HK1116165A1 - - Google Patents

Info

Publication number
HK1116165A1
HK1116165A1 HK08105432.7A HK08105432A HK1116165A1 HK 1116165 A1 HK1116165 A1 HK 1116165A1 HK 08105432 A HK08105432 A HK 08105432A HK 1116165 A1 HK1116165 A1 HK 1116165A1
Authority
HK
Hong Kong
Prior art keywords
disorders
cyanoindol
benzofuran
carbamoyl
butyl
Prior art date
Application number
HK08105432.7A
Other languages
English (en)
Inventor
Andreas Bathe
Bernd Helfert
Steffen Neuenfeld
Heike Kniel
Matthias Bartels
Susanne Rudolph
Henning Bottcher
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8177643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1116165(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HK1116165A1 publication Critical patent/HK1116165A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
HK08105432.7A 2001-06-19 2008-05-16 HK1116165A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01113647 2001-06-19

Publications (1)

Publication Number Publication Date
HK1116165A1 true HK1116165A1 (uk) 2008-12-19

Family

ID=8177643

Family Applications (2)

Application Number Title Priority Date Filing Date
HK04108857A HK1066003A1 (en) 2001-06-19 2004-11-10 Polymorphic forms of 1-'4 (5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
HK08105432.7A HK1116165A1 (uk) 2001-06-19 2008-05-16

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK04108857A HK1066003A1 (en) 2001-06-19 2004-11-10 Polymorphic forms of 1-'4 (5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride

Country Status (30)

Country Link
US (15) US7381726B2 (uk)
EP (1) EP1397357B9 (uk)
JP (3) JP4624667B2 (uk)
KR (1) KR20040012922A (uk)
CN (2) CN101139345B (uk)
AR (1) AR034595A1 (uk)
AT (1) ATE437871T1 (uk)
AU (1) AU2002320822B2 (uk)
BR (1) BR0210495A (uk)
CA (16) CA2782519A1 (uk)
CY (1) CY1109447T1 (uk)
CZ (2) CZ304471B6 (uk)
DE (1) DE60233133D1 (uk)
DK (1) DK1397357T3 (uk)
EC (1) ECSP044943A (uk)
EE (1) EE05454B1 (uk)
ES (1) ES2330314T3 (uk)
HK (2) HK1066003A1 (uk)
HU (1) HU229601B1 (uk)
IL (2) IL159426A0 (uk)
MX (1) MXPA03011723A (uk)
MY (1) MY151087A (uk)
NZ (1) NZ530642A (uk)
PL (1) PL208708B1 (uk)
PT (1) PT1397357E (uk)
RU (1) RU2303598C2 (uk)
SK (2) SK288162B6 (uk)
UA (1) UA76758C2 (uk)
WO (1) WO2002102794A2 (uk)
ZA (1) ZA200400329B (uk)

