PH21785A - Substituted androsta-1,4-diene-3,17-dione derivatives - Google Patents

Substituted androsta-1,4-diene-3,17-dione derivatives

Info

Publication number
PH21785A
PH21785A PH33989A PH33989A PH21785A PH 21785 A PH21785 A PH 21785A PH 33989 A PH33989 A PH 33989A PH 33989 A PH33989 A PH 33989A PH 21785 A PH21785 A PH 21785A
Authority
PH
Philippines
Prior art keywords
diene
dione derivatives
substituted androsta
androsta
substituted
Prior art date
Application number
PH33989A
Other languages
English (en)
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Enrico Di Salle
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH21785(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of PH21785A publication Critical patent/PH21785A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PH33989A 1985-07-09 1986-07-08 Substituted androsta-1,4-diene-3,17-dione derivatives PH21785A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (1)

Publication Number Publication Date
PH21785A true PH21785A (en) 1988-02-24

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
PH33989A PH21785A (en) 1985-07-09 1986-07-08 Substituted androsta-1,4-diene-3,17-dione derivatives

Country Status (38)

Country Link
US (2) US4808616A (cs)
JP (1) JPS6212797A (cs)
KR (1) KR950003614B1 (cs)
CN (1) CN86104664B (cs)
AT (1) AT395157B (cs)
AU (1) AU578840B2 (cs)
BE (1) BE905067A (cs)
BG (1) BG61370B2 (cs)
BR (1) BR1100240A (cs)
CA (1) CA1277656C (cs)
CH (1) CH668599A5 (cs)
CS (2) CS258498B2 (cs)
CZ (1) CZ413591A3 (cs)
DE (1) DE10199030I1 (cs)
DK (1) DK163520C (cs)
ES (2) ES8801304A1 (cs)
FI (1) FI83424C (cs)
FR (1) FR2584725B1 (cs)
GB (2) GB8517360D0 (cs)
GR (1) GR861780B (cs)
HK (1) HK94190A (cs)
HU (1) HU194274B (cs)
IE (1) IE58949B1 (cs)
IL (1) IL79336A (cs)
IT (1) IT1196436B (cs)
MY (1) MY102294A (cs)
NL (2) NL193616C (cs)
NO (2) NO165547C (cs)
NZ (1) NZ216763A (cs)
PH (1) PH21785A (cs)
PT (1) PT82944B (cs)
SE (1) SE468988B (cs)
SG (1) SG80490G (cs)
SK (1) SK413591A3 (cs)
SU (2) SU1442077A3 (cs)
UA (1) UA6046A1 (cs)
YU (2) YU44585B (cs)
ZA (1) ZA865079B (cs)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
WO1992017489A1 (fr) * 1991-03-28 1992-10-15 Teikoku Hormone Mfg. Co., Ltd. Nouveau derive oxa- ou azasteroide
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
HU221191B1 (en) * 1992-09-30 2002-08-28 Teikoku Hormone Mfg Co Ltd 7-substituted oxasteroid compounds, process for their preparation and pharmaceutical compositions containing the same
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
US20030158168A1 (en) * 2000-08-09 2003-08-21 Giorgio Massimini Composition for combined use of aromatase inhibitors
KR20030043955A (ko) * 2000-09-08 2003-06-02 파마시아 이탈리아 에스.피.에이. 화학적 예방제로서 엑스메스탄
ATE337787T1 (de) * 2001-01-26 2006-09-15 Pfizer Italia Srl Exemestan zur behandlung von hormonabhängigen störungen
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
LT3351246T (lt) 2001-02-19 2019-07-10 Novartis Pharma Ag Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui
PL392652A1 (pl) 2001-05-16 2010-12-06 Novartis Ag Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
ES2316758T3 (es) 2002-05-16 2009-04-16 Novartis Ag Uso de aglutinantes del receptor edg en el cancer.
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ES2382609T3 (es) * 2004-01-16 2012-06-11 Cedarburg Pharmaceuticals, Inc. Exemestano y sus productos intermedios y métodos de preparación de los mismos
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
