HK1207072A1 - 3,5-diaminopyrazole kinase inhibitors 35- - Google Patents
3,5-diaminopyrazole kinase inhibitors 35-Info
- Publication number
- HK1207072A1 HK1207072A1 HK15107683.0A HK15107683A HK1207072A1 HK 1207072 A1 HK1207072 A1 HK 1207072A1 HK 15107683 A HK15107683 A HK 15107683A HK 1207072 A1 HK1207072 A1 HK 1207072A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kinase inhibitors
- diaminopyrazole
- diaminopyrazole kinase
- inhibitors
- kinase
- Prior art date
Links
- KGBBJPZIDRELDP-UHFFFAOYSA-N 1h-pyrazole-3,5-diamine Chemical compound NC=1C=C(N)NN=1 KGBBJPZIDRELDP-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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PCT/US2013/031464 WO2013138613A1 (en) | 2012-03-16 | 2013-03-14 | 3,5-diaminopyrazole kinase inhibitors |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201341367A (zh) | 2012-03-16 | 2013-10-16 | Axikin Pharmaceuticals Inc | 3,5-二胺基吡唑激酶抑制劑 |
US10285243B2 (en) | 2013-05-31 | 2019-05-07 | Signify North America Corporation | Systems and methods for providing a self-adjusting light source |
US10585004B1 (en) | 2015-07-15 | 2020-03-10 | Signify North America Corporation | Systems and methods for determining ambient temperature using lighting based sensors |
US11693383B1 (en) | 2013-05-31 | 2023-07-04 | Signify Holding B.V. | Systems and methods for providing hub-based motion detection using distributed, light-based motion sensors |
NZ631142A (en) * | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
WO2015170218A1 (en) | 2014-05-07 | 2015-11-12 | Pfizer Inc. | Tropomyosin-related kinase inhibitors |
JP2017516845A (ja) | 2014-05-22 | 2017-06-22 | ノース チャイナ ファーマシューティカル カンパニー リミテッド | 血液凝固因子Xa阻害剤としてのヒドラジド化合物 |
US9726537B2 (en) | 2014-10-31 | 2017-08-08 | Stack Labs, Inc. | Systems and methods for determining ambient illumination having a bypass switch |
MY191736A (en) * | 2014-12-23 | 2022-07-13 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
CN104910075B (zh) * | 2015-06-23 | 2017-04-12 | 安徽农业大学 | 一种双吡唑希夫碱化合物及其制备方法及其作为杀菌剂的应用 |
US9642216B1 (en) | 2015-08-11 | 2017-05-02 | Stack Labs, Inc. | Systems and methods for synchronizing lighting devices |
US10512138B1 (en) | 2015-09-15 | 2019-12-17 | Signify North America Corporation | Systems and methods for self learning ambient light sensors |
CN105418616B (zh) * | 2015-12-26 | 2018-01-12 | 山东大学 | 一种含有 4‑氨基吡唑结构的jak 激酶抑制剂及其制备方法和应用 |
WO2024138109A2 (en) * | 2022-12-23 | 2024-06-27 | Acrivon Therapeutics, Inc. | Phenyl-pyrazole carboxamide compounds |
Family Cites Families (198)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
KR890002631B1 (ko) | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물 |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
US5612059A (en) | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
JPH072743B2 (ja) | 1988-10-21 | 1995-01-18 | 富士写真フイルム株式会社 | 1H−ピラゾロ〔5,1−c〕−1,2,4−トリアゾール類およびピラゾール誘導体の製造方法 |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
CA2119155C (en) | 1991-10-18 | 1999-06-15 | Dennis Paul Phillion | Fungicides for the control of take-all disease of plants |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5294612A (en) | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
HRP921338B1 (en) | 1992-10-02 | 2002-04-30 | Monsanto Co | Fungicides for the control of take-all disease of plants |
TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
US6087324A (en) | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
DE4405207A1 (de) | 1994-02-18 | 1995-08-24 | Bayer Ag | N-Pyrazolylaniline und N-Pyrazolylaminopyridine |
US5958458A (en) | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
