HK1179942A1 - 皮膚增白 增亮 化合物系列 - Google Patents

皮膚增白 增亮 化合物系列

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Publication number
HK1179942A1
HK1179942A1 HK13107258.7A HK13107258A HK1179942A1 HK 1179942 A1 HK1179942 A1 HK 1179942A1 HK 13107258 A HK13107258 A HK 13107258A HK 1179942 A1 HK1179942 A1 HK 1179942A1
Authority
HK
Hong Kong
Prior art keywords
lightening
compounds
series
skin whitening
whitening
Prior art date
Application number
HK13107258.7A
Other languages
English (en)
Inventor
K Nandy Sandip
Liu Jiyun
Mikhailovitch Nesterov Alexandre
Hertel Carmen
A Padmapriya Abeysinghe
Original Assignee
Unigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigen Inc filed Critical Unigen Inc
Publication of HK1179942A1 publication Critical patent/HK1179942A1/zh

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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/257Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/295Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23BPRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00Preservation or chemical ripening of fruit or vegetables
    • A23B7/14Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
    • A23B7/153Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of liquids or solids
    • A23B7/154Organic compounds; Microorganisms; Enzymes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463Organic compounds; Microorganisms; Enzymes
    • A23L3/3481Organic compounds containing oxygen
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    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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    • AHUMAN NECESSITIES
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/11Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
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    • C07C39/12Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
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    • C07C43/00Ethers; Compounds having groups, groups or groups
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    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
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    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/72Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Rheumatology (AREA)
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  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
HK13107258.7A 2008-07-21 2013-06-21 皮膚增白 增亮 化合物系列 HK1179942A1 (zh)

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1748767T3 (pl) 2004-05-28 2012-08-31 Unigen Inc 1-(3-metylo-2,4-dimetoksyfenylo)-3-(2',4'-dihydroksyfenylo)-propan jako silny inhibitor tyrozynazy
JP2011528719A (ja) * 2008-07-21 2011-11-24 ユニジェン・インコーポレーテッド スキンホワイトニング(色を薄くする)化合物系列
AU2009331298B2 (en) * 2008-12-22 2015-04-30 Pola Chemical Industries Inc. Melanin production inhibitor
FR2969149B1 (fr) * 2010-12-16 2012-12-28 Oreal Procede de depigmentation des matieres keratiniques a l' aide de composes derives de resorcinol
FR2971249B1 (fr) * 2011-02-07 2013-10-18 Fabre Pierre Dermo Cosmetique Derives heterocycliques du resorcinol, leur preparation et leurs utilisations cosmetiques
KR102113823B1 (ko) * 2011-03-24 2020-05-21 유니젠, 인크. 디아릴프로판의 제조를 위한 화합물 및 방법
EP2554273A1 (en) 2011-08-02 2013-02-06 Omya Development AG Atomizing nozzle device and use of the same
FR2978660B1 (fr) * 2011-08-05 2013-09-20 Oreal Utilisation d'antagoniste du recepteur cb1 en tant qu'agent blanchissant et/ou anti-brunissement des matieres keratiniques
RU2014147075A (ru) * 2012-04-25 2016-06-10 Мерк Патент Гмбх Применение производных дициклогексилметанола с антимикробными свойствами
