HK94190A - Substituted androsta-1,4-diene-3,17-diones and process for their preparation - Google Patents

Substituted androsta-1,4-diene-3,17-diones and process for their preparation Download PDF

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Publication number
HK94190A
HK94190A HK941/90A HK94190A HK94190A HK 94190 A HK94190 A HK 94190A HK 941/90 A HK941/90 A HK 941/90A HK 94190 A HK94190 A HK 94190A HK 94190 A HK94190 A HK 94190A
Authority
HK
Hong Kong
Prior art keywords
diene
diones
preparation
substituted androsta
androsta
Prior art date
Application number
HK941/90A
Other languages
English (en)
Inventor
Buzzetti Franco
Barbugian Natale
Lombardi Paolo
Di-Salle Enrico
Original Assignee
Pharmacia Italia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK94190(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.
Publication of HK94190A publication Critical patent/HK94190A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK941/90A 1985-07-09 1990-11-15 Substituted androsta-1,4-diene-3,17-diones and process for their preparation HK94190A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (1)

Publication Number Publication Date
HK94190A true HK94190A (en) 1990-11-23

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
HK941/90A HK94190A (en) 1985-07-09 1990-11-15 Substituted androsta-1,4-diene-3,17-diones and process for their preparation

Country Status (38)

Country Link
US (2) US4808616A (cs)
JP (1) JPS6212797A (cs)
KR (1) KR950003614B1 (cs)
CN (1) CN86104664B (cs)
AT (1) AT395157B (cs)
AU (1) AU578840B2 (cs)
BE (1) BE905067A (cs)
BG (1) BG61370B2 (cs)
BR (1) BR1100240A (cs)
CA (1) CA1277656C (cs)
CH (1) CH668599A5 (cs)
CS (2) CS257794B2 (cs)
CZ (1) CZ413591A3 (cs)
DE (1) DE10199030I1 (cs)
DK (1) DK163520C (cs)
ES (2) ES8801304A1 (cs)
FI (1) FI83424C (cs)
FR (1) FR2584725B1 (cs)
GB (2) GB8517360D0 (cs)
GR (1) GR861780B (cs)
HK (1) HK94190A (cs)
HU (1) HU194274B (cs)
IE (1) IE58949B1 (cs)
IL (1) IL79336A (cs)
IT (1) IT1196436B (cs)
MY (1) MY102294A (cs)
NL (2) NL193616C (cs)
NO (2) NO165547C (cs)
NZ (1) NZ216763A (cs)
PH (1) PH21785A (cs)
PT (1) PT82944B (cs)
SE (1) SE468988B (cs)
SG (1) SG80490G (cs)
SK (1) SK413591A3 (cs)
SU (2) SU1442077A3 (cs)
UA (1) UA6046A1 (cs)
YU (2) YU44585B (cs)
ZA (1) ZA865079B (cs)

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GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
WO1994007908A1 (fr) * 1992-09-30 1994-04-14 Teikoku Hormone Mfg. Co., Ltd. Nouveau compose oxa ou azasteroide substitue en position 7
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) * 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
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GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
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AU2001289865B2 (en) * 2000-09-08 2007-03-01 Pharmacia Italia S.P.A. Exemestane as chemopreventing agent
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
JP2004519490A (ja) * 2001-01-26 2004-07-02 フアルマシア・イタリア・エツセ・ピー・アー エキセメスタンによるホルモン依存性異常症の組合せ治療方法
ES2921798T3 (es) 2001-02-19 2022-08-31 Novartis Pharma Ag Derivado de rapamicina para el tratamiento de tumores sólidos
SK14042003A3 (sk) 2001-05-16 2004-05-04 Novartis Ag Kombinácia N-{5-[4-metylpiperazinometyl)benzoylamido]-2- metylfenyl}-4-(3-pyridyl)-2-pyrimidínamínu chemoterapeutického činidla a farmaceutický prostriedok, ktorý ju obsahuje
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
PL372103A1 (en) 2002-05-16 2005-07-11 Novartis Ag Use of edg receptor binding agents in cancer
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
WO2005070951A1 (en) 2004-01-16 2005-08-04 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
JP5255444B2 (ja) 2005-09-30 2013-08-07 エンディース エルエルシー （ｓ）−６−メチルオキサアルキルエキセメスタン化合物および関連する使用方法
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
BRPI0711385A2 (pt) 2006-05-09 2011-11-08 Novartis Ag combinação compreendendo um quelante de ferro e um agente anti-neoplástico e seu uso
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
UA96076C2 (en) 2007-10-16 2011-09-26 Репрос Терапьютикс Инк. Use of trans-clomiphene
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
US8288571B2 (en) * 2008-01-21 2012-10-16 Cadila Healthcare Limited Process for preparing aromatiase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
CA2794565C (en) 2010-04-08 2018-08-21 Emory University Substituted androst-4-ene diones
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
US20120071455A1 (en) 2010-09-14 2012-03-22 Yarger James G 6-substituted demethyl-estradiol derivatives as selective er-beta agonists
HK1204979A1 (en) 2012-02-29 2015-12-11 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
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US11633382B2 (en) 2015-11-10 2023-04-25 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
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Also Published As

