dendritične stanice s in vitro sintetiziranom mRNA, oligoribonukleotidne ili poliribonukleotidne molekule koja ne sadrži Ψ ili m1Ψ,
gdje kvantiteta IL-12, IFN-α, TNF-α, RANTES-a, MIP-1α, MIP-1β, IL-6, IFN-β ili IL-8 izlučenih iz mišje ili ljudske dendritične stanice u reakciji spomenutog spajanja s in vitro sintetiziranom mRNA oligoribonukleotidne ili poliribonukleotidne molekule sadrži Ψ ili je m1Ψ manje od odgovarajuće količine IL-12, IFN-α, TNF-α, RANTES-a, MIP-1α, MIP-1β, IL-6, IFN-β ili IL-8 izlučenih iz mišje ili ljudske dendritične stanice u reakciji na spomenuto spajanje s in vitro sintetiziranom kopijom mRNA oligoribonukleotidne ili poliribonukleotidne molekule koja ne sadrži spomenuti Ψ ili m1Ψ.
2. Upotreba prema patentnom zahtjevu 1, naznačena time da spomenuta in vitro sintetizirana mRNA, oligoribonukleotidne ili poliribonukleotidne molekule koja sadrži Ψ ili m1Ψ, dalje sadrži m5C (5-metilcitidin).
3. Upotreba prema patentnom zahtjevu 1 ili 2, naznačena time da spomenuta in vitro sintetizirana mRNA, oligoribonukleotidne ili poliribonukleotidne molekule kodira rekombinantni protein izabran iz grupe koja sadrži: eritropoetin (EPO); detektabilni enzim izabran iz luciferaze krijesnice, luciferaze renile, bakterijsku beta-galaktozidazu (lacZ), i zeleni fluorescentni protein (GFP); transkripcijski faktor izabran iz MYC i SRY a MCOP; faktor rasta ili citokin izabran grupe koja sadrži faktor rasta izveden iz trombocita (PDGF), vaskularni endotelijani faktor rasta (VEGF), transformirajući faktor rasta -beta 1 (TGF-beta1), faktor rasta sličan inzulinu (IGF), alfa-melanocit-stimulirajući hormon (alfa-MSH); faktor rasta sličan inzulinu-I (IGF-I); IL-4; IL-13; i IL-10; inducibilnu sintazu dušikovog oksida (iNOS); protein toplinskog stresa; regulator provodljivosti transmembranske cistične fibroze (CFTR); enzim s antioksidativinim djelovanjem izabran između katalaze, fosfolipid hiperoksid glutation peroksidaze, superoksid dismutaze-1, i superoksid dismutaze-2; 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HRAS; HVBS1; IDDM2; IGER; INS; JBS; KCNJ11; KCNJ1; KCNQ1; LDHA; LRP5; MEN1; MLL; MYBPC3; MYO7A; NNO1; OPPG; OPTB1; PAX6; PC; PDX1; PGL2; PGR; PORC; PTH; PTS; PVRL1; PYGM; RAG1; RAG2; ROM1; RRAS2; SAA1; SCA5; SCZD2; SDHD; SERPING1; SMPD1; TCIRG1; TCL2; TECTA; TH; TREH; TSG101; TYR; USH1C; VMD2; VRNI; WT1; WT2; ZNF145; A2M; AAAS; ACADS; ACLS; ACVRL1; ALDH2; AMHR2; AOM; AQP2; ATD; ATP2A2; BDC; CIR; CD4; CDK4; CNA1; COL2A1; CYP27B1; DRPLA; ENUR2