HK1135090A1 - Pyridine carboxamides as 11-beta-hsd1 inhibitors - Google Patents
Pyridine carboxamides as 11-beta-hsd1 inhibitorsInfo
- Publication number
- HK1135090A1 HK1135090A1 HK10101460.7A HK10101460A HK1135090A1 HK 1135090 A1 HK1135090 A1 HK 1135090A1 HK 10101460 A HK10101460 A HK 10101460A HK 1135090 A1 HK1135090 A1 HK 1135090A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- beta
- hsd1 inhibitors
- pyridine carboxamides
- carboxamides
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86424706P | 2006-11-03 | 2006-11-03 | |
US86430306P | 2006-11-03 | 2006-11-03 | |
PCT/GB2007/004131 WO2008053194A2 (fr) | 2006-11-03 | 2007-10-31 | Composés chimiques |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1135090A1 true HK1135090A1 (en) | 2010-05-28 |
Family
ID=39304797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10101460.7A HK1135090A1 (en) | 2006-11-03 | 2010-02-09 | Pyridine carboxamides as 11-beta-hsd1 inhibitors |
Country Status (31)
Country | Link |
---|---|
US (3) | US7964618B2 (fr) |
EP (2) | EP2233480B1 (fr) |
JP (1) | JP5165688B2 (fr) |
KR (1) | KR101465275B1 (fr) |
CN (3) | CN101787016B (fr) |
AR (1) | AR063458A1 (fr) |
AT (1) | ATE475649T1 (fr) |
AU (1) | AU2007315955B2 (fr) |
BR (1) | BRPI0717970C1 (fr) |
CA (1) | CA2668006C (fr) |
CL (1) | CL2007003176A1 (fr) |
CO (1) | CO6321130A2 (fr) |
CY (1) | CY1110813T1 (fr) |
DE (1) | DE602007008137D1 (fr) |
DK (1) | DK2086939T3 (fr) |
ES (2) | ES2423206T3 (fr) |
HK (1) | HK1135090A1 (fr) |
HR (1) | HRP20100522T1 (fr) |
IL (1) | IL198231A0 (fr) |
MX (1) | MX2009004707A (fr) |
NO (1) | NO20091603L (fr) |
NZ (1) | NZ576501A (fr) |
PE (1) | PE20081487A1 (fr) |
PL (1) | PL2086939T3 (fr) |
PT (1) | PT2086939E (fr) |
RS (1) | RS51451B (fr) |
RU (1) | RU2451674C2 (fr) |
SI (1) | SI2086939T1 (fr) |
TW (1) | TW200827346A (fr) |
UY (1) | UY30681A1 (fr) |
WO (1) | WO2008053194A2 (fr) |
Families Citing this family (32)
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WO2007058346A1 (fr) | 2005-11-21 | 2007-05-24 | Shionogi & Co., Ltd. | COMPOSE HETEROCYCLIQUE PRESENTANT UNE ACTIVITE INHIBITRICE DE LA 11-β-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE I |
TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
ES2535317T3 (es) | 2007-05-18 | 2015-05-08 | Shionogi & Co., Ltd. | Derivado heterocíclico que contiene nitrógeno que tiene actividad inhibidora de la 11 beta-hidroxiesteroide deshidrogenasa de tipo 1 |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
JP5441705B2 (ja) * | 2007-10-15 | 2014-03-12 | 武田薬品工業株式会社 | アミド化合物およびその用途 |
WO2009056881A1 (fr) * | 2007-10-29 | 2009-05-07 | Astrazeneca Ab | Composés chimiques 313 |
WO2009098501A1 (fr) * | 2008-02-04 | 2009-08-13 | Astrazeneca Ab | Nouvelles formes cristallines de 4- [4- (2- adamantylcarbamoyle) -5-tert-butyl-pyrazol-1-yl] |
WO2009130496A1 (fr) * | 2008-04-22 | 2009-10-29 | Astrazeneca Ab | Pyrimidine-5-carboxamides substitués |
EP2243479A3 (fr) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Nouvel amide et dérivés d'amidine et utilisations associées |
US8586751B2 (en) | 2009-06-12 | 2013-11-19 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
US20110092526A1 (en) * | 2009-10-20 | 2011-04-21 | Astrazeneca Ab | Adamantyl Iminocarbonyl-Substituted Pyrimidines As Inhibitors Of 11-Beta-HSD1 826 |
JP2013512243A (ja) * | 2009-11-24 | 2013-04-11 | アラーガン インコーポレイテッド | 治療的有用性を有する受容体調節物質としての新規化合物 |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
KR20110123657A (ko) * | 2010-05-07 | 2011-11-15 | 에스케이케미칼주식회사 | 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
UA110802C2 (uk) | 2010-09-23 | 2016-02-25 | Еббві Бахамаз Лтд. | Моногідрат похідного азаадамантану |
US8471027B2 (en) * | 2011-04-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Adamantyl compounds |
JP5697800B2 (ja) * | 2011-07-21 | 2015-04-08 | シュエンジュウ・ファーマ・カンパニー・リミテッド | 複素環置換ピリミジン化合物 |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
CN102659657B (zh) * | 2012-04-24 | 2014-08-06 | 徐州医学院 | 一种蛋白酶抑制剂pf429242的合成方法 |
BR112014031108A2 (pt) | 2012-06-20 | 2017-06-27 | Hoffmann La Roche | compostos de pirazol substituído como antagonistas de lpar |
US9321738B2 (en) | 2012-06-20 | 2016-04-26 | Hoffman-La Roche Inc. | N-alkyltriazole compounds as LPAR antagonists |
