HRP20200243T1 - Postupak za razlikovanje pluripotentne matične stanice inducirane od mezenhimalne matične stanice u kondrocit - Google Patents
Postupak za razlikovanje pluripotentne matične stanice inducirane od mezenhimalne matične stanice u kondrocit Download PDFInfo
- Publication number
- HRP20200243T1 HRP20200243T1 HRP20200243TT HRP20200243T HRP20200243T1 HR P20200243 T1 HRP20200243 T1 HR P20200243T1 HR P20200243T T HRP20200243T T HR P20200243TT HR P20200243 T HRP20200243 T HR P20200243T HR P20200243 T1 HRP20200243 T1 HR P20200243T1
- Authority
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- Croatia
- Prior art keywords
- medium
- stem cells
- mem
- pluripotent stem
- dmem
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 7
- 210000001612 chondrocyte Anatomy 0.000 title claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 title claims 4
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
- 239000002609 medium Substances 0.000 claims 19
- 239000007758 minimum essential medium Substances 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 4
- 239000006147 Glasgow's Minimal Essential Medium Substances 0.000 claims 4
- 239000007760 Iscove's Modified Dulbecco's Medium Substances 0.000 claims 4
- 229940018973 ecklonia cava extract Drugs 0.000 claims 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 4
- 239000012980 RPMI-1640 medium Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 229910010252 TiO3 Inorganic materials 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 229910052681 coesite Inorganic materials 0.000 claims 1
- 229910052593 corundum Inorganic materials 0.000 claims 1
- 229910052906 cristobalite Inorganic materials 0.000 claims 1
- 239000008367 deionised water Substances 0.000 claims 1
- 229910021641 deionized water Inorganic materials 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- 238000011177 media preparation Methods 0.000 claims 1
- NOTVAPJNGZMVSD-UHFFFAOYSA-N potassium monoxide Inorganic materials [K]O[K] NOTVAPJNGZMVSD-UHFFFAOYSA-N 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229940054269 sodium pyruvate Drugs 0.000 claims 1
- 229910052682 stishovite Inorganic materials 0.000 claims 1
- 229910052905 tridymite Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229910001845 yogo sapphire Inorganic materials 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1369—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from blood-borne mesenchymal stem cells, e.g. MSC from umbilical blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Claims (7)
1. Postupak za razlikovanje mezenhimalnih matičnih stanica u kondrocit, koji obuhvaća korake:
(a) dodavanje ekstrakta Ecklonia cava u medij stanične kulture;
(b) izdvajanje mezenhimalnih matičnih stanica u inducirane pluripotentne matične stanice u mediju;
i
(c) razlikovanje induciranih pluripotentnih matičnih stanica u kondrocit.
2. Postupak prema zahtjevu 1, naznačen time što se Ecklonia cava ekstrakt dodaje mediju izabranom iz grupe koji se sastoji od DMEM (Dulbeccov modificirani Eagle medij), MEM (minimalni esencijalni medij), BME (bazni medij Eagle), RPMI 1640, F-10, F-12, DMEM-F12, α-MEM (α-minimalni esencijalni medij), G-MEM (Glasgowski minimalni esencijalni medij), IMDM (Iscove modificirani Dulbeccov medij), Mac-Coy je 5A medij, AmnioMax potpuni medij, AminoMax II potpuni medij, Changov medij i MesemCult-XF medij.
3. Postupak prema zahtjevu 1, naznačen time što se Ecklonia cava ekstrakt dodaje mediju u količini od 100-400 µg/ml.
4. Postupak prema zahtjevu 1, naznačen time što medij dalje sadrži 0.01-10% v/v pročišćene deionizirane vode koja sadrži SiO2, Al2O3, TiO3, Fe2O3, CaO, Na2O, K2O i LiO.
5. Postupak prema zahtjevu 1, naznačen time šte se korak c) provodi uporabom medija koji sadrži deksametazon, askorbinsku kiselinu (AsA), natrijev piruvat, prolin, inzulin-transferin-selen (ITS) i TGF.
6. Postupak prema zahtjevu 5, naznačen time što je medij odabran iz grupe koja se sastoji od DMEM (Dulbeccov modificirani Eagle medij), MEM (minimalni esencijalni medij), BME (bazni medij Eagle), RPMI 1640, F-10, F-12, DMEM-F12, α-MEM (a-minimalni esencijalni medij), G-MEM (Glasgowski minimalni esencijalni medij), IMDM (Iscove modificirani Dulbeccov medij), Mac-Coy je 5A medij, AmnioMax potpuni medij, AminoMax II potpuni medij, Changov medij i MesemCult-XF medij.
