HK1089444A1 - Dihydropteridinones, method for the production and use thereof in the form of drugs - Google Patents

Dihydropteridinones, method for the production and use thereof in the form of drugs

Info

Publication number
HK1089444A1
HK1089444A1 HK06109960.1A HK06109960A HK1089444A1 HK 1089444 A1 HK1089444 A1 HK 1089444A1 HK 06109960 A HK06109960 A HK 06109960A HK 1089444 A1 HK1089444 A1 HK 1089444A1
Authority
HK
Hong Kong
Prior art keywords
dihydropteridinones
drugs
production
isomers
rests
Prior art date
Application number
HK06109960.1A
Other languages
English (en)
Inventor
Matthias Hoffmann
Matthias Grauert
Trixi Brandl
Steffen Breitfelder
Christian Eickmeier
Martin Steegmaier
Gisela Schnapp
Anke Baum
Jens Juergen Quant
Flavio Solca
Florian Colbatzky
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of HK1089444A1 publication Critical patent/HK1089444A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06109960.1A 2003-02-26 2006-09-07 Dihydropteridinones, method for the production and use thereof in the form of drugs HK1089444A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2003/001935 WO2004076454A1 (fr) 2003-02-26 2003-02-26 Dihydropteridinones, prodede de production et utilisation de ces dernieres comme medicaments

Publications (1)

Publication Number Publication Date
HK1089444A1 true HK1089444A1 (en) 2006-12-01

Family

ID=32921552

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109960.1A HK1089444A1 (en) 2003-02-26 2006-09-07 Dihydropteridinones, method for the production and use thereof in the form of drugs

Country Status (27)

