HRP20211373T1 - Postupci i pripravci za kliničko izvođenje alogene stanice i terapeutska uporaba - Google Patents
Postupci i pripravci za kliničko izvođenje alogene stanice i terapeutska uporaba Download PDFInfo
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- HRP20211373T1 HRP20211373T1 HRP20211373TT HRP20211373T HRP20211373T1 HR P20211373 T1 HRP20211373 T1 HR P20211373T1 HR P20211373T T HRP20211373T T HR P20211373TT HR P20211373 T HRP20211373 T HR P20211373T HR P20211373 T1 HRP20211373 T1 HR P20211373T1
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- cultivation
- subepithelial layer
- stem cells
- exosomes
- express
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- 238000000034 method Methods 0.000 title claims 10
- 238000009795 derivation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000001808 exosome Anatomy 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 210000003954 umbilical cord Anatomy 0.000 claims 4
- 239000006228 supernatant Substances 0.000 claims 3
- 102100025222 CD63 antigen Human genes 0.000 claims 2
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 238000002224 dissection Methods 0.000 claims 2
- 230000001146 hypoxic effect Effects 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0603—Embryonic cells ; Embryoid bodies
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- Diabetes (AREA)
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Claims (12)
1. Izolirani egzosomi ekstrahirani iz stanica dobivenih iz subepitelnog sloja tkiva pupčane vrpce sisavaca i sposobnih za samo obnavljanje i ekspanziju kulture, te stanice eksprimiraju CD90, CD44, CD146, ili SOX2 i OCT4, te pri čemu stanice ne eksprimiraju NANOG, a pri čemu egzosomi eksprimiraju CD63.
2. Izolirani egzosomi prema bilo kojem od prethodnih patentnih zahtjeva, naznačeni time što izolirani egzosomi eksprimiraju CD9.
3. Izolirani egzosomi prema bilo kojem od prethodnih patentnih zahtjeva, naznačeni time što su za uporabu u terapiji.
4. Postupak pročišćavanja egzosoma, naznačen time što obuhvaća:
uzgoj matičnih stanica iz subepitelnog sloja pupčane vrpce sisavaca u normoksičnoj ili hipoksičnoj okolini za uzgoj;
prikupljanje supernatanta iz uzgojenih matičnih stanica;
pročišćavanje egzosoma iz supernatanta, pri čemu egzosomi eksprimiraju CD63.
5. Postupak prema patentnom zahtjevu 4, naznačen time što uzgoj matičnih stanica nadalje obuhvaća uzgoj matičnih stanica u normoksičnoj okolini za uzgoj.
6. Postupak prema patentnom zahtjevu 4, naznačen time što uzgoj matičnih stanica nadalje obuhvaća uzgoj matičnih stanica u hipoksičnoj okolini za uzgoj.
7. Postupak prema bilo kojem od patentnih zahtjeva 4 do 6, naznačen time što uzgoj matičnih stanica nadalje obuhvaća:
seciranje subepitelnog sloja iz pupčane vrpce;
postavljanje seciranog subepitelnog sloja unutarnjom stranom prema dolje na supstrat tako da unutarnja strana subepitelnog sloja dolazi u dodir sa supstratom;
kultiviranje subepitelnog sloja na supstratu; i
uklanjanje eksplantata za ekspanziju primarnih stanica.
8. Postupak prema patentnom zahtjevu 7, naznačen time što seciranje subepitelnog sloja nadalje uključuje uklanjanje Whartonove sluzi iz pupčane vrpce.
9. Postupak prema patentnom zahtjevu 7, naznačen time što se subepitelni sloj uzgaja u mediju za uzgoj koji sadrži lizat trombocita.
10. Postupak prema patentnom zahtjevu 9, naznačen time što je supstrat posuda za kultiviranje, pri čemu je posuda za kultiviranje plastika tretirana staničnom kulturom, a subepitelni sloj je postavljen na nju bez ikakve dodatne prethodne obrade plastike tretirane staničnom kulturom.
11. Postupak prema patentnom zahtjevu 7, naznačen time što se uzgoj subepitelnog sloja i uklanjanje eksplantata provode bez upotrebe bilo kakvih enzima.
