HRP20202042T1 - Modulacija tumorske imunosti - Google Patents
Modulacija tumorske imunosti Download PDFInfo
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- HRP20202042T1 HRP20202042T1 HRP20202042TT HRP20202042T HRP20202042T1 HR P20202042 T1 HRP20202042 T1 HR P20202042T1 HR P20202042T T HRP20202042T T HR P20202042TT HR P20202042 T HRP20202042 T HR P20202042T HR P20202042 T1 HRP20202042 T1 HR P20202042T1
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- 206010028980 Neoplasm Diseases 0.000 title claims 7
- 230000036039 immunity Effects 0.000 title 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 14
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 14
- 239000000556 agonist Substances 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 229940124060 PD-1 antagonist Drugs 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 6
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 206010073069 Hepatic cancer Diseases 0.000 claims 2
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 2
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 2
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 2
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 2
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 2
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 2
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 2
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 206010047741 Vulval cancer Diseases 0.000 claims 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 2
- 208000008383 Wilms tumor Diseases 0.000 claims 2
- 208000037842 advanced-stage tumor Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 201000008026 nephroblastoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
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- Mycology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (17)
1. Kombinacija PD-1 antagonista, koji je antitijelo ili njegov antigen-vezujući fragment, i koji se veže za PD-1, i GITR agonista, koji je antitijelo ili njegov antigen-vezujući fragment, i koji se veže za GITR, za uporabu u postupku liječenja tumora kod pacijenta, naznačena time što se PD-1 antagonist i GITR agonist primjenjuju istovremeno ili jedan za drugim.
2. Kombinacija za uporabu prema patentnom zahtjevu 1, naznačena time što
a. PD-1 antagonist je MK3475; i
b. GITR agonist je antitijelo ili njegov antigen-vezujući fragment, koji se veže za GITR koji sadrži varijabilnu regiju imunoglobulinskog lakog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 82
i
varijabilnu regiju imunoglobulinskog teškog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 81.
3. Kombinacija za uporabu prema patentnom zahtjevu 2 naznačena time što je GITR agonist antitijelo.
4. Kombinacija za uporabu prema patentnom zahtjevu 2, naznačena time što je GITR agonist antitijelo humanizirano.
5. Kombinacija za uporabu prema patentnom zahtjevu 1, naznačena time što je PD-1 antagonist MK-3475.
6. Kombinacija za uporabu prema patentnom zahtjevu 2, naznačena time što je GITR agonist antitijelo koje sadrži:
varijabilnu domenu imunoglobulinskog lakog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 82, pri čemu, amino kiselina 31 je Q i amino kiselina 57 je Q, i varijabilnu domenu imunoglobulinskog teškog lanca koja sadrži amino kiselinsku sekvencu koja je amino kiselinska sekvenca izložena u SEQ ID NO:81.
7. Kombinacija za uporabu prema patentnom zahtjevu 1, naznačena time što se PD-1 antagonist i GITR agonist primjenjuju istovremeno ili jedan za drugim najmanje jedanput.
8. Kombinacija za uporabu prema patentnom zahtjevu 1, naznačena time što se PD-1 antagonist i GITR agonist primjenjuju istovremeno ili jedan za drugim najmanje 2 puta.
9. Kombinacija za uporabu prema patentnom zahtjevu 1, naznačena time što tumor predstavlja tumor u uznapredovalom stadiju.
10. Kombinacija za uporabu prema patentnom zahtjevu 9, naznačena time što je tumor u uznapredovalom stadiju odabran iz grupe koja se sastoji od raka skvamoznih stanica, sitnostaničnog raka pluća, nesitnostaničnog raka pluća, gastrointestinalnog raka, raka gušterače, glioblastoma, glioma, raka grlića maternice, raka jajnika, raka jetre, hepatičnog karcinoma, hepatoma, raka mjehura, raka dojke, raka debelog crijeva, kolorektalnog raka, endometrijalnog karcinoma, mijeloma, multiplog mijeloma, karcinoma slinovnice, raka bubrega, karcinoma bubrežnih stanica, Vilmsovih tumora, karcinoma bazalnih stanica, melanoma, raka prostate, raka vulve, raka štitne žlijezde, raka testisa i raka jednjaka.
11. Bispecifično antitijelo ili njegov antigen-vezujući fragment za uporabu u liječenju tumora kod pacijenta, koji sadrži prvu ruku koja se veže za PD-1 ili PD-L1 i djeluje kao antagonist PD-1 aktivnosti, a koja predstavlja antigen-vezujući fragment MK-3475, i drugu ruku koja se veže za GITR i djeluje kao agonist GITR aktivnosti, a koja predstavlja antigen-vezujući fragment koji sadrži varijabilnu regiju imunoglobulinskog lakog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 82 i varijabilnu regiju imunoglobulinskog teškog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 81.
