HRP20201525T1 - Postupak za pripremu pluripotentne matične stanice inducirane iz mezenhimalne matične stanice korištenjem frakcije florotanina - Google Patents
Postupak za pripremu pluripotentne matične stanice inducirane iz mezenhimalne matične stanice korištenjem frakcije florotanina Download PDFInfo
- Publication number
- HRP20201525T1 HRP20201525T1 HRP20201525TT HRP20201525T HRP20201525T1 HR P20201525 T1 HRP20201525 T1 HR P20201525T1 HR P20201525T T HRP20201525T T HR P20201525TT HR P20201525 T HRP20201525 T HR P20201525T HR P20201525 T1 HRP20201525 T1 HR P20201525T1
- Authority
- HR
- Croatia
- Prior art keywords
- medium
- stem cells
- agardh
- phlorotannin fraction
- phlorotannin
- Prior art date
Links
- 229920001339 phlorotannin Polymers 0.000 title claims 6
- 238000000034 method Methods 0.000 title claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 title claims 3
- 210000000130 stem cell Anatomy 0.000 title 1
- 239000002609 medium Substances 0.000 claims 7
- 239000013028 medium composition Substances 0.000 claims 5
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 3
- 241000031729 Dictyopteris prolifera Species 0.000 claims 2
- 241000199923 Dictyota dichotoma Species 0.000 claims 2
- 241001512722 Ecklonia cava Species 0.000 claims 2
- 239000006147 Glasgow's Minimal Essential Medium Substances 0.000 claims 2
- 239000007760 Iscove's Modified Dulbecco's Medium Substances 0.000 claims 2
- 241000631640 Ishige okamurae Species 0.000 claims 2
- 241000199919 Phaeophyceae Species 0.000 claims 2
- 241001260874 Sargassum horneri Species 0.000 claims 2
- 241000593524 Sargassum patens Species 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000032459 dedifferentiation Effects 0.000 claims 2
- 239000007758 minimum essential medium Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims 1
- 239000012980 RPMI-1640 medium Substances 0.000 claims 1
- 229910010252 TiO3 Inorganic materials 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 229910052681 coesite Inorganic materials 0.000 claims 1
- 229910052593 corundum Inorganic materials 0.000 claims 1
- 229910052906 cristobalite Inorganic materials 0.000 claims 1
- 239000008367 deionised water Substances 0.000 claims 1
- 229910021641 deionized water Inorganic materials 0.000 claims 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- NOTVAPJNGZMVSD-UHFFFAOYSA-N potassium monoxide Inorganic materials [K]O[K] NOTVAPJNGZMVSD-UHFFFAOYSA-N 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229910052682 stishovite Inorganic materials 0.000 claims 1
- 229910052905 tridymite Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229910001845 yogo sapphire Inorganic materials 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
- C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1392—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from mesenchymal stem cells from other natural sources
Claims (6)
1. Uporaba sastava medija koji sadrži 20 do 150 µg / ml frakcije florotanina koja je spoj Biekol predstavljen sljedećom kemijskom formulom 1 ili njegove soli za dediferencijaciju mezenhimalnih matičnih stanica u inducirane pluripotentne matične stanice
[image]
2. Uporaba sastava medija prema zahtjevu 1, naznačena time što se frakcija florotanina ekstrahira i izolira iz jedne vrste smeđih algi odabranih iz skupine koja se sastoji od Ecklonia cava, Dictyopteris prolifera Okamura, Dictyota dichotoma Lamouroux, Sargassum horneri C. Agardh, Sargassum patens C Agardh, i Ishige okamurae Yendo, ili umjetno sintetiziran.
3. Uporaba sastava medija prema zahtjevu 1, naznačena time što je frakcija florotanina uključena u medij odabran iz skupine koja se sastoji od DMEM (Dulbeccov modificirani Eagle medij), MEM (minimalni esencijalni medij), BME (bazni Eagle medij), RPMI 1640, F-10, F-12, DMEM F-12, α-MEM (α-minimalni esencijalni medij), G-MEM (Glasgowov minimalni esencijalni medij), IMDM (Iscoveov modificirani Dulbeccov medij), MacCoyev 5A medij, AminoMax II kompletan medij i MesenCult-XF medij.
4. Uporaba sastava medija prema zahtjevu 1, naznačena time što sastav medija nadalje sadrži 1 do 10 v / v% pročišćene deionizirane vode koja sadrži Si02, Al2O3, TiO3, Fe2O3, CaO, Na2O, K2O i LiO.
