AR034595A1 - Formas polimorficas del clorhidrato de 1-(4-(5-cianoindol-3-il)butil)-4-(2-carbamoilbenzofuran-5-il)piperazina. - Google Patents

Formas polimorficas del clorhidrato de 1-(4-(5-cianoindol-3-il)butil)-4-(2-carbamoilbenzofuran-5-il)piperazina.

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Publication number
AR034595A1
AR034595A1 ARP020102289A ARP020102289A AR034595A1 AR 034595 A1 AR034595 A1 AR 034595A1 AR P020102289 A ARP020102289 A AR P020102289A AR P020102289 A ARP020102289 A AR P020102289A AR 034595 A1 AR034595 A1 AR 034595A1
Authority
AR
Argentina
Prior art keywords
disorders
piperazine
cyanoindole
benzofuran
carbamoyl
Prior art date
Application number
ARP020102289A
Other languages
English (en)
Inventor
Bernd Helfert
Kniel Heike
Susanne Rudolph
Boettcher Henning Dr
Bathe Andreas Dr
Neuenfeld Steffen Dr
Bartels Matthias Dr
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8177643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR034595(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR034595A1 publication Critical patent/AR034595A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Nuevas modificaciones cristalinas del clorhidrato de 1-[4-(5-cianoindol-3-il)butil]-4-(2-carbamoil-benzofuran-5-il) -piperazina, modificación cristalina del diclorohidrato de 1-[4-(5-cianoindol-3-il)butil]-4-(2-carbamoil-benzofuran-5-il)-piperazina y al clorhidrato de 1-[4-(5-cianoindol-3-il)butil]-4-(2-carbamoil-benzofuran-5-il)-piperazina amorfo, que son apropiados en particular para la preparación de medicamentos sólidos para el tratamiento o prevención de trastornos depresivos, trastornos de ansiedad, trastornos bipolares, manía, demencia, trastornos relacionados con el abuso de sustancias químicas, disfunciones sexuales, trastornos de la alimentación, obesidad, fibromialgia, trastornos del sueno, trastornos psiquiátricos, infarto cerebral, tensión, para la terapia de los efectos colaterales en el tratamiento de la hipertensión, trastornos cerebrales, dolor crónico, acromegalia, hipogonadismo, amenorrea secundaria, síndrome premenstrual y lactación puerperal no deseada.
ARP020102289A 2001-06-19 2002-06-19 Formas polimorficas del clorhidrato de 1-(4-(5-cianoindol-3-il)butil)-4-(2-carbamoilbenzofuran-5-il)piperazina. AR034595A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01113647 2001-06-19

Publications (1)

Publication Number Publication Date
AR034595A1 true AR034595A1 (es) 2004-03-03

Family

ID=8177643

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102289A AR034595A1 (es) 2001-06-19 2002-06-19 Formas polimorficas del clorhidrato de 1-(4-(5-cianoindol-3-il)butil)-4-(2-carbamoilbenzofuran-5-il)piperazina.

Country Status (30)

Country Link
US (15) US7381726B2 (es)
EP (1) EP1397357B9 (es)
JP (3) JP4624667B2 (es)
KR (1) KR20040012922A (es)
CN (2) CN101139345B (es)
AR (1) AR034595A1 (es)
AT (1) ATE437871T1 (es)
AU (1) AU2002320822B2 (es)
BR (1) BR0210495A (es)
CA (16) CA2782628A1 (es)
CY (1) CY1109447T1 (es)
CZ (2) CZ304471B6 (es)
DE (1) DE60233133D1 (es)
DK (1) DK1397357T3 (es)
EC (1) ECSP044943A (es)
EE (1) EE05454B1 (es)
ES (1) ES2330314T3 (es)
HK (2) HK1066003A1 (es)
HU (1) HU229601B1 (es)
IL (2) IL159426A0 (es)
MX (1) MXPA03011723A (es)
MY (1) MY151087A (es)
NZ (1) NZ530642A (es)
PL (1) PL208708B1 (es)
PT (1) PT1397357E (es)
RU (1) RU2303598C2 (es)
SK (2) SK288162B6 (es)
UA (1) UA76758C2 (es)
WO (1) WO2002102794A2 (es)
ZA (1) ZA200400329B (es)

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CN105820157B (zh) * 2015-01-09 2021-05-25 石药集团中奇制药技术（石家庄）有限公司 一种盐酸维拉佐酮晶型及其制备方法
CN106518854A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 一种盐酸维拉佐酮晶型ⅳ的制备方法
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TR201702104A2 (tr) 2017-02-13 2018-08-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vi̇lazodon hi̇droklorür farmasöti̇k bi̇leşi̇mleri̇
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CA2782791A1 (en) 2002-12-27
UA76758C2 (uk) 2006-09-15
SK162004A3 (en) 2004-04-06
US20110294824A1 (en) 2011-12-01
CN101139345A (zh) 2008-03-12
DE60233133D1 (de) 2009-09-10
US20140275115A1 (en) 2014-09-18
PL208708B1 (pl) 2011-05-31
CA2782615A1 (en) 2002-12-27
CA2782628A1 (en) 2002-12-27
JP2010132688A (ja) 2010-06-17
ECSP044943A (es) 2004-02-26
SK288334B6 (sk) 2016-02-02
JP2010132687A (ja) 2010-06-17
US20110294825A1 (en) 2011-12-01
ATE437871T1 (de) 2009-08-15
US20150080411A1 (en) 2015-03-19
US20040147528A1 (en) 2004-07-29
US20210251986A1 (en) 2021-08-19
US8236804B2 (en) 2012-08-07
CA2782857A1 (en) 2002-12-27
IL159426A (en) 2011-12-29
MY151087A (en) 2014-04-15
CY1109447T1 (el) 2014-08-13
US8921375B2 (en) 2014-12-30
HUP0400236A2 (hu) 2004-06-28
CZ304471B6 (cs) 2014-05-21
PL364576A1 (en) 2004-12-13
CA2782515A1 (en) 2002-12-27
RU2004100824A (ru) 2005-06-20
CN1516699A (zh) 2004-07-28
CA2782519A1 (en) 2002-12-27
CA2782761A1 (en) 2002-12-27
CZ200426A3 (cs) 2004-04-14
US20100016332A1 (en) 2010-01-21
US7981894B2 (en) 2011-07-19
US7381726B2 (en) 2008-06-03
HU229601B1 (en) 2014-02-28
US8673921B2 (en) 2014-03-18
HK1066003A1 (en) 2005-03-11
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EE200400019A (et) 2004-04-15
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CN101139345B (zh) 2012-07-11
WO2002102794A3 (en) 2003-02-20
CA2683040A1 (en) 2002-12-27
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EP1397357A2 (en) 2004-03-17
NZ530642A (en) 2006-09-29
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