DE602007012365D1 - Verfahren zur herstellung von hexahydrofuroä2,3-büfuran-3-ol - Google Patents
Verfahren zur herstellung von hexahydrofuroä2,3-büfuran-3-olInfo
- Publication number
- DE602007012365D1 DE602007012365D1 DE602007012365T DE602007012365T DE602007012365D1 DE 602007012365 D1 DE602007012365 D1 DE 602007012365D1 DE 602007012365 T DE602007012365 T DE 602007012365T DE 602007012365 T DE602007012365 T DE 602007012365T DE 602007012365 D1 DE602007012365 D1 DE 602007012365D1
- Authority
- DE
- Germany
- Prior art keywords
- büfuran
- preparing
- hexahydrofuro
- furan
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06123752 | 2006-11-09 | ||
PCT/EP2007/062119 WO2008055970A2 (en) | 2006-11-09 | 2007-11-09 | Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007012365D1 true DE602007012365D1 (de) | 2011-03-17 |
Family
ID=37692659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007012365T Active DE602007012365D1 (de) | 2006-11-09 | 2007-11-09 | Verfahren zur herstellung von hexahydrofuroä2,3-büfuran-3-ol |
Country Status (22)
Country | Link |
---|---|
US (1) | US8153829B2 (de) |
EP (1) | EP2089371B1 (de) |
JP (1) | JP5491862B2 (de) |
CN (2) | CN102432621B (de) |
AT (1) | ATE497499T1 (de) |
AU (1) | AU2007316562B2 (de) |
BR (1) | BRPI0718706B8 (de) |
CA (1) | CA2669014C (de) |
CY (1) | CY1111407T1 (de) |
DE (1) | DE602007012365D1 (de) |
DK (1) | DK2089371T3 (de) |
ES (1) | ES2359949T3 (de) |
HR (1) | HRP20110258T1 (de) |
IL (1) | IL198270A (de) |
ME (1) | ME01232B (de) |
MX (1) | MX2009004957A (de) |
PL (1) | PL2089371T3 (de) |
PT (1) | PT2089371E (de) |
RS (1) | RS51675B (de) |
RU (1) | RU2464266C2 (de) |
SI (1) | SI2089371T1 (de) |
WO (1) | WO2008055970A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010075887A1 (en) * | 2008-12-30 | 2010-07-08 | Oxyrane (Uk) Limited | Methods and intermediates useful in the synthesis of hexahydrofuro[2,3-b]furan-3-ol |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
JP2013509400A (ja) * | 2009-10-30 | 2013-03-14 | ルパン リミテッド | ダルナビルの新規調製方法および微粒子径のダルナビルエタノール付加物 |
PT2513116E (pt) | 2009-12-16 | 2015-10-14 | Hetero Research Foundation | Polimorfos de darunavir |
EP2528923B1 (de) | 2010-01-28 | 2014-07-30 | Mapi Pharma Limited | Verfahren zur herstellung von darunavir und darunavir-zwischenprodukten |
ES2595235T3 (es) | 2010-05-20 | 2016-12-28 | Hetero Research Foundation | Sal clorhidrato cristalina de darunavir |
CN102617586B (zh) * | 2011-01-26 | 2016-04-06 | 浙江九洲药业股份有限公司 | 地瑞那韦中间体的制备方法 |
WO2014031468A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole hexahydrofuro[3,2-b]furan derivatives |
CN103864813B (zh) * | 2012-12-18 | 2017-02-22 | 上海迪赛诺化学制药有限公司 | 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法 |
CN103896886A (zh) * | 2012-12-31 | 2014-07-02 | 上海迪赛诺化学制药有限公司 | 一种达鲁那韦中间体及其制备方法和应用 |
TW201514188A (zh) * | 2013-03-13 | 2015-04-16 | Lantheus Medical Imaging Inc | 製備釓磷維塞三鈉單水合物之方法 |
CN103664976B (zh) * | 2013-12-12 | 2015-11-04 | 惠州市莱佛士制药技术有限公司 | 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法 |
CN107344944B (zh) * | 2016-05-07 | 2021-03-05 | 成都博腾药业有限公司 | 一种制备地瑞那韦中间体的方法 |
CN112300186B (zh) * | 2019-08-01 | 2024-04-30 | 浙江九洲药业股份有限公司 | 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006030A1 (en) | 1993-08-24 | 1995-03-02 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
AU699483B2 (en) * | 1994-03-07 | 1998-12-03 | Vertex Pharmaceuticals Incorporated | Sulphonamide derivatives as aspartyl protease inhibitors |
CA2186483A1 (en) | 1995-02-03 | 1996-08-08 | Akira Nishiyama | Processes for producing .alpha.-halo ketones, .alpha.-halohydrins and epoxides |
US5753660A (en) | 1995-11-15 | 1998-05-19 | G. D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5856531A (en) * | 1996-10-21 | 1999-01-05 | Eastman Chemical Company | Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran |
JP2002515888A (ja) * | 1996-10-21 | 2002-05-28 | イーストマン ケミカル カンパニー | 3―アルキルテトラヒドロフランの製造方法 |
