PE20001599A1 - Procedimientos e intermedios para preparar compuestos anticancerosos - Google Patents

Procedimientos e intermedios para preparar compuestos anticancerosos

Info

Publication number
PE20001599A1
PE20001599A1 PE2000000277A PE0002772000A PE20001599A1 PE 20001599 A1 PE20001599 A1 PE 20001599A1 PE 2000000277 A PE2000000277 A PE 2000000277A PE 0002772000 A PE0002772000 A PE 0002772000A PE 20001599 A1 PE20001599 A1 PE 20001599A1
Authority
PE
Peru
Prior art keywords
alkyl
formula
compounds
intermediates
procedures
Prior art date
Application number
PE2000000277A
Other languages
English (en)
Inventor
Richard Shelton Lehner
Dinos Paul Santafianos
Timothy Norris
Original Assignee
Pfizer Prod Inc
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Osi Pharm Inc filed Critical Pfizer Prod Inc
Publication of PE20001599A1 publication Critical patent/PE20001599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0002—Preliminary treatment
    • C22B15/0004—Preliminary treatment without modification of the copper constituent
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0063—Hydrometallurgy
    • C22B15/0065—Leaching or slurrying
    • C22B15/0067—Leaching or slurrying with acids or salts thereof
    • C22B15/0071—Leaching or slurrying with acids or salts thereof containing sulfur
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DIAZINA DE FORMULA 1; DONDE R1 Y R2 SON ALQUILO C1-C10, ALCOXI C1-C10 OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C6; R15 ES H, ALQUILO C1-C10, (CH2)q(ARILO C6-C10); q ES 0-4; G ES C(OH)R3R4, SiR3R4R5; R3, R4 Y R5 SON ALQUILO C1-C6; QUE COMPRENDE TRATAR UN COMPUESTO DE FORMULA 2 CON a) UN HIDROXIDO DE METAL ALCALINO, ALCALINOTERREO EN UN DISOLVENTE TAL COMO BUTAN-2-OL, ISOPROPANOL; CUANDO G ES C(OH)R3R4; b) UN COMPUESTO FLUORURO DE TETRA(ALQUIL C1-C6)AMONIO EN UN DISOLVENTE APROTICO TAL COMO TETRAHIDROFURANO, ETER DIETILICO, DIMETOXIETANO, TOLUENO, DICLOROMETANO, ENTRE OTROS; CUANDO G ES -SiR3R4R5. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS INTERMEDIOS. LOS COMPUESTOS DE FORMULA I PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS, CANCER
PE2000000277A 1999-03-31 2000-03-30 Procedimientos e intermedios para preparar compuestos anticancerosos PE20001599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12707299P 1999-03-31 1999-03-31

Publications (1)

Publication Number Publication Date
PE20001599A1 true PE20001599A1 (es) 2001-01-18

Family

ID=22428179

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000277A PE20001599A1 (es) 1999-03-31 2000-03-30 Procedimientos e intermedios para preparar compuestos anticancerosos

Country Status (50)

Country Link
US (1) US6476040B1 (es)
EP (1) EP1044969B1 (es)
JP (2) JP3420549B2 (es)
KR (2) KR100430210B1 (es)
CN (2) CN1215061C (es)
AP (2) AP1655A (es)
AR (1) AR018705A1 (es)
AT (1) ATE348098T1 (es)
AU (2) AU781402B2 (es)
BG (1) BG65194B1 (es)
BR (1) BRPI0001486B8 (es)
CA (2) CA2302965C (es)
CO (1) CO5160273A1 (es)
CR (1) CR6165A (es)
CZ (1) CZ299426B6 (es)
DE (1) DE60032275T2 (es)
DK (1) DK1044969T3 (es)
DZ (1) DZ3030A1 (es)
EA (3) EA004654B1 (es)
EE (1) EE04589B1 (es)
EG (1) EG22506A (es)
ES (1) ES2278578T3 (es)
GE (1) GEP20022653B (es)
GT (1) GT200000037A (es)
HK (1) HK1029790A1 (es)
HR (1) HRP20000182B1 (es)
HU (1) HU227698B1 (es)
ID (1) ID25427A (es)
IL (2) IL135245A0 (es)
IS (1) IS2468B (es)
MA (1) MA25087A1 (es)
MY (1) MY136270A (es)
NO (2) NO321952B1 (es)
NZ (2) NZ512818A (es)
OA (1) OA11335A (es)
PA (1) PA8491901A1 (es)
PE (1) PE20001599A1 (es)
PL (1) PL339330A1 (es)
PT (1) PT1044969E (es)
RS (1) RS49836B (es)
SG (2) SG121687A1 (es)
SK (1) SK287339B6 (es)
SV (1) SV2002000047A (es)
TN (1) TNSN00064A1 (es)
TR (1) TR200000837A2 (es)
TW (1) TW553939B (es)
UA (2) UA80955C2 (es)
UY (1) UY26086A1 (es)
YU (1) YU13200A (es)
ZA (1) ZA200001586B (es)

