BR0210495A - Formas polimórficas de cloridrato de 1-'4-(5-cianoindol-3-il) butil]-4-(2-carbamoilbenzofuran-5-il)-piperazina - Google Patents

Formas polimórficas de cloridrato de 1-'4-(5-cianoindol-3-il) butil]-4-(2-carbamoilbenzofuran-5-il)-piperazina

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Publication number
BR0210495A
BR0210495A BR0210495-4A BR0210495A BR0210495A BR 0210495 A BR0210495 A BR 0210495A BR 0210495 A BR0210495 A BR 0210495A BR 0210495 A BR0210495 A BR 0210495A
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BR
Brazil
Prior art keywords
disorders
cyanoindol
butyl
piperazine
treatment
Prior art date
Application number
BR0210495-4A
Other languages
English (en)
Inventor
Andreas Bathe
Bernd Helfert
Steffen Neuenfeld
Heike Kniel
Matthias Bartels
Susanne Rudolph
Henning Boettcher
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8177643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0210495(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0210495A publication Critical patent/BR0210495A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
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  • Pregnancy & Childbirth (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

"FORMAS POLIMóRFICAS DE CLORIDRATO DE 1-<39>4 -(5-CIANOINDOL-3-IL)BUTIL]-4-(2-CARBAMOILBENZOFURAN-5-I L)-PIPERAZINA". A invenção refere-se a novas modificações cristalinas do cloridrato de 1-[4-(5-cianoindol-3-il)butil]-4-(2-carbamoil-benzofuran-5-il)-piperazina , modificação cristalina do dicloridrato de 1-[4-(5-cianoindol-3-il)butil]-4(2-carbamoil-benzofuran-5-il)-piperazina e cloridrato de 1-[4-(5-cianoindol-3il)buti]-4-(2-carbamoil-benzofuran-5-il)-piperazina amorfo que são adequados, em particular, para a preparação de medicamentos sólidos para o tratamento ou prevenção de distúrbios depressivos, distúrbios da ansiedade, distúrbios bipolares, mania, demência, distúrbios relacionados com substâncias, disfunção sexual, distúrbios da fome, obesidade, fibromialgia, distúrbios do sono, distúrbios psiquiátricos, infarto cerebral, tensão, para a terapia de efeitos colaterais no tratamento de hipogonadismo, amenorréia secundária, síndrome pré-menstrual e lactação puerperal indesejada.
BR0210495-4A 2001-06-19 2002-06-05 Formas polimórficas de cloridrato de 1-'4-(5-cianoindol-3-il) butil]-4-(2-carbamoilbenzofuran-5-il)-piperazina BR0210495A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113647 2001-06-19
PCT/EP2002/006153 WO2002102794A2 (en) 2001-06-19 2002-06-05 Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride

Publications (1)

Publication Number Publication Date
BR0210495A true BR0210495A (pt) 2004-08-17

Family

ID=8177643

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210495-4A BR0210495A (pt) 2001-06-19 2002-06-05 Formas polimórficas de cloridrato de 1-'4-(5-cianoindol-3-il) butil]-4-(2-carbamoilbenzofuran-5-il)-piperazina

Country Status (30)

Country Link
US (15) US7381726B2 (pt)
EP (1) EP1397357B9 (pt)
JP (3) JP4624667B2 (pt)
KR (1) KR20040012922A (pt)
CN (2) CN101139345B (pt)
AR (1) AR034595A1 (pt)
AT (1) ATE437871T1 (pt)
AU (1) AU2002320822B2 (pt)
BR (1) BR0210495A (pt)
CA (16) CA2782628A1 (pt)
CY (1) CY1109447T1 (pt)
CZ (2) CZ305220B6 (pt)
DE (1) DE60233133D1 (pt)
DK (1) DK1397357T3 (pt)
EC (1) ECSP044943A (pt)
EE (1) EE05454B1 (pt)
ES (1) ES2330314T3 (pt)
HK (2) HK1066003A1 (pt)
HU (1) HU229601B1 (pt)
IL (2) IL159426A0 (pt)
MX (1) MXPA03011723A (pt)
MY (1) MY151087A (pt)
NZ (1) NZ530642A (pt)
PL (1) PL208708B1 (pt)
PT (1) PT1397357E (pt)
RU (1) RU2303598C2 (pt)
SK (2) SK288162B6 (pt)
UA (1) UA76758C2 (pt)
WO (1) WO2002102794A2 (pt)
ZA (1) ZA200400329B (pt)