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UA76758C2 (uk) * 2001-06-19 2006-09-15 Мерк Патент Гмбх Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
DE10326939A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
DE10326940A1 (de) * 2003-06-16 2005-01-05 Merck Patent Gmbh Indol-Derivate
US9708300B2 (en) 2011-03-20 2017-07-18 Cadila Healthcare Limited Amorphous form of vilazodone hydrochloride and process for its preparation
CN102219783B (zh) * 2011-05-05 2013-07-03 天津市汉康医药生物技术有限公司 盐酸维拉佐酮及其组合物
US9505744B2 (en) 2011-11-23 2016-11-29 Assia Chemical Industries Ltd. Solid state forms of vilazodone and vilazodone hydrochloride
US20140378472A1 (en) 2011-12-12 2014-12-25 Ranbaxy Laboratories Limited Amorphous vilazodone hydrochloride, a process for its preparation and pharmaceutical compositions thereof
WO2013153492A2 (en) 2012-04-12 2013-10-17 Alembic Pharmaceuticals Limited Process for the preparation of vilazodone hydrochloride and its amorphous form
EP2838894A1 (en) * 2012-04-16 2015-02-25 Ranbaxy Laboratories Limited Process for the preparation of crystalline vilazodone hydrochloride
WO2013164794A1 (en) * 2012-05-04 2013-11-07 Ranbaxy Laboratories Limited Crystalline forms of vilazodone hydrochloride
US20150126525A1 (en) 2012-05-11 2015-05-07 Dr. Reddy's Laboratories Limited Crystalline forms of vilazodone hydrochloride and vilazodone free base
WO2013175361A1 (en) 2012-05-24 2013-11-28 Ranbaxy Laboratories Limited Process for the preparation of vilazodone hydrochloride
CN102702180A (zh) * 2012-05-25 2012-10-03 吉林三善恩科技开发有限公司 一种维拉佐酮有机药物共晶及其制备方法
US8835635B2 (en) * 2012-06-05 2014-09-16 Symed Labs Limited Amorphous form of vilazodone hydrochloride substantially free of crystalline forms
WO2013182946A2 (en) 2012-06-06 2013-12-12 Ranbaxy Laboratories Limited Process for the preparation of vilazodone hydrochloride
CA2876741A1 (en) 2012-06-13 2013-12-19 Apotex Inc. Forms of vilazodone and processes for the preparation thereof
WO2014028473A1 (en) 2012-08-13 2014-02-20 Assia Chemical Industries Ltd. New salts of vilazodone and solid state forms thereof
WO2014049609A2 (en) * 2012-09-26 2014-04-03 Cadila Healthcare Limited Novel salts of vilazodone
WO2014049612A2 (en) * 2012-09-27 2014-04-03 Msn Laboratories Limited Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts
WO2014064715A2 (en) 2012-10-22 2014-05-01 Cadila Healthcare Limited Amorphous form of vilazodone hydrochloride and process for preparing thereof
CN103772368B (zh) * 2012-10-24 2016-08-03 杭州和泽医药科技有限公司 盐酸维拉佐酮iv晶型的制备方法及其应用
CN103772367B (zh) * 2012-10-24 2016-05-25 杭州和泽医药科技有限公司 盐酸维拉佐酮v晶型的制备方法及其应用
WO2014087428A1 (en) * 2012-12-07 2014-06-12 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of vilazodone and intermediates thereof
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法
WO2014178013A1 (en) 2013-04-30 2014-11-06 Ranbaxy Laboratories Limited Vilazodone impurities, process for their preparation, and their use as reference standards
WO2014199313A1 (en) 2013-06-12 2014-12-18 Lupin Limited Substantially pure vilazodone hydrochloride and a process thereof
EP2824104A1 (en) 2013-07-12 2015-01-14 Sandoz AG Process for the preparation of form III of Vilazodone hydrochloride
WO2015019256A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Pharmaceutical composition of vilazodone and processes of preparation thereof
WO2015019237A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Pharmaceutical composition of vilazodone
WO2015037010A1 (en) * 2013-09-13 2015-03-19 Symed Labs Limited Preparation of vilazodone hydrochloride crystalline form iv
CN104610238A (zh) * 2013-11-01 2015-05-13 北京英科博雅科技有限公司 一种维拉佐酮盐酸盐iii晶型新的制备方法
ITMI20131839A1 (it) * 2013-11-06 2015-05-07 Dipharma Francis Srl Co-cristallo di un farmaco antidepressivo
WO2015102019A2 (en) * 2013-12-30 2015-07-09 Msn Laboratories Private Limited Process for the preparation of polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-2-benzofuran carboxamide hydrochloride
CN105017233A (zh) * 2014-04-23 2015-11-04 天津药物研究院 一种盐酸维拉佐酮晶体、其制备方法、药物组合物和用途
CN105820157B (zh) * 2015-01-09 2021-05-25 石药集团中奇制药技术(石家庄)有限公司 一种盐酸维拉佐酮晶型及其制备方法
CN106518854A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 一种盐酸维拉佐酮晶型ⅳ的制备方法
TR201702103A2 (tr) 2017-02-13 2018-08-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vilazodon hi̇droklorürün tablet formlari
TR201702104A2 (tr) 2017-02-13 2018-08-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vi̇lazodon hi̇droklorür farmasöti̇k bi̇leşi̇mleri̇
CN107098889A (zh) * 2017-03-17 2017-08-29 北京万全德众医药生物技术有限公司 盐酸维拉佐酮药物晶型ⅲ的制备方法
CN109503560A (zh) * 2017-09-14 2019-03-22 北京万全德众医药生物技术有限公司 盐酸维拉佐酮ⅺ晶型的制备方法

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US5521241A (en) * 1994-08-30 1996-05-28 W. R. Grace & Co.-Conn. Styrene copolymer-based plastisol containing glycidyl methacrylate
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TW518218B (en) * 1999-05-27 2003-01-21 Merck Patent Gmbh Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
AU7591001A (en) 2000-07-13 2002-01-30 Hydrogen Energy America Llc Method and apparatus for controlled generation of hydrogen by dissociation of water
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Also Published As

