ME01232B - Etode za dobivanje heksahidrofuro[2,3-b]furan-3-ola - Google Patents

Etode za dobivanje heksahidrofuro[2,3-b]furan-3-ola

Info

Publication number
ME01232B
ME01232B MEP-2011-65A MEP6511A ME01232B ME 01232 B ME01232 B ME 01232B ME P6511 A MEP6511 A ME P6511A ME 01232 B ME01232 B ME 01232B
Authority
ME
Montenegro
Prior art keywords
hexahydrofuro
furan
methods
preparation
enantiomer
Prior art date
Application number
MEP-2011-65A
Other languages
English (en)
French (fr)
Inventor
Sébastien François Emmanuel LEMAIRE
Andras Horvath
Wim Albert Alex Aelterman
Thomas Joachim Landewald Rammeloo
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37692659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01232(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of ME01232B publication Critical patent/ME01232B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MEP-2011-65A 2006-11-09 2007-11-09 Etode za dobivanje heksahidrofuro[2,3-b]furan-3-ola ME01232B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06123752 2006-11-09
EP07822416A EP2089371B1 (en) 2006-11-09 2007-11-09 Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
PCT/EP2007/062119 WO2008055970A2 (en) 2006-11-09 2007-11-09 Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol

Publications (1)

Publication Number Publication Date
ME01232B true ME01232B (me) 2013-06-20

Family

ID=37692659

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2011-65A ME01232B (me) 2006-11-09 2007-11-09 Etode za dobivanje heksahidrofuro[2,3-b]furan-3-ola

Country Status (22)

Country Link
US (1) US8153829B2 (me)
EP (1) EP2089371B1 (me)
JP (1) JP5491862B2 (me)
CN (2) CN101541775B (me)
AT (1) ATE497499T1 (me)
AU (1) AU2007316562B2 (me)
BR (1) BRPI0718706B8 (me)
CA (1) CA2669014C (me)
CY (1) CY1111407T1 (me)
DE (1) DE602007012365D1 (me)
DK (1) DK2089371T3 (me)
ES (1) ES2359949T3 (me)
HR (1) HRP20110258T1 (me)
IL (1) IL198270A (me)
ME (1) ME01232B (me)
MX (1) MX2009004957A (me)
PL (1) PL2089371T3 (me)
PT (1) PT2089371E (me)
RS (1) RS51675B (me)
RU (1) RU2464266C2 (me)
SI (1) SI2089371T1 (me)
WO (1) WO2008055970A2 (me)

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WO2010075887A1 (en) * 2008-12-30 2010-07-08 Oxyrane (Uk) Limited Methods and intermediates useful in the synthesis of hexahydrofuro[2,3-b]furan-3-ol
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
US9062065B2 (en) 2009-10-30 2015-06-23 Lupin Limited Process for preparation of darunavir and darunavir ethanolate of fine particle size
CN102686594A (zh) 2009-12-16 2012-09-19 熙德隆研究基金会 地瑞那韦的多晶型物
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
EP2571355B1 (en) 2010-05-20 2016-09-07 Hetero Research Foundation Crystalline hydrochloride salt of darunavir
CN102617586B (zh) * 2011-01-26 2016-04-06 浙江九洲药业股份有限公司 地瑞那韦中间体的制备方法
EP2887807B1 (en) * 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
CN103896886A (zh) * 2012-12-31 2014-07-02 上海迪赛诺化学制药有限公司 一种达鲁那韦中间体及其制备方法和应用
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN113307783B (zh) * 2016-05-07 2023-04-07 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
CN112300186B (zh) * 2019-08-01 2024-04-30 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法

