HRP20100522T1 - Piridin karboksamidi kao inhibitori 11-beta-hsd1 - Google Patents
Piridin karboksamidi kao inhibitori 11-beta-hsd1 Download PDFInfo
- Publication number
- HRP20100522T1 HRP20100522T1 HR20100522T HRP20100522T HRP20100522T1 HR P20100522 T1 HRP20100522 T1 HR P20100522T1 HR 20100522 T HR20100522 T HR 20100522T HR P20100522 T HRP20100522 T HR P20100522T HR P20100522 T1 HRP20100522 T1 HR P20100522T1
- Authority
- HR
- Croatia
- Prior art keywords
- pyridin
- acetic acid
- propylsulfanyl
- cyclohexylcarbamoyl
- piperidyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title 1
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 30
- 125000005843 halogen group Chemical group 0.000 claims abstract 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 23
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 23
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 21
- 125000001424 substituent group Chemical group 0.000 claims abstract 21
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 19
- 239000001257 hydrogen Substances 0.000 claims abstract 19
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 18
- -1 phenylC1-3alkyl Chemical group 0.000 claims abstract 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 16
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 14
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 14
- 229910052717 sulfur Chemical group 0.000 claims abstract 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 13
- 125000000217 alkyl group Chemical group 0.000 claims abstract 13
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 13
- 239000001301 oxygen Chemical group 0.000 claims abstract 13
- 239000011593 sulfur Chemical group 0.000 claims abstract 13
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 11
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 11
- 125000005842 heteroatom Chemical group 0.000 claims abstract 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 10
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 9
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 8
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims abstract 6
- 125000004122 cyclic group Chemical group 0.000 claims abstract 6
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 6
- 125000002950 monocyclic group Chemical group 0.000 claims abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 3
- 125000005592 polycycloalkyl group Polymers 0.000 claims abstract 3
- 125000006413 ring segment Chemical group 0.000 claims abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract 2
- 125000002619 bicyclic group Chemical group 0.000 claims abstract 2
- 125000001589 carboacyl group Chemical group 0.000 claims abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 124
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 47
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 24
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- 150000002431 hydrogen Chemical group 0.000 claims 7
- JAEIBKXSIXOLOL-UHFFFAOYSA-N pyrrolidin-1-ium-3-carboxylate Chemical compound OC(=O)C1CCNC1 JAEIBKXSIXOLOL-UHFFFAOYSA-N 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- OTVUUOKTGJTVOI-NXEDIBJZSA-N (3r,5s)-4-[[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]amino]adamantane-1-carboxylic acid Chemical compound C1([C@]2([H])CC3C[C@]1(CC(C3)(C2)C(O)=O)[H])NC(N=C1SCCC)=CC=C1C(=O)NC1CCCCC1 OTVUUOKTGJTVOI-NXEDIBJZSA-N 0.000 claims 2