CA2624269C (en) 2005-09-30 2016-03-22 Endece, Llc Exemestane compounds, compositions and related uses thereof
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
WO2007128820A1 (en) 2006-05-09 2007-11-15 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
CN102940619A (zh) 2007-10-16 2013-02-27 利普生物药剂公司 用于治疗代谢综合征的珠氯米芬
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
ES2461092T3 (es) * 2008-01-21 2014-05-16 Cadila Healthcare Limited Procedimiento para preparar el inhibidor de aromatasa Exemestano
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
WO2010127297A1 (en) 2009-05-01 2010-11-04 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
US8969327B2 (en) 2010-04-08 2015-03-03 Emory University Substituted androst-4-ene diones
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
ES2605960T3 (es) 2010-09-14 2017-03-17 Endece, Llc Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta
MX2014009322A (es) 2012-02-29 2014-11-10 Repros Therapeutics Inc Terapia de combinacion para el tratamiento de la deficiencia androgenica.
US20170165246A1 (en) 2014-02-11 2017-06-15 Novartis Ag Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
JP7048505B2 (ja) 2015-11-10 2022-04-05 パラクリン セラピューティクス エービー Ｐｄｇｆ－ｃｃ阻害剤および抗エストロゲン剤によるｅｒ陰性乳癌の処置
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929985A (cs) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
HUT42780A (en) 1987-08-28
SE8603046D0 (sv) 1986-07-08
FI862871A0 (fi) 1986-07-07
US4808616A (en) 1989-02-28
AT395157B (de) 1992-10-12
KR950003614B1 (ko) 1995-04-17
SK413591A3 (en) 1995-07-11
NO165547C (no) 1991-02-27
ES556550A0 (es) 1987-12-16
CH668599A5 (de) 1989-01-13
YU44628B (en) 1990-10-31
FI862871A7 (fi) 1987-01-10
NL300017I1 (nl) 2000-11-01
FR2584725B1 (fr) 1988-05-13
FI83424C (fi) 1991-07-10
CS258498B2 (en) 1988-08-16
SE8603046L (sv) 1987-01-10
DK324386A (da) 1987-01-10
ATA181986A (de) 1992-02-15
SG80490G (en) 1990-11-23
YU120186A (en) 1988-02-29
NO2000009I1 (no) 2000-10-05
AU5979986A (en) 1987-01-15
ZA865079B (en) 1987-03-25
HU194274B (en) 1988-01-28
DK163520B (da) 1992-03-09
YU44585B (en) 1990-10-31
NL193616B (nl) 1999-12-01
HK94190A (en) 1990-11-23
DK163520C (da) 1992-07-27
CZ413591A3 (en) 1994-03-16
IT1196436B (it) 1988-11-16
US4904650A (en) 1990-02-27
SU1442077A3 (ru) 1988-11-30
SE468988B (sv) 1993-04-26
NO862753L (no) 1987-01-12
DE10199030I1 (de) 2001-10-04
PT82944A (en) 1986-08-01
NL8601785A (nl) 1987-02-02
UA6046A1 (uk) 1994-12-29
GR861780B (en) 1986-11-11
KR870001140A (ko) 1987-03-11
SU1501923A3 (ru) 1989-08-15
ES8801304A1 (es) 1987-12-16
DK324386D0 (da) 1986-07-08
PT82944B (pt) 1989-01-30
IE58949B1 (en) 1993-12-01
GB8517360D0 (en) 1985-08-14
AU578840B2 (en) 1988-11-03
GB8616585D0 (en) 1986-08-13
CS257794B2 (en) 1988-06-15
JPS6212797A (ja) 1987-01-21
YU103687A (en) 1988-08-31
BG61370B2 (bg) 1997-06-30
NZ216763A (en) 1988-05-30
NL193616C (nl) 2000-04-04
GB2177700B (en) 1988-12-07
GB2177700A (en) 1987-01-28
CN86104664A (zh) 1987-02-18
ES557466A0 (es) 1988-06-01
IT8621004A0 (it) 1986-07-02
IL79336A0 (en) 1986-10-31
JPH0443919B2 (cs) 1992-07-20
CN86104664B (zh) 1988-06-29
NO862753D0 (no) 1986-07-08
BR1100240A (pt) 1999-12-28
ES8802429A1 (es) 1988-06-01
FI83424B (fi) 1991-03-28
CA1277656C (en) 1990-12-11
NL300017I2 (nl) 2001-01-02
NO165547B (no) 1990-11-19
BE905067A (fr) 1987-01-08
CS521486A2 (en) 1987-09-17
IL79336A (en) 1991-06-10
FR2584725A1 (fr) 1987-01-16
IE861821L (en) 1987-01-09
MY102294A (en) 1992-05-15

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