US5990313A (en) * | 1996-10-21 | 1999-11-23 | Eastman Chemical Company | Preparation of 3-alkyltetrahydrofurans |
AP1717A (en) | 1998-06-19 | 2007-01-30 | Vertex Pharma | Sulfonamide inhibitors of aspartyl protease. |
CA2336160C (en) | 1998-06-23 | 2015-02-17 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of compounds for treating hiv |
AU4828199A (en) | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
CA2306741A1 (en) | 1998-08-25 | 2000-03-02 | Kazumi Okuro | Process for the preparation of (2r, 3s)-3-amino-1,2-oxirane |
EP1661893A3 (de) | 1999-01-29 | 2006-06-07 | Kaneka Corporation | Verfahren zur Herstellung von threo-1,2-epoxy-3-amino-4-phenylbutan-Derivaten |
EP1159278B1 (de) | 1999-02-12 | 2005-11-30 | Vertex Pharmaceuticals Incorporated | Aspartyl-protease-inhibitoren |
AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
NZ518580A (en) | 1999-10-06 | 2004-01-30 | Us Gov Health & Human Serv | Hexahydrofuro[2,3-B]furan-3-YL-N- {3-[1,3-benzodioxol-5-ylsulfonyl) (isobutyl) amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor |
AU2002255473A1 (en) | 2000-10-24 | 2002-09-04 | Glaxo Group Limited | Process for preparing intermediates of hiv protease inhibitors |
KR20020046948A (ko) | 2000-12-12 | 2002-06-21 | 에가시라 구니오 | 에폭사이드 결정의 제조방법 |
DE60234952D1 (de) * | 2001-09-10 | 2010-02-11 | Tibotec Pharm Ltd | VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL |
AU2002326925A1 (en) | 2001-09-20 | 2003-04-01 | Smithkline Beecham Corporation | Process for preparing protease inhibitor intermediates |
EA007120B8 (ru) * | 2002-05-16 | 2012-03-30 | Тиботек Фармасьютикалз Лтд. | Псевдополиморфные формы ингибитора вич-протеазы |
PT1532127E (pt) * | 2002-06-27 | 2007-01-31 | Smithkline Beecham Corp | Preparação de estereoisómeros de ( 3alfa, 3alfa/beta, 6alfa/beta )hexa-hidrofuro ( 2,3-b ) furan-3-ol |
WO2004033462A2 (en) | 2002-10-09 | 2004-04-22 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS |
EP1589018A4 (de) * | 2002-12-27 | 2007-03-14 | Sumitomo Chemical Co | Herstellungsverfahren für hexahydrofurofuranol-derivate, zwischenprodukt davon und herstellungsverfahren dafür |
BRPI0417272B8 (pt) * | 2003-12-23 | 2021-05-25 | Janssen R&D Ireland | processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato |
TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備(3R,3aS,6aR)六氫-呋喃并〔2,3-b〕呋喃-3-醇之方法 |
-
2007
- 2007-11-09 CN CN201110342987.1A patent/CN102432621B/zh active Active
- 2007-11-09 DK DK07822416.9T patent/DK2089371T3/da active
- 2007-11-09 AT AT07822416T patent/ATE497499T1/de active
- 2007-11-09 ME MEP-2011-65A patent/ME01232B/me unknown
- 2007-11-09 CA CA2669014A patent/CA2669014C/en active Active
- 2007-11-09 CN CN2007800418345A patent/CN101541775B/zh active Active
- 2007-11-09 RS RS20110169A patent/RS51675B/en unknown
- 2007-11-09 PT PT07822416T patent/PT2089371E/pt unknown
- 2007-11-09 WO PCT/EP2007/062119 patent/WO2008055970A2/en active Application Filing
- 2007-11-09 RU RU2009121792/04A patent/RU2464266C2/ru active
- 2007-11-09 EP EP07822416A patent/EP2089371B1/de active Active
- 2007-11-09 AU AU2007316562A patent/AU2007316562B2/en active Active
- 2007-11-09 JP JP2009535738A patent/JP5491862B2/ja active Active
- 2007-11-09 ES ES07822416T patent/ES2359949T3/es active Active
- 2007-11-09 MX MX2009004957A patent/MX2009004957A/es active IP Right Grant
- 2007-11-09 DE DE602007012365T patent/DE602007012365D1/de active Active
- 2007-11-09 SI SI200730567T patent/SI2089371T1/sl unknown
- 2007-11-09 BR BRPI0718706A patent/BRPI0718706B8/pt active IP Right Grant
- 2007-11-09 US US12/447,537 patent/US8153829B2/en active Active
- 2007-11-09 PL PL07822416T patent/PL2089371T3/pl unknown
-
2009
- 2009-04-21 IL IL198270A patent/IL198270A/en active IP Right Grant
-
2011
- 2011-04-11 HR HR20110258T patent/HRP20110258T1/hr unknown
- 2011-05-02 CY CY20111100423T patent/CY1111407T1/el unknown
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