- MFLSCKDFADLNLG-FQEVSTJZSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(3,4-dihydro-1h-isoquinolin-2-yl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1N2CC3=CC=CC=C3CC2)=CC=C1C(=O)NC1CCCCC1 MFLSCKDFADLNLG-FQEVSTJZSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 claims 2
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 2
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims 2
- 235000019260 propionic acid Nutrition 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- WUYAHJJXCBDIKJ-NPWKZODJSA-N (1s,5r)-3-[5-(2-adamantylcarbamoyl)-6-ethylsulfanylpyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound C1C(CC2C3)CC3CC1C2NC(=O)C1=CC=C(N2C[C@@H]3[C@@H](C3C(O)=O)C2)N=C1SCC WUYAHJJXCBDIKJ-NPWKZODJSA-N 0.000 claims 1
- HEAOWUYQOYGPJY-XDIGRCDVSA-N (1s,5r)-3-[6-cyclohexylsulfanyl-5-(3-pyridin-3-ylpyrrolidine-1-carbonyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound C([C@@H]1C([C@@H]1C1)C(=O)O)N1C(N=C1SC2CCCCC2)=CC=C1C(=O)N(C1)CCC1C1=CC=CN=C1 HEAOWUYQOYGPJY-XDIGRCDVSA-N 0.000 claims 1
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 claims 1
- KXRYVJZOORPUHV-BWVQPMQLSA-N (3r)-1-[5-(2-adamantylcarbamoyl)-6-ethylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SCC)=NC=1N1CC[C@@H](C(O)=O)C1 KXRYVJZOORPUHV-BWVQPMQLSA-N 0.000 claims 1
- LPURRRBKLBZUPO-WFBUYENLSA-N (3r)-1-[5-(2-adamantylcarbamoyl)-6-methylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SC)=NC=1N1CC[C@@H](C(O)=O)C1 LPURRRBKLBZUPO-WFBUYENLSA-N 0.000 claims 1
- XJLSEXAGTJCILF-RXMQYKEDSA-N (R)-nipecotic acid zwitterion Chemical compound OC(=O)[C@@H]1CCCNC1 XJLSEXAGTJCILF-RXMQYKEDSA-N 0.000 claims 1
- TUQXAEMHWYQEKQ-UHFFFAOYSA-N 1-[1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-4-yl]cyclobutane-1-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CC2)C2(CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 TUQXAEMHWYQEKQ-UHFFFAOYSA-N 0.000 claims 1
- ZLGMJDQCLXIRIW-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidine-4-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 ZLGMJDQCLXIRIW-UHFFFAOYSA-N 0.000 claims 1
- IPWNSFXRBGOKPT-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound CCCSC1=NC(N2CC(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 IPWNSFXRBGOKPT-UHFFFAOYSA-N 0.000 claims 1
- DLFCVUOKIZFDKH-IBWORTCRSA-N 2-[(3r)-1-[5-(2-adamantylcarbamoyl)-6-cyclopentylsulfanylpyridin-2-yl]pyrrolidin-3-yl]oxyacetic acid Chemical compound C1[C@H](OCC(=O)O)CCN1C(N=C1SC2CCCC2)=CC=C1C(=O)NC1C(C2)CC3CC2CC1C3 DLFCVUOKIZFDKH-IBWORTCRSA-N 0.000 claims 1
- SCSGTNXILYPGSQ-XMYZRKPFSA-N 2-[(3r)-1-[5-(2-adamantylcarbamoyl)-6-methylsulfanylpyridin-2-yl]pyrrolidin-3-yl]acetic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SC)=NC=1N1CC[C@H](CC(O)=O)C1 SCSGTNXILYPGSQ-XMYZRKPFSA-N 0.000 claims 1
- CULOQDXMEBSGMA-OAHLLOKOSA-N 2-[(3r)-1-[5-(cyclohexylcarbamoyl)-3-fluoro-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound FC=1C=C(C(=O)NC2CCCCC2)C(SCCC)=NC=1N1CCC[C@H](CC(O)=O)C1 CULOQDXMEBSGMA-OAHLLOKOSA-N 0.000 claims 1
- NCDZABJPWMBMIQ-MRXNPFEDSA-N 2-[(3r)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1 NCDZABJPWMBMIQ-MRXNPFEDSA-N 0.000 claims 1
- UZTXBBWTQKNEIG-OAHLLOKOSA-N 2-[(3r)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@@H](CC(O)=O)CC2)=CC=C1C(=O)NC1CCCCC1 UZTXBBWTQKNEIG-OAHLLOKOSA-N 0.000 claims 1
- FLIPCDXQSSQHMS-SCUMNGBJSA-N 2-[(3s)-1-[5-(1-adamantylcarbamoyl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C1=CC=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C=N1 FLIPCDXQSSQHMS-SCUMNGBJSA-N 0.000 claims 1