Publication number Publication date
FI862871A0 (fi) 1986-07-07
US4904650A (en) 1990-02-27
ES557466A0 (es) 1988-06-01
DK324386D0 (da) 1986-07-08
NO862753D0 (no) 1986-07-08
NL193616B (nl) 1999-12-01
CN86104664B (zh) 1988-06-29
ATA181986A (de) 1992-02-15
AU5979986A (en) 1987-01-15
YU44628B (en) 1990-10-31
GR861780B (en) 1986-11-11
PT82944B (pt) 1989-01-30
KR870001140A (ko) 1987-03-11
CN86104664A (zh) 1987-02-18
CS257794B2 (en) 1988-06-15
NL300017I2 (nl) 2001-01-02
IL79336A0 (en) 1986-10-31
SU1501923A3 (ru) 1989-08-15
DK163520C (da) 1992-07-27
DE10199030I1 (de) 2001-10-04
GB2177700B (en) 1988-12-07
PH21785A (en) 1988-02-24
HU194274B (en) 1988-01-28
GB8517360D0 (en) 1985-08-14
US4808616A (en) 1989-02-28
ES556550A0 (es) 1987-12-16
SE468988B (sv) 1993-04-26
AU578840B2 (en) 1988-11-03
CS521486A2 (en) 1987-09-17
CH668599A5 (de) 1989-01-13
NO2000009I1 (no) 2000-10-05
BG61370B2 (bg) 1997-06-30
IT8621004A0 (it) 1986-07-02
FR2584725A1 (fr) 1987-01-16
AT395157B (de) 1992-10-12
NZ216763A (en) 1988-05-30
CS258498B2 (en) 1988-08-16
MY102294A (en) 1992-05-15
FI83424C (fi) 1991-07-10
IE58949B1 (en) 1993-12-01
NL300017I1 (nl) 2000-11-01
YU120186A (en) 1988-02-29
FR2584725B1 (fr) 1988-05-13
ZA865079B (en) 1987-03-25
JPS6212797A (ja) 1987-01-21
SE8603046D0 (sv) 1986-07-08
NO165547B (no) 1990-11-19
BE905067A (fr) 1987-01-08
UA6046A1 (uk) 1994-12-29
NO165547C (no) 1991-02-27
PT82944A (en) 1986-08-01
CZ413591A3 (en) 1994-03-16
NL193616C (nl) 2000-04-04
FI83424B (fi) 1991-03-28
GB2177700A (en) 1987-01-28
BR1100240A (pt) 1999-12-28
SK413591A3 (en) 1995-07-11
IE861821L (en) 1987-01-09
SE8603046L (sv) 1987-01-10
NO862753L (no) 1987-01-12
DK163520B (da) 1992-03-09
DK324386A (da) 1987-01-10
ES8801304A1 (es) 1987-12-16
NL8601785A (nl) 1987-02-02
IL79336A (en) 1991-06-10
YU103687A (en) 1988-08-31
IT1196436B (it) 1988-11-16
YU44585B (en) 1990-10-31
CA1277656C (en) 1990-12-11
JPH0443919B2 (cs) 1992-07-20
HUT42780A (en) 1987-08-28
FI862871A7 (fi) 1987-01-10
ES8802429A1 (es) 1988-06-01
GB8616585D0 (en) 1986-08-13
KR950003614B1 (ko) 1995-04-17
SU1442077A3 (ru) 1988-11-30
SG80490G (en) 1990-11-23

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Effective date: 20060707