FR2991985B1 (fr) * 2012-06-19 2019-11-08 L'oreal Procede de depigmentation des matieres keratiniques a l'aide de nouveaux composes derives de resorcinol
JP6537788B2 (ja) * 2014-06-25 2019-07-03 ロレアル ナノエマルション若しくはマイクロエマルションの形態の又はラメラ構造を有する組成物
CN104892388B (zh) * 2015-06-10 2017-01-25 江南大学 3‑(2,4‑二羟基‑苯基)‑1,5‑二‑(2‑羟基‑苯基)‑戊烷‑1,5‑二酮的合成方法及其用途
US9738581B2 (en) * 2015-06-16 2017-08-22 Hong Kong Baptist University Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions
FR3045600B1 (fr) * 2015-12-16 2018-01-26 L'oreal Derives de resorcinol pour leur utilisation cosmetique
CN105924342B (zh) * 2016-05-18 2019-06-04 江南大学 1,5-二-(2,4-二羟基-苯基)-3-(3,4-二羟基-苯基)-戊烷-1,5-二酮的合成方法及其应用
MY187342A (en) * 2016-11-15 2021-09-22 Univ Hong Kong Baptist Univ Skin-protection composition containing dendrobium-based ingredients
FR3071731B1 (fr) * 2017-09-29 2020-06-19 L'oreal Derives de resorcinol pour leur utilisation cosmetique
CN113454054B (zh) * 2018-10-14 2024-01-02 尤尼根公司 治疗皮肤病和其他病况的一系列化合物
JP7239310B2 (ja) * 2018-12-12 2023-03-14 花王株式会社 1-フェニル-2-フェニルエタン誘導体
JP7376058B2 (ja) * 2019-01-23 2023-11-08 国立大学法人宇都宮大学 レゾルシノール誘導体およびこれを含むチロシナーゼ活性阻害剤
CN113543782B (zh) * 2019-02-01 2024-01-16 仁荷大学校产学协力团 用于防止头发变白以及预防或治疗白发症或白癜风的药物组合物
FR3095325B1 (fr) 2019-04-24 2022-05-13 Idscent Dispositif d’echantillonnage de parfum

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA238730A (en) 1924-03-18 R. Curme Henry Process of oxidising dibenzyl
US1596613A (en) * 1925-12-15 1926-08-17 Lehn & Fink Inc 2, 4-dihydroxydiphenylethane and process of making it
US2557921A (en) * 1948-01-30 1951-06-26 Universal Oil Prod Co Stabilization of edible fats and oils
US2719866A (en) * 1951-08-04 1955-10-04 Lilly Co Eli Substituted resorcinols
US3133967A (en) * 1960-02-04 1964-05-19 Boehringer Sohn Ingelheim 1-(3, 4-dialkoxy-phenol)-1-dialkylamino-3-and-4-piienyl butanes
JPS496311B1 (zh) 1970-01-09 1974-02-13
HU163394B (zh) * 1971-12-20 1973-08-28
DE2644591A1 (de) * 1976-10-02 1978-04-06 Bayer Ag Verfahren zur herstellung von arylsulfoniumsalzen
US5008294A (en) 1985-02-11 1991-04-16 Chemex Pharmaceuticals, Inc. Methods of treating tumors with compositions of catecholic butanes
US4678664A (en) * 1982-09-30 1987-07-07 Basf Corporation Mineral oil gels
EP0122523A3 (en) * 1983-04-18 1987-05-27 Andrews Paper and Chemical Co., Inc. Diazotype compositions and materials
JPS60258538A (ja) * 1984-06-06 1985-12-20 Ricoh Co Ltd ジアゾ複写材料
JPS6125137A (ja) * 1984-07-13 1986-02-04 Ricoh Co Ltd ジアゾ複写材料
US4880637A (en) 1985-02-11 1989-11-14 Chemex Pharmaceuticals, Inc. Compositions of catecholic butanes with zinc
JPS62178562A (ja) * 1986-01-30 1987-08-05 Japan Synthetic Rubber Co Ltd 1,2−キノンジアジド化合物の製造方法
JPS62185037A (ja) * 1986-02-12 1987-08-13 Tsumura Juntendo Inc カルコン誘導体
JPH01501790A (ja) 1986-11-19 1989-06-22 ケメックス ファーマシューティカルズ,インコーポレイティド リポキシゲナーゼ阻害剤
FR2609711B1 (fr) * 1987-01-21 1989-06-16 Rhone Poulenc Chimie Procede de preparation d'hydroxybiphenyles
JPH0211537A (ja) * 1988-06-30 1990-01-16 Kaken Pharmaceut Co Ltd ジヒドロカルコン誘導体の製造方法
CA1327869C (en) * 1989-02-17 1994-03-15 Yvan Guindon Ribonucleotide reductase inhibitors
JPH02273750A (ja) * 1989-04-14 1990-11-08 Hitachi Chem Co Ltd ポジ型ホトレジスト組成物およびレジストパターンの製造法
JPH03242650A (ja) * 1990-02-20 1991-10-29 Fuji Photo Film Co Ltd ポジ型フオトレジスト組成物
JPH03251494A (ja) * 1990-03-01 1991-11-08 Oji Paper Co Ltd 感熱記録体
JPH05213729A (ja) 1992-01-31 1993-08-24 Kao Corp メラニン抑制剤
US5430062A (en) 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
EP0641301A1 (en) 1992-05-21 1995-03-08 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
GB2268225B (en) 1992-06-29 1995-07-05 Ford Motor Co A fuel supply arrangement