CA2193725A1 (en) | 1994-06-24 | 1996-01-04 | David Cavalla | Aryl derivative compounds and uses to inhibit phosphodiesterase iv acti vity |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
US5597826A (en) | 1994-09-14 | 1997-01-28 | Pfizer Inc. | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
US5798119A (en) | 1995-06-13 | 1998-08-25 | S. C. Johnson & Son, Inc. | Osmotic-delivery devices having vapor-permeable coatings |
CA2224381A1 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
US6039975A (en) | 1995-10-17 | 2000-03-21 | Hoffman-La Roche Inc. | Colon targeted delivery system |
US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
EP0885890A1 (en) | 1996-02-26 | 1998-12-23 | Sumitomo Pharmaceuticals Company, Limited | Sulfonylureidopyrazole derivatives |
US5959109A (en) | 1996-05-15 | 1999-09-28 | Neurocrine Biosciences, Inc. | Compounds and methods for increasing endogenous levels of corticotropin-releasing factor |
TW345603B (en) | 1996-05-29 | 1998-11-21 | Gmundner Fertigteile Gmbh | A noise control device for tracks |
US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
US6419961B1 (en) | 1996-08-29 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
US6139865A (en) | 1996-10-01 | 2000-10-31 | Eurand America, Inc. | Taste-masked microcapsule compositions and methods of manufacture |
US6375987B1 (en) | 1996-10-01 | 2002-04-23 | Gattefossé, S.A. | Process for the manufacture of pharmaceutical composition with modified release of active principle comprising the matrix |
CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
DE69730093T2 (de) | 1996-10-31 | 2006-07-20 | Takeda Pharmaceutical Co. Ltd. | Zubereitung mit verzögerter Freisetzung |
US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
DE19648576C2 (de) | 1996-11-23 | 1999-08-12 | Lohmann Therapie Syst Lts | Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt |
KR20000057693A (ko) | 1996-12-20 | 2000-09-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 지효성 제제의 제조 방법 |
US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
US6613358B2 (en) | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
KR19990085365A (ko) | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
US7169410B1 (en) | 1998-05-19 | 2007-01-30 | Sdg, Inc. | Targeted liposomal drug delivery system |
JP4613275B2 (ja) | 1998-11-02 | 2011-01-12 | エラン ファーマ インターナショナル,リミティド | 多粒子改質放出組成物 |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6271359B1 (en) | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
HN2000000051A (es) | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
DE60011100T2 (de) | 1999-08-27 | 2005-06-16 | Abbott Laboratories, Abbott Park | Als cox-hemmer verwendbare sulfonylphenylpyrazol-verbindungen |
US6472416B1 (en) | 1999-08-27 | 2002-10-29 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors |
US7119108B1 (en) | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
CA2387892A1 (en) | 1999-10-18 | 2001-04-26 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
US7393842B2 (en) | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
US8084467B2 (en) | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
BR0108908A (pt) | 2000-03-03 | 2002-12-24 | Pfizer Prod Inc | Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos |
US6623756B1 (en) | 2000-04-27 | 2003-09-23 | Noveon Ip Holdings Corp. | Directly compressed solid dosage articles |
AU2001276608A1 (en) | 2000-08-30 | 2002-03-13 | Pfizer Products Inc. | Sustained release formulations for growth hormone secretagogues |
US20040020514A1 (en) | 2002-07-18 | 2004-02-05 | Orsillo James E. | Probe device cleaner and method |
CN100355750C (zh) * | 2000-09-15 | 2007-12-19 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的吡唑化合物 |