5. Postupak za pripremu induciranih pluripotentnih matičnih stanica, postupak sadrži: dodavanje 20 do 150 µg / ml frakcije florotanina koja je spoj Biekol predstavljen sljedećom kemijskom formulom 1 ili njegove soli u mediju stanične kulture; i dediferencijacija mezenhimalnih matičnih stanica u inducirane pluripotentne matične stanice u mediju
[image]
6. Postupak prema patentnom zahtjevu 5, naznačen time što se frakcija florotanina ekstrahira i izolira iz jedne vrste smeđih algi odabranih iz skupine koja se sastoji od Ecklonia cava, Dictyopteris prolifera Okamura, Dictyota dichotoma Lamouroux, Sargassum horneri C. Agardh, Sargassum patens C. Agardh, i Ishige okamurae Yendo, ili umjetno sintetiziran.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140062526 | 2014-05-23 | ||
| KR1020150071240A KR101699761B1 (ko) | 2014-05-23 | 2015-05-21 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
| EP15795825.7A EP3147352B1 (en) | 2014-05-23 | 2015-05-22 | Method for preparing induced pluripotency stem cells from mesenchymal stem cells by using phlorotannin fraction |
| PCT/KR2015/005183 WO2015178728A1 (ko) | 2014-05-23 | 2015-05-22 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201525T1 true HRP20201525T1 (hr) | 2021-02-19 |
Family
ID=54883407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201525TT HRP20201525T1 (hr) | 2014-05-23 | 2020-09-23 | Postupak za pripremu pluripotentne matične stanice inducirane iz mezenhimalne matične stanice korištenjem frakcije florotanina |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10131881B2 (hr) |
| EP (1) | EP3147352B1 (hr) |
| JP (1) | JP6839982B2 (hr) |
| KR (1) | KR101699761B1 (hr) |
| CN (1) | CN105960452B (hr) |
| AU (1) | AU2015262123B2 (hr) |
| CA (1) | CA2949949C (hr) |
| CY (1) | CY1123348T1 (hr) |
| DK (1) | DK3147352T3 (hr) |
| ES (1) | ES2820577T3 (hr) |
| HR (1) | HRP20201525T1 (hr) |
| HU (1) | HUE050877T2 (hr) |
| IL (1) | IL249170A0 (hr) |
| LT (1) | LT3147352T (hr) |
| MX (1) | MX2016015357A (hr) |
| MY (1) | MY179152A (hr) |
| PH (1) | PH12016502330A1 (hr) |
| PL (1) | PL3147352T3 (hr) |
| PT (1) | PT3147352T (hr) |
| RS (1) | RS60817B1 (hr) |
| RU (1) | RU2668803C2 (hr) |
| SG (1) | SG11201609804RA (hr) |
| SI (1) | SI3147352T1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2790669T3 (es) | 2013-11-01 | 2020-10-28 | Bbhc Co Ltd | Método para la producción de célula madre pluripotente inducida a partir de célula madre mesenquimatosa y célula madre pluripotente inducida producida mediante el método |
| KR101966315B1 (ko) * | 2017-04-26 | 2019-04-08 | 제주대학교 산학협력단 | 감태 추출물과 괭생이모자반 추출물을 이용한 면역억제용 조성물 |
| US20220015403A1 (en) * | 2018-12-05 | 2022-01-20 | Botamedi Inc. | Composition for improving flavor of food, containing phlorotannin as active ingredient |
| WO2021145742A1 (ko) * | 2020-01-17 | 2021-07-22 | 주식회사 만나스 | 플로로탄닌을 유효성분으로 포함하는 운동 기능 개선용 조성물 |
| CN111557869A (zh) * | 2020-06-19 | 2020-08-21 | 湖北楚天香妆生物科技有限公司 | 昆布提取物的应用 |
| CN114438037A (zh) * | 2022-01-25 | 2022-05-06 | 深圳市乐土生物医药有限公司 | 一种制备诱导性间充质干细胞的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5818874A (ja) * | 1981-07-28 | 1983-02-03 | Shin Kobe Electric Mach Co Ltd | 鉛蓄電池の製造法 |
| JP2932660B2 (ja) | 1990-10-09 | 1999-08-09 | 松下電器産業株式会社 | スクリーン印刷用スキージ装置 |
| JP4146146B2 (ja) | 2002-03-25 | 2008-09-03 | 熊本県 | フロロタンニン類を主成分とする抗菌剤 |
| US7910755B2 (en) * | 2004-09-29 | 2011-03-22 | Harbor Biosciences, Inc. | Stem cell expansion and uses |
| AU2007294731B2 (en) * | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| WO2009157610A1 (en) * | 2008-06-26 | 2009-12-30 | Pusan National University Industry-University Cooperation Foundation | Selenium dedifferentiated cell, preparation method and usage thereof |
| JP2010030917A (ja) * | 2008-07-25 | 2010-02-12 | Guraiko Materials:Kk | 肝炎予防剤又は肝炎治療剤 |