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DE69415326T2 (de) 1993-08-24 1999-06-02 G.D. Searle & Co., Chicago, Ill. Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
DE69512220T2 (de) 1994-03-07 2000-03-16 Vertex Pharmaceuticals Inc. Sulfonamidderivate als aspartylprotease-inhibitoren
JP3665343B2 (ja) 1995-02-03 2005-06-29 株式会社カネカ α−ハロケトン、α−ハロヒドリン及びエポキシドの製造法
WO1997018205A1 (en) 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5990313A (en) * 1996-10-21 1999-11-23 Eastman Chemical Company Preparation of 3-alkyltetrahydrofurans
EP0932607A2 (en) * 1996-10-21 1999-08-04 Eastman Chemical Company Preparation of 3-alkyltetrahydrofurans
US5856531A (en) * 1996-10-21 1999-01-05 Eastman Chemical Company Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran
DK1086076T3 (da) 1998-06-19 2005-03-29 Vertex Pharma Sulfonamidinhibitorer af aspartylprotease
WO1999067417A2 (en) 1998-06-23 1999-12-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fitness assay and associated methods
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
US6278002B1 (en) 1998-08-25 2001-08-21 Kaneka Corporation Process for the preparation of (2r,3s)-3-amino-1,2-oxirane
ATE334121T1 (de) 1999-01-29 2006-08-15 Kaneka Corp Verfahren zur herstellung von threo-1,2-epoxy-3- amino-4-phenylbutan-derivaten
DK1159278T3 (da) 1999-02-12 2006-04-10 Vertex Pharma Inhibitorer af aspartylprotease
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
OA12053A (en) 1999-10-06 2006-05-02 Tibotec Pharm Ltd HexahydrofuroÄ2,3-bÜfuran-3-yl-N-ä3-Ä(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)aminoÜ-1-benzyl-2-hydroxypropylücarbamate as retroviral protease inhibitor.
WO2002060905A2 (en) 2000-10-24 2002-08-08 Glaxo Group Ltd METHOD FOR PREPARING HIV PROTEASE INHIBITOR INTERMEDIATES
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
DE60234952D1 (de) * 2001-09-10 2010-02-11 Tibotec Pharm Ltd VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL
DE60213874T2 (de) 2001-09-20 2007-10-18 Smithkline Beecham Corp. Verfahren zur herstellung von protease hemmenden zwischenprodukten
DK2767539T3 (en) * 2002-05-16 2017-09-11 Janssen Sciences Ireland Uc Pseudopolymorphic forms of an HIV protease inhibitor
US20050261507A1 (en) * 2002-06-27 2005-11-24 Doan Brian D Preparation of stereoisomers of (3alpha/beta, 6alpha/beta)hexahydrofuro[2,3-b]furan-3-ol
WO2004033462A2 (en) 2002-10-09 2004-04-22 The Board Of Trustees Of The University Of Illinois METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS
WO2004060895A1 (ja) 2002-12-27 2004-07-22 Sumitomo Chemical Company, Limited ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法
PL1725566T3 (pl) * 2003-12-23 2009-11-30 Janssen Sciences Ireland Uc Sposób wytwarzania (1s,2r)-3-[[(4-aminofenylo)sulfonylo](izobutylo)amino]-1-benzylo-2-hydroksypropylokarbaminianu (3r,3as,6ar)-heksahydrofuro-[2,3-b]furan-3-ylu
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
EP2089371A2 (en) 2009-08-19
CY1111407T1 (el) 2015-08-05
IL198270A (en) 2014-02-27
US8153829B2 (en) 2012-04-10
HRP20110258T1 (hr) 2011-05-31
SI2089371T1 (sl) 2011-05-31
CN102432621A (zh) 2012-05-02
BRPI0718706B1 (pt) 2021-03-23
CN101541775A (zh) 2009-09-23
ES2359949T3 (es) 2011-05-30
JP2010509290A (ja) 2010-03-25
CA2669014A1 (en) 2008-05-15
PT2089371E (pt) 2011-04-18
AU2007316562A1 (en) 2008-05-15
CA2669014C (en) 2016-01-26
ATE497499T1 (de) 2011-02-15
BRPI0718706A2 (pt) 2014-01-07
DK2089371T3 (da) 2011-05-16
RS51675B (en) 2011-10-31
IL198270A0 (en) 2009-12-24
WO2008055970A2 (en) 2008-05-15
AU2007316562B2 (en) 2013-02-21
CN101541775B (zh) 2011-12-28
RU2009121792A (ru) 2010-12-20
WO2008055970A3 (en) 2008-06-26
RU2464266C2 (ru) 2012-10-20
MX2009004957A (es) 2009-05-19
DE602007012365D1 (de) 2011-03-17
US20100094028A1 (en) 2010-04-15
EP2089371B1 (en) 2011-02-02
CN102432621B (zh) 2016-02-17
PL2089371T3 (pl) 2011-06-30
BRPI0718706B8 (pt) 2021-05-25
JP5491862B2 (ja) 2014-05-14

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