HRP20120477T1 - Nova anti plgf protutijela - Google Patents
Nova anti plgf protutijela Download PDFInfo
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- HRP20120477T1 HRP20120477T1 HRP20120477TT HRP20120477T HRP20120477T1 HR P20120477 T1 HRP20120477 T1 HR P20120477T1 HR P20120477T T HRP20120477T T HR P20120477TT HR P20120477 T HRP20120477 T HR P20120477T HR P20120477 T1 HRP20120477 T1 HR P20120477T1
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- 102100035194 Placenta growth factor Human genes 0.000 claims abstract 9
- 239000012634 fragment Substances 0.000 claims abstract 4
- 230000002265 prevention Effects 0.000 claims abstract 2
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 108091034117 Oligonucleotide Proteins 0.000 claims 12
- 241000699660 Mus musculus Species 0.000 claims 10
- 108010082093 Placenta Growth Factor Proteins 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 101001001487 Homo sapiens Phosphatidylinositol-glycan biosynthesis class F protein Proteins 0.000 abstract 1
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 abstract 1
- 208000034038 Pathologic Neovascularization Diseases 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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Abstract
Molekula koji veže antigen sposoban da veže PlGFnaznačena time da sadrži CDR područja koja odgovaraju sekvencama SEQ ID NO do Patent sadrži još patentnih zahtjeva
Claims (20)
1. Molekula koji veže antigen sposoban da veže PlGF, naznačena time, da sadrži CDR područja koja odgovaraju sekvencama SEQ ID NO: 17 do 22.
2. Molekula koja veže antigen prema zahtjevu 1, naznačena time, da je navedena molekula odabrana iz skupine koja sadrži Fab, Fab' ili F(ab')2, kombinacije barem dva područja koja određuju komplementarnost (CDR), jedno-lančanog varijabilnog područja koje je spojeno na membranu ili pojedinačnu varijabilnu domenu.
3. Molekula koja veže antigen prema zahtjevu 1, naznačena time, da sadrži varijabilno područje teškog lanca koji sadrži sekvencu SEQ ID NO: 2, te također sadrži varijabilno područje lakog lanca koji sadrži sekvencu SEQ ID NO. 4.
4. Molekula koja veže antigen prema bilo kojem od zahtjeva 1 do 3, naznačena time, da navedena molekula predstavlja protutijelo 16D3, proizvedeno u staničnoj liniji koja je pohranjena kao LMBP 6399CB, ili njegov fragment.
5. Molekula koja veže antigen prema bilo kojem od zahtjeva 1 do 3, naznačena time, da navedena molekula predstavlja humanizirano protutijelo ili fragment protutijela.
6. Molekula koja veže antigen prema zahtjevu 1, naznačena time, da navedena molekula predstavlja jedno-lančani varijabilni fragment.
7. Molekula koja veže antigen prema zahtjevu 1, naznačena time, da navedena molekula sadrži amino-kiselinsku sekvencu SEQ ID NO: 24.
8. Molekula koja veže antigen prema zahtjevu 1, naznačena time, da navedena molekula sadrži amino-kiselinsku sekvencu SEQ ID NO: 26.
9. Stanična linija, naznačena time, da proizvodi molekulu koja veže antigen prema zahtjevu 1.
10. Stanična linija prema zahtjevu 9, naznačena time, da je navedena linija pohranjena kao LMBP 6399CB.
11. Farmaceutski pripravak, naznačen time, da kao aktivnu komponentu sadrži molekulu koja veže PlGF prema bilo kojem od zahtjeva 1 do 8 u smjesi sa farmaceutski prihvatljivim nosačem.
12. Farmaceutski pripravak prema zahtjevu 11, naznačen time, da nadalje sadrži terapeutski učinkovitu količinu drugog anti-angiogenog sredstva.
13. Polinukleotid, naznačen time, da kodira molekulu koja veže antigen prema bilo kojem od zahtjeva 1 do 8.
14. Uporaba molekule koja veže antigen prema bilo kojem od zahtjeva 1 do 8, naznačena time, da se navedena molekula upotrebljava za pretraživanje spojeva sa aditivnim učinkom u inhibiciji PlGF kod liječenja raka.
