JPS57197257A - Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof - Google Patents

Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof

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Publication number
JPS57197257A
JPS57197257A JP56083276A JP8327681A JPS57197257A JP S57197257 A JPS57197257 A JP S57197257A JP 56083276 A JP56083276 A JP 56083276A JP 8327681 A JP8327681 A JP 8327681A JP S57197257 A JPS57197257 A JP S57197257A
Authority
JP
Japan
Prior art keywords
syn
isomer
salt
oxo
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56083276A
Other languages
Japanese (ja)
Inventor
Ikuo Ueda
Masakazu Kobayashi
Tadashi Kitaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP56083276A priority Critical patent/JPS57197257A/en
Publication of JPS57197257A publication Critical patent/JPS57197257A/en
Pending legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A syn-isomer of a compound expressed by formulaI(Xa is halogen; Ra 1 is alkenyl or cycloalkenyl; Za is carboxy; Xa is halogen; Ra 1 is cycloalkenyl; Za is protected carboxy; or Xa is Br; Ra 1 is alkenyl, Za is protected carboxy) and a salt thereof.
EXAMPLE: 2-Allyloxyimino-3-oxo-4-bromobutyric acid (syn-isomer).
USE: Useful as a synthetic raw material for cephalosporin compounds having improved antimicrobial action.
PROCESS: A syn compound expressed by formula IV (R1 is alkenyl, etc.; Z is protected carboxy) or a salt thereof is reacted with a pyridinium halide perhalide in the presence of a Lewis acid to give the aimed compound expressed by formula V (X is halogen) in high yield.
COPYRIGHT: (C)1982,JPO&Japio
JP56083276A 1981-05-29 1981-05-29 Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof Pending JPS57197257A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56083276A JPS57197257A (en) 1981-05-29 1981-05-29 Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56083276A JPS57197257A (en) 1981-05-29 1981-05-29 Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof

Publications (1)

Publication Number Publication Date
JPS57197257A true JPS57197257A (en) 1982-12-03

Family

ID=13797829

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56083276A Pending JPS57197257A (en) 1981-05-29 1981-05-29 Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof

Country Status (1)

Country Link
JP (1) JPS57197257A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845257A (en) * 1986-05-21 1989-07-04 Takeda Chemical Industries, Ltd. 4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845257A (en) * 1986-05-21 1989-07-04 Takeda Chemical Industries, Ltd. 4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives

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