7. Uporaba pripravka medija koji sadrži Ecklonia cava ekstrakt za izdvajanje mezenhimalnih matičnih stanica u inducirane pluripotentne matične stanice, naznačen time što su inducirane pluripotentne matične stanice sposobne diferencirati se u kondrocit.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130132055A KR101542846B1 (ko) | 2013-11-01 | 2013-11-01 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법 |
| PCT/KR2013/009953 WO2015064805A1 (ko) | 2013-11-01 | 2013-11-05 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법 |
| EP13896782.3A EP3064574B1 (en) | 2013-11-01 | 2013-11-05 | Method for differentiating pluripotent stem cell induced from mesenchymal stem cell into chondrocyte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200243T1 true HRP20200243T1 (hr) | 2020-09-04 |
Family
ID=53004393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200243TT HRP20200243T1 (hr) | 2013-11-01 | 2020-02-13 | Postupak za razlikovanje pluripotentne matične stanice inducirane od mezenhimalne matične stanice u kondrocit |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9994820B2 (hr) |
| EP (1) | EP3064574B1 (hr) |
| JP (1) | JP6711760B2 (hr) |
| KR (1) | KR101542846B1 (hr) |
| CN (1) | CN105705632B (hr) |
| AU (1) | AU2013403888B2 (hr) |
| CY (1) | CY1122798T1 (hr) |
| DK (1) | DK3064574T3 (hr) |
| ES (1) | ES2773973T3 (hr) |
| HR (1) | HRP20200243T1 (hr) |
| HU (1) | HUE048458T2 (hr) |
| LT (1) | LT3064574T (hr) |
| PL (1) | PL3064574T3 (hr) |
| PT (1) | PT3064574T (hr) |
| RS (1) | RS60193B1 (hr) |
| SI (1) | SI3064574T1 (hr) |
| WO (1) | WO2015064805A1 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2790669T3 (es) | 2013-11-01 | 2020-10-28 | Bbhc Co Ltd | Método para la producción de célula madre pluripotente inducida a partir de célula madre mesenquimatosa y célula madre pluripotente inducida producida mediante el método |
| KR101699761B1 (ko) * | 2014-05-23 | 2017-01-25 | 주식회사 비비에이치씨 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
| CN109136178A (zh) * | 2018-08-30 | 2019-01-04 | 丰泽康生物医药（深圳）有限公司 | 一种提高外周血多潜能细胞向软骨细胞分化的无血清培养基 |
| CN114555101A (zh) * | 2019-08-27 | 2022-05-27 | 河北医科大学第三医院 | 多潜能关节祖细胞、其组合物及制备方法 |
| CN112662616A (zh) * | 2021-01-27 | 2021-04-16 | 朱灏 | 一种高效率的人间充质干细胞诱导分化成软骨的方法 |
| KR20230000033A (ko) * | 2021-06-23 | 2023-01-02 | 연세대학교 산학협력단 | 위 세포 배양용 조성물 |
| CN113652396B (zh) * | 2021-08-24 | 2023-08-29 | 赛尔医学科技(山东)有限公司 | 一种脂肪间充质干细胞成骨诱导组合物及成骨诱导方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003280687A1 (en) * | 2002-10-31 | 2004-05-25 | Hitoshi Niwa | Composition for culturing multipotent stem cells and utilization of the same |
| US20100135970A1 (en) | 2006-10-27 | 2010-06-03 | Caritas St. Elizabeth Medical Center Of Boston, In | Methods for Reprogramming Adult Somatic Cells and Uses Thereof |
| WO2010003062A2 (en) * | 2008-07-03 | 2010-01-07 | The Regents Of The University Of California | Biomaterials and implants for enhanced cartilage formation, and methods for making and using them |