US6468338B1 (en) | 2000-10-12 | 2002-10-22 | Eastman Kodak Company | Dye for ink jet ink |
US6464767B1 (en) | 2000-10-12 | 2002-10-15 | Eastman Kodak Company | Ink jet printing method |
ATE326462T1 (de) | 2000-12-21 | 2006-06-15 | Vertex Pharma | Pyrazolverbindungen als protein-kinase- inhibitoren |
EP1353674A1 (en) | 2000-12-29 | 2003-10-22 | Alteon, Inc. | Method for treating glaucoma ivb |
DE10108480A1 (de) | 2001-02-22 | 2002-09-05 | Bayer Ag | Pyrazolylpyrimidine |
US6770645B2 (en) | 2001-03-16 | 2004-08-03 | Pfizer Inc. | Pharmaceutically active compounds |
GB0106661D0 (en) | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
JP2002309137A (ja) | 2001-04-12 | 2002-10-23 | Fuji Photo Film Co Ltd | インクジェット記録用インク組成物 |
US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US20040097547A1 (en) | 2001-04-16 | 2004-05-20 | Taveras Arthur G. | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
MXPA03009441A (es) | 2001-04-16 | 2004-02-12 | Schering Corp | Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc. |
ATE339418T1 (de) | 2001-06-01 | 2006-10-15 | Vertex Pharma | Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen |
US7255876B2 (en) | 2001-07-27 | 2007-08-14 | Astellas Pharma, Inc. | Composition comprises sustained-release fine particles and manufacturing method thereof |
AU2002331766A1 (en) | 2001-08-31 | 2003-03-18 | University Of Connecticut | Novel pyrazole analogs acting on cannabinoid receptors |
US20040062804A1 (en) | 2001-09-28 | 2004-04-01 | Der-Yang Lee | Modified release dosage forms |
MXPA04003439A (es) | 2001-10-12 | 2004-07-08 | Schering Corp | Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc. |
US7223782B2 (en) | 2001-11-01 | 2007-05-29 | Icagen, Inc. | Pyrazole-amides and -sulfonamides |
WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
WO2003037335A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 5-heteroatom-substituted pyrazoles |
CA2435729C (en) | 2001-12-19 | 2005-12-13 | Astrazeneca Ab | New film coating |
BRPI0215312B8 (pt) | 2001-12-24 | 2021-05-25 | Astrazeneca Ab | composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto |
US20050113283A1 (en) | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
US20040024085A1 (en) | 2002-01-30 | 2004-02-05 | Takahiro Ishizuka | Ink composition and inkjet recording method |
JP2005524662A (ja) | 2002-02-28 | 2005-08-18 | ビオタ インコーポレーティッド | ヌクレオシド5’−一リン酸模倣物およびこれらのプロドラッグ |
US6958161B2 (en) | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
US20030232836A1 (en) | 2002-05-23 | 2003-12-18 | Stewart Andrew O. | Acetamides and benzamides that are useful in treating sexual dysfunction |
US20040029887A1 (en) | 2002-05-23 | 2004-02-12 | Bhatia Pramila A. | Acetamides and benzamides that are useful in treating sexual dysfunction |
US20060009461A1 (en) | 2002-05-23 | 2006-01-12 | Bhatia Pramila A | Acetamides and benzamides that are useful in treating sexual dysfunction |
WO2003099266A2 (en) | 2002-05-23 | 2003-12-04 | Abbott Laboratories | Acetamides and benzamides that are useful in treating sexual dysfunction |
US6989451B2 (en) | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
EP1565150A1 (fr) | 2002-11-20 | 2005-08-24 | L'oreal | Utilisation d'un compose pyrazolcarboxamide pour stimuler la pousse des fibres keratiniques et/ou freiner leur chute |
FR2847160A1 (fr) | 2002-11-20 | 2004-05-21 | Oreal | Composition capillaire contenant un compose pyrasol-carboxamide, son utilisation pour stimuler la pousse des cheveux et/ou freiner leur chute |
US7485322B2 (en) | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
JP2004238296A (ja) * | 2003-02-04 | 2004-08-26 | Kissei Pharmaceut Co Ltd | 新規なトリアゾロピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