15. Uporaba molekule koja veže antigen prema bilo kojem od zahtjeva 1 do 8, naznačena time, da se navedena molekula koristi kao in vitro dijagnostički alat.
16. Uporaba molekule koja veže antigen prema bilo kojem od zahtjeva 1 do 8, naznačena time, da se navedena molekula koristi za pretraživanje drugih molekula koje vežu antigen, a koje su sposobne vezati isti epitop iz PlGF.
17. Postupak za odabir molekula koje vežu antigen i koje su sposobne vezati isti PlGF epitop kao i protutijelo 16D3 prema zahtjevu 4, naznačen time, da sadrži korake:
a) osiguravanja molekule koja veže PlGF; te
b) odabira molekule koja veže PlGF, a koja je sposobna vezati isti PlGF epitop kao i protutijelo 16D3 bazirano na reakciji sa navedenim epitopom ili bazirano na ogledu sa protutijelom 16D3.
18. Molekula koja veže antigen prema bilo kojem od zahtjeva 1 do 8 ili polinukleotid prema zahtjevu 13, naznačeni time, da se upotrebljavanju kod liječenja i/ili sprječavanja neželjene angiogeneze kod patoloških stanja sisavaca.
19. Molekula koja veže antigen ili polinukleotid prema zahtjevu 18, naznačeni time, da je navedeno patološko stanje odabrano iz skupine koja sadrži rak, upalu, nastanak adhezije, bolesti oka, plućnu hipertenziju i propusnost stijenki krvnih žila.
20. Molekula koja veže antigen ili polinukleotid prema zahtjevu 19, naznačeni time, da je navedeni rak odabran iz skupine koja sadrži rak debelog crijeva, rak dojke, rak gušterače i melanome.
LISTA SEKVENCI
POPIS SEKVENCI
<110> Thromb-X nv
Collen Research Foundation vzw
Vlaams Interuniversitair Instituut voor Biotechnologie (VIB)
Stassen, Jean-Marie
Carmeliet, Peter
Collen, Desire
<120> NOVA ANTI-PLGF PROTUTIJELA
<130> T3326-PCT
<150> US 60/664,768
<151> 2005-03-24
<160> 30
<170> PatentIn verzija 3.3
<210> 1
<211> 348
<212> DNK
<213> Mus musculus
<220>
<221> CDS
<222> (1)..(348)
<223> mišji varijabilni dio teškog lanca 16D3
<400> 1
[image]
[image]
<210> 2
<211> 116
<212> PRT
<213> Mus musculus
<400> 2
[image]
<210> 3
<211> 336
<212> DNK
<213> Mus musculus
<220>
<221> CDS
<222> (1) .. (336)
<223> mišji varijabilni dio lakog lanca 16D3
<400> 3
[image]
<210> 4
<211> 112
<212> PRT
<213> Mus musculus
<400> 4
[image]
[image]
<210> 5
<211> 348
<212> DNK
<213> Umjetna sekvenca
<220>
<223> Humanizirani fragment protutijela
<220>
<221> CDS
<222> (1)..(348)
<223> Humanizirani varijabilni dio teškog lanca 16D3
<400> 5
[image]
[image]
<210> 6
<211> 116
<212> PRT
<213> Umjetna sekvenca
<220>
<223> Sintetički konstrukt
<400> 6
[image]
<210> 7
<211> 336
<212> DNK
<213> Umjetna sekvenca
<220>
<223> Humanizirani fragment protutijela
<220>
<221> CDS
<222> (1)..(336)
<223> Humanizirani varijabilni dio lakog lanca 16D3
<400> 7
[image]
<210> 8
<211> 112
<212> PRT
<213> Umjetna sekvenca
<220>
<223> Sintetički konstrukt
<400> 8
[image]
<210> 9
<211> 24
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 9
atggratgga gctgkatcwt thtc 24
<210> 10
<211> 25
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 10
casaymcagg ggccagtgga tagac 25
<210> 11
<211> 27
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 11
atgragtcac akacycaggt cttyrta 27
<210> 12
<211> 24
