HK1211603A1 - Anti-pcsk9 antibodies with ph-dependent binding characteristics ph--pcsk9 - Google Patents

Anti-pcsk9 antibodies with ph-dependent binding characteristics ph--pcsk9

Info

Publication number
HK1211603A1
HK1211603A1 HK15112390.4A HK15112390A HK1211603A1 HK 1211603 A1 HK1211603 A1 HK 1211603A1 HK 15112390 A HK15112390 A HK 15112390A HK 1211603 A1 HK1211603 A1 HK 1211603A1
Authority
HK
Hong Kong
Prior art keywords
pcsk9
binding characteristics
dependent binding
antibodies
pcsk9 antibodies
Prior art date
Application number
HK15112390.4A
Other languages
English (en)
Chinese (zh)
Inventor
George D Yancopoulos
Nicholas J Papadopoulos
Andrew J Murphy
Neil Stahl
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1211603A1 publication Critical patent/HK1211603A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK15112390.4A 2012-08-13 2015-12-16 Anti-pcsk9 antibodies with ph-dependent binding characteristics ph--pcsk9 HK1211603A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261682349P 2012-08-13 2012-08-13
US201261703342P 2012-09-20 2012-09-20
US201261734398P 2012-12-07 2012-12-07
US201361761383P 2013-02-06 2013-02-06
US201361828258P 2013-05-29 2013-05-29
PCT/US2013/054456 WO2014028354A1 (en) 2012-08-13 2013-08-12 Anti-pcsk9 antibodies with ph-dependent binding characteristics

Publications (1)

Publication Number Publication Date
HK1211603A1 true HK1211603A1 (en) 2016-05-27

Family

ID=50066319

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112390.4A HK1211603A1 (en) 2012-08-13 2015-12-16 Anti-pcsk9 antibodies with ph-dependent binding characteristics ph--pcsk9

Country Status (16)

Country Link
US (1) US9540449B2 (ko)
EP (1) EP2882778B1 (ko)
JP (1) JP6309521B2 (ko)
KR (1) KR20150041662A (ko)
CN (1) CN104540852B (ko)
AR (1) AR092098A1 (ko)
AU (1) AU2013302925B2 (ko)
CA (1) CA2881679C (ko)
EA (1) EA028244B1 (ko)
HK (1) HK1211603A1 (ko)
IL (1) IL236785B (ko)
MX (1) MX363213B (ko)
NZ (1) NZ704771A (ko)
TW (1) TWI596115B (ko)
UY (1) UY34975A (ko)
WO (1) WO2014028354A1 (ko)

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US9540449B2 (en) 2017-01-10

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