US20060270628A1 (en) | 2003-04-29 | 2006-11-30 | Jagattaran Das | Antiinfective 1,2,3-triazole derivatives, process for their preparation and pharmaceutical compositions containing them |
DK1631295T3 (da) | 2003-06-06 | 2010-06-21 | Arexis Ab | Anvendelse af kondenserede heterocykliske forbindelser som SCCE-inhibitorer ved behandling af hudsygdomme |
PL1644493T3 (pl) | 2003-06-27 | 2010-11-30 | Axikin Pharmaceuticals Inc | Regulacja kinazy regulowanej w COPD (kinaza RC) |
WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
US7514567B2 (en) | 2003-07-08 | 2009-04-07 | Astrazeneca Ab | Oxazolidinone nicotinic acetylcholine receptor agonists |
GB0319793D0 (en) | 2003-08-22 | 2003-09-24 | Lilly Co Eli | Pyridinylmorpholine derivatives |
MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
KR100843526B1 (ko) | 2004-02-27 | 2008-07-03 | 에프. 호프만-라 로슈 아게 | 피라졸의 접합 유도체 |
MXPA06009462A (es) | 2004-02-27 | 2007-03-15 | Hoffmann La Roche | Derivados pirazolo heteroaril fusionados. |
KR20050091462A (ko) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | 푸로피리미딘 화합물 및 이를 포함하는 ddr2 티로신키나아제 활성 저해제 |
US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
EP1735319B1 (en) | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
US7897607B2 (en) | 2004-04-07 | 2011-03-01 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
US7033425B2 (en) | 2004-04-15 | 2006-04-25 | Eastman Kodak Company | Ink jet ink set |
WO2005103010A2 (en) | 2004-04-21 | 2005-11-03 | Astrazeneca Ab | Pyrazole derivatives useful for the treatment of cancer |
US7399317B2 (en) | 2004-08-26 | 2008-07-15 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
ES2355923T3 (es) | 2004-08-26 | 2011-04-01 | Pfizer, Inc. | Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa. |
US7662482B2 (en) | 2004-09-01 | 2010-02-16 | Dow Global Technologies, Inc. | Adhesion promoter |
US7531560B2 (en) | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
US8153630B2 (en) | 2004-11-17 | 2012-04-10 | Miikana Therapeutics, Inc. | Kinase inhibitors |
SI1846394T1 (sl) | 2005-02-04 | 2012-06-29 | Astrazeneca Ab | Pirazolilaminopiridinski derivati uporabni kot kinazni inhibitorji |
ATE473975T1 (de) | 2005-02-16 | 2010-07-15 | Astrazeneca Ab | Chemische verbindungen |
ES2308731T3 (es) | 2005-02-16 | 2008-12-01 | Astrazeneca Ab | Compuestos quimicos. |
TW200639073A (en) | 2005-03-29 | 2006-11-16 | Mitsubishi Kagaku Media Co Ltd | Optical recording medium, metal complex compound, and organic dye compound |
TW200716630A (en) * | 2005-04-07 | 2007-05-01 | Teijin Pharma Ltd | Pyrazolo[1,5-a] pyridine derivative or medically acceptable salt thereof |
CN101208093A (zh) | 2005-04-27 | 2008-06-25 | 阿斯利康(瑞典)有限公司 | 吡唑-嘧啶衍生物在治疗疼痛中的用途 |
CN101218229A (zh) | 2005-05-05 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 吡唑基-氨基取代的嘧啶及其在癌症治疗中的应用 |
CN101253165A (zh) | 2005-06-29 | 2008-08-27 | 先灵公司 | 作为cxc-化学活素受体配体的二取代的二唑 |
EP1917259B1 (en) | 2005-08-18 | 2012-01-25 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
WO2007023382A2 (en) | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
JP2007056213A (ja) | 2005-08-26 | 2007-03-08 | Fujifilm Corp | 焼結含油軸受油用組成物、並びにそれを用いた軸受け装置及び摺動部材 |
SG166827A1 (en) | 2005-11-03 | 2010-12-29 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
ATE508126T1 (de) | 2005-11-16 | 2011-05-15 | Vertex Pharma | Als kinaseinhibitoren geeignete aminopyrimidine |
AU2006320580B2 (en) | 2005-11-30 | 2011-06-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met and uses thereof |
WO2007084868A2 (en) | 2006-01-17 | 2007-07-26 | Kalypsys, Inc. | Treatment of disorders by activation of the unfolded protein response |