Country Link
EP (1) EP1599478B1 (fr)
JP (1) JP3876265B2 (fr)
KR (1) KR100983462B1 (fr)
CN (2) CN100537570C (fr)
AT (1) ATE361924T1 (fr)
AU (1) AU2003215591B2 (fr)
BR (1) BR0318145A (fr)
CA (1) CA2517020C (fr)
CY (1) CY1106752T1 (fr)
DE (1) DE50307267D1 (fr)
DK (1) DK1599478T3 (fr)
EA (1) EA008778B1 (fr)
ES (1) ES2287583T3 (fr)
HK (1) HK1089444A1 (fr)
HR (1) HRP20050735B1 (fr)
IL (1) IL170419A (fr)
ME (1) ME00376B (fr)
MX (1) MXPA05009068A (fr)
NO (1) NO332538B1 (fr)
NZ (1) NZ542498A (fr)
PL (1) PL226417B1 (fr)
PT (1) PT1599478E (fr)
RS (1) RS52386B (fr)
SI (1) SI1599478T1 (fr)
TW (1) TWI313600B (fr)
UA (1) UA80743C2 (fr)
WO (1) WO2004076454A1 (fr)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE102004029784A1 (de) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060035903A1 (en) 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US7728134B2 (en) * 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US7759485B2 (en) * 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
EP1632493A1 (fr) 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dérivés de dihydropteridine, méthodes de préparation et utilisation en tant que médicament
EP1630163A1 (fr) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinones, procédés de préparation et leur utilisation en tant que médicaments
EP1784406A1 (fr) * 2004-08-27 2007-05-16 Boehringer Ingelheim International GmbH Dihydrpteridinones, procédés de préparation et leur utilisation en tant que médicaments
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
DE102004058337A1 (de) 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2009515852A (ja) 2005-11-11 2009-04-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｅｇｆｒ／ｈｅｒ２インヒビターを含む癌の組み合わせ治療
AU2012256410B2 (en) * 2006-02-08 2016-04-28 Boehringer Ingelheim International Gmbh Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
WO2007095188A2 (fr) 2006-02-14 2007-08-23 Vertex Pharmaceuticals Incorporated Dihydrodiazepines servant d'inhibiteurs des proteines kinases
US20090312336A1 (en) * 2006-05-19 2009-12-17 Astrazeneca Ab Dihydropteridine compounds as anti proliferative agents
TW200808325A (en) 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds
MX2009003793A (es) 2006-10-09 2009-12-14 Takeda Pharmaceutical Inhibidores de cinasa.
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
ES2631003T3 (es) 2006-10-19 2017-08-25 Signal Pharmaceuticals, Llc Compuestos heteroarilo, sus composiciones y métodos de tratamiento con ellos
ATE497961T1 (de) 2006-12-14 2011-02-15 Vertex Pharma Als proteinkinaseinhibitoren geeignete verbindungen
CN101678022A (zh) 2006-12-21 2010-03-24 弗特克斯药品有限公司 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物
EP1953163A1 (fr) * 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Dérivés de Pteridinone comme inhibiteurs des Kinases PI3
EP2185559A1 (fr) 2007-08-03 2010-05-19 Boehringer Ingelheim International GmbH Forme cristalline d'un dérivé de dihydroptéridione
US8563542B2 (en) 2007-09-28 2013-10-22 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
WO2009067547A1 (fr) * 2007-11-19 2009-05-28 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase de type polo
JP5400791B2 (ja) * 2007-12-04 2014-01-29 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 置換ジヒドロプテリジン−６−オン誘導体、その製造方法及びキナーゼ阻害剤としてのその使用
EP2100894A1 (fr) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase)
EP2112152A1 (fr) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones comme inhibiteurs Plk
GB0807452D0 (en) * 2008-04-24 2008-05-28 Chroma Therapeutics Ltd PLK inhibitors
WO2010008459A1 (fr) * 2008-06-23 2010-01-21 Vertex Pharmaceuticals Incorporated Inhibiteurs de protéine kinase
US9492417B2 (en) 2008-08-21 2016-11-15 The Johns Hopkins University Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
WO2010025073A1 (fr) * 2008-08-28 2010-03-04 Takeda Pharmaceutical Company Limited Dihydroimidazo [ 1, 5-f] ptéridines en tant qu'inhibiteurs de kinases de type polo (plk)
US8110578B2 (en) 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
PT2364314E (pt) 2008-12-09 2014-06-09 Gilead Sciences Inc Moduladores de recetores toll-like
US9266890B2 (en) * 2009-01-06 2016-02-23 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
ES2604667T3 (es) 2009-06-17 2017-03-08 Vertex Pharmaceuticals Incorporated Inhibidores de la replicación de virus de influenza
NO2477987T3 (fr) 2009-09-14 2018-06-09
CN102020643A (zh) * 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
MX2012003476A (es) 2009-09-25 2012-06-19 Vertex Pharma Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa.
JP2013505927A (ja) 2009-09-25 2013-02-21 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼ阻害剤として有用なピリミジン誘導体の調製方法
EP2493472B1 (fr) 2009-10-26 2016-12-07 Signal Pharmaceuticals, LLC Procédés de synthèse et de purification de composés hétéroaryles
EP2325185A1 (fr) 2009-10-28 2011-05-25 GPC Biotech AG Inhibiteur de Plk
MX2012007273A (es) * 2009-12-23 2012-12-17 Elan Pharm Inc Pteridinonas como inhibidores de la quinasa tipo polo.
US20120329803A1 (en) * 2010-02-17 2012-12-27 Boehringer Ingelheim International Gmbh Dihydropteridinones, method for production and use thereof
CN102190669A (zh) * 2010-03-19 2011-09-21 江苏恒瑞医药股份有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
WO2012027495A1 (fr) 2010-08-27 2012-03-01 University Of The Pacific Analogues de pipérazinylpyrimidine en tant qu'inhibiteurs de protéine kinase
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
KR20140014110A (ko) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
US20130131069A1 (en) 2011-05-13 2013-05-23 Boehringer Ingelheim International Gmbh Method for treatment of solid malignancies including advanced or metastatic solid malignancies
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MY183661A (en) 2011-10-19 2021-03-05 Signal Pharm Llc Treatment of cancer with tor kinase inhibitors
