CY1122798T1 - Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε χονδροκυτταρο - Google Patents

Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε χονδροκυτταρο

Info

Publication number
CY1122798T1
CY1122798T1 CY20201100102T CY201100102T CY1122798T1 CY 1122798 T1 CY1122798 T1 CY 1122798T1 CY 20201100102 T CY20201100102 T CY 20201100102T CY 201100102 T CY201100102 T CY 201100102T CY 1122798 T1 CY1122798 T1 CY 1122798T1
Authority
CY
Cyprus
Prior art keywords
stem cell
cell
differentiation
plorizant
meseghymal
Prior art date
Application number
CY20201100102T
Other languages
English (en)
Inventor
Won Ju Jung
Ho Bin Kim
Min Sun Oh
Kye Ho Lee
Sang Yeon Lee
Original Assignee
Bbhc Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bbhc Co. Ltd. filed Critical Bbhc Co. Ltd.
Publication of CY1122798T1 publication Critical patent/CY1122798T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1369—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from blood-borne mesenchymal stem cells, e.g. MSC from umbilical blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Abstract

Η παρούσα εφεύρεση αφορά σε μια σύνθεση μέσου το οποίο περιέχει εκχύλισμα Εcklonia cava για τη διαφοροποίηση ενός επαγόμενου πλειοδύναμου βλαστικού κυττάρου, που παράγεται με τη χρήση της σύνθεσης του μέσου σε ένα χονδροκύτταρο. Κατά τη χρήση της σύνθεσης του μέσου σύμφωνα με την παρούσα εφεύρεση, τα επαγόμενα πλειοδύναμα βλαστικά κύτταρα με τη χρήση των μεσεγχυματικών βλαστικών κυττάρων μπορούν να παραχθούν αποτελεσματικά, και τα πλειοδύναμα βλαστικά κύτταρα που παράχθηκαν μπορούν να χρησιμοποιηθούν ως κυτταρικός θεραπευτικός παράγοντας λόγω της ικανότητας τους να διαφοροποιούνται σε χονδροκύτταρα.
CY20201100102T 2013-11-01 2020-02-04 Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε χονδροκυτταρο CY1122798T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130132055A KR101542846B1 (ko) 2013-11-01 2013-11-01 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법
PCT/KR2013/009953 WO2015064805A1 (ko) 2013-11-01 2013-11-05 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 연골세포로 분화시키는 방법

Publications (1)

Publication Number Publication Date
CY1122798T1 true CY1122798T1 (el) 2021-05-05

Family

ID=53004393

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100102T CY1122798T1 (el) 2013-11-01 2020-02-04 Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε χονδροκυτταρο

Country Status (17)

Country Link
US (1) US9994820B2 (el)
EP (1) EP3064574B1 (el)
JP (1) JP6711760B2 (el)
KR (1) KR101542846B1 (el)
CN (1) CN105705632B (el)
AU (1) AU2013403888B2 (el)
CY (1) CY1122798T1 (el)
DK (1) DK3064574T3 (el)
ES (1) ES2773973T3 (el)
HR (1) HRP20200243T1 (el)
HU (1) HUE048458T2 (el)
LT (1) LT3064574T (el)
PL (1) PL3064574T3 (el)
PT (1) PT3064574T (el)
RS (1) RS60193B1 (el)
SI (1) SI3064574T1 (el)
WO (1) WO2015064805A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2790669T3 (es) 2013-11-01 2020-10-28 Bbhc Co Ltd Método para la producción de célula madre pluripotente inducida a partir de célula madre mesenquimatosa y célula madre pluripotente inducida producida mediante el método
KR101699761B1 (ko) * 2014-05-23 2017-01-25 주식회사 비비에이치씨 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법
CN109136178A (zh) * 2018-08-30 2019-01-04 丰泽康生物医药（深圳）有限公司 一种提高外周血多潜能细胞向软骨细胞分化的无血清培养基
CN114555101A (zh) * 2019-08-27 2022-05-27 河北医科大学第三医院 多潜能关节祖细胞、其组合物及制备方法
CN112662616A (zh) * 2021-01-27 2021-04-16 朱灏 一种高效率的人间充质干细胞诱导分化成软骨的方法
KR20230000033A (ko) * 2021-06-23 2023-01-02 연세대학교 산학협력단 위 세포 배양용 조성물
CN113652396B (zh) * 2021-08-24 2023-08-29 赛尔医学科技(山东)有限公司 一种脂肪间充质干细胞成骨诱导组合物及成骨诱导方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003280687A1 (en) * 2002-10-31 2004-05-25 Hitoshi Niwa Composition for culturing multipotent stem cells and utilization of the same
US20100135970A1 (en) 2006-10-27 2010-06-03 Caritas St. Elizabeth Medical Center Of Boston, In Methods for Reprogramming Adult Somatic Cells and Uses Thereof
WO2010003062A2 (en) * 2008-07-03 2010-01-07 The Regents Of The University Of California Biomaterials and implants for enhanced cartilage formation, and methods for making and using them
KR101127964B1 (ko) 2008-12-02 2012-04-16 한국전자통신연구원 사용자 적응형 연결 제어 장치 및 그를 포함하는 네트워크 시스템
KR101016761B1 (ko) 2009-02-26 2011-02-25 부경대학교 산학협력단 피부 미백활성을 갖는 감태 추출물
JP2012210154A (ja) * 2009-08-03 2012-11-01 Keio Gijuku 分化細胞由来多能性幹細胞の樹立方法
WO2011037301A1 (ko) 2009-09-22 2011-03-31 서울대학교병원 성체세포로부터 만능줄기세포를 유도하는 방법 및 그 방법에 의해 제조된 만능줄기세포
US8349609B2 (en) 2009-11-24 2013-01-08 University Of Connecticut Differentiation of human embryonic and induced pluripotent stem cells
KR20120002134A (ko) * 2010-06-30 2012-01-05 서울대학교산학협력단 지방 기질 세포의 역분화를 유도하는 방법
KR20120040488A (ko) 2010-10-19 2012-04-27 충남대학교산학협력단 곰피와 감태 추출물 유래의 플로로탄닌을 포함하는 화장품 조성물
KR101309538B1 (ko) * 2010-11-17 2013-09-23 한양대학교 산학협력단 엑콜 화합물을 함유하는 암 줄기세포 성장 억제용 조성물
KR101887956B1 (ko) 2011-08-10 2018-08-13 (주)아모레퍼시픽 효소 처리 감태 추출물을 포함하는 피부 미백용 조성물

