ATE497499T1 - Verfahren zur herstellung von hexahydrofuroä2,3- büfuran-3-ol - Google Patents

Verfahren zur herstellung von hexahydrofuroä2,3- büfuran-3-ol

Info

Publication number
ATE497499T1
ATE497499T1 AT07822416T AT07822416T ATE497499T1 AT E497499 T1 ATE497499 T1 AT E497499T1 AT 07822416 T AT07822416 T AT 07822416T AT 07822416 T AT07822416 T AT 07822416T AT E497499 T1 ATE497499 T1 AT E497499T1
Authority
AT
Austria
Prior art keywords
bufuran
producing
hexahydrofuro
furan
methods
Prior art date
Application number
AT07822416T
Other languages
English (en)
Inventor
Sebastien Francois Emmanuel Lemaire
Andras Horvath
Wim Albert Alex Aelterman
Thomas Joachim Landewald Rammeloo
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37692659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE497499(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE497499T1 publication Critical patent/ATE497499T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07822416T 2006-11-09 2007-11-09 Verfahren zur herstellung von hexahydrofuroä2,3- büfuran-3-ol ATE497499T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123752 2006-11-09
PCT/EP2007/062119 WO2008055970A2 (en) 2006-11-09 2007-11-09 Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol

Publications (1)

Publication Number Publication Date
ATE497499T1 true ATE497499T1 (de) 2011-02-15

Family

ID=37692659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07822416T ATE497499T1 (de) 2006-11-09 2007-11-09 Verfahren zur herstellung von hexahydrofuroä2,3- büfuran-3-ol

Country Status (22)

Country Link
US (1) US8153829B2 (de)
EP (1) EP2089371B1 (de)
JP (1) JP5491862B2 (de)
CN (2) CN102432621B (de)
AT (1) ATE497499T1 (de)
AU (1) AU2007316562B2 (de)
BR (1) BRPI0718706B8 (de)
CA (1) CA2669014C (de)
CY (1) CY1111407T1 (de)
DE (1) DE602007012365D1 (de)
DK (1) DK2089371T3 (de)
ES (1) ES2359949T3 (de)
HR (1) HRP20110258T1 (de)
IL (1) IL198270A (de)
ME (1) ME01232B (de)
MX (1) MX2009004957A (de)
PL (1) PL2089371T3 (de)
PT (1) PT2089371E (de)
RS (1) RS51675B (de)
RU (1) RU2464266C2 (de)
SI (1) SI2089371T1 (de)
WO (1) WO2008055970A2 (de)

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WO2010075887A1 (en) * 2008-12-30 2010-07-08 Oxyrane (Uk) Limited Methods and intermediates useful in the synthesis of hexahydrofuro[2,3-b]furan-3-ol
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
JP2013509400A (ja) * 2009-10-30 2013-03-14 ルパン リミテッド ダルナビルの新規調製方法および微粒子径のダルナビルエタノール付加物
CN102686594A (zh) 2009-12-16 2012-09-19 熙德隆研究基金会 地瑞那韦的多晶型物
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
EP2571355B1 (de) 2010-05-20 2016-09-07 Hetero Research Foundation Kristallines hydrochloridsalz von darunavir
CN102617586B (zh) * 2011-01-26 2016-04-06 浙江九洲药业股份有限公司 地瑞那韦中间体的制备方法
EP2887807B1 (de) * 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazol-hexahydrofuro[3,2-b]furanderivate als amp-aktivierte proteinkinase-aktivatoren
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
CN103896886A (zh) * 2012-12-31 2014-07-02 上海迪赛诺化学制药有限公司 一种达鲁那韦中间体及其制备方法和应用
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN113307783B (zh) * 2016-05-07 2023-04-07 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
CN112300186B (zh) * 2019-08-01 2024-04-30 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法