US9351974B2 (en) 2011-11-10 2016-05-31 OSI Pharmaceuticals, LLC Substituted pteridinones for the treatment of cancer
MY169749A (en) 2011-12-02 2019-05-15 Signal Pharm Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
JP5807750B2 (ja) * 2012-01-05 2015-11-10 トヨタ自動車株式会社 締付装置及び締付方法
US9006226B2 (en) 2012-02-23 2015-04-14 Boehringer Ingelheim International Gmbh Dihydropteridinones I
US8865716B2 (en) 2012-02-23 2014-10-21 Boehringer Ingelheim International Gmbh Dihydropteridinones II
NZ628410A (en) 2012-02-24 2016-03-31 Signal Pharm Llc Methods for treating non-small cell lung cancer using tor kinase inhibitor combination therapy
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
US20140154304A1 (en) 2012-11-30 2014-06-05 Boehringer Ingelheim International Gmbh Combination therapy with volasertib
NZ630467A (en) 2013-01-16 2017-02-24 Signal Pharm Llc Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
EP2958919B1 (fr) * 2013-02-21 2019-05-22 Boehringer Ingelheim International GmbH Dihydroptéridinones i
EP2958918B1 (fr) 2013-02-21 2016-12-07 Boehringer Ingelheim International GmbH Dihydroptéridinones ii
CA2908957C (fr) 2013-04-17 2021-05-18 Signal Pharmaceuticals, Llc Polytherapie comportant un compose dihydropyrazino-pyrazine et un antagoniste d'un recepteur des androgenes pour le traitement du cancer de la prostate
WO2014172423A1 (fr) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Formulations pharmaceutiques, procédés, formes solides et méthodes d'utilisation associés à la 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
TWI631949B (zh) 2013-04-17 2018-08-11 標誌製藥公司 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法
EP4218763A1 (fr) 2013-04-17 2023-08-02 Signal Pharmaceuticals, LLC 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one pour le traitement du glioblastome multiforme
MX368286B (es) 2013-04-17 2019-09-27 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.
EP2986319A1 (fr) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Thérapie combinée comprenant un inhibiteur de la kinase tor et du n-(3-(5-fluoro-2-(4-(2-méthoxyéthoxy)phénylamino)pyrimidin-4-ylamino)phényl)acrylamide pour le traitement d'un cancer
WO2014172426A1 (fr) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Traitement du cancer par des dihydropyrazino-pyrazines
CN107474051B (zh) 2013-05-29 2020-10-30 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
EP3024464A1 (fr) 2013-07-26 2016-06-01 Boehringer Ingelheim International GmbH Traitement du syndrome myélodysplasique
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
WO2015117087A1 (fr) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Utilisations des dérivés de diazépane
KR20160111520A (ko) * 2014-01-31 2016-09-26 다나-파버 캔서 인스티튜트 인크. 디히드로프테리디논 유도체 및 그의 용도
EP3131551A4 (fr) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC Formes solides comprenant 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one, et co-formateur, compositions et procédés d'utilisation de ces dernières
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US9737535B2 (en) 2014-04-16 2017-08-22 Signal Pharmaceuticals, Llc Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
WO2015160882A1 (fr) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Formes solides comprenant de la 7-(6- (2-hydroxypropan-2-yl) pyridin-3-yl)-1-(trans)-4-méthoxycyclohexyl)-3, 4-dihydropyrazino[2,3-b] pyrazin-2(1h)-one, et un co-formeur, leurs compositions et leurs procédés d'utilisation
CN104003989B (zh) * 2014-05-26 2015-11-11 苏州明锐医药科技有限公司 伏拉塞替及其中间体的制备方法
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
CA2955009A1 (fr) 2014-07-14 2016-01-21 Signal Pharmaceuticals, Llc Methodes de traitement d'un cancer a l'aide de composes de pyrrolopyrimidine substitues, compositions de ceux-ci
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
MX2017001756A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de diazepano y sus usos.
MX2017001757A (es) * 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
CA2960436C (fr) 2014-09-16 2021-01-05 Gilead Sciences, Inc. Formes solides d'un modulateur de recepteurs de type toll
ES2845205T3 (es) 2014-09-16 2021-07-26 Gilead Sciences Inc Métodos para preparar moduladores de receptores tipo Toll
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
WO2016183120A1 (fr) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibiteurs de la réplication des virus de la grippe
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
UA123946C2 (uk) 2015-09-11 2021-06-30 Дана-Фарбер Кенсер Інстітьют, Інк. Ацетамідтієнотриазолодіазепіни й шляхи їх застосування
US10751306B2 (en) 2015-11-06 2020-08-25 The Johns Hopkins University Methods of treating liver fibrosis by administering 3-bromopyruvate
WO2017091673A2 (fr) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Inhibiteurs de bromodomaines bivalents et leurs utilisations
CN105801582A (zh) * 2016-04-12 2016-07-27 合肥工业大学 一类新型二氢蝶啶酮类衍生物及其制备方法和在医药上的用途
DE102017005091A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one
DE102017005089A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one
CN106977584B (zh) * 2017-04-19 2019-12-06 吉林大学 靶向泛素化降解plk1和brd4蛋白的化合物及其应用
BR112019027402A2 (pt) 2017-06-22 2020-07-07 Celgene Corporation tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b
WO2019126696A1 (fr) * 2017-12-22 2019-06-27 Dana-Farber Cancer Institute, Inc. Inhibiteurs de nek et procédés d'utilisation
EP3743067A1 (fr) 2018-01-25 2020-12-02 Boehringer Ingelheim International GmbH Traitement combiné de leucémie myéloïde aiguë
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN110343109B (zh) * 2019-08-21 2021-11-23 郑州大学 一种二氢蝶啶酮-磺酰胺类衍生物及其药学上可接受的盐、其制备方法及其应用
WO2023196943A1 (fr) 2022-04-08 2023-10-12 Inhibrx, Inc. Polythérapie comprenant un agoniste de dr5 et un inhibiteur de plk1 ou un inhibiteur de cdk