- KQLRCVBCXCJKNB-APWXSCSYSA-N 2-[(3s)-1-[5-(2-adamantylcarbamoyl)-6-cyclohexylsulfanylpyridin-2-yl]pyrrolidin-3-yl]oxyacetic acid Chemical compound C1[C@@H](OCC(=O)O)CCN1C(N=C1SC2CCCCC2)=CC=C1C(=O)NC1C(C2)CC3CC2CC1C3 KQLRCVBCXCJKNB-APWXSCSYSA-N 0.000 claims 1
- DLFCVUOKIZFDKH-KEBNJSOGSA-N 2-[(3s)-1-[5-(2-adamantylcarbamoyl)-6-cyclopentylsulfanylpyridin-2-yl]pyrrolidin-3-yl]oxyacetic acid Chemical compound C1[C@@H](OCC(=O)O)CCN1C(N=C1SC2CCCC2)=CC=C1C(=O)NC1C(C2)CC3CC2CC1C3 DLFCVUOKIZFDKH-KEBNJSOGSA-N 0.000 claims 1
- DEZDNNQATPOEGF-SXFOCMKRSA-N 2-[(3s)-1-[5-(2-adamantylcarbamoyl)-6-methylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(C)=NC=1N1CCC[C@@H](CC(O)=O)C1 DEZDNNQATPOEGF-SXFOCMKRSA-N 0.000 claims 1
- OQGIUZADBRQLNO-HNNXBMFYSA-N 2-[(3s)-1-[5-(4,4-difluoropiperidine-1-carbonyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N1CCC(F)(F)CC1 OQGIUZADBRQLNO-HNNXBMFYSA-N 0.000 claims 1
- AGRNYJCBLOMLGJ-HNNXBMFYSA-N 2-[(3s)-1-[5-(4-carbamoylpiperidine-1-carbonyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N1CCC(C(N)=O)CC1 AGRNYJCBLOMLGJ-HNNXBMFYSA-N 0.000 claims 1
- CULOQDXMEBSGMA-HNNXBMFYSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-3-fluoro-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound FC=1C=C(C(=O)NC2CCCCC2)C(SCCC)=NC=1N1CCC[C@@H](CC(O)=O)C1 CULOQDXMEBSGMA-HNNXBMFYSA-N 0.000 claims 1
- MABNZVPFIQPNQO-FQEVSTJZSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(2-pyridin-3-ylethylsulfanyl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1SCCC=2C=NC=CC=2)=CC=C1C(=O)NC1CCCCC1 MABNZVPFIQPNQO-FQEVSTJZSA-N 0.000 claims 1
- FAHINHOKFSWBQD-XHBOBUFASA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(3-methylbutoxy)pyridin-2-yl]piperidin-3-yl]acetic acid;2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(3-phenylpropoxy)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CC(C)CCOC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1.C1[C@H](CC(=O)O)CCCN1C(N=C1OCCCC=2C=CC=CC=2)=CC=C1C(=O)NC1CCCCC1 FAHINHOKFSWBQD-XHBOBUFASA-N 0.000 claims 1
- YIVHEVFYXYIMQI-IBGZPJMESA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(4-ethylsulfonylpiperazin-1-yl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1CN(S(=O)(=O)CC)CCN1C1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1 YIVHEVFYXYIMQI-IBGZPJMESA-N 0.000 claims 1
- WEGLHTQFGNFPQQ-DEOSSOPVSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(4-phenylmethoxycarbonylpiperazin-1-yl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1N2CCN(CC2)C(=O)OCC=2C=CC=CC=2)=CC=C1C(=O)NC1CCCCC1 WEGLHTQFGNFPQQ-DEOSSOPVSA-N 0.000 claims 1
- NYJBPBKPVXQXIF-QFIPXVFZSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(4-phenylpiperazin-1-yl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1N2CCN(CC2)C=2C=CC=CC=2)=CC=C1C(=O)NC1CCCCC1 NYJBPBKPVXQXIF-QFIPXVFZSA-N 0.000 claims 1
- URDPPCFQBYGOEK-QUJONECCSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-[2-(4-fluorophenyl)ethoxy]pyridin-2-yl]piperidin-3-yl]acetic acid;2-[(3s)-1-[5-(cyclohexylcarbamoyl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C1=CC=C(C(=O)NC2CCCCC2)C=N1.C1[C@H](CC(=O)O)CCCN1C(N=C1OCCC=2C=CC(F)=CC=2)=CC=C1C(=O)NC1CCCCC1 URDPPCFQBYGOEK-QUJONECCSA-N 0.000 claims 1
- COVVXBQQRFUZQA-NRFANRHFSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-[4-(4-fluorobenzoyl)piperazin-1-yl]pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1N2CCN(CC2)C(=O)C=2C=CC(F)=CC=2)=CC=C1C(=O)NC1CCCCC1 COVVXBQQRFUZQA-NRFANRHFSA-N 0.000 claims 1