| KR101166257B1 (ko) * | 2009-06-16 | 2012-07-19 | 한국생명공학연구원 | 미분화 다능성줄기세포의 제작, 유지 및 증식을 위한 뉴로펩타이드 ｙ를 포함하는 배지 조성물 및 이를 이용한 다능성줄기세포의 배양 방법 |
| CN103210082A (zh) * | 2010-09-15 | 2013-07-17 | 雷蒙特亚特特拉维夫大学有限公司 | 扩增胰岛β细胞和使其再分化的方法 |
| KR101807704B1 (ko) * | 2011-04-12 | 2017-12-13 | 차의과학대학교 산학협력단 | 역분화-증진제를 이용한 역분화 만능 줄기세포의 제조방법 |
| WO2013180395A1 (ko) * | 2012-05-29 | 2013-12-05 | 한국생명공학연구원 | 다능성 줄기세포의 제작, 유지, 증식을 증진하는 대사산물 및 이를 포함하는 조성물과 배양방법 |
| KR101542848B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 골아세포로 분화시키는 방법 |
| KR101542847B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 신경세포로 분화시키는 방법 |
| KR101542849B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 간세포로 분화시키는 방법 |
| KR101542850B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 지방세포로 분화시키는 방법 |
| KR101542846B1 (ko) * | 2013-11-01 | 2015-08-10 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법 |
| KR101544195B1 (ko) | 2013-11-01 | 2015-08-12 | 주식회사 비비에이치씨 | 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 및 그 방법에 의해 제조된 유도만능 줄기세포 |
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2015
- 2015-05-21 KR KR1020150071240A patent/KR101699761B1/ko active IP Right Grant
- 2015-05-22 PL PL15795825T patent/PL3147352T3/pl unknown
- 2015-05-22 DK DK15795825.7T patent/DK3147352T3/da active
- 2015-05-22 SI SI201531351T patent/SI3147352T1/sl unknown
- 2015-05-22 AU AU2015262123A patent/AU2015262123B2/en active Active
- 2015-05-22 EP EP15795825.7A patent/EP3147352B1/en active Active
- 2015-05-22 MY MYPI2016704340A patent/MY179152A/en unknown
- 2015-05-22 CN CN201580007099.0A patent/CN105960452B/zh active Active
- 2015-05-22 PT PT157958257T patent/PT3147352T/pt unknown
- 2015-05-22 HU HUE15795825A patent/HUE050877T2/hu unknown
- 2015-05-22 RU RU2016150687A patent/RU2668803C2/ru active
- 2015-05-22 JP JP2016548353A patent/JP6839982B2/ja active Active
- 2015-05-22 LT LTEP15795825.7T patent/LT3147352T/lt unknown
- 2015-05-22 ES ES15795825T patent/ES2820577T3/es active Active
- 2015-05-22 RS RS20201114A patent/RS60817B1/sr unknown
- 2015-05-22 US US15/116,210 patent/US10131881B2/en active Active
- 2015-05-22 SG SG11201609804RA patent/SG11201609804RA/en unknown
- 2015-05-22 MX MX2016015357A patent/MX2016015357A/es unknown
- 2015-05-22 CA CA2949949A patent/CA2949949C/en active Active
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2016
- 2016-11-23 IL IL249170A patent/IL249170A0/en active IP Right Grant
- 2016-11-23 PH PH12016502330A patent/PH12016502330A1/en unknown
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2020
- 2020-09-21 CY CY20201100887T patent/CY1123348T1/el unknown
- 2020-09-23 HR HRP20201525TT patent/HRP20201525T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1123348T1 (el) | 2021-12-31 |
| AU2015262123A1 (en) | 2016-08-25 |
| MY179152A (en) | 2020-10-29 |
| JP6839982B2 (ja) | 2021-03-10 |
| ES2820577T3 (es) | 2021-04-21 |
| EP3147352B1 (en) | 2020-08-12 |
| CA2949949A1 (en) | 2015-11-26 |
| EP3147352A1 (en) | 2017-03-29 |
| SI3147352T1 (sl) | 2021-01-29 |
| JP2017516455A (ja) | 2017-06-22 |
| LT3147352T (lt) | 2020-12-10 |
| EP3147352A4 (en) | 2018-01-24 |
| CN105960452B (zh) | 2019-11-22 |
| PH12016502330B1 (en) | 2017-02-06 |
| RU2016150687A (ru) | 2018-06-25 |
| PL3147352T3 (pl) | 2021-01-25 |
| IL249170A0 (en) | 2017-01-31 |
| CN105960452A (zh) | 2016-09-21 |
| AU2015262123B2 (en) | 2018-04-19 |
| CA2949949C (en) | 2023-03-28 |
| PT3147352T (pt) | 2020-09-29 |
| US20170107481A1 (en) | 2017-04-20 |
| HUE050877T2 (hu) | 2021-01-28 |
| RU2016150687A3 (hr) | 2018-06-25 |
| RU2668803C2 (ru) | 2018-10-02 |
| KR101699761B1 (ko) | 2017-01-25 |
| SG11201609804RA (en) | 2016-12-29 |
| US10131881B2 (en) | 2018-11-20 |
| MX2016015357A (es) | 2017-06-20 |
| RS60817B1 (sr) | 2020-10-30 |
| PH12016502330A1 (en) | 2017-02-06 |
| KR20150135136A (ko) | 2015-12-02 |
| DK3147352T3 (da) | 2020-09-28 |
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