EE04589B1 - Vähivastaste ühendite valmistamise protsessid ja vaheühendid - Google Patents

Vähivastaste ühendite valmistamise protsessid ja vaheühendid

Info

Publication number
EE04589B1
EE04589B1 EEP200000255A EEP200000255A EE04589B1 EE 04589 B1 EE04589 B1 EE 04589B1 EE P200000255 A EEP200000255 A EE P200000255A EE P200000255 A EEP200000255 A EE P200000255A EE 04589 B1 EE04589 B1 EE 04589B1
Authority
EE
Estonia
Prior art keywords
intermediates
processes
preparation
anticancer compounds
anticancer
Prior art date
Application number
EEP200000255A
Other languages
English (en)
Estonian (et)
Inventor
Shelton Lehner Richard
Norris Timothy
Paul Santafianos Dinos
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of EE200000255A publication Critical patent/EE200000255A/xx
Publication of EE04589B1 publication Critical patent/EE04589B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0002—Preliminary treatment
    • C22B15/0004—Preliminary treatment without modification of the copper constituent
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B15/00—Obtaining copper
    • C22B15/0063—Hydrometallurgy
    • C22B15/0065—Leaching or slurrying
    • C22B15/0067—Leaching or slurrying with acids or salts thereof
    • C22B15/0071—Leaching or slurrying with acids or salts thereof containing sulfur
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Metallurgy (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000255A 1999-03-31 2000-03-30 Vähivastaste ühendite valmistamise protsessid ja vaheühendid EE04589B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12707299P 1999-03-31 1999-03-31

Publications (2)

Publication Number Publication Date
EE200000255A EE200000255A (et) 2000-12-15
EE04589B1 true EE04589B1 (et) 2006-02-15

Family

ID=22428179

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000255A EE04589B1 (et) 1999-03-31 2000-03-30 Vähivastaste ühendite valmistamise protsessid ja vaheühendid

Country Status (50)

Country Link
US (1) US6476040B1 (hu)
EP (1) EP1044969B1 (hu)
JP (2) JP3420549B2 (hu)
KR (2) KR100430210B1 (hu)
CN (2) CN1215061C (hu)
AP (2) AP1655A (hu)
AR (1) AR018705A1 (hu)
AT (1) ATE348098T1 (hu)
AU (2) AU781402B2 (hu)
BG (1) BG65194B1 (hu)
BR (1) BRPI0001486B8 (hu)
CA (2) CA2427221C (hu)
CO (1) CO5160273A1 (hu)
CR (1) CR6165A (hu)
CZ (1) CZ299426B6 (hu)
DE (1) DE60032275T2 (hu)
DK (1) DK1044969T3 (hu)
DZ (1) DZ3030A1 (hu)
EA (3) EA004654B1 (hu)
EE (1) EE04589B1 (hu)
EG (1) EG22506A (hu)
ES (1) ES2278578T3 (hu)
GE (1) GEP20022653B (hu)
GT (1) GT200000037A (hu)
HK (1) HK1029790A1 (hu)
HR (1) HRP20000182B1 (hu)
HU (1) HU227698B1 (hu)
ID (1) ID25427A (hu)
IL (2) IL168036A (hu)
IS (1) IS2468B (hu)
MA (1) MA25087A1 (hu)
MY (1) MY136270A (hu)
NO (2) NO321952B1 (hu)
NZ (2) NZ512818A (hu)
OA (1) OA11335A (hu)
PA (1) PA8491901A1 (hu)
PE (1) PE20001599A1 (hu)
PL (1) PL339330A1 (hu)
PT (1) PT1044969E (hu)
RS (1) RS49836B (hu)
SG (2) SG115536A1 (hu)
SK (1) SK287339B6 (hu)
SV (1) SV2002000047A (hu)
TN (1) TNSN00064A1 (hu)
TR (1) TR200000837A2 (hu)
TW (1) TW553939B (hu)
UA (2) UA80955C2 (hu)
UY (1) UY26086A1 (hu)
YU (1) YU13200A (hu)
ZA (1) ZA200001586B (hu)

Families Citing this family (68)

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UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
ES2282299T3 (es) 2000-10-20 2007-10-16 EISAI R&D MANAGEMENT CO., LTD. Compuestos aromaticos con anillos de nitrogeno como agentes anticancerigenos.
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US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
EP1521747B1 (en) 2002-07-15 2018-09-05 Symphony Evolution, Inc. Receptor-type kinase modulators and methods of use
US7148231B2 (en) * 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
JPWO2004080462A1 (ja) 2003-03-10 2006-06-08 エーザイ株式会社 ｃ−Ｋｉｔキナーゼ阻害剤
WO2005003100A2 (en) 2003-07-03 2005-01-13 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
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CA2537812C (en) 2003-09-26 2013-01-22 Exelixis, Inc. C-met modulators and method of use
CN100450998C (zh) 2003-11-11 2009-01-14 卫材R&D管理有限公司 脲衍生物的制备方法
ME01267B (me) 2004-05-06 2013-06-20 Warner Lambert Co 4-fenilaminokinazolin-6-ilamidi
JP4834553B2 (ja) 2004-09-17 2011-12-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 医薬組成物
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
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US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
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EP1925941B1 (en) * 2005-08-01 2012-11-28 Eisai R&D Management Co., Ltd. Method for prediction of the efficacy of vascularization inhibitor
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
CN101316590B (zh) 2005-11-07 2011-08-03 卫材R&D管理有限公司 血管生成抑制剂和c-kit激酶抑制剂的组合使用
US20090247576A1 (en) * 2005-11-22 2009-10-01 Eisai R & D Management Co., Ltd. Anti-tumor agent for multiple myeloma
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CN101616671A (zh) 2007-01-19 2009-12-30 卫材R&D管理有限公司 胰腺癌治疗用组合物
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CN103420924B (zh) * 2012-05-25 2016-08-31 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
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Also Published As