US7427414B2 (en) | 2006-01-18 | 2008-09-23 | Astron Research Limited | Modified release oral dosage form using co-polymer of polyvinyl acetate |
US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
GB0605691D0 (en) | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic Compounds |
BRPI0716174A2 (pt) | 2006-09-01 | 2013-09-24 | Cv Therapeutics Inc | mÉtodos e composiÇÕes para aumentar a tolerabilidade de paciente durante mÉtodos de imagem do miocÁrdio. |
US20090081120A1 (en) | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
WO2008030448A1 (en) | 2006-09-07 | 2008-03-13 | Millennium Pharmaceuticals, Inc. | Phenethylamide derivatives with kinase inhibitory activity |
UY30796A1 (es) | 2006-12-15 | 2008-07-31 | Bayer Schering Pharma Ag | 3-h-pirazolopiridinas y sales de éstas, composiciones farmacéuticas que las comprenden, métodos para prepararlas, y sus usos |
EP2137158A4 (en) | 2007-02-28 | 2012-04-18 | Methylgene Inc | LOW-MOLECULAR INHIBITORS OF PROTEINARGININE METHYLTRANSFERASES (PRMTS) |
US7947698B2 (en) | 2007-03-23 | 2011-05-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
CN101679299A (zh) | 2007-04-19 | 2010-03-24 | 诺瓦提斯公司 | 作为代谢型谷氨酸受体-5调节剂的烟酸衍生物 |
AU2008262291A1 (en) | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
WO2009032703A1 (en) | 2007-08-28 | 2009-03-12 | Irm Llc | 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors |
PL2195312T3 (pl) | 2007-10-09 | 2013-04-30 | Merck Patent Gmbh | Pochodne pirydynowe użyteczne jako aktywatory glukokinazowe |
US20100292447A1 (en) | 2007-10-12 | 2010-11-18 | Merck Patent Gesellschaft | Method and agent for refolding proteins |
EA201070611A1 (ru) | 2007-11-13 | 2010-12-30 | Айкос Корпорейшн | Ингибиторы человеческой фосфатидилинозитол-3-киназы дельта |
US20090143451A1 (en) | 2007-11-14 | 2009-06-04 | Andrews William H | Compounds that increase telomerase reverse transcriptase (tert) expression and methods for using the same |
JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ido阻害剤 |
JP5559702B2 (ja) | 2008-02-25 | 2014-07-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコキナーゼ活性化剤 |
JP5117885B2 (ja) | 2008-02-29 | 2013-01-16 | 富士フイルム株式会社 | 色素化合物、着色組成物、感熱転写記録用インクシート、感熱転写記録方法、カラートナー、インクジェット用インクおよびカラーフィルター |
CN101970417A (zh) | 2008-03-14 | 2011-02-09 | 巴斯夫欧洲公司 | 作为杀真菌剂使用的取代的吡嗪基甲基磺酰胺 |
JP2009235122A (ja) | 2008-03-25 | 2009-10-15 | Fujifilm Corp | インク組成物、インクセット、及び画像記録方法 |
US20110039695A1 (en) | 2008-04-10 | 2011-02-17 | Basf Se | Substituted Pyridazinylmethyl Sulfonamides |
TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
RU2514427C2 (ru) | 2008-06-16 | 2014-04-27 | Юниверсити Оф Теннесси Рисёч Фаундейшн | Соединения для лечения рака |
CA2726508C (en) | 2008-06-17 | 2016-06-07 | Astrazeneca Ab | Pyridine compounds |
ES2572615T3 (es) | 2008-08-15 | 2016-06-01 | Nivalis Therapeutics, Inc. | Nuevos inhibidores pirrólicos de S-nitrosoglutatión reductasa como agentes terapéuticos |
BRPI0920237A2 (pt) | 2008-10-21 | 2015-12-29 | Metabolex Inc | agonistas do receptor aril gpr120 e suas respectivas utilizações |
WO2010048559A2 (en) | 2008-10-24 | 2010-04-29 | Calcimedica Inc. | Phenylpyrazole inhibitors of store operated calcium release |
US20110253929A1 (en) | 2008-12-22 | 2011-10-20 | Basf Se | Mixtures of hydrophobic and hydrophilic ionic liquids and use thereof in liquid ring compressors |
WO2010096314A1 (en) | 2009-02-18 | 2010-08-26 | Amgen Inc. | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS |
HUE047643T2 (hu) | 2009-03-02 | 2020-05-28 | Stemsynergy Therapeutics Inc | Módszerek és készítmények rák kezelésére és a WNT által közvetített hatások csökkentésére egy sejtben |