12. Bispecifično antitijelo ili njegov antigen-vezujući fragment za uporabu prema patentnom zahtjevu 13, naznačeno time što druga ruka ima:
a) varijabilnu domenu imunoglobulinskog teškog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 81; i
b) varijabilnu domenu imunoglobulinskog lakog lanca koja sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 82, pri čemu, amino kiselina 31 je Q i amino kiselina 57 je Q.
13. Bispecifično antitijelo ili njegov antigen-vezujući fragment za uporabu prema patentnom zahtjevu 12, naznačeno time što tumor predstavlja tumor u uznapredovalom stadiju.
14. Bispecifično antitijelo ili njegov antigen-vezujući fragment za uporabu prema patentnom zahtjevu 16, naznačeno time što je tumor u uznapredovalom stadiju odabran iz grupe koja se sastoji od raka skvamoznih stanica, sitnostaničnog raka pluća, nesitnostaničnog raka pluća, gastrointestinalnog raka, raka gušterače, glioblastoma, glioma, raka grlića maternice, raka jajnika, raka jetre, hepatičnog karcinoma, hepatoma, raka mjehura, raka dojke, raka debelog crijeva, kolorektalnog raka, endometrijalnog karcinoma, mijeloma, multiplog mijeloma, karcinoma slinovnice, raka bubrega, karcinoma bubrežnih stanica, Vilmsovih tumora, karcinoma bazalnih stanica, melanoma, raka prostate, raka vulve, raka štitne žlijezde, raka testisa i raka jednjaka.
15. Farmaceutska kombinacija koja sadrži PD-1 antagonist i GITR agonist, naznačena time što:
a) PD-1 antagonist je MK-3475, i
b) GITR agonist je antitijelo koje sadrži:
imunoglobulinski laki lanac koji sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 82; i
imunoglobulinski teški lanac koji sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 81.
16. Farmaceutska kombinacija prema patentnom zahtjevu 15 naznačena time što imunoglobulinski laki lanac sadrži amino kiselinsku sekvencu izloženu u SEQ ID NO: 82, pri čemu, amino kiselina 31 je Q i amino kiselina 57 je Q.
17. Kombinacija za uporabu prema patentnom zahtjevu 1 naznačena time što je PD-1 antagonist BMS-936558.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361867976P | 2013-08-20 | 2013-08-20 | |
PCT/US2014/051402 WO2015026684A1 (en) | 2013-08-20 | 2014-08-18 | Modulation of tumor immunity |
EP14761460.6A EP3036256B1 (en) | 2013-08-20 | 2014-08-18 | Modulation of tumor immunity |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20202042T1 true HRP20202042T1 (hr) | 2021-04-30 |
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Application Number | Title | Priority Date | Filing Date |
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HRP20202042TT HRP20202042T1 (hr) | 2013-08-20 | 2020-12-21 | Modulacija tumorske imunosti |
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Families Citing this family (133)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101586617B1 (ko) | 2007-06-18 | 2016-01-20 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 pd-1에 대한 항체 |
EP2473531A4 (en) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | ANTI-GITRANT ANTIBODIES |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
BR112016013896A2 (pt) * | 2013-12-17 | 2017-10-10 | Genentech Inc | métodos de tratamento de câncer positivo para her2 usando antagonistas de ligação do eixo de pd-1 e anticorpos anti-her2 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
BR112016020919A2 (pt) | 2014-03-12 | 2018-01-23 | Yeda Res & Dev | redução dos níveis ou da atividade sistêmica de células t regulatórias para o tratamento de doença e lesão do snc |
US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
AU2015266958A1 (en) | 2014-05-28 | 2016-12-08 | Agenus Inc. | Anti-GITR antibodies and methods of use thereof |
ES2755395T3 (es) | 2014-06-06 | 2020-04-22 | Bristol Myers Squibb Co | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (GITR) y usos de los mismos |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
US9993551B2 (en) | 2014-09-13 | 2018-06-12 | Novartis Ag | Combination therapies of EGFR inhibitors |
KR20170066546A (ko) | 2014-10-03 | 2017-06-14 | 노파르티스 아게 | 조합 요법 |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
TWI716362B (zh) | 2014-10-14 | 2021-01-21 | 瑞士商諾華公司 | 針對pd-l1之抗體分子及其用途 |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
EP3223845B1 (en) | 2014-11-26 | 2021-05-19 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd20 |
TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
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