12. Postupak prema bilo kojem od patentnih zahtjeva 4 do 11, naznačen time što se supernatant sakuplja pri svakoj promjeni medija.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582070P | 2011-12-30 | 2011-12-30 | |
| US201261591211P | 2012-01-26 | 2012-01-26 | |
| EP17191442.7A EP3321355B1 (en) | 2011-12-30 | 2012-12-31 | Methods and compositions for the clinical derivation of an allogenic cell and therapeutic uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211373T1 true HRP20211373T1 (hr) | 2021-11-26 |
Family
ID=48698707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211373TT HRP20211373T1 (hr) | 2011-12-30 | 2021-08-30 | Postupci i pripravci za kliničko izvođenje alogene stanice i terapeutska uporaba |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US9803176B2 (hr) |
| EP (2) | EP3321355B1 (hr) |
| JP (1) | JP6548897B2 (hr) |
| CA (2) | CA2862661C (hr) |
| DK (1) | DK3321355T3 (hr) |
| ES (2) | ES2890126T3 (hr) |
| HR (1) | HRP20211373T1 (hr) |
| HU (1) | HUE056817T2 (hr) |
| PL (1) | PL3321355T3 (hr) |
| PT (1) | PT3321355T (hr) |
| SI (1) | SI3321355T1 (hr) |
| WO (1) | WO2013102219A1 (hr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8182840B2 (en) | 2005-09-27 | 2012-05-22 | Tissue Tech, Inc. | Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition |
| WO2012170905A1 (en) | 2011-06-10 | 2012-12-13 | Tissuetech, Inc. | Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof |
| WO2015088286A1 (ko) | 2013-12-12 | 2015-06-18 | 사회복지법인 삼성생명공익재단 | 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물 |
| US9919011B2 (en) | 2014-03-18 | 2018-03-20 | Samsung Life Public Welfare Foundation | Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome |
| JP2017517255A (ja) * | 2014-05-21 | 2017-06-29 | ミメディクス グループ インコーポレイテッド | 微粉化ホウォートンゼリー |
| TW201603818A (zh) | 2014-06-03 | 2016-02-01 | 組織科技股份有限公司 | 組成物及方法 |
| AU2015287920A1 (en) | 2014-07-08 | 2017-01-19 | Mimedx Group, Inc. | Micronized wharton's jelly |
| US20160243288A1 (en) | 2015-02-23 | 2016-08-25 | Tissuetech, Inc. | Apparatuses and methods for treating ophthalmic diseases and disorders |
| TWI720984B (zh) | 2015-05-20 | 2021-03-11 | 美商帝聖工業公司 | 用於防止上皮細胞增生及上皮-間質轉移之組合物及方法 |
| CN108138137A (zh) * | 2015-08-12 | 2018-06-08 | 车比奥泰有限公司 | 增强的脐带来源的粘着干细胞、其制备方法及其用途 |
| TW201733600A (zh) | 2016-01-29 | 2017-10-01 | 帝聖工業公司 | 胎兒扶持組織物及使用方法 |
| EP3474869A4 (en) * | 2016-06-24 | 2020-01-08 | Osiris Therapeutics, Inc. | COMPOSITIONS DERIVED FROM HUMAN TISSUE AND USES THEREOF |
| KR102048228B1 (ko) * | 2016-12-02 | 2019-11-25 | 가톨릭대학교 산학협력단 | Ｔ 세포 자극용 엑소좀 및 이의 약제학적 용도 |
| KR101864234B1 (ko) * | 2017-07-04 | 2018-06-04 | 인하대학교 산학협력단 | 음경해면체 유래 엑소좀을 유효성분으로 포함하는, 발기부전 예방, 개선 또는 치료용 조성물 |
| US11285177B2 (en) | 2018-01-03 | 2022-03-29 | Globus Medical, Inc. | Allografts containing viable cells and methods thereof |
| CN108239621B (zh) * | 2018-01-24 | 2020-08-18 | 北京臻溪谷医学研究中心（有限合伙） | 一种胎盘亚全能干细胞分离、扩增、冻存、复苏干细胞的方法 |
| US20230338428A1 (en) * | 2020-09-08 | 2023-10-26 | Amit Patel | Allogenic umbilical cord stem cells for treating severe respiratory conditions |
| US20230057957A1 (en) * | 2021-08-23 | 2023-02-23 | Therapeutic Solutions International, Inc. | Umbilical cord mesenchymal stem cells for treatment of chronic obstructive pulmonary disease and lung degeneration |
| US20240003871A1 (en) * | 2022-06-29 | 2024-01-04 | FUJIFILM Cellular Dynamics, Inc. | Ipsc-derived astrocytes and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| WO1999061587A1 (en) | 1998-05-29 | 1999-12-02 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
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| EP1594957B1 (en) | 2003-02-11 | 2010-08-25 | John E. Davies | Progenitor cells from wharton's jelly of human umbilical cord |