- LRBFVDFSHJWKQP-CRMCKAOTSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-[methyl(2-phenylethyl)amino]pyridin-2-yl]piperidin-3-yl]acetic acid;2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-[methyl(propyl)amino]pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCN(C)C1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1.N=1C(N2C[C@H](CC(O)=O)CCC2)=CC=C(C(=O)NC2CCCCC2)C=1N(C)CCC1=CC=CC=C1 LRBFVDFSHJWKQP-CRMCKAOTSA-N 0.000 claims 1
- UVLKNKMJZSBROZ-HNNXBMFYSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-cyclopropylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1C2CC2)=CC=C1C(=O)NC1CCCCC1 UVLKNKMJZSBROZ-HNNXBMFYSA-N 0.000 claims 1
- ZRWLIWLEJVTMNH-KRWDZBQOSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-piperazin-1-ylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1N2CCNCC2)=CC=C1C(=O)NC1CCCCC1 ZRWLIWLEJVTMNH-KRWDZBQOSA-N 0.000 claims 1
- NCDZABJPWMBMIQ-INIZCTEOSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1 NCDZABJPWMBMIQ-INIZCTEOSA-N 0.000 claims 1
- UZTXBBWTQKNEIG-HNNXBMFYSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CC2)=CC=C1C(=O)NC1CCCCC1 UZTXBBWTQKNEIG-HNNXBMFYSA-N 0.000 claims 1
- AMSUENPUCKPGGN-GTPINHCMSA-N 2-[(3s)-1-[5-[(4-hydroxycyclohexyl)carbamoyl]-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCC(O)CC1 AMSUENPUCKPGGN-GTPINHCMSA-N 0.000 claims 1
- QYVSMIVRWCSXAZ-SFHVURJKSA-N 2-[(3s)-1-[5-[cyclohexyl(cyclopropyl)carbamoyl]-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N(C1CCCCC1)C1CC1 QYVSMIVRWCSXAZ-SFHVURJKSA-N 0.000 claims 1
- ZMLDBFQNSHTHBA-FQEVSTJZSA-N 2-[(3s)-1-[5-[cyclohexyl(cyclopropylmethyl)carbamoyl]-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N(C1CCCCC1)CC1CC1 ZMLDBFQNSHTHBA-FQEVSTJZSA-N 0.000 claims 1
- AROMIVMFUAPFKU-SFHVURJKSA-N 2-[(3s)-1-[5-[cyclohexyl(ethyl)carbamoyl]-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N(CC)C1CCCCC1 AROMIVMFUAPFKU-SFHVURJKSA-N 0.000 claims 1
- SIRPPHOMDWANGK-INIZCTEOSA-N 2-[(3s)-1-[5-[methyl(oxan-4-yl)carbamoyl]-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N(C)C1CCOCC1 SIRPPHOMDWANGK-INIZCTEOSA-N 0.000 claims 1
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- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- VKVXVPNFWYSSNF-XHFVKCHCSA-N N1(CCCCC1)C(=O)C=1C=CC(=NC1SCCC)N1C[C@@H](CCC1)CC(=O)O.C(CC)SC1=C(C=CC(=N1)N1C[C@@H](CCC1)CC(=O)O)C(=O)N1CC(CC1)C1=NC=CC=C1 Chemical compound N1(CCCCC1)C(=O)C=1C=CC(=NC1SCCC)N1C[C@@H](CCC1)CC(=O)O.C(CC)SC1=C(C=CC(=N1)N1C[C@@H](CCC1)CC(=O)O)C(=O)N1CC(CC1)C1=NC=CC=C1 VKVXVPNFWYSSNF-XHFVKCHCSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N alpha-isobutyric acid Natural products CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 1
- WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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PCT/GB2007/004131 WO2008053194A2 (en) | 2006-11-03 | 2007-10-31 | Pyridine carboxamides as 11-beta-hsd1 inhibitors |
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2009
- 2009-04-20 IL IL198231A patent/IL198231A0/en unknown
- 2009-04-22 NO NO20091603A patent/NO20091603L/no not_active Application Discontinuation
- 2009-04-29 CO CO09043382A patent/CO6321130A2/es not_active Application Discontinuation
- 2009-08-14 US US12/541,565 patent/US8673938B2/en active Active
- 2009-08-14 US US12/541,574 patent/US20090312372A1/en not_active Abandoned
-
2010
- 2010-02-09 HK HK10101460.7A patent/HK1135090A1/xx unknown
- 2010-09-22 HR HR20100522T patent/HRP20100522T1/hr unknown
- 2010-10-04 CY CY20101100879T patent/CY1110813T1/el unknown
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