Also Published As

Publication number Publication date
DK3064574T3 (da) 2020-03-23
JP2016537023A (ja) 2016-12-01
KR101542846B1 (ko) 2015-08-10
KR20150050861A (ko) 2015-05-11
EP3064574A4 (en) 2017-09-06
PL3064574T3 (pl) 2020-07-27
AU2013403888A1 (en) 2016-06-16
LT3064574T (lt) 2020-05-25
CN105705632A (zh) 2016-06-22
US9994820B2 (en) 2018-06-12
ES2773973T3 (es) 2020-07-15
EP3064574A1 (en) 2016-09-07
RS60193B1 (sr) 2020-06-30
US20160257936A1 (en) 2016-09-08
WO2015064805A1 (ko) 2015-05-07
SI3064574T1 (sl) 2020-07-31
WO2015064805A8 (ko) 2016-07-21
PT3064574T (pt) 2020-02-28
HUE048458T2 (hu) 2020-07-28
AU2013403888B2 (en) 2018-04-05
CN105705632B (zh) 2021-09-14
EP3064574B1 (en) 2020-01-22
JP6711760B2 (ja) 2020-06-17
HRP20200243T1 (hr) 2020-09-04

Similar Documents

Publication Publication Date Title
CY1122798T1 (el) Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε χονδροκυτταρο
CY1122791T1 (el) Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε ηπατοκυτταρο
CY1122954T1 (el) Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε νευρωνα
EA201591926A1 (ru) Способ многоцветной проточной цитометрии для идентификации популяции клеток, в частности мезенхимальных стволовых клеток
CY1123348T1 (el) Μεθοδος για την παρασκευη ενισχυμενων πολυδυναμων βλαστοκυτταρων απο μεσεγχυματικα βλαστοκυτταρα με τη χρηση κλασματος φλοροταννινης
CY1122842T1 (el) Μεθοδος για τη διαφοροποιηση του πλειοδυναμου βλαστικου κυτταρου επαγομενη απο το μεσεγχυματικο βλαστικο κυτταρο σε οστεοβλαστες
GB2548740A (en) Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
EA201590488A1 (ru) Способы модификации клеток-хозяев
AR095774A1 (es) Anticuerpos anti-il-4 y anticuerpos biespecíficos y sus usos
PE20210107A1 (es) Anticuerpos anti-cd3 y metodos de uso
AR093446A1 (es) Anticuerpos de antihemaglutinina y metodos de uso
EA201690529A1 (ru) Способы модификации клетки-хозяина
AR090903A1 (es) Anticuerpos e inmunoconjugados anti-pmel17
BR112013002811A2 (pt) meios básicos simplificados para cultura celular pluripotente de humano
EA201391602A1 (ru) Контролируемое высвобождение иммунодепрессантов из синтетических наноносителей
EA201890137A1 (ru) Среда для культивирования клеток с добавлением таурина и способы применения
AR094375A1 (es) Métodos de uso de inhibidores del ciclo celular para modular una o más propiedades de un cultivo celular
BR112016007177A8 (pt) método e composição para intensificar o desempenho de um coletor em uma separação por flotação em espuma de suspensão em um meio
PE20150681A1 (es) Metodo para producir l-aminoacidos
CO7461129A2 (es) Beta-glucosidasa de magnaporthe grisea
CO2017002253A2 (es) Compuesto dirigido a il-23a y tnf-alfa
MX2015005627A (es) Sistemas y metodos para conversion de profundidad de datos sismicos 3d utlizando redes neuronales artificiales.
EA201391523A1 (ru) Композиции и способы для переноса энергии митохондрий аутологичных герминативных клеток
RS54073B1 (en) STROMAL MATERIAL CELLS
HK1222198A1 (zh) 用於提高幹細胞再生能力的培養基組合物及使用它的幹細胞培養方法