HRP20020712B1 - Farmaceutske strukture koje sadrže derivate azetidina, novi derivati azetidina i njihovo pripremanje - Google Patents
Farmaceutske strukture koje sadrže derivate azetidina, novi derivati azetidina i njihovo pripremanjeInfo
- Publication number
- HRP20020712B1 HRP20020712B1 HRP20020712AA HRP20020712A HRP20020712B1 HR P20020712 B1 HRP20020712 B1 HR P20020712B1 HR P20020712A A HRP20020712A A HR P20020712AA HR P20020712 A HRP20020712 A HR P20020712A HR P20020712 B1 HRP20020712 B1 HR P20020712B1
- Authority
- HR
- Croatia
- Prior art keywords
- azetidine derivatives
- preparation
- compositions containing
- pharmaceutival
- novel
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001539 azetidines Chemical class 0.000 title 2
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Ovaj izum se odnosi na farmaceutske strukture koje sadrže kao aktivni princip najmanje jedan spoj formule:u kojojX predstavlja atom vodika ili halogena; Rpredstavlja atom vodika ili (C-C)alkilnu grupu; Ri R, međusobno neovisno, predstavljaju atom vodika ili (C-C)alkilnu grupu, ili drugačije Ri Rzajedno s atomom dušika na koji su vezani, čine pirolidinil, piperidinil, morfolinil ili 4-(C-C)-alkilpiperazinil grupu, i Het predstavlja heteroaromatsku grupu piridinil, kinolinil, izokinolinil, pirimidinil, pirazinil ili piridazinil tipa koja može nositi jedan ili više atoma halogena i/ili jednu ili više (C-C)alkil i/ili (C-C)alkoksi grupe; u obliku baza ili adicijskih soli s kiselinama, hidrata ili solvata; farmaceutske pripravke koji ih sadrže, postupke za njihovo pripravljanje te međuprodukte sinteze.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0002776A FR2805817B1 (fr) | 2000-03-03 | 2000-03-03 | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
PCT/FR2001/000602 WO2001064634A1 (fr) | 2000-03-03 | 2001-03-01 | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20020712A2 HRP20020712A2 (en) | 2005-10-31 |
HRP20020712B1 true HRP20020712B1 (hr) | 2012-11-30 |
Family
ID=8847706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20020712AA HRP20020712B1 (hr) | 2000-03-03 | 2002-08-30 | Farmaceutske strukture koje sadrže derivate azetidina, novi derivati azetidina i njihovo pripremanje |
Country Status (36)
Country | Link |
---|---|
EP (1) | EP1263722B1 (hr) |
JP (1) | JP4883867B2 (hr) |
KR (1) | KR100819572B1 (hr) |
CN (1) | CN100386314C (hr) |
AT (1) | ATE478841T1 (hr) |
AU (1) | AU780880B2 (hr) |
BG (1) | BG66001B1 (hr) |
BR (1) | BR0108893B1 (hr) |
CA (1) | CA2400141C (hr) |
CY (1) | CY1111071T1 (hr) |
CZ (1) | CZ301254B6 (hr) |
DE (1) | DE60142891D1 (hr) |
DK (1) | DK1263722T3 (hr) |
DZ (1) | DZ3312A1 (hr) |
EA (1) | EA007109B1 (hr) |
EE (1) | EE05103B1 (hr) |
ES (1) | ES2351276T3 (hr) |
FR (1) | FR2805817B1 (hr) |
HR (1) | HRP20020712B1 (hr) |
HU (1) | HUP0400636A3 (hr) |
IL (2) | IL151321A0 (hr) |
MA (1) | MA26880A1 (hr) |
ME (1) | MEP9509A (hr) |
MX (1) | MXPA02008349A (hr) |
NO (1) | NO324524B1 (hr) |
NZ (1) | NZ521077A (hr) |
OA (1) | OA12222A (hr) |
PL (1) | PL208021B1 (hr) |
PT (1) | PT1263722E (hr) |
SI (1) | SI1263722T1 (hr) |
