HRP20000182B1 - Processes and intermediates for preparing anti-cancer compounds - Google Patents

Processes and intermediates for preparing anti-cancer compounds

Info

Publication number
HRP20000182B1
HRP20000182B1 HR20000182A HRP20000182A HRP20000182B1 HR P20000182 B1 HRP20000182 B1 HR P20000182B1 HR 20000182 A HR20000182 A HR 20000182A HR P20000182 A HRP20000182 A HR P20000182A HR P20000182 B1 HRP20000182 B1 HR P20000182B1
Authority
HR
Croatia
Prior art keywords
alkyl
intermediates
processes
alkoxy
compound
Prior art date
Application number
HR20000182A
Other languages
English (en)
Croatian (hr)
Inventor
Shelton Lehner Richard
Norris Tymothy
Paul Santafianos Dinos
Original Assignee
Pfizer Products Inc.
Osi Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc., Osi Pharmaceuticals filed Critical Pfizer Products Inc.
Publication of HRP20000182A2 publication Critical patent/HRP20000182A2/hr
Publication of HRP20000182B1 publication Critical patent/HRP20000182B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0002—Preliminary treatment
    • C22B15/0004—Preliminary treatment without modification of the copper constituent
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0063—Hydrometallurgy
    • C22B15/0065—Leaching or slurrying
    • C22B15/0067—Leaching or slurrying with acids or salts thereof
    • C22B15/0071—Leaching or slurrying with acids or salts thereof containing sulfur
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20000182A 1999-03-31 2000-03-31 Processes and intermediates for preparing anti-cancer compounds HRP20000182B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12707299P 1999-03-31 1999-03-31

Publications (2)

Publication Number Publication Date
HRP20000182A2 HRP20000182A2 (en) 2001-04-30
HRP20000182B1 true HRP20000182B1 (en) 2007-10-31

Family

ID=22428179

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000182A HRP20000182B1 (en) 1999-03-31 2000-03-31 Processes and intermediates for preparing anti-cancer compounds

Country Status (50)

Country Link
US (1) US6476040B1 (hu)
EP (1) EP1044969B1 (hu)
JP (2) JP3420549B2 (hu)
KR (2) KR100430210B1 (hu)
CN (2) CN1215061C (hu)
AP (2) AP1655A (hu)
AR (1) AR018705A1 (hu)
AT (1) ATE348098T1 (hu)
AU (2) AU781402B2 (hu)
BG (1) BG65194B1 (hu)
BR (1) BRPI0001486B8 (hu)
CA (2) CA2302965C (hu)
CO (1) CO5160273A1 (hu)
CR (1) CR6165A (hu)
CZ (1) CZ299426B6 (hu)
DE (1) DE60032275T2 (hu)
DK (1) DK1044969T3 (hu)
DZ (1) DZ3030A1 (hu)
EA (3) EA004654B1 (hu)
EE (1) EE04589B1 (hu)
EG (1) EG22506A (hu)
ES (1) ES2278578T3 (hu)
GE (1) GEP20022653B (hu)
GT (1) GT200000037A (hu)
HK (1) HK1029790A1 (hu)
HR (1) HRP20000182B1 (hu)
HU (1) HU227698B1 (hu)
ID (1) ID25427A (hu)
IL (2) IL135245A0 (hu)
IS (1) IS2468B (hu)
MA (1) MA25087A1 (hu)
MY (1) MY136270A (hu)
NO (2) NO321952B1 (hu)
NZ (2) NZ512818A (hu)
OA (1) OA11335A (hu)
PA (1) PA8491901A1 (hu)
PE (1) PE20001599A1 (hu)
PL (1) PL339330A1 (hu)
PT (1) PT1044969E (hu)
RS (1) RS49836B (hu)
SG (2) SG121687A1 (hu)
SK (1) SK287339B6 (hu)
SV (1) SV2002000047A (hu)
TN (1) TNSN00064A1 (hu)
TR (1) TR200000837A2 (hu)
TW (1) TW553939B (hu)
UA (2) UA80955C2 (hu)
UY (1) UY26086A1 (hu)
YU (1) YU13200A (hu)
ZA (1) ZA200001586B (hu)

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US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
KR100600550B1 (ko) 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
EP1408980A4 (en) 2001-06-21 2004-10-20 Ariad Pharma Inc NEW QUINAZOLINES AND THEIR USE
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
ES2400339T3 (es) 2002-07-15 2013-04-09 Symphony Evolution, Inc. Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer
US7148231B2 (en) * 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
EP1604665B1 (en) 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. C-kit kinase inhibitor
CN1984660B (zh) 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
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EP2612853A1 (en) 2003-09-26 2013-07-10 Exelixis Inc. c-Met modulators and methods of use
US7683172B2 (en) 2003-11-11 2010-03-23 Eisai R&D Management Co., Ltd. Urea derivative and process for preparing the same
UA85706C2 (en) * 2004-05-06 2009-02-25 Уорнер-Ламберт Компани Ллси 4-phenylaminoquinazolin-6-yl amides
WO2006030826A1 (ja) 2004-09-17 2006-03-23 Eisai R & D Management Co., Ltd. 医薬組成物
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
SI1859793T1 (sl) * 2005-02-28 2011-08-31 Eisai R&D Man Co Ltd Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka
WO2007015569A1 (ja) * 2005-08-01 2007-02-08 Eisai R & D Management Co., Ltd. 血管新生阻害物質の効果を予測する方法
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JPWO2007052849A1 (ja) 2005-11-07 2009-04-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質とｃ−ｋｉｔキナーゼ阻害物質との併用
US20090247576A1 (en) * 2005-11-22 2009-10-01 Eisai R & D Management Co., Ltd. Anti-tumor agent for multiple myeloma
WO2007136103A1 (ja) 2006-05-18 2007-11-29 Eisai R & D Management Co., Ltd. 甲状腺癌に対する抗腫瘍剤
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WO2008026748A1 (fr) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
US8372856B2 (en) * 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
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US8349855B2 (en) * 2007-02-21 2013-01-08 Natco Pharma Limited Polymorphs of erlotinib hydrochloride and method of preparation
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CN103420924B (zh) * 2012-05-25 2016-08-31 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
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CN103333124B (zh) * 2013-05-28 2015-03-25 埃斯特维华义制药有限公司 一种制备盐酸厄洛替尼晶型f的方法
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Also Published As

