HRP20110258T1 - Postupci za dobivanje heksahidrofuro[2,3-b]furan-3-ola - Google Patents
Postupci za dobivanje heksahidrofuro[2,3-b]furan-3-ola Download PDFInfo
- Publication number
- HRP20110258T1 HRP20110258T1 HR20110258T HRP20110258T HRP20110258T1 HR P20110258 T1 HRP20110258 T1 HR P20110258T1 HR 20110258 T HR20110258 T HR 20110258T HR P20110258 T HRP20110258 T HR P20110258T HR P20110258 T1 HRP20110258 T1 HR P20110258T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- alkyl
- image
- arylalkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 15
- RCDXYCHYMULCDZ-UHFFFAOYSA-N 2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-ol Chemical compound O1CCC2C(O)COC21 RCDXYCHYMULCDZ-UHFFFAOYSA-N 0.000 title claims abstract 3
- RCDXYCHYMULCDZ-HCWXCVPCSA-N (3as,4r,6ar)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-ol Chemical compound O1CC[C@H]2[C@@H](O)CO[C@H]21 RCDXYCHYMULCDZ-HCWXCVPCSA-N 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 4
- 150000003608 titanium Chemical class 0.000 claims 4
- JKTCBAGSMQIFNL-UHFFFAOYSA-N 2,3-dihydrofuran Chemical compound C1CC=CO1 JKTCBAGSMQIFNL-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 239000007795 chemical reaction product Substances 0.000 claims 3
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical class OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims 3
- 239000010936 titanium Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 claims 2
- 238000007363 ring formation reaction Methods 0.000 claims 2
- 235000011006 sodium potassium tartrate Nutrition 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- ZHOFTVOJICJJNF-UHFFFAOYSA-N 1-(2-propan-2-yloxyoxolan-3-yl)ethane-1,2-diol Chemical compound CC(C)OC1OCCC1C(O)CO ZHOFTVOJICJJNF-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- HYMFICVSTYUSOC-UHFFFAOYSA-N ethyl 2-hydroxy-2-(2-propan-2-yloxyoxolan-3-yl)acetate Chemical compound CCOC(=O)C(O)C1CCOC1OC(C)C HYMFICVSTYUSOC-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- -1 radical halogen Chemical class 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 150000003609 titanium compounds Chemical class 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06123752 | 2006-11-09 | ||
| PCT/EP2007/062119 WO2008055970A2 (en) | 2006-11-09 | 2007-11-09 | Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110258T1 true HRP20110258T1 (hr) | 2011-05-31 |
Family
ID=37692659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110258T HRP20110258T1 (hr) | 2006-11-09 | 2011-04-11 | Postupci za dobivanje heksahidrofuro[2,3-b]furan-3-ola |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8153829B2 (sl) |
| EP (1) | EP2089371B1 (sl) |
| JP (1) | JP5491862B2 (sl) |
| CN (2) | CN101541775B (sl) |
| AT (1) | ATE497499T1 (sl) |
| AU (1) | AU2007316562B2 (sl) |
| BR (1) | BRPI0718706B8 (sl) |
| CA (1) | CA2669014C (sl) |
| CY (1) | CY1111407T1 (sl) |
| DE (1) | DE602007012365D1 (sl) |
| DK (1) | DK2089371T3 (sl) |
| ES (1) | ES2359949T3 (sl) |
| HR (1) | HRP20110258T1 (sl) |
| IL (1) | IL198270A (sl) |
| ME (1) | ME01232B (sl) |
| MX (1) | MX2009004957A (sl) |
| PL (1) | PL2089371T3 (sl) |
| PT (1) | PT2089371E (sl) |