| KR101127964B1 (ko) | 2008-12-02 | 2012-04-16 | 한국전자통신연구원 | 사용자 적응형 연결 제어 장치 및 그를 포함하는 네트워크 시스템 |
| KR101016761B1 (ko) | 2009-02-26 | 2011-02-25 | 부경대학교 산학협력단 | 피부 미백활성을 갖는 감태 추출물 |
| JP2012210154A (ja) * | 2009-08-03 | 2012-11-01 | Keio Gijuku | 分化細胞由来多能性幹細胞の樹立方法 |
| WO2011037301A1 (ko) | 2009-09-22 | 2011-03-31 | 서울대학교병원 | 성체세포로부터 만능줄기세포를 유도하는 방법 및 그 방법에 의해 제조된 만능줄기세포 |
| US8349609B2 (en) | 2009-11-24 | 2013-01-08 | University Of Connecticut | Differentiation of human embryonic and induced pluripotent stem cells |
| KR20120002134A (ko) * | 2010-06-30 | 2012-01-05 | 서울대학교산학협력단 | 지방 기질 세포의 역분화를 유도하는 방법 |
| KR20120040488A (ko) | 2010-10-19 | 2012-04-27 | 충남대학교산학협력단 | 곰피와 감태 추출물 유래의 플로로탄닌을 포함하는 화장품 조성물 |
| KR101309538B1 (ko) * | 2010-11-17 | 2013-09-23 | 한양대학교 산학협력단 | 엑콜 화합물을 함유하는 암 줄기세포 성장 억제용 조성물 |
| KR101887956B1 (ko) | 2011-08-10 | 2018-08-13 | (주)아모레퍼시픽 | 효소 처리 감태 추출물을 포함하는 피부 미백용 조성물 |
-
2013
- 2013-11-01 KR KR1020130132055A patent/KR101542846B1/ko active IP Right Grant
- 2013-11-05 JP JP2016552370A patent/JP6711760B2/ja active Active
- 2013-11-05 LT LTEP13896782.3T patent/LT3064574T/lt unknown
- 2013-11-05 RS RS20200146A patent/RS60193B1/sr unknown
- 2013-11-05 SI SI201331669T patent/SI3064574T1/sl unknown
- 2013-11-05 EP EP13896782.3A patent/EP3064574B1/en active Active
- 2013-11-05 ES ES13896782T patent/ES2773973T3/es active Active
- 2013-11-05 US US15/033,358 patent/US9994820B2/en active Active
- 2013-11-05 PL PL13896782T patent/PL3064574T3/pl unknown
- 2013-11-05 PT PT138967823T patent/PT3064574T/pt unknown
- 2013-11-05 CN CN201380080663.2A patent/CN105705632B/zh active Active
- 2013-11-05 DK DK13896782.3T patent/DK3064574T3/da active
- 2013-11-05 WO PCT/KR2013/009953 patent/WO2015064805A1/ko active Application Filing
- 2013-11-05 HU HUE13896782A patent/HUE048458T2/hu unknown
- 2013-11-05 AU AU2013403888A patent/AU2013403888B2/en active Active
-
2020
- 2020-02-04 CY CY20201100102T patent/CY1122798T1/el unknown
- 2020-02-13 HR HRP20200243TT patent/HRP20200243T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3064574T3 (da) | 2020-03-23 |
| JP2016537023A (ja) | 2016-12-01 |
| KR101542846B1 (ko) | 2015-08-10 |
| KR20150050861A (ko) | 2015-05-11 |
| EP3064574A4 (en) | 2017-09-06 |
| PL3064574T3 (pl) | 2020-07-27 |
| AU2013403888A1 (en) | 2016-06-16 |
| LT3064574T (lt) | 2020-05-25 |
| CN105705632A (zh) | 2016-06-22 |
| US9994820B2 (en) | 2018-06-12 |
| ES2773973T3 (es) | 2020-07-15 |
| EP3064574A1 (en) | 2016-09-07 |
| RS60193B1 (sr) | 2020-06-30 |
| US20160257936A1 (en) | 2016-09-08 |
| WO2015064805A1 (ko) | 2015-05-07 |
| SI3064574T1 (sl) | 2020-07-31 |
| WO2015064805A8 (ko) | 2016-07-21 |
| CY1122798T1 (el) | 2021-05-05 |
| PT3064574T (pt) | 2020-02-28 |
| HUE048458T2 (hu) | 2020-07-28 |
| AU2013403888B2 (en) | 2018-04-05 |
| CN105705632B (zh) | 2021-09-14 |
| EP3064574B1 (en) | 2020-01-22 |
| JP6711760B2 (ja) | 2020-06-17 |
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