; FEOM1; FGF23; FPF; GNB3; GNS; HAL; HBP1; HMGA2; HMN2; HPD; IGF1; KCNA1; KERA; KRAS2; KRT1; KRT2A; KRT3; KRT4; KRT5; KRT6A; KRT6B; KRTHB6; LDHB; LYZ; MGCT; MPE; MVK; MYL2; OAP; PAH; PPKB; PRB3; PTPN11; PXR1; RLS; RSN; SAS; SAX1; SCA2; SCNN1A; SMAL; SPPM; SPSMA; TBX3; TBX5; TCF1; TPI1; TSC3; ULR; VDR; VWF; ATP7B; BRCA2; BRCD1; CLN5; CPB2; ED2; EDNRB; ENUR1; ERCC5; F10; F7; GJB2; GJB6; IPF1; MBS1; MCOR; NYS4; PCCA; RB1; RHOK; SCZD7; SGCG; SLC10A2; SLC25A15; STARP1; ZNF198; ACHM1; ARVD1; BCH; CTAA1; DAD1; DFNB5; EML1; GALC; GCH1; IBGC1; IGH@; IGHC group; 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ITGB4; KRT10; KRT12; KRT13; KRT14; KRT14L1; KRT14L2; KRT14L3; KRT16; KRT16L1; KRT16L2; KRT17; KRT9; MAPT; MDB; MDCR; MGI; MHS2; MKS1; MPO; MYO15A; NAGLU; NAPB; NF1; NME1; P4HB; PAFAH1B1; PECAM1; PEX12; PHB; PMP22; PRKAR1A; PRKCA; PRKWNK4; PRP8; PRPF8; PTLAH; RARA; RCV1; RMSA1; RP17; RSS; SCN4A; SERPINF2; SGCA; SGSH; SHBG; SLC2A4; SLC4A1; SLC6A4; SMCR; SOST; SOX9; SSTR2; SYM1; SYNS1; TCF2; THRA; TIMP2; TOC; TOP2A; TP53; TRIM37; VBCH; ATP8B1; BCL2; CNSN; CORD1; CYB5; DCC; F5F8D; FECH; FEO; LAMA3; LCFS2; MADH4; MAFD1; MC2R; MCL; MYP2; NPC1; SPPK; TGFBRE; TGIF; TTR; AD2; AMH; APOC2; APOE; ATHS; BAX; BCK- DHA; BCL3; BFIC; C3; CACNA1A; CCO; CEACAM5; COMP; CRX; DBA; DDU; DFNA4; DLL3; DM1; DMWD; E11S; ELA2; EPOR; ERCC2; ETFB; EXT3; EYCL1; FTL; FUT1; FUT2; FUT6; GAMT; GCDH; GPI; GUSM; HB1; HCL1; HHC2; HHC3; ICAM3; INSR; JAK3; KLK3; LDLR; LHB; LIG1; LOH19CR1; LYL1; MAN2B1; MCOLN1; MDRV; MLLT1; NOTCH3; NPHS1; OFC3; OPA3; PEPD; PRPF31; PRTN3; PRX; PSG1; PVR; RYR1; SLC5A5; SLC7A9; STK11; TBXA2R; TGFB1; TNNI3; TYROBP; ADA; AHCY; AVP; CDAN2; CDPD1; CHED1; CHED2; CHRNA4; CST3; EDN3; EEGV1; FTLL1; GDF5; GNAS; GSS; HNF4A; JAG1; KCNQ2; MKKS; NBIA1; PCK1; PI3; PPCD; PPGB; PRNP; THBD; TOP1; AIRE; APP; CBS; COL6A1; COL6A2; CSTB; DCR; DSCR1; FPDMM; HLCS; HPE1; ITGB2; KCNE1; KNO; PRSS7; RUNX1; SOD1; TAM; ADSL; ARSA; BCR; CECR; CHEK2; COMT; CRYBB2; CSF2RB; CTHM; CYP2D6; CYP2D7P1; DGCR; DIA1; EWSR1; GGT1; MGCR; MN1; NAGA; NE2; OGS2; PDGFB; PPARA; PRODH; SCO2; SCZD4; SERPIND1; SLC5A1; SOX10; TCN2; TIMP3; TST; VCF; ABCD1; ACTL1; ADFN; AGMX2; AHDS; AIC; AIED; AIH3; ALAS2; AMCD; AMELX; ANOP1; AR; ARAF1; ARSC2; ARSE; ARTS; ARX; ASAT; ASSP5; ATP7A; ATRX; AVPR2; BFLS; BGN; BTK; BZX; C1HR; CACNA1F; CALB3; CBBM; CCT; CDR1; CFNS; CGF1; CHM; CHR39c; CIDX; CLA2; CLCN5; CLS; CMTX2; CMTX3; CND; COD1; COD2; COL4A5; COL4A6; CPX; CVD1; CYBB; DCX; DFN2; DFN4; DFN6; DHOF; DIAPH2; DKC1; DMD; DSS; DYT3; EBM; EBP; ED1; ELK1; EMD; EVR2; F8; F9; FCP1; FDPSL5; FGD1; FGS1; FMR1; FMR2; G6PD; GABRA3; GATA1; GDI1; GDXY; GJB1; GK; GLA; GPC3; GRPR; GTD; GUST; HMS1; HPRT1; HPT; HTC2; HTR2c; HYR; IDS; IHG1; IL2RG; INDX; IP1; IP2; JMS; KAL1; KFSD; L1CAM; LAMP2; MAA; MAFD2; MAOA; MAOB; MCF2; MCS; MEAX; MECP2; MF4; MGC1; MIC5; MID1; MLLT7; MLS; MRSD; MRX14; MRX1; MRX20; MRX2; MRX3; MRX40; MRXA; MSD; MTM1; MYCL2; MYP1; NDP; NHS; NPHL1; NROB1; NSX; NYS1; NYX; OA1; OASD; OCRL; ODT1; OFD1; OPA2; OPD1; OPEM; OPN1LW; OPN1MW; OTC; P3; PDHA1; PDR; PFC; PFKFB1; PGK1; PGK1P1; PGS; PHEX; PHKA1; PHKA2; PHP; PIGA; PLP1; POF1; POLA; POU3F4; PPMX; PRD; PRPS1; PRPS2; PRS; RCCP2; RENBP; RENS1; RP2; RP6; RPGR; RPS4X; RPS6KA3; RS1; S11; SDYS; SEDL; SERPINA7; SH2D1A; SHFM2; SLC25A5; SMAX2; SRPX; SRS; STS; SYN1; SYP; TAF1; TAZ; TBX22; TDD; TFE3; THAS; THC; TIMM8A; TIM1; TKCR; TNFSF5; UBE1; UBE2A; WAS; WSN; WTS; WWS; XIC; XIST; XK; XM; XS; ZFX; ZIC3; ZNF261; ZNF41; ZNF6; AMELY; ASSP6; AZF1; AZF2; DAZ; GCY; RPS4Y; SMCY; ZFY; ABAT; AEZ; AFA; AFD1; ASAH1; ASD1; ASMT; CCAT; CECR9; CEPA; CLA3; CLN4; CSF2RA; CTS1; DF; DIH1; DWS; DYT2; DYT4; EBR3; ECT; EEF1A1L14; EYCL2; FANCB; GCSH; GCSL; GIP; GTS; HHG; HMI; HOAC; HOKPP2; HRPT1; HSD3B3; HTC1; HV1S; ICHQ; ICR1; ICR5; IL3RA; KAL2; KMS; KRT18; KSS; LCAT; LHON; LIMM; MANBB; MCPH2; MEB; MELAS; MIC2; MPFD; MS; MSS; MTATP6; MTCO1; MTC03; MTCYB; MTND1; MTND2; MTND4; MTND5; MTND6; MTRNR1; MTRNR2; MTTE; MTTG; MTTI; MTTK; MTTL1; MTTL2; MTTN; MTTP; MTTS1; NAMSD; OCD1; OPD2; PCK2; PCLD; PCOS1; PFKM; PKD3; PRCA1; PRO1; PROP1; RBS; RFXAP; RP; SHOX; SLC25A6; SPG5B; STO; SUOX; THM; i TTD.
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US71016405P | 2005-08-23 | 2005-08-23 | |
EP19168984.3A EP3611266B1 (en) | 2005-08-23 | 2006-08-21 | Rna containing modified nucleosides and methods of use thereof |
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HRP20230113TT HRP20230113T3 (hr) | 2005-08-23 | 2006-08-21 | Rna koji sadrži modificirane nukleozide i metode njegove upotrebe |
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US (9) | US8278036B2 (hr) |
EP (5) | EP4174179A3 (hr) |
DK (1) | DK2578685T3 (hr) |
ES (2) | ES2735531T3 (hr) |
HR (1) | HRP20230113T3 (hr) |
HU (1) | HUE043492T2 (hr) |
LT (1) | LT2578685T (hr) |
PL (1) | PL2578685T3 (hr) |
PT (1) | PT2578685T (hr) |
RS (1) | RS63964B1 (hr) |
SI (1) | SI3611266T1 (hr) |
TR (1) | TR201909609T4 (hr) |
WO (1) | WO2007024708A2 (hr) |
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