| RS (1) | RS51675B (sl) |
| RU (1) | RU2464266C2 (sl) |
| SI (1) | SI2089371T1 (sl) |
| WO (1) | WO2008055970A2 (sl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010075887A1 (en) * | 2008-12-30 | 2010-07-08 | Oxyrane (Uk) Limited | Methods and intermediates useful in the synthesis of hexahydrofuro[2,3-b]furan-3-ol |
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| BR112012009956A2 (pt) | 2009-10-30 | 2015-09-29 | Lupin Ltd | um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula. |
| PT2513116E (pt) | 2009-12-16 | 2015-10-14 | Hetero Research Foundation | Polimorfos de darunavir |
| JP2013518096A (ja) | 2010-01-28 | 2013-05-20 | マピ ファーマ リミテッド | ダルナビル及びダルナビル中間体の調製方法 |
| ES2595235T3 (es) | 2010-05-20 | 2016-12-28 | Hetero Research Foundation | Sal clorhidrato cristalina de darunavir |
| CN102617586B (zh) * | 2011-01-26 | 2016-04-06 | 浙江九洲药业股份有限公司 | 地瑞那韦中间体的制备方法 |
| WO2014031468A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole hexahydrofuro[3,2-b]furan derivatives |
| CN103864813B (zh) * | 2012-12-18 | 2017-02-22 | 上海迪赛诺化学制药有限公司 | 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法 |
| CN103896886A (zh) * | 2012-12-31 | 2014-07-02 | 上海迪赛诺化学制药有限公司 | 一种达鲁那韦中间体及其制备方法和应用 |
| TW201514188A (zh) * | 2013-03-13 | 2015-04-16 | Lantheus Medical Imaging Inc | 製備釓磷維塞三鈉單水合物之方法 |
| CN103664976B (zh) * | 2013-12-12 | 2015-11-04 | 惠州市莱佛士制药技术有限公司 | 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法 |
| CN107344944B (zh) * | 2016-05-07 | 2021-03-05 | 成都博腾药业有限公司 | 一种制备地瑞那韦中间体的方法 |
| CN112300186B (zh) * | 2019-08-01 | 2024-04-30 | 浙江九洲药业股份有限公司 | 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2127938T3 (es) | 1993-08-24 | 1999-05-01 | Searle & Co | Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| DK0749421T3 (da) * | 1994-03-07 | 2000-03-20 | Vertex Pharma | Sulfonamidderivater som aspartylproteaseinhibitorer |
| CN1091088C (zh) | 1995-02-03 | 2002-09-18 | 钟渊化学工业株式会社 | α－卤代酮、α－卤代醇和环氧化物的制备方法 |
| AU7722296A (en) | 1995-11-15 | 1997-06-05 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5990313A (en) * | 1996-10-21 | 1999-11-23 | Eastman Chemical Company | Preparation of 3-alkyltetrahydrofurans |
| JP2002515888A (ja) * | 1996-10-21 | 2002-05-28 | イーストマン ケミカル カンパニー | ３―アルキルテトラヒドロフランの製造方法 |
| US5856531A (en) * | 1996-10-21 | 1999-01-05 | Eastman Chemical Company | Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran |
| PT1086076E (pt) | 1998-06-19 | 2005-05-31 | Vertex Pharma | Inibidores de sulfonamida de aspartil protease |
| WO1999067254A2 (en) | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| EP1088098B2 (en) | 1998-06-23 | 2015-07-01 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Fitness assay and methods for reducing resistance of hiv to therapy |
| KR20010031394A (ko) | 1998-08-25 | 2001-04-16 | 후루타 타케시 | (2ｒ,3ｓ)-3-아미노-1,2-옥시란의 제조법 |
| ES2267494T3 (es) | 1999-01-29 | 2007-03-16 | Kaneka Corporation | Procedimiento para la preparacion de derivados de treo-1,2-epoxi-3-amino-4-fenilbutano. |
| PE20010560A1 (es) | 1999-02-12 | 2001-05-04 | Vertex Pharma | Sulfonamidas y amidas como inhibidores de aspartil proteasa |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