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CN105017233A (zh) * 2014-04-23 2015-11-04 天津药物研究院 一种盐酸维拉佐酮晶体、其制备方法、药物组合物和用途
CN105820157B (zh) * 2015-01-09 2021-05-25 石药集团中奇制药技术（石家庄）有限公司 一种盐酸维拉佐酮晶型及其制备方法
CN106518854A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 一种盐酸维拉佐酮晶型ⅳ的制备方法
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TR201702104A2 (tr) 2017-02-13 2018-08-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vi̇lazodon hi̇droklorür farmasöti̇k bi̇leşi̇mleri̇
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CA2782868A1 (en) 2002-12-27
CA2683040C (en) 2012-09-25
SK288162B6 (sk) 2014-03-04
AU2002320822B2 (en) 2007-11-15
US20140275115A1 (en) 2014-09-18
JP5411734B2 (ja) 2014-02-12
JP2010132688A (ja) 2010-06-17
IL159426A0 (en) 2004-06-01
RU2303598C2 (ru) 2007-07-27
UA76758C2 (uk) 2006-09-15
WO2002102794A2 (en) 2002-12-27
US7981894B2 (en) 2011-07-19
EE05454B1 (et) 2011-08-15
US8921375B2 (en) 2014-12-30
EP1397357A2 (en) 2004-03-17
US7834020B2 (en) 2010-11-16
PL208708B1 (pl) 2011-05-31
SK288334B6 (sk) 2016-02-02
JP4624667B2 (ja) 2011-02-02
US8236804B2 (en) 2012-08-07
WO2002102794A3 (en) 2003-02-20
CN100384841C (zh) 2008-04-30
ES2330314T3 (es) 2009-12-09
US20190343831A1 (en) 2019-11-14
ATE437871T1 (de) 2009-08-15
JP5714824B2 (ja) 2015-05-07
EE200400019A (et) 2004-04-15
US9624204B2 (en) 2017-04-18
US20170182037A1 (en) 2017-06-29
US20100016332A1 (en) 2010-01-21
CA2782515A1 (en) 2002-12-27
JP2010132687A (ja) 2010-06-17
US7381726B2 (en) 2008-06-03
MXPA03011723A (es) 2004-03-19
CA2451028A1 (en) 2002-12-27
CZ200426A3 (cs) 2004-04-14
US20110294824A1 (en) 2011-12-01
PT1397357E (pt) 2009-11-03
US20110183994A1 (en) 2011-07-28
US20110294825A1 (en) 2011-12-01
US20110312971A1 (en) 2011-12-22
US8318744B2 (en) 2012-11-27
CA2782628A1 (en) 2002-12-27
CY1109447T1 (el) 2014-08-13
EP1397357B1 (en) 2009-07-29
US8673921B2 (en) 2014-03-18
NZ530642A (en) 2006-09-29
CA2782623A1 (en) 2002-12-27
CA2782761A1 (en) 2002-12-27
CA2782615A1 (en) 2002-12-27
CZ304471B6 (cs) 2014-05-21
MY151087A (en) 2014-04-15
ECSP044943A (es) 2004-02-26
US20110190317A1 (en) 2011-08-04
RU2004100824A (ru) 2005-06-20
SK162004A3 (en) 2004-04-06
JP2004534803A (ja) 2004-11-18
CA2782517A1 (en) 2002-12-27
CN1516699A (zh) 2004-07-28
US8193195B2 (en) 2012-06-05
CA2451028C (en) 2012-07-17
CA2782865A1 (en) 2002-12-27
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PL364576A1 (en) 2004-12-13
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US20140024658A1 (en) 2014-01-23
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CA2782857A1 (en) 2002-12-27
CN101139345B (zh) 2012-07-11
HK1066003A1 (en) 2005-03-11
CZ305220B6 (cs) 2015-06-17
CA2683040A1 (en) 2002-12-27
HUP0400236A3 (en) 2010-06-28
US20150080411A1 (en) 2015-03-19
US20040147528A1 (en) 2004-07-29
DE60233133D1 (de) 2009-09-10
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US20210251986A1 (en) 2021-08-19
CA2782494A1 (en) 2002-12-27
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ZA200400329B (en) 2005-06-29
HUP0400236A2 (hu) 2004-06-28
US20130102616A1 (en) 2013-04-25
HK1116165A1 (pt) 2008-12-19
KR20040012922A (ko) 2004-02-11
HU229601B1 (en) 2014-02-28
US8927552B2 (en) 2015-01-06
EP1397357B9 (en) 2009-11-18

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