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UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
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Also Published As

Publication number Publication date
SK287339B6 (sk) 2010-07-07
AR018705A1 (es) 2001-11-28
AU2005201494B2 (en) 2008-02-07
AP1265A (en) 2004-03-26
SV2002000047A (es) 2002-01-23
CA2427221A1 (en) 2000-09-30
AP1655A (en) 2006-09-01
NZ503683A (en) 2001-09-28
HU227698B1 (en) 2011-12-28
CA2427221C (en) 2008-09-16
IL135245A0 (en) 2001-05-20
YU13200A (sh) 2002-10-18
EP1044969B1 (en) 2006-12-13
JP2000290262A (ja) 2000-10-17
HUP0001353A3 (en) 2002-01-28
CN1699350A (zh) 2005-11-23
IS2468B (is) 2008-12-15
NO20001648D0 (no) 2000-03-30
KR100430209B1 (ko) 2004-05-03
SG121687A1 (en) 2006-05-26
BG104278A (en) 2001-08-31
TR200000837A2 (tr) 2000-11-21
EA200000274A3 (ru) 2003-02-27
JP4074509B2 (ja) 2008-04-09
HK1029790A1 (en) 2001-04-12
KR20020084903A (ko) 2002-11-13
EA004654B1 (ru) 2004-06-24
ZA200001586B (en) 2001-10-01
TW553939B (en) 2003-09-21
KR20010014658A (ko) 2001-02-26
PL339330A1 (en) 2000-10-09
BR0001486A (pt) 2001-05-02
EA005892B1 (ru) 2005-06-30
OA11335A (en) 2003-12-10
NO321952B1 (no) 2006-07-24
CN100351242C (zh) 2007-11-28
AP2000001778A0 (en) 2000-03-31
AU2262000A (en) 2000-10-05
EA200201245A1 (ru) 2003-04-24
GEP20022653B (en) 2002-03-25
EG22506A (en) 2003-03-31
EP1044969A2 (en) 2000-10-18
AU781402B2 (en) 2005-05-19
EE04589B1 (et) 2006-02-15
KR100430210B1 (ko) 2004-05-03
EA005561B1 (ru) 2005-04-28
EE200000255A (et) 2000-12-15
NO20054715L (no) 2000-10-02
CZ299426B6 (cs) 2008-07-23
ATE348098T1 (de) 2007-01-15
PT1044969E (pt) 2007-05-31
EA200201244A1 (ru) 2003-04-24
EA200000274A2 (ru) 2000-10-30
PA8491901A1 (es) 2001-12-14
ID25427A (id) 2000-10-05
DE60032275T2 (de) 2007-07-12
CA2302965C (en) 2004-02-17
BRPI0001486B1 (pt) 2019-01-29
JP2003176274A (ja) 2003-06-24
CZ20001155A3 (cs) 2001-03-14
IS5411A (is) 2000-10-02
UA70928C2 (uk) 2004-11-15
BG65194B1 (bg) 2007-06-29
SK4442000A3 (en) 2000-10-09
NO324745B1 (no) 2007-12-03
TNSN00064A1 (fr) 2005-11-10
CN1215061C (zh) 2005-08-17
UA80955C2 (en) 2007-11-26
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RS49836B (sr) 2008-08-07
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NZ512818A (en) 2003-01-31
CR6165A (es) 2008-10-10
HRP20000182A2 (en) 2001-04-30
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AU2005201494A1 (en) 2005-05-05
MY136270A (en) 2008-09-30
EP1044969A3 (en) 2000-11-29
DE60032275D1 (de) 2007-01-25
DZ3030A1 (fr) 2004-03-27
NO20001648L (no) 2000-10-02
CO5160273A1 (es) 2002-05-30
CA2302965A1 (en) 2000-09-30
HRP20000182B1 (en) 2007-10-31
IL168036A (en) 2006-12-10
ES2278578T3 (es) 2007-08-16
GT200000037A (es) 2001-09-21
MA25087A1 (fr) 2000-10-01
BRPI0001486B8 (pt) 2021-05-25
JP3420549B2 (ja) 2003-06-23
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US6476040B1 (en) 2002-11-05
HU0001353D0 (en) 2000-06-28

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