SK (1) | SK287445B6 (hr) |
TW (1) | TWI304399B (hr) |
UA (1) | UA73554C2 (hr) |
WO (1) | WO2001064634A1 (hr) |
YU (1) | YU66002A (hr) |
ZA (1) | ZA200206912B (hr) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2002022579A2 (en) | 2000-09-11 | 2002-03-21 | Sepracor, Inc. | Antipsychotic sulfonamide-heterocycles, and methods of use thereof |
FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
US20020091114A1 (en) | 2000-10-04 | 2002-07-11 | Odile Piot-Grosjean | Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity |
AU2002319627A1 (en) | 2001-07-20 | 2003-03-03 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
FR2833842B1 (fr) * | 2001-12-21 | 2004-02-13 | Aventis Pharma Sa | Compositions pharmaceutiques a base de derives d'azetidine |
WO2003075917A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
JP3813152B2 (ja) | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
KR100741231B1 (ko) | 2002-07-29 | 2007-07-19 | 에프. 호프만-라 로슈 아게 | 신규 벤조다이옥솔 |
DE60322114D1 (de) | 2003-01-02 | 2008-08-21 | Hoffmann La Roche | Pyrrolyl-thiazole und ihre verwendung als inverse agonisten des cb 1 rezeptors |
CN101012193A (zh) | 2003-01-02 | 2007-08-08 | 霍夫曼-拉罗奇有限公司 | 新cb 1受体反激动剂 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP1601665A2 (en) * | 2003-03-07 | 2005-12-07 | Glaxo Group Limited | Urea derivatives |
EP1617839B1 (en) * | 2003-05-01 | 2008-06-18 | Vernalis Research Limited | The use of azetidinecarboxamide derivatives in therapy |
US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
AU2004252109B2 (en) * | 2003-06-11 | 2010-04-08 | Merck Sharp & Dohme Corp. | Substituted 3-alkyl and 3-alkenyl azetidine derivatives |
MXPA05013733A (es) | 2003-06-20 | 2006-03-08 | Hoffmann La Roche | 2-aminobenzotiazoles como agonistas inversos del receptor de cb1. |
JP4765627B2 (ja) | 2003-09-22 | 2011-09-07 | Msd株式会社 | 新規ピペリジン誘導体 |
CA2547804A1 (en) | 2003-12-08 | 2005-06-30 | F. Hoffmann-La Roche Ag | Novel thiazole derivatives |
BRPI0507120A (pt) | 2004-01-28 | 2007-06-19 | Hoffmann La Roche | compostos, processo para a manufatura dos mesmos, composições farmacêuticas que os compreendem, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com a modulação de receptores de cb1 e sua utilização |
EP1574211A1 (en) | 2004-03-09 | 2005-09-14 | Inserm | Use of antagonists of the CB1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases |
EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
MXPA06012813A (es) | 2004-05-10 | 2007-01-26 | Hoffmann La Roche | Pirrol o imidazol amidas para tratar la obesidad. |
FR2876688B1 (fr) * | 2004-10-14 | 2007-03-16 | Aventis Pharma Sa | Nouveau produit, procede et intermediaires de preparation de derives d'azetidine |
FR2876689B1 (fr) | 2004-10-14 | 2008-02-22 | Aventis Pharma Sa | Nouveau procede et intermediaires de preparation de derives de n-(1-benzhydryl-azetidin-3-yl)-n-phenyl-methylsulfonamide |
CN101048382B (zh) | 2004-10-27 | 2010-05-05 | 霍夫曼-拉罗奇有限公司 | 新型吲哚或苯并咪唑衍生物 |
ATE486067T1 (de) | 2004-11-09 | 2010-11-15 | Hoffmann La Roche | Dibenzosuberon-derivate |
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