HK5593A - Stabilization of antibiotic compositions with salts - Google Patents

Stabilization of antibiotic compositions with salts Download PDF

Info

Publication number
HK5593A
HK5593A HK55/93A HK5593A HK5593A HK 5593 A HK5593 A HK 5593A HK 55/93 A HK55/93 A HK 55/93A HK 5593 A HK5593 A HK 5593A HK 5593 A HK5593 A HK 5593A
Authority
HK
Hong Kong
Prior art keywords
zwitterion
salt
salts
group
alpha
Prior art date
Application number
HK55/93A
Other languages
English (en)
Inventor
Arthur Kaplan Murray
Ballard Bogardus Joseph
Rao Palepu Nageswara
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HK5593A publication Critical patent/HK5593A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
HK55/93A 1987-01-09 1993-01-28 Stabilization of antibiotic compositions with salts HK5593A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/001,945 US4808617A (en) 1985-12-18 1987-01-09 Lyophilized or precipitated cephalosporin zwitterion and salt combination

Publications (1)

Publication Number Publication Date
HK5593A true HK5593A (en) 1993-02-05

Family

ID=21698538

Family Applications (1)

Application Number Title Priority Date Filing Date
HK55/93A HK5593A (en) 1987-01-09 1993-01-28 Stabilization of antibiotic compositions with salts

Country Status (33)

Country Link
US (1) US4808617A (cs)
JP (1) JP2568226B2 (cs)
KR (1) KR950010154B1 (cs)
AR (1) AR243501A1 (cs)
AT (1) AT388672B (cs)
AU (1) AU606361B2 (cs)
BE (1) BE1002114A3 (cs)
CA (1) CA1307464C (cs)
CH (1) CH676202A5 (cs)
CS (1) CS265249B2 (cs)
CY (1) CY1679A (cs)
DD (1) DD264614A5 (cs)
DE (1) DE3740588C2 (cs)
DK (1) DK166404B1 (cs)
ES (1) ES2008951A6 (cs)
FI (1) FI89006C (cs)
FR (1) FR2609396B1 (cs)
GB (1) GB2199746B (cs)
GR (1) GR871860B (cs)
HK (1) HK5593A (cs)
HU (1) HU199686B (cs)
IE (1) IE61238B1 (cs)
IL (1) IL84346A (cs)
IT (1) IT1215666B (cs)
LU (1) LU87102A1 (cs)
NL (1) NL193266C (cs)
OA (1) OA08796A (cs)
PT (1) PT86157B (cs)
SE (1) SE467910B (cs)
SG (1) SG114792G (cs)
SU (1) SU1575942A3 (cs)
YU (1) YU46689B (cs)
ZA (1) ZA88114B (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
WO2005094800A2 (en) * 2004-03-31 2005-10-13 Lupin Ltd. A co-precipitated cefepime composition and process for preparation thereof
WO2006109324A2 (en) * 2005-04-13 2006-10-19 Lupin Limited Processes for preparation of amorphous cefepime acid addition salts
JP5491119B2 (ja) * 2009-10-02 2014-05-14 日東電工株式会社 薬物含有微粒子を含む医薬組成物およびその製造方法
EP2777705A1 (en) 2013-03-15 2014-09-17 Cubist Pharmaceuticals, Inc. Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274990A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
ES2800603T3 (es) 2013-09-09 2021-01-04 Merck Sharp & Dohme Tratamiento de infecciones con ceftolozano/tazobactam en sujetos con insuficiencia renal
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
JP6218204B2 (ja) 2014-09-04 2017-10-25 塩野義製薬株式会社 カテコール基を有するセファロスポリン類を含有する製剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953439A (en) * 1973-08-01 1976-04-27 Smithkline Corporation Substituted phenylglycylcephalosporins
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
US4604386A (en) * 1984-07-09 1986-08-05 Eli Lilly And Company 3-(alkynylalkyloxy) cephalosporins
JPS61130223A (ja) * 1984-11-28 1986-06-18 Shionogi & Co Ltd 抗菌性凍結乾燥製剤
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables

Also Published As

Publication number Publication date
NL8800025A (nl) 1988-08-01
GR871860B (en) 1988-05-10
FI875122L (fi) 1988-07-10
IT1215666B (it) 1990-02-22
HUT46223A (en) 1988-10-28
ATA341687A (de) 1989-01-15
GB2199746B (en) 1990-10-24
CS265249B2 (en) 1989-10-13
US4808617A (en) 1989-02-28
HU199686B (en) 1990-03-28
FR2609396A1 (fr) 1988-07-15
NL193266B (nl) 1999-01-04
DK577387A (da) 1988-07-10
IE872970L (en) 1988-07-09
FR2609396B1 (fr) 1993-01-29
KR880008811A (ko) 1988-09-13
NL193266C (nl) 1999-05-06
BE1002114A3 (fr) 1990-07-10
PT86157B (pt) 1991-02-08
AT388672B (de) 1989-08-10
DK166404B1 (da) 1993-05-17
JP2568226B2 (ja) 1996-12-25
ZA88114B (cs) 1988-06-27
GB8725875D0 (en) 1987-12-09
PT86157A (en) 1987-12-01
OA08796A (fr) 1989-03-31
ES2008951A6 (es) 1989-08-16
KR950010154B1 (ko) 1995-09-11
FI875122A0 (fi) 1987-11-19
FI89006B (fi) 1993-04-30
SU1575942A3 (ru) 1990-06-30
AU606361B2 (en) 1991-02-07
CS15888A2 (en) 1989-01-12
SG114792G (en) 1992-12-24
AR243501A1 (es) 1993-08-31
DE3740588A1 (de) 1988-07-21
AU8085687A (en) 1989-05-11
SE8800036D0 (sv) 1988-01-08
GB2199746A (en) 1988-07-20
IT8819013A0 (it) 1988-01-07
IE61238B1 (en) 1994-10-19
IL84346A (en) 1992-05-25
LU87102A1 (fr) 1988-08-23
FI89006C (fi) 1993-08-10
SE467910B (sv) 1992-10-05
JPS63208522A (ja) 1988-08-30
CY1679A (en) 1993-10-10
DD264614A5 (de) 1989-02-08
CA1307464C (en) 1992-09-15
SE8800036L (sv) 1988-07-10
IL84346A0 (en) 1988-04-29
YU2388A (en) 1989-10-31
CH676202A5 (cs) 1990-12-28
DE3740588C2 (de) 1996-07-11
DK577387D0 (da) 1987-11-03
YU46689B (sh) 1994-04-05

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Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20071103