| DE60039244D1 (de) | 1999-10-06 | 2008-07-31 | Tibotec Pharm Ltd | HEXAHYDROFUROi2,3-B FURAN-3-YL-N- 3-i(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO -1-BENZYL-2-HYDROXYPROPYL CARBAMAT ALS RETROVIRUSPROTEASEHEMMER |
| WO2002060905A2 (en) | 2000-10-24 | 2002-08-08 | Glaxo Group Ltd | METHOD FOR PREPARING HIV PROTEASE INHIBITOR INTERMEDIATES |
| KR20020046948A (ko) | 2000-12-12 | 2002-06-21 | 에가시라 구니오 | 에폭사이드 결정의 제조방법 |
| AP1758A (en) * | 2001-09-10 | 2007-07-30 | Tibotec Pharm Ltd | Method for the preparation of hexahydro-furo [2,3-b]furan-3-ol. |
| ES2265052T3 (es) | 2001-09-20 | 2007-02-01 | Smithkline Beecham Corporation | Procedimiento de preparacion de intermedios de inhibidores de proteasa. |
| JP4864320B2 (ja) * | 2002-05-16 | 2012-02-01 | テイボテク・フアーマシユーチカルズ・リミテツド | Ｈｉｖプロテアーゼ阻害剤の疑似多形相 |
| SI1532127T1 (sl) * | 2002-06-27 | 2006-12-31 | Smithkline Beecham Corp | Priprava stereoizomerov (3alfa, 3alfa/beta, 6alfa/beta) heksahydrofuro(2,3-b)-furan-3-ola |
| US6919465B2 (en) | 2002-10-09 | 2005-07-19 | The Board Of Trustees Of The University Of Illinois | Method of preparing (3R, 3aS, 6aR)-3-hydroxyhexahydrofuro[2,3,-b] furan and related compounds |
| AU2003275675A1 (en) * | 2002-12-27 | 2004-07-29 | Sumitomo Chemical Company, Limited | Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same |
| BRPI0417272B8 (pt) * | 2003-12-23 | 2021-05-25 | Janssen R&D Ireland | processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato |
| TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
-
2007
- 2007-11-09 EP EP07822416A patent/EP2089371B1/en active Active
- 2007-11-09 PL PL07822416T patent/PL2089371T3/pl unknown
- 2007-11-09 PT PT07822416T patent/PT2089371E/pt unknown
- 2007-11-09 RU RU2009121792/04A patent/RU2464266C2/ru active
- 2007-11-09 CN CN2007800418345A patent/CN101541775B/zh active Active
- 2007-11-09 DK DK07822416.9T patent/DK2089371T3/da active
- 2007-11-09 CA CA2669014A patent/CA2669014C/en active Active
- 2007-11-09 ME MEP-2011-65A patent/ME01232B/me unknown
- 2007-11-09 AU AU2007316562A patent/AU2007316562B2/en active Active
- 2007-11-09 MX MX2009004957A patent/MX2009004957A/es active IP Right Grant
- 2007-11-09 SI SI200730567T patent/SI2089371T1/sl unknown
- 2007-11-09 RS RS20110169A patent/RS51675B/en unknown
- 2007-11-09 WO PCT/EP2007/062119 patent/WO2008055970A2/en active Application Filing
- 2007-11-09 DE DE602007012365T patent/DE602007012365D1/de active Active
- 2007-11-09 CN CN201110342987.1A patent/CN102432621B/zh active Active
- 2007-11-09 BR BRPI0718706A patent/BRPI0718706B8/pt active IP Right Grant
- 2007-11-09 ES ES07822416T patent/ES2359949T3/es active Active
- 2007-11-09 JP JP2009535738A patent/JP5491862B2/ja active Active
- 2007-11-09 US US12/447,537 patent/US8153829B2/en active Active
- 2007-11-09 AT AT07822416T patent/ATE497499T1/de active
-
2009
- 2009-04-21 IL IL198270A patent/IL198270A/en active IP Right Grant
-
2011
- 2011-04-11 HR HR20110258T patent/HRP20110258T1/hr unknown
- 2011-05-02 CY CY20111100423T patent/CY1111407T1/el unknown
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