EP3821892A1 (fr) | 2019-11-12 | 2021-05-19 | University of Leeds | Acide acétique (s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridine-2-yl)pipéridine-3-yl) pour son utilisation dans la guérison de plaies |
GB202216324D0 (en) * | 2022-11-02 | 2022-12-14 | Cerevance Ltd | Novel compounds |
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GR66581B (fr) * | 1978-02-21 | 1981-03-27 | Delalande Sa | |
CA1307786C (fr) | 1984-12-14 | 1992-09-22 | Keiichi Yokoyama | Derives quinazoline et preparations antihypertension contenant les memescomposes comme ingredients actifs |
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GB0327761D0 (en) | 2003-11-29 | 2003-12-31 | Astrazeneca Ab | Compounds |
KR20060101772A (ko) | 2003-12-19 | 2006-09-26 | 화이자 인코포레이티드 | 당뇨병 및 비만을 치료하기 위한,11-베타-하이드록시스테로이드 데하이드로게나제 유형1(11-베타-hsd-1)의 저해제로서의벤젠설폰일아미노-피리딘-2-일 유도체 및 관련 화합물 |
ES2313304T3 (es) | 2004-02-24 | 2009-03-01 | Glaxo Group Limited | Derivados de piridina y su uso como moduladores del receptor cb2. |
WO2005097751A2 (fr) * | 2004-03-31 | 2005-10-20 | Janssen Pharmaceutica, N.V. | Composes heterocycliques non-imidazole |
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CA2585735A1 (fr) | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Nouveaux composes d'adamantyl amides substitues ou non |
EP1809290A2 (fr) | 2004-11-03 | 2007-07-25 | Vertex Pharmaceuticals Incorporated | Derives de la pyrimidine en tant que modulateurs de canaux ioniques et leurs methodes d'utilisation |
US7511175B2 (en) | 2005-01-05 | 2009-03-31 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
PL1928840T3 (pl) * | 2005-04-05 | 2012-01-31 | Hoffmann La Roche | 1H-pirazolo-4-karboksyamidy, ich wytwarzanie i ich zastosowanie jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej |
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WO2006106423A2 (fr) | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Nouveaux composes de derives aminosulfonyles |
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WO2006132436A1 (fr) | 2005-06-08 | 2006-12-14 | Japan Tobacco Inc. | Composé hétérocyclique |
ES2334518T3 (es) | 2005-06-16 | 2010-03-11 | Pfizer, Inc. | Derivados de n-(piridin-2-il)-sulfonamida. |
KR20110084339A (ko) | 2005-07-09 | 2011-07-21 | 아스트라제네카 아베 | 당뇨병 치료에 있어 glk 활성화제로서 사용하기 위한 헤테로아릴 벤즈아미드 유도체 |
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CN101316837A (zh) | 2005-11-01 | 2008-12-03 | 詹森药业有限公司 | 作为葡萄糖激酶变构调节剂的取代的吡咯酮类 |
WO2007052843A1 (fr) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | Compose amide heterocyclique et son utilisation |
WO2007058346A1 (fr) | 2005-11-21 | 2007-05-24 | Shionogi & Co., Ltd. | COMPOSE HETEROCYCLIQUE PRESENTANT UNE ACTIVITE INHIBITRICE DE LA 11-β-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE I |
KR20080091503A (ko) | 2006-01-31 | 2008-10-13 | 인사이트 코포레이션 | 아미도 화합물 및 약제로서의 이의 용도 |
SI1999114T1 (sl) | 2006-03-22 | 2015-10-30 | F. Hoffmann-La Roche Ag | Pirazoli kot 11-beta-hsd-1 |
JP2009532418A (ja) | 2006-04-07 | 2009-09-10 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型活性化合物 |
JP2009534440A (ja) | 2006-04-27 | 2009-09-24 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | カリウムチャンネルモジュレーターとしてのcbxカンナビノイド受容体モジュレーターの使用 |
US20100022589A1 (en) * | 2006-07-27 | 2010-01-28 | Mccoull William | Pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
ES2535317T3 (es) | 2007-05-18 | 2015-05-08 | Shionogi & Co., Ltd. | Derivado heterocíclico que contiene nitrógeno que tiene actividad inhibidora de la 11 beta-hidroxiesteroide deshidrogenasa de tipo 1 |
JP5189165B2 (ja) | 2007-07-17 | 2013-04-24 | エフ.ホフマン−ラ ロシュ アーゲー | 11β−ヒドロキシステロイドデヒドロゲナーゼの阻害剤 |
BRPI0819177A2 (pt) | 2007-11-06 | 2015-05-05 | Astrazeneca Ab | Composto, forma cristalina, composição farmacêutica, método para produzir um efeito inibidor de 11betahsd1, processo para preparar um composto |
WO2009098501A1 (fr) | 2008-02-04 | 2009-08-13 | Astrazeneca Ab | Nouvelles formes cristallines de 4- [4- (2- adamantylcarbamoyle) -5-tert-butyl-pyrazol-1-yl] |
WO2009130496A1 (fr) * | 2008-04-22 | 2009-10-29 | Astrazeneca Ab | Pyrimidine-5-carboxamides substitués |
JP2012516327A (ja) | 2009-01-30 | 2012-07-19 | アストラゼネカ アクチボラグ | カルボキシ含有ピラゾールアミド化合物を製造するための新規な方法 |
US20110092526A1 (en) | 2009-10-20 | 2011-04-21 | Astrazeneca Ab | Adamantyl Iminocarbonyl-Substituted Pyrimidines As Inhibitors Of 11-Beta-HSD1 826 |
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