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DE69512220T2 (de) 1994-03-07 2000-03-16 Vertex Pharma Sulfonamidderivate als aspartylprotease-inhibitoren
US5929284A (en) 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
US5753660A (en) 1995-11-15 1998-05-19 G. D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5990313A (en) * 1996-10-21 1999-11-23 Eastman Chemical Company Preparation of 3-alkyltetrahydrofurans
JP2002515888A (ja) * 1996-10-21 2002-05-28 イーストマン ケミカル カンパニー ３―アルキルテトラヒドロフランの製造方法
US5856531A (en) * 1996-10-21 1999-01-05 Eastman Chemical Company Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran
BR9912169A (pt) 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
DK1088098T4 (en) 1998-06-23 2015-09-14 Us Of America Represented By The Secretary Dept Of Health And Human Services Fitnessassay and methods for reducing HIV resistance to therapy
US6278002B1 (en) 1998-08-25 2001-08-21 Kaneka Corporation Process for the preparation of (2r,3s)-3-amino-1,2-oxirane
EP1067125B1 (de) 1999-01-29 2006-07-26 Kaneka Corporation VERFAHREN ZUR HERSTELLUNG VON threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTAN-DERIVATEN
PT1159278E (pt) 1999-02-12 2006-06-30 Vertex Pharma Inibidores de aspartil-protease
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
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EP1222192B8 (de) 1999-10-06 2008-10-01 Tibotec Pharmaceuticals Ltd. Hexahydrofuro¬2,3-b furan-3-yl-n- 3-¬(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino -1-benzyl-2-hydroxypropyl carbamat als retrovirusproteasehemmer
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US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
BRPI0212341B8 (pt) * 2001-09-10 2021-05-25 Janssen R&D Ireland compostos intermediários de inibidores de protease de hiv e processo para preparação dos mesmos
JP2005510467A (ja) 2001-09-20 2005-04-21 スミスクライン ビーチャム コーポレーション プロテアーゼ阻害剤中間体の調製方法
US7700645B2 (en) * 2002-05-16 2010-04-20 Tibotec Pharmaceuticals Ltd. Pseudopolymorphic forms of a HIV protease inhibitor
AU2003247651A1 (en) * 2002-06-27 2004-01-19 Smithkline Beecham Corporation PREPARATION OF STEREOISOMERS OF (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO(2,3-b)FURAN-3-OL
WO2004033462A2 (en) 2002-10-09 2004-04-22 The Board Of Trustees Of The University Of Illinois METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS
EP1589018A4 (de) 2002-12-27 2007-03-14 Sumitomo Chemical Co Herstellungsverfahren für hexahydrofurofuranol-derivate, zwischenprodukt davon und herstellungsverfahren dafür
DE602004021640D1 (de) * 2003-12-23 2009-07-30 Tibotec Pharm Ltd Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
ES2359949T3 (es) 2011-05-30
JP2010509290A (ja) 2010-03-25
RS51675B (en) 2011-10-31
CN101541775A (zh) 2009-09-23
MX2009004957A (es) 2009-05-19
CN102432621B (zh) 2016-02-17
DE602007012365D1 (de) 2011-03-17
CN102432621A (zh) 2012-05-02
US8153829B2 (en) 2012-04-10
IL198270A0 (en) 2009-12-24
EP2089371A2 (de) 2009-08-19
CA2669014A1 (en) 2008-05-15
BRPI0718706A2 (pt) 2014-01-07
HRP20110258T1 (hr) 2011-05-31
AU2007316562A1 (en) 2008-05-15
EP2089371B1 (de) 2011-02-02
CY1111407T1 (el) 2015-08-05
IL198270A (en) 2014-02-27
JP5491862B2 (ja) 2014-05-14
WO2008055970A3 (en) 2008-06-26
DK2089371T3 (da) 2011-05-16
CN101541775B (zh) 2011-12-28
BRPI0718706B1 (pt) 2021-03-23
CA2669014C (en) 2016-01-26
SI2089371T1 (sl) 2011-05-31
AU2007316562B2 (en) 2013-02-21
RU2464266C2 (ru) 2012-10-20
BRPI0718706B8 (pt) 2021-05-25
ME01232B (me) 2013-06-20
RU2009121792A (ru) 2010-12-20
WO2008055970A2 (en) 2008-05-15
US20100094028A1 (en) 2010-04-15
PT2089371E (pt) 2011-04-18
PL2089371T3 (pl) 2011-06-30

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