Publication number Publication date
SK287339B6 (sk) 2010-07-07
AR018705A1 (es) 2001-11-28
AU2005201494B2 (en) 2008-02-07
AP1265A (en) 2004-03-26
SV2002000047A (es) 2002-01-23
CA2427221A1 (en) 2000-09-30
AP1655A (en) 2006-09-01
NZ503683A (en) 2001-09-28
HU227698B1 (en) 2011-12-28
CA2427221C (en) 2008-09-16
IL135245A0 (en) 2001-05-20
YU13200A (sh) 2002-10-18
EP1044969B1 (en) 2006-12-13
JP2000290262A (ja) 2000-10-17
HUP0001353A3 (en) 2002-01-28
CN1699350A (zh) 2005-11-23
IS2468B (is) 2008-12-15
NO20001648D0 (no) 2000-03-30
KR100430209B1 (ko) 2004-05-03
SG121687A1 (en) 2006-05-26
BG104278A (en) 2001-08-31
TR200000837A2 (tr) 2000-11-21
EA200000274A3 (ru) 2003-02-27
JP4074509B2 (ja) 2008-04-09
HK1029790A1 (en) 2001-04-12
KR20020084903A (ko) 2002-11-13
EA004654B1 (ru) 2004-06-24
ZA200001586B (en) 2001-10-01
TW553939B (en) 2003-09-21
KR20010014658A (ko) 2001-02-26
PL339330A1 (en) 2000-10-09
BR0001486A (pt) 2001-05-02
EA005892B1 (ru) 2005-06-30
OA11335A (en) 2003-12-10
NO321952B1 (no) 2006-07-24
CN100351242C (zh) 2007-11-28
AP2000001778A0 (en) 2000-03-31
AU2262000A (en) 2000-10-05
EA200201245A1 (ru) 2003-04-24
GEP20022653B (en) 2002-03-25
EG22506A (en) 2003-03-31
EP1044969A2 (en) 2000-10-18
AU781402B2 (en) 2005-05-19
EE04589B1 (et) 2006-02-15
KR100430210B1 (ko) 2004-05-03
EA005561B1 (ru) 2005-04-28
EE200000255A (et) 2000-12-15
NO20054715L (no) 2000-10-02
CZ299426B6 (cs) 2008-07-23
ATE348098T1 (de) 2007-01-15
PT1044969E (pt) 2007-05-31
EA200201244A1 (ru) 2003-04-24
PE20001599A1 (es) 2001-01-18
EA200000274A2 (ru) 2000-10-30
PA8491901A1 (es) 2001-12-14
ID25427A (id) 2000-10-05
DE60032275T2 (de) 2007-07-12
CA2302965C (en) 2004-02-17
BRPI0001486B1 (pt) 2019-01-29
JP2003176274A (ja) 2003-06-24
CZ20001155A3 (cs) 2001-03-14
IS5411A (is) 2000-10-02
UA70928C2 (uk) 2004-11-15
BG65194B1 (bg) 2007-06-29
SK4442000A3 (en) 2000-10-09
NO324745B1 (no) 2007-12-03
TNSN00064A1 (fr) 2005-11-10
CN1215061C (zh) 2005-08-17
UA80955C2 (en) 2007-11-26
SG115536A1 (en) 2005-10-28
CN1276370A (zh) 2000-12-13
RS49836B (sr) 2008-08-07
UY26086A1 (es) 2000-10-31
NZ512818A (en) 2003-01-31
CR6165A (es) 2008-10-10
HRP20000182A2 (en) 2001-04-30
HUP0001353A2 (hu) 2001-05-28
AU2005201494A1 (en) 2005-05-05
MY136270A (en) 2008-09-30
EP1044969A3 (en) 2000-11-29
DE60032275D1 (de) 2007-01-25
DZ3030A1 (fr) 2004-03-27
NO20001648L (no) 2000-10-02
CO5160273A1 (es) 2002-05-30
CA2302965A1 (en) 2000-09-30
IL168036A (en) 2006-12-10
ES2278578T3 (es) 2007-08-16
GT200000037A (es) 2001-09-21
MA25087A1 (fr) 2000-10-01
BRPI0001486B8 (pt) 2021-05-25
JP3420549B2 (ja) 2003-06-23
DK1044969T3 (da) 2007-04-23
US6476040B1 (en) 2002-11-05
HU0001353D0 (en) 2000-06-28

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