IT1256354B (it) 1992-08-31 1995-12-01 Francesca Pelizzoni Derivati della combretastatina ad attivita' anti-tumorale e procedimento per la loro preparazione
GB9322007D0 (en) * 1993-10-26 1993-12-15 Unilever Plc Cosmetic composition
KR960015406B1 (ko) 1993-11-16 1996-11-13 주식회사 태평양 코지산 유도체
US5585492A (en) * 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US7056935B2 (en) * 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
JPH08337510A (ja) 1995-06-15 1996-12-24 Advanced Sukin Res Kenkyusho:Kk メラニン生成抑制剤
CN1055077C (zh) * 1995-11-24 2000-08-02 三井化学株式会社 氢化查耳酮衍生物,含有所述衍生物的化妆品组合物及其制备方法
JP3799645B2 (ja) * 1996-01-18 2006-07-19 住友化学株式会社 多価フェノール系化合物のキノンジアジドスルホン酸エステルおよびその用途
JP3799644B2 (ja) * 1996-01-18 2006-07-19 住友化学株式会社 フェノール系2核体化合物、その製法および用途
RU2156771C2 (ru) 1996-05-30 2000-09-27 Институт нефтехимии и катализа с опытным заводом АН РБ Способ совместного получения 1-(диалкиламино)-2-фенилалюмациклопропана и 1-(диалкиламино)-2,4-дифенилалюмациклопентана
JPH1072330A (ja) * 1996-09-03 1998-03-17 Kansai Kouso Kk チロシナーゼ活性阻害剤及び化粧料
KR100509878B1 (ko) 1997-02-07 2005-08-25 아벤티스 파마슈티칼스 인크. (4-피페리디닐)-1h-2-벤조피란 유도체 및 이를 함유하는 정신병 치료용 약제학적 조성물
KR100270410B1 (ko) 1997-03-06 2000-11-01 성재갑 타이로시네이즈 활성 저해능을 갖는 신규 1,3-디페닐프로판 유도체 및 그의 제조방법
US6077503A (en) 1997-07-30 2000-06-20 Amway Corporation Skin whitener composition containing mercaptodextran
BR9803596A (pt) * 1997-09-23 2000-04-25 Pfizer Prod Inc Derivados do resorcinol.
JP3636423B2 (ja) * 1997-12-16 2005-04-06 三井化学株式会社 ハイドロカルコン誘導体を有効成分とする化粧料
JPH11255638A (ja) * 1998-03-13 1999-09-21 Kansai Kouso Kk チロシナーゼ活性阻害剤及び化粧料
JP2002524504A (ja) * 1998-09-11 2002-08-06 イレクサス・ピーティーワイ・リミテッド Fc受容体調節剤およびそれの使用
US6296857B1 (en) * 1998-09-23 2001-10-02 Beiersdorf Aktiengesellschaft Cosmetic or dermatological preparations comprising oligopeptides for lightening the skin of age marks and/or for preventing tanning of the skin, in particular tanning of the skin caused by UV radiation
JP2000095721A (ja) * 1998-09-28 2000-04-04 Mitsui Chemicals Inc 新規ハイドロカルコン誘導体、該誘導体を含む化粧料およびこれらの製造方法
AU5319700A (en) * 1999-06-02 2000-12-18 S. Mbua Ngale Efange Nicotine receptor ligands
US6214874B1 (en) * 1999-10-15 2001-04-10 John Hopkins University Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N
US6630510B1 (en) 1999-10-28 2003-10-07 Merck & Co., Inc. Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections
US6221604B1 (en) * 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
EP1267868B1 (en) * 2000-02-29 2007-07-18 MediQuest Therapeutics, Inc. Inhibitors of melanocyte tyrosinase as topical skin lighteners
JP2001335472A (ja) * 2000-05-24 2001-12-04 Kansai Koso Kk チロシナーゼ活性阻害剤及び化粧料
DE60134854D1 (de) 2000-06-30 2008-08-28 Procter & Gamble Orale zubereitungen, die wirtsantwortmodulierenden wirkstoffe enthalten
JP3504594B2 (ja) 2000-07-28 2004-03-08 株式会社ノエビア 皮膚外用剤
BR0113798A (pt) 2000-09-11 2003-07-08 Pfizer Prod Inc Derivados de resorcinol
DE60110516T2 (de) 2000-09-21 2005-10-13 Solvias Ag Phosphinite-oxazoline und Metallkomplexe
CA2423262A1 (en) * 2000-09-21 2002-03-28 Pfizer Products Inc. Resorcinol derivatives
DE10051034A1 (de) 2000-10-14 2002-04-18 Henkel Kgaa Oxidationsmittel enthaltend 2-Chlor-4-aminophenol
WO2002035580A2 (en) 2000-10-24 2002-05-02 Molecular Electronics Corporation Three-terminal field-controlled molecular devices
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
JP2002193990A (ja) 2000-12-25 2002-07-10 Mitsui Chemicals Inc ハイドロカルコン配糖体および該配糖体を有効成分として配合した化粧料
ES2241999T3 (es) * 2001-05-25 2005-11-01 Wella Aktiengesellschaft Derivados de 1,3-dihidroxibenceno y productos para el teñido de fibras que los contienen.