FR2943057B1 (fr) | 2009-03-12 | 2011-06-03 | Centre Nat Rech Scient | DERIVES DE 10-AMINO-1,2,3,4-TETRAHYDROPYRIDO°2,1-a!ISOINDOL-6(10bH)- ONES, LEUR PROCEDE DE PREPARATION ET LEURS UTILISATIONS THERAPEUTIQUES |
AR075858A1 (es) | 2009-03-18 | 2011-05-04 | Schering Corp | Compuestos biciclicos como inhibidores de diacilglicerol aciltransferasa |
WO2010108115A1 (en) | 2009-03-20 | 2010-09-23 | Sanford-Burnham Medical Research Institute | Allosteric jnk inhibitors |
GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
JP2012529535A (ja) * | 2009-06-12 | 2012-11-22 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼモジュレーターとして有用なニコチンアミド化合物 |
WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
WO2011056895A1 (en) | 2009-11-03 | 2011-05-12 | University Of Notre Dame Du Lac | Ionic liquids comprising heteraromatic anions |
AU2010347233B2 (en) | 2010-03-01 | 2015-06-18 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
GB201010196D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
WO2012154880A1 (en) | 2011-05-09 | 2012-11-15 | Proteostasis Therapeutics, Inc. | Proteostasis regulators for treating cystic fibrosis and other protein misfolding diseases |
TW201341367A (zh) | 2012-03-16 | 2013-10-16 | Axikin Pharmaceuticals Inc | 3,5-二胺基吡唑激酶抑制劑 |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
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2013
- 2013-03-14 TW TW102109147A patent/TW201341367A/zh unknown
- 2013-03-14 EP EP13713018.3A patent/EP2852586A1/en not_active Withdrawn
- 2013-03-14 KR KR1020147028946A patent/KR20140138293A/ko not_active Application Discontinuation
- 2013-03-14 CN CN201380025256.1A patent/CN104302640A/zh active Pending
- 2013-03-14 NZ NZ628080A patent/NZ628080A/en not_active IP Right Cessation
- 2013-03-14 CN CN201380025007.2A patent/CN104334545A/zh active Pending
- 2013-03-14 AR ARP130100838A patent/AR092809A1/es unknown
- 2013-03-14 MX MX2014011115A patent/MX2014011115A/es unknown
- 2013-03-14 US US13/830,712 patent/US9365556B2/en not_active Expired - Fee Related
- 2013-03-14 AU AU2013205306A patent/AU2013205306B2/en not_active Ceased
- 2013-03-14 JP JP2015500620A patent/JP6134376B2/ja not_active Expired - Fee Related
- 2013-03-14 AU AU2013205240A patent/AU2013205240B2/en not_active Ceased
- 2013-03-14 WO PCT/US2013/031473 patent/WO2013138617A1/en active Application Filing
- 2013-03-14 RU RU2014141674A patent/RU2014141674A/ru not_active Application Discontinuation
- 2013-03-14 JP JP2015500618A patent/JP6120941B2/ja active Active
- 2013-03-14 SG SG10201507714XA patent/SG10201507714XA/en unknown
- 2013-03-14 CA CA2867469A patent/CA2867469A1/en not_active Abandoned
- 2013-03-14 NZ NZ628084A patent/NZ628084A/en not_active IP Right Cessation
- 2013-03-14 CA CA2867467A patent/CA2867467A1/en not_active Abandoned
- 2013-03-14 US US13/830,486 patent/US8916555B2/en not_active Expired - Fee Related
- 2013-03-14 SG SG11201405761WA patent/SG11201405761WA/en unknown
- 2013-03-14 EP EP13712119.0A patent/EP2834232A1/en not_active Withdrawn
- 2013-03-14 WO PCT/US2013/031464 patent/WO2013138613A1/en active Application Filing
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2014
- 2014-09-15 IL IL234654A patent/IL234654A0/en unknown
- 2014-09-16 ZA ZA2014/06777A patent/ZA201406777B/en unknown
- 2014-09-16 PH PH12014502056A patent/PH12014502056A1/en unknown
- 2014-11-24 US US14/552,226 patent/US9382237B2/en not_active Expired - Fee Related
- 2014-12-17 US US14/574,007 patent/US9346792B2/en not_active Expired - Fee Related
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2015
- 2015-08-10 HK HK15107683.0A patent/HK1207072A1/xx unknown
- 2015-09-24 HK HK15109388.4A patent/HK1208678A1/xx unknown
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