HRP20000585B1 - Substituted bisindolymaleimides for the inhibition of cell proliferation - Google Patents

Substituted bisindolymaleimides for the inhibition of cell proliferation

Info

Publication number
HRP20000585B1
HRP20000585B1 HR20000585A HRP20000585A HRP20000585B1 HR P20000585 B1 HRP20000585 B1 HR P20000585B1 HR 20000585 A HR20000585 A HR 20000585A HR P20000585 A HRP20000585 A HR P20000585A HR P20000585 B1 HRP20000585 B1 HR P20000585B1
Authority
HR
Croatia
Prior art keywords
bisindolymaleimides
inhibition
substituted
cell proliferation
methyl
Prior art date
Application number
HR20000585A
Other languages
English (en)
Croatian (hr)
Inventor
Hooda Dhingra Urvashi
Mary Huryn Donna
Ke June
Federico Weber Giuseppe
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20000585A2 publication Critical patent/HRP20000585A2/hr
Publication of HRP20000585B1 publication Critical patent/HRP20000585B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20000585A 1998-03-17 1999-03-10 Substituted bisindolymaleimides for the inhibition of cell proliferation HRP20000585B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7833198P 1998-03-17 1998-03-17
PCT/EP1999/001534 WO1999047518A1 (en) 1998-03-17 1999-03-10 Substituted bisindolymaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number Publication Date
HRP20000585A2 HRP20000585A2 (en) 2001-08-31
HRP20000585B1 true HRP20000585B1 (en) 2009-02-28

Family

ID=22143350

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000585A HRP20000585B1 (en) 1998-03-17 1999-03-10 Substituted bisindolymaleimides for the inhibition of cell proliferation

Country Status (33)

Country Link
US (1) US6048887A (cs)
EP (1) EP1064279B1 (cs)
JP (2) JP5026633B2 (cs)
KR (1) KR100659411B1 (cs)
CN (1) CN1127500C (cs)
AR (1) AR018162A1 (cs)
AT (1) ATE243693T1 (cs)
AU (1) AU755673B2 (cs)
BR (1) BR9908882A (cs)
CA (1) CA2322689C (cs)
CO (1) CO5070675A1 (cs)
CZ (1) CZ299068B6 (cs)
DE (1) DE69909068T2 (cs)
DK (1) DK1064279T3 (cs)
ES (1) ES2203111T3 (cs)
HR (1) HRP20000585B1 (cs)
HU (1) HU228831B1 (cs)
ID (1) ID26353A (cs)
IL (1) IL138247A (cs)
MA (1) MA26613A1 (cs)
MY (1) MY121046A (cs)
NO (1) NO320306B1 (cs)
NZ (1) NZ506476A (cs)
PE (1) PE20000340A1 (cs)
PL (1) PL195323B1 (cs)
PT (1) PT1064279E (cs)
RS (1) RS49965B (cs)
RU (1) RU2208612C2 (cs)
SA (1) SA99191295B1 (cs)
TR (1) TR200002580T2 (cs)
TW (1) TW539676B (cs)
WO (1) WO1999047518A1 (cs)
ZA (1) ZA992072B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1127500C (zh) * 1998-03-17 2003-11-12 弗·哈夫曼-拉罗切有限公司 抑制细胞增殖的取代双吲哚基马来酰亚胺
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
DK1224181T3 (da) * 1999-10-12 2004-04-13 Hoffmann La Roche Substituerede pyrroler som antiproliferative midler til behandling af cancer
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US6469179B1 (en) 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6482847B2 (en) 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
WO2008117935A1 (en) * 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same
CN102924437B (zh) * 2012-11-19 2014-07-02 东华大学 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0328026A1 (de) * 1988-02-10 1989-08-16 F. Hoffmann-La Roche Ag Substituierte Pyrrole
WO1998004551A1 (en) * 1996-07-29 1998-02-05 F. Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004552A1 (en) * 1996-07-29 1998-02-05 F. Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004553A1 (en) * 1996-07-29 1998-02-05 F.Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE69434294T2 (de) * 1993-12-23 2005-12-29 Eli Lilly And Co., Indianapolis Proteinkinase c-inhibitoren
CN1127500C (zh) * 1998-03-17 2003-11-12 弗·哈夫曼-拉罗切有限公司 抑制细胞增殖的取代双吲哚基马来酰亚胺

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0328026A1 (de) * 1988-02-10 1989-08-16 F. Hoffmann-La Roche Ag Substituierte Pyrrole
WO1998004551A1 (en) * 1996-07-29 1998-02-05 F. Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004552A1 (en) * 1996-07-29 1998-02-05 F. Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004553A1 (en) * 1996-07-29 1998-02-05 F.Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation

Also Published As

Publication number Publication date
PL342964A1 (en) 2001-07-16
PL195323B1 (pl) 2007-09-28
ES2203111T3 (es) 2004-04-01
US6048887A (en) 2000-04-11
MA26613A1 (fr) 2004-12-20
YU55200A (sh) 2002-11-15
DK1064279T3 (da) 2003-10-06
CO5070675A1 (es) 2001-08-28
ATE243693T1 (de) 2003-07-15
AR018162A1 (es) 2001-10-31
PE20000340A1 (es) 2000-05-13
ID26353A (id) 2000-12-14
ZA992072B (en) 1999-09-22
EP1064279A1 (en) 2001-01-03
IL138247A (en) 2005-08-31
BR9908882A (pt) 2000-11-21
CA2322689A1 (en) 1999-09-23
DE69909068D1 (de) 2003-07-31
EP1064279B1 (en) 2003-06-25
HUP0101258A3 (en) 2002-08-28
KR100659411B1 (ko) 2006-12-18
AU755673B2 (en) 2002-12-19
HU228831B1 (en) 2013-05-28
RU2208612C2 (ru) 2003-07-20
DE69909068T2 (de) 2004-05-06
CZ20003384A3 (cs) 2000-12-13
TR200002580T2 (tr) 2000-11-21
HK1036452A1 (en) 2002-01-04
HUP0101258A2 (hu) 2001-10-28
NO20004579L (no) 2000-09-14
CA2322689C (en) 2008-11-25
CN1127500C (zh) 2003-11-12
PT1064279E (pt) 2003-10-31
TW539676B (en) 2003-07-01
IL138247A0 (en) 2001-10-31
NZ506476A (en) 2003-12-19
NO20004579D0 (no) 2000-09-14
CZ299068B6 (cs) 2008-04-16
CN1293671A (zh) 2001-05-02
SA99191295B1 (ar) 2006-04-26
JP2010222366A (ja) 2010-10-07
MY121046A (en) 2005-12-30
KR20010041995A (ko) 2001-05-25
NO320306B1 (no) 2005-11-21
WO1999047518A1 (en) 1999-09-23
JP2002506864A (ja) 2002-03-05
AU3409999A (en) 1999-10-11
RS49965B (sr) 2008-09-29
JP5026633B2 (ja) 2012-09-12
HRP20000585A2 (en) 2001-08-31

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Legal Events

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Payment date: 20180306

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Effective date: 20190310