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU777468B2 (en) * 1999-09-15 2004-10-21 Warner-Lambert Company Pteridinones as kinase inhibitors
WO2002076985A1 (fr) * 2001-03-23 2002-10-03 Smithkline Beecham Corporation Composes utiles en tant qu'inhibiteurs de kinases pour le traitement des maladies hyperproliferatives
HUP0401293A3 (en) * 2001-09-04 2008-03-28 Boehringer Ingelheim Pharma Novel dihydropteridinones, method for producing the same and the use thereof as medicaments

Also Published As

Publication number Publication date
TWI313600B (en) 2009-08-21
KR20050113198A (ko) 2005-12-01
CN100537570C (zh) 2009-09-09
DK1599478T3 (da) 2007-09-17
CN101200457A (zh) 2008-06-18
NO332538B1 (no) 2012-10-15
ATE361924T1 (de) 2007-06-15
JP3876265B2 (ja) 2007-01-31
MXPA05009068A (es) 2005-10-19
NO20054414L (no) 2005-09-23
AU2003215591A1 (en) 2004-09-17
ES2287583T3 (es) 2007-12-16
NZ542498A (en) 2009-01-31
JP2006514667A (ja) 2006-05-11
RS52386B (en) 2013-02-28
RS20050648A (en) 2007-11-15
PT1599478E (pt) 2007-05-31
HRP20050735B1 (hr) 2013-08-31
SI1599478T1 (sl) 2007-10-31
EA008778B1 (ru) 2007-08-31
TW200417369A (en) 2004-09-16
PL226417B1 (pl) 2017-07-31
CN1745081A (zh) 2006-03-08
AU2003215591B2 (en) 2010-06-17
EP1599478B1 (fr) 2007-05-09
CA2517020C (fr) 2012-06-26
CA2517020A1 (fr) 2004-09-10
KR100983462B1 (ko) 2010-09-27
PL378168A1 (pl) 2006-03-06
EA200501222A1 (ru) 2006-04-28
DE50307267D1 (de) 2007-06-21
EP1599478A1 (fr) 2005-11-30
BR0318145A (pt) 2006-02-21
MEP58808A (en) 2011-05-10
UA80743C2 (en) 2007-10-25
ME00376B (me) 2011-10-10
CY1106752T1 (el) 2012-05-23
WO2004076454A1 (fr) 2004-09-10
IL170419A (en) 2013-11-28
HRP20050735A2 (en) 2006-07-31

Similar Documents

Publication Publication Date Title
HK1089444A1 (en) Dihydropteridinones, method for the production and use thereof in the form of drugs
MXPA04002067A (es) Nuevas dihidropteridinonas, procedimientos para su preparacion y su uso como medicamento.
SG158848A1 (en) Method for producing annelated piperazin-2-one derivatives and intermediates of said method
TW200621779A (en) Process for the manufacture of dihydropteridinones
WO2005123736A8 (fr) Nouveaux 2-benzylaminodihydropteridinones, procede de production associe et leur utilisation en tant que medicaments
MXPA05012362A (es) Yodopirazolilcarboxanilidas.
ZA200604719B (en) DPP-IV inhibitors
MX2007002470A (es) Fenilaminotiazoles sustituidos y su uso.
PL1758852T3 (pl) Podstawione związki cyklopentenu
MY141853A (en) 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
GEP20084361B (en) Piperidinylcarbonyl-pyrro-lidines and their use as melanocortin agonists
IL183636A0 (en) Quinoline derivative, use and production thereof, and drug containing the same
WO2003106450A8 (fr) Phenylaminopyrimidines et leur utilisation en tant qu'inhibiteurs de la rho-kinase
MXPA05011962A (es) Oxiarenos substituidos.
PL1670778T3 (pl) Przegrupowane pentanole, sposób ich wytwarzania i ich zastosowanie jako środków hamujących zapalenia
UA94080C2 (ru) Ациклически-замещенные производные фуропиримидина и их применение для лечения сердечно-сосудистых заболеваний
MXPA03009548A (es) Arilsulfonamidas como agentes antivirales.
TW200621703A (en) Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
IL165558A0 (en) N-benzoylureidocinnamate derivatives method for production and use thereof
MXPA06004308A (es) Isopentilcarboxanilidas para la lucha contra los microorganismos indeseables.
WO2004024681A3 (fr) NOUVEAUX COMPOSES COMPRENANT UN GROUPEMENT THIOCARBONYLSULFANYLE UTILES POUR LA SYNTHESE DE COMPOSES α-PERFLUOROALKYLAMINES PAR VOIE RADICALAIRE
MXPA04000623A (es) Derivados de tetrahidropiridazina y su uso como pesticidas.
TW200407314A (en) Preparation of 4, 6-dichloro-5-fluoropyrimidine
RS20060049A (en) Novel n-substituted indolyl-3-glycoxylic acid amides, use thereof as a medicament and method for the production thereof
MXPA03003466A (es) Derivados de piranosido.

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180226