JPS5728070A - Monosodium salt dihydrate of 1,2,3-triazole-5-thiol and its preparation - Google Patents
Monosodium salt dihydrate of 1,2,3-triazole-5-thiol and its preparationInfo
- Publication number
- JPS5728070A JPS5728070A JP10240780A JP10240780A JPS5728070A JP S5728070 A JPS5728070 A JP S5728070A JP 10240780 A JP10240780 A JP 10240780A JP 10240780 A JP10240780 A JP 10240780A JP S5728070 A JPS5728070 A JP S5728070A
- Authority
- JP
- Japan
- Prior art keywords
- triazole
- thiol
- preparation
- monosodium salt
- salt dihydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LLCOQBODWBFTDD-UHFFFAOYSA-N 1h-triazol-1-ium-4-thiolate Chemical compound SC1=CNN=N1 LLCOQBODWBFTDD-UHFFFAOYSA-N 0.000 title 1
- WZWGGYFEOBVNLA-UHFFFAOYSA-N sodium;dihydrate Chemical compound O.O.[Na] WZWGGYFEOBVNLA-UHFFFAOYSA-N 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- ACXMTAJLYQCRGF-PBFPGSCMSA-N cefatrizine Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)[C@H](N)C=2C=CC(O)=CC=2)CC=1CSC1=CN=N[N]1 ACXMTAJLYQCRGF-PBFPGSCMSA-N 0.000 abstract 1
- 229960002420 cefatrizine Drugs 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- PVGHNTXQMCYYGF-UHFFFAOYSA-N thiadiazol-5-amine Chemical compound NC1=CN=NS1 PVGHNTXQMCYYGF-UHFFFAOYSA-N 0.000 abstract 1
- 150000007944 thiolates Chemical class 0.000 abstract 1
Abstract
NEW MATERIAL:The compound of the formula.
USE: A synthetic intermediate for cephalosporin antibiotic cephatrizin. The compound of the formula is readily isolated as crystals from an aqueous solution thereof and easily storable and handleable due to no hygroscopicity.
PROCESS: 5-Amino-1,2,3-thiadiazole is rearranged in the presence of one mole or more NaOH in an aqueous solution, and the reaction solution is then adjusted to a pH of 7W10 to recover the aimed resultant thiolate as a solid.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10240780A JPS5728070A (en) | 1980-07-28 | 1980-07-28 | Monosodium salt dihydrate of 1,2,3-triazole-5-thiol and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10240780A JPS5728070A (en) | 1980-07-28 | 1980-07-28 | Monosodium salt dihydrate of 1,2,3-triazole-5-thiol and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5728070A true JPS5728070A (en) | 1982-02-15 |
| JPS611068B2 JPS611068B2 (en) | 1986-01-13 |
Family
ID=14326577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10240780A Granted JPS5728070A (en) | 1980-07-28 | 1980-07-28 | Monosodium salt dihydrate of 1,2,3-triazole-5-thiol and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5728070A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112759556A (en) * | 2020-06-29 | 2021-05-07 | 南京合创药业有限公司 | Synthetic method for preparing 5-mercapto-1, 2, 3-triazole sodium salt by one-pot method |
-
1980
- 1980-07-28 JP JP10240780A patent/JPS5728070A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112759556A (en) * | 2020-06-29 | 2021-05-07 | 南京合创药业有限公司 | Synthetic method for preparing 5-mercapto-1, 2, 3-triazole sodium salt by one-pot method |
| CN112759556B (en) * | 2020-06-29 | 2022-04-19 | 南京合创药业有限公司 | Synthetic method for preparing 5-mercapto-1, 2, 3-triazole sodium salt by one-pot method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS611068B2 (en) | 1986-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5452096A (en) | Cephem compound, its preparation and bacteriostatic agent containing the same | |
| JPS5536493A (en) | 2-lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compound, its salt, their preparation, and preventive and remedy comprising them as active constituent | |
| JPS56125392A (en) | Cepham and cephem compound and preparation thereof | |
| ES8303423A1 (en) | New cephem compounds and processes for preparation thereof. | |
| CA1245639A (en) | Preparation of the diphosphate salt of vancomycin | |
| ES412859A1 (en) | Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof | |
| PL249964A1 (en) | Process for preparing novel derivatives of 7-//z/-2-/2-aminothiazolyl-4/-2-oxyiminoacetamide/-3-cephemo-4-carboxylic acid | |
| JPS5728070A (en) | Monosodium salt dihydrate of 1,2,3-triazole-5-thiol and its preparation | |
| JPS5533500A (en) | 3,7-disubstituted-3-cephem-4-carboxylic acid, its salt, their preparation, and preventive and remedy for microbism | |
| JPS5535096A (en) | 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent | |
| JPS57205320A (en) | Formation of needlelike zinc oxide particle | |
| JPS5511600A (en) | Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same | |
| JPS5225740A (en) | Preparation of o-acyl-amidinophenols or acid addition salts thereof | |
| JPS5246093A (en) | 2-alkyl-7-substituted-2, or 3-cephem-4-carboxylic compounds, their sal ts, and preparation thereof | |
| ES8504829A1 (en) | Alpha-hydroxy-beta-haloethylphosphinic acids and their salts, and their production and use. | |
| JPS5629567A (en) | Alpha-cycloalkylthio-phenylacetic acid | |
| JPS56108794A (en) | Preparation of 7-amino-3-thiadiazolylthiomethyl-3-cephem- 4-carboxylic acid derivative | |
| JPS52125184A (en) | Novel cephalosporin compounds | |
| ES8407028A1 (en) | Optically active imidazolylpropanol compounds, and their production and use. | |
| JPS5219622A (en) | Process for preparation of tartaric acid salts | |
| JPS5677294A (en) | Aluminum compound substance of sucrose sulfate and dihydroxy aluminum allantoinate | |
| EP0111569A4 (en) | Hydroxyalkanesulfonic acids and their derivatives, and process for their preparation. | |
| JPS5653688A (en) | Novel cephalosporin derivative and its preparation | |
| JPS57197257A (en) | Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid compound, its salt and preparation thereof | |
| JPS5728069A (en) | Barium salt of 1,2,3-triazole-5-thiol |