Publication number Publication date
CZ20001155A3 (cs) 2001-03-14
GEP20022653B (en) 2002-03-25
IS5411A (is) 2000-10-02
NZ503683A (en) 2001-09-28
CA2427221C (en) 2008-09-16
NO321952B1 (no) 2006-07-24
MA25087A1 (fr) 2000-10-01
UA80955C2 (en) 2007-11-26
HUP0001353A2 (hu) 2001-05-28
EA200000274A3 (ru) 2003-02-27
YU13200A (sh) 2002-10-18
EG22506A (en) 2003-03-31
EP1044969A2 (en) 2000-10-18
US6476040B1 (en) 2002-11-05
HUP0001353A3 (en) 2002-01-28
AU2005201494A1 (en) 2005-05-05
CN1276370A (zh) 2000-12-13
KR20020084903A (ko) 2002-11-13
NZ512818A (en) 2003-01-31
AP1655A (en) 2006-09-01
EA200000274A2 (ru) 2000-10-30
SV2002000047A (es) 2002-01-23
OA11335A (en) 2003-12-10
NO324745B1 (no) 2007-12-03
EE200000255A (et) 2000-12-15
NO20001648L (no) 2000-10-02
HU0001353D0 (en) 2000-06-28
CN100351242C (zh) 2007-11-28
CA2302965C (en) 2004-02-17
DE60032275D1 (de) 2007-01-25
TR200000837A2 (tr) 2000-11-21
DE60032275T2 (de) 2007-07-12
CZ299426B6 (cs) 2008-07-23
CO5160273A1 (es) 2002-05-30
DZ3030A1 (fr) 2004-03-27
KR100430209B1 (ko) 2004-05-03
HRP20000182A2 (en) 2001-04-30
CR6165A (es) 2008-10-10
PA8491901A1 (es) 2001-12-14
TW553939B (en) 2003-09-21
NO20001648D0 (no) 2000-03-30
ES2278578T3 (es) 2007-08-16
ATE348098T1 (de) 2007-01-15
CA2427221A1 (en) 2000-09-30
EP1044969A3 (en) 2000-11-29
BR0001486A (pt) 2001-05-02
BG65194B1 (bg) 2007-06-29
KR100430210B1 (ko) 2004-05-03
CN1699350A (zh) 2005-11-23
EA004654B1 (ru) 2004-06-24
SG115536A1 (en) 2005-10-28
BG104278A (en) 2001-08-31
GT200000037A (es) 2001-09-21
CN1215061C (zh) 2005-08-17
KR20010014658A (ko) 2001-02-26
MY136270A (en) 2008-09-30
BRPI0001486B8 (pt) 2021-05-25
ID25427A (id) 2000-10-05
JP3420549B2 (ja) 2003-06-23
AP1265A (en) 2004-03-26
HRP20000182B1 (en) 2007-10-31
IL168036A (en) 2006-12-10
AU2005201494B2 (en) 2008-02-07
PE20001599A1 (es) 2001-01-18
TNSN00064A1 (fr) 2005-11-10
EA005561B1 (ru) 2005-04-28
PL339330A1 (en) 2000-10-09
EA005892B1 (ru) 2005-06-30
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IS2468B (is) 2008-12-15
UY26086A1 (es) 2000-10-31
EA200201244A1 (ru) 2003-04-24
JP2003176274A (ja) 2003-06-24
BRPI0001486B1 (pt) 2019-01-29
RS49836B (sr) 2008-08-07
UA70928C2 (uk) 2004-11-15
CA2302965A1 (en) 2000-09-30
EA200201245A1 (ru) 2003-04-24
HU227698B1 (en) 2011-12-28
EP1044969B1 (en) 2006-12-13
ZA200001586B (en) 2001-10-01
IL135245A0 (en) 2001-05-20
SK4442000A3 (en) 2000-10-09
JP4074509B2 (ja) 2008-04-09
DK1044969T3 (da) 2007-04-23
JP2000290262A (ja) 2000-10-17
SG121687A1 (en) 2006-05-26
SK287339B6 (sk) 2010-07-07
AP2000001778A0 (en) 2000-03-31
AU2262000A (en) 2000-10-05
NO20054715L (no) 2000-10-02
PT1044969E (pt) 2007-05-31
AR018705A1 (es) 2001-11-28

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