| AU2004252570C1 (en) | 2003-06-27 | 2012-03-01 | Ethicon, Incorporated | Soft tissue repair and regeneration using postpartum-derived cells |
| CN101040042B (zh) * | 2004-08-16 | 2013-06-19 | 细胞研究私人有限公司 | 自脐带羊膜分离干/祖细胞 |
| WO2007106089A1 (en) | 2006-03-14 | 2007-09-20 | Spherical Dynamics, Inc. | System for and method for psychological assessment |
| SI2120977T1 (sl) * | 2007-02-12 | 2014-01-31 | Anthrogenesis Coroporation | Zdravljenje vnetnih bolezni z uporabo placentarnih matičnih celic |
| PT103843B (pt) | 2007-10-04 | 2008-08-12 | Medinfar Produtos Farmaceutico | Método de isolamento de células precursoras a partir do cordão umbilical humano |
| CA2743573C (en) * | 2008-11-21 | 2021-04-27 | Anthrogenesis Corporation | Treatment of diseases, disorders or conditions of the lung using placental cells |
| CN101748096B (zh) * | 2008-12-17 | 2013-03-13 | 北京汉氏联合生物技术有限公司 | 亚全能干细胞、其制备方法及其用途 |
| MX337480B (es) * | 2009-09-23 | 2016-03-08 | Davinci Biosciences Llc | Celulas madre del revestimiento de cordon umbilical y metodos y material para aislar y cultivar las mismas. |
| CN101890050B (zh) * | 2010-07-14 | 2012-07-04 | 江苏大学 | 脐带间质干细胞来源膜性囊泡及其应用 |
| EP2540819A1 (en) | 2011-06-27 | 2013-01-02 | Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) | Method for cultivating cells in platelet-lysate-containing medium |
-
2012
- 2012-12-31 EP EP17191442.7A patent/EP3321355B1/en active Active
- 2012-12-31 HU HUE17191442A patent/HUE056817T2/hu unknown
- 2012-12-31 SI SI201231950T patent/SI3321355T1/sl unknown
- 2012-12-31 ES ES17191442T patent/ES2890126T3/es active Active
- 2012-12-31 US US13/732,204 patent/US9803176B2/en active Active
- 2012-12-31 PL PL17191442T patent/PL3321355T3/pl unknown
- 2012-12-31 PT PT171914427T patent/PT3321355T/pt unknown
- 2012-12-31 CA CA2862661A patent/CA2862661C/en active Active
- 2012-12-31 ES ES12862921.9T patent/ES2656614T3/es active Active
- 2012-12-31 EP EP12862921.9A patent/EP2798058B1/en active Active
- 2012-12-31 JP JP2014550544A patent/JP6548897B2/ja active Active
- 2012-12-31 CA CA3113484A patent/CA3113484A1/en active Pending
- 2012-12-31 WO PCT/US2012/072331 patent/WO2013102219A1/en active Application Filing
- 2012-12-31 DK DK17191442.7T patent/DK3321355T3/da active
-
2017
- 2017-10-31 US US15/799,743 patent/US20190218519A1/en not_active Abandoned
-
2021
- 2021-05-17 US US17/322,672 patent/US20220041992A1/en not_active Abandoned
- 2021-08-30 HR HRP20211373TT patent/HRP20211373T1/hr unknown
- 2021-12-22 US US17/559,545 patent/US20220251514A1/en active Pending
- 2021-12-22 US US17/559,539 patent/US20220251513A1/en active Pending
- 2021-12-22 US US17/559,583 patent/US20220251515A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2798058B1 (en) | 2017-10-18 |
| CA3113484A1 (en) | 2013-07-04 |
| EP3321355B1 (en) | 2021-08-25 |
| US20130216505A1 (en) | 2013-08-22 |
| ES2890126T3 (es) | 2022-01-17 |
| JP6548897B2 (ja) | 2019-07-24 |
| EP3321355A1 (en) | 2018-05-16 |
| PL3321355T3 (pl) | 2021-12-27 |
| PT3321355T (pt) | 2021-09-28 |
| US20220251514A1 (en) | 2022-08-11 |
| HUE056817T2 (hu) | 2022-03-28 |
| DK3321355T3 (da) | 2021-11-08 |
| US9803176B2 (en) | 2017-10-31 |
| JP2015503918A (ja) | 2015-02-05 |
| WO2013102219A1 (en) | 2013-07-04 |
| EP2798058A4 (en) | 2015-05-20 |
| US20220251515A1 (en) | 2022-08-11 |
| US20190218519A1 (en) | 2019-07-18 |
| US20220251513A1 (en) | 2022-08-11 |
| SI3321355T1 (sl) | 2021-11-30 |
| US20220041992A1 (en) | 2022-02-10 |
| CA2862661C (en) | 2021-05-25 |
| CA2862661A1 (en) | 2013-07-04 |
| ES2656614T3 (es) | 2018-02-27 |
| EP2798058A1 (en) | 2014-11-05 |
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