Publication number Publication date
US20110294825A1 (en) 2011-12-01
CA2782494A1 (en) 2002-12-27
NZ530642A (en) 2006-09-29
CN101139345B (zh) 2012-07-11
CA2782521A1 (en) 2002-12-27
CA2782791A1 (en) 2002-12-27
US20110190317A1 (en) 2011-08-04
JP5714824B2 (ja) 2015-05-07
IL159426A (en) 2011-12-29
AU2002320822B2 (en) 2007-11-15
PL364576A1 (en) 2004-12-13
CA2782623A1 (en) 2002-12-27
US8927552B2 (en) 2015-01-06
CA2782868A1 (en) 2002-12-27
CA2782515A1 (en) 2002-12-27
UA76758C2 (uk) 2006-09-15
AR034595A1 (es) 2004-03-03
PL208708B1 (pl) 2011-05-31
SK288334B6 (sk) 2016-02-02
WO2002102794A3 (en) 2003-02-20
JP2010132687A (ja) 2010-06-17
CA2683040C (en) 2012-09-25
US20130102616A1 (en) 2013-04-25
CA2451028A1 (en) 2002-12-27
HUP0400236A3 (en) 2010-06-28
EE200400019A (et) 2004-04-15
US20210251986A1 (en) 2021-08-19
IL159426A0 (en) 2004-06-01
RU2004100824A (ru) 2005-06-20
CY1109447T1 (el) 2014-08-13
US7834020B2 (en) 2010-11-16
US20090023749A1 (en) 2009-01-22
ZA200400329B (en) 2005-06-29
CZ304471B6 (cs) 2014-05-21
SK162004A3 (en) 2004-04-06
US9624204B2 (en) 2017-04-18
US20110294824A1 (en) 2011-12-01
JP2010132688A (ja) 2010-06-17
MY151087A (en) 2014-04-15
JP5411734B2 (ja) 2014-02-12
US8236804B2 (en) 2012-08-07
HU229601B1 (en) 2014-02-28
US8193195B2 (en) 2012-06-05
ECSP044943A (es) 2004-02-26
US20100016332A1 (en) 2010-01-21
CN1516699A (zh) 2004-07-28
EP1397357B9 (en) 2009-11-18
CN101139345A (zh) 2008-03-12
BR0210495A (pt) 2004-08-17
CA2782615A1 (en) 2002-12-27
PT1397357E (pt) 2009-11-03
US20140275115A1 (en) 2014-09-18
US8673921B2 (en) 2014-03-18
US7981894B2 (en) 2011-07-19
CA2782857A1 (en) 2002-12-27
CA2451028C (en) 2012-07-17
CA2782761A1 (en) 2002-12-27
US20150080411A1 (en) 2015-03-19
CZ305220B6 (cs) 2015-06-17
US20140024658A1 (en) 2014-01-23
KR20040012922A (ko) 2004-02-11
CA2782519A1 (en) 2002-12-27
CA2782862A1 (en) 2002-12-27
EP1397357B1 (en) 2009-07-29
CA2782628A1 (en) 2002-12-27
EE05454B1 (et) 2011-08-15
US8921375B2 (en) 2014-12-30
JP4624667B2 (ja) 2011-02-02
RU2303598C2 (ru) 2007-07-27
MXPA03011723A (es) 2004-03-19
DE60233133D1 (de) 2009-09-10
CA2683040A1 (en) 2002-12-27
HK1066003A1 (en) 2005-03-11
US7381726B2 (en) 2008-06-03
US8318744B2 (en) 2012-11-27
US20110183994A1 (en) 2011-07-28
HUP0400236A2 (hu) 2004-06-28
CZ200426A3 (cs) 2004-04-14
ATE437871T1 (de) 2009-08-15
US20110312971A1 (en) 2011-12-22
WO2002102794A2 (en) 2002-12-27
EP1397357A2 (en) 2004-03-17
CN100384841C (zh) 2008-04-30
US20170182037A1 (en) 2017-06-29
DK1397357T3 (da) 2009-10-05
CA2782865A1 (en) 2002-12-27
US20040147528A1 (en) 2004-07-29
US20190343831A1 (en) 2019-11-14
ES2330314T3 (es) 2009-12-09
CA2782517A1 (en) 2002-12-27
SK288162B6 (sk) 2014-03-04
JP2004534803A (ja) 2004-11-18

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