CA2452159A1 (en) 2001-07-23 2003-02-06 Galileo Laboratories, Inc. Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods
JP2003040980A (ja) * 2001-07-31 2003-02-13 Nitto Denko Corp 半導体封止用樹脂組成物およびそれを用いた半導体装置
GB0126889D0 (en) 2001-11-08 2002-01-02 Paterson Inst For Cancer Res Compounds and their uses
DE10161253A1 (de) 2001-12-13 2003-06-26 Dragoco Gerberding Co Ag Verwendung von Dihydropinosylvin und dessen Derivaten als Inhibitoren
US6562791B1 (en) 2002-03-29 2003-05-13 Council Of Scientific And Industrial Research Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof
JP2003302761A (ja) * 2002-04-08 2003-10-24 Sumitomo Bakelite Co Ltd ポジ型感光性樹脂組成物及び半導体装置
US6600004B1 (en) * 2002-04-10 2003-07-29 General Electric Company Method of preparing polyestercarbonates
US7705188B2 (en) 2002-04-10 2010-04-27 Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of the Arizona State University Structural modification of resveratrol: sodium resverastatin phosphate
CN1462739A (zh) 2002-05-30 2003-12-24 浙江工业大学 2,2'-二氨基联苄二磷酸盐低压液相催化加氢制备方法
US6852310B2 (en) 2002-08-23 2005-02-08 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Skin lightening agents, compositions and methods
NZ541479A (en) * 2003-02-11 2008-11-28 Vernalis Cambridge Liimited Isoxazole compounds as inhibitors of heat shock proteins
CN1238361C (zh) 2003-02-21 2006-01-25 南开大学 螺环双膦配体
DE10324566A1 (de) * 2003-05-30 2004-12-16 Symrise Gmbh & Co. Kg Verwendung von Diphenylmethan-Derivaten als Tyrosinase-Inhibitoren
JP4569211B2 (ja) * 2003-07-31 2010-10-27 住友ベークライト株式会社 フェノール化合物、ポジ型感光性樹脂組成物、半導体装置及び表示素子、並びに半導体装置及び表示素子の製造方法
JP2005097144A (ja) * 2003-09-24 2005-04-14 Mitsubishi Chemicals Corp 2核フェノール類の製造方法
PL1748767T3 (pl) * 2004-05-28 2012-08-31 Unigen Inc 1-(3-metylo-2,4-dimetoksyfenylo)-3-(2',4'-dihydroksyfenylo)-propan jako silny inhibitor tyrozynazy
US20050271608A1 (en) 2004-06-05 2005-12-08 Gupta Shyam K Skin whitening compositions based on hydroxyaryl alkyl ketones and their isosteric derivatives
DE102004036047A1 (de) * 2004-07-24 2006-02-23 Bioghurt Biogarde Gmbh & Co. Kg Physiologisch aktive Zusammensetzung
US7334392B2 (en) 2004-10-29 2008-02-26 General Electric Company Counter-rotating gas turbine engine and method of assembling same
EP2368442B1 (en) * 2005-07-27 2014-12-17 Symrise AG Use of hesperetin for enhancing the sweet taste
JP2007121873A (ja) * 2005-10-31 2007-05-17 Fujifilm Corp 感光性樹脂組成物及びそれを用いた半導体装置の製造方法
JP5244400B2 (ja) * 2005-12-26 2013-07-24 株式会社林原 アルキルレゾルシノール配糖体とその製造方法並びに用途
JP4986110B2 (ja) * 2006-01-12 2012-07-25 国立大学法人九州大学 レゾルシノール誘導体を含有するメラニン生成抑制剤
US20070224301A1 (en) * 2006-03-21 2007-09-27 Ribnicky David M Compounds from an extract of Artemisia and methods for treating disorders
FR2900047B1 (fr) * 2006-04-21 2012-11-30 Oreal Utilisation d'un derive diphenyl-methane pour le soin des peaux grasses
JP5150894B2 (ja) 2006-08-03 2013-02-27 国立大学法人宇都宮大学 チロシナーゼの活性阻害剤とその製造方法
US7781410B2 (en) 2006-08-04 2010-08-24 Johnson & Johnson Consumer Companies, Inc. Compositions containing chalcones and use thereof
US7339076B1 (en) 2006-11-28 2008-03-04 E.I. Du Pont De Nemours And Company Process for the synthesis of 2,5-dihydroxyterephthalic acid
CN101215306A (zh) * 2008-01-07 2008-07-09 中国科学院昆明植物研究所 熊果苷糖酯衍生物,其组合物和其应用
US8449936B2 (en) * 2008-02-25 2013-05-28 Givaudan Sa Flavor molecules
US8715761B2 (en) * 2008-02-25 2014-05-06 Givaudan S.A. Flavor molecules
JP2011528719A (ja) 2008-07-21 2011-11-24 ユニジェン・インコーポレーテッド スキンホワイトニング(色を薄くする)化合物系列
KR102113823B1 (ko) 2011-03-24 2020-05-21 유니젠, 인크. 디아릴프로판의 제조를 위한 화합물 및 방법

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