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 12
gctcactgga tggtgggaag atgg 24
<210> 13
<211> 31
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 13
ccaccggtga cattgtgctg acccagtctc c 31
<210> 14
<211> 34
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 14
caccgtacgt tttatttcca actttgtccc cgag 34
<210> 15
<211> 22
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 15
caggtccagc tgcagcagtc tg 22
<210> 16
<211> 40
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 16
gatgggccct tggtcgacgc tgaggagact gtgagcaggg 40
<210> 17
<211> 8
<212> PRT
<213> Mus musculus
<220>
<221> misc
<222> (1)..(8)
<223> CDR1 teški lanac 16D3
<400> 17
[image]
<210> 18
<211> 8
<212> PRT
<213> Mus musculus
<220>
<221> MISC FEATURE
<222> (1)..(8)
<223> CDR2 teški lanac 16D3
<400> 18
[image]
<210> 19
<211> 9
<212> PRT
<213> Mus musculus
<220>
<221> MISC_FEATURE
<222> (1)..(9)
<223> CDR3 teški lanac 16D3
<400> 19
[image]
<210> 20
<211> 12
<212> PRT
<213> Mus musculus
<220>
<221> misc
<222> (1)..(12)
<223> CDR1 laki lanac 16D3
<400> 20
[image]
<210> 21
<211> 3
<212> PRT
<213> Mus musculus
<220>
<221> misc
<222> (1)..(3)
<223> CDR2 laki lanac 16D3
<400> 21
[image]
<210> 22
<211> 8
<212> PRT
<213> Mus musculus
<220>
<221> MISC_FEATURE
<222> (1)..(8)
<223> CDR3 laki lanac 16D3
<400> 22
[image]
<210> 23
<211> 786
<212> DNK
<213> Umjetna sekvenca
<220>
<223> 16D3 ScFv
<220>
<221> CDS
<222> (1)..(786)
<220>
<221> misc
<222> (1)..(348)
<223> Teški lanac
<220>
<221> misc
<222> (349)..(393)
<223> Linker
<220>
<221> misc
<222> (394)..(729)
<223> Laki lanac
<220>
<221> misc
<222> (736)..(762)
<223> HA-Tag
<220>
<221> misc
<222> (769)..(786)
<223> His-Tag
<400> 23
[image]
[image]
[image]
<210> 24
<211> 262
<212> PRT
<213> Umjetna sekvenca
<220>
<223> Sintetički konstrukt
<400> 24
[image]
[image]
<210> 25
<211> 786
<212> DNK
<213> Umjetna sekvenca
<220>
<223> Humanizirana 16D3 ScFv
<220>
<221> CDS
<222> (1)..(786)
<220>
<221> misc
<222> (1)..(348)
<223> Teški lanac
<220>
<221> misc
<222> (349)..(393)
<223> linker
<220>
<221> misc
<222> (394)..(729)
<223> Laki lanac
<220>
<221> misc
<222> (736)..(762)
<223> HA-tag
<220>
<221> misc
<222> (769)..(786)
<223> HA-tag
<400> 25
[image]
[image]
<210> 26
<211> 262
<212> PRT
<213> Umjetna sekvenca
<220>
<223> Sintetički konstrukt
<400> 26
[image]
[image]
[image]
<210> 27
<211> 22
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 27
caggtccagc tgcagcagtc tg 22
<210> 28
<211> 40
<212> DNK
<213> Umjetna sekvenca
<220>
<223> oligonukleotidna početnica
<400> 28
gatgggccct tggtcgacgc tgaggagact gtgagcaggg 40
<210> 29
<211> 31
<212> DNK
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| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
| US10035847B2 (en) | 2013-10-02 | 2018-07-31 | The Rockefeller University | Amyloid protofibril antibodies and methods of use thereof |
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| CA2974699A1 (en) | 2015-01-23 | 2016-07-